Published in Rev Physiol Biochem Pharmacol on January 01, 1983
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Starvation and diabetes increase the amount of pyruvate dehydrogenase kinase isoenzyme 4 in rat heart. Biochem J (1998) 2.11
Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony. J Clin Invest (2006) 2.09
Molecular and phylogenetic characterization of pyruvate and 2-ketoisovalerate ferredoxin oxidoreductases from Pyrococcus furiosus and pyruvate ferredoxin oxidoreductase from Thermotoga maritima. J Bacteriol (1996) 1.83
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Pyruvate ferredoxin oxidoreductase from the hyperthermophilic archaeon, Pyrococcus furiosus, functions as a CoA-dependent pyruvate decarboxylase. Proc Natl Acad Sci U S A (1997) 1.44
Kinase activator protein mediates longer-term effects of starvation on activity of pyruvate dehydrogenase kinase in rat liver mitochondria. Biochem J (1986) 1.38
Effect of the antilipolytic nicotinic acid analogue acipimox on whole-body and skeletal muscle glucose metabolism in patients with non-insulin-dependent diabetes mellitus. J Clin Invest (1991) 1.36
Evidence for the bacterial origin of genes encoding fermentation enzymes of the amitochondriate protozoan parasite Entamoeba histolytica. J Bacteriol (1997) 1.32
Characterization of 2-ketoisovalerate ferredoxin oxidoreductase, a new and reversible coenzyme A-dependent enzyme involved in peptide fermentation by hyperthermophilic archaea. J Bacteriol (1996) 1.31
Sensitivity of pyruvate dehydrogenase phosphate phosphatase to magnesium ions. Similar effects of spermine and insulin. Biochem J (1986) 1.30
The 2-oxoacid dehydrogenase complexes in mitochondria can produce superoxide/hydrogen peroxide at much higher rates than complex I. J Biol Chem (2014) 1.29
Characterization of a fourth type of 2-keto acid-oxidizing enzyme from a hyperthermophilic archaeon: 2-ketoglutarate ferredoxin oxidoreductase from Thermococcus litoralis. J Bacteriol (1996) 1.29
Modulation of pyruvate dehydrogenase kinase activity in cultured hepatocytes by glucagon and n-octanoate. Biochem J (1986) 1.28
Low immunogenicity of the common lipoamide dehydrogenase subunit (E3) of mammalian pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multienzyme complexes. Biochem J (1985) 1.20
Pyruvate dehydrogenase activity in Streptococcus mutans. Infect Immun (1985) 1.15
The mechanism of the hormonal activation of respiration in isolated hepatocytes and its importance in the regulation of gluconeogenesis. Biochem J (1986) 1.14
Insulin reverses effects of starvation on the activity of pyruvate dehydrogenase kinase in cultured hepatocytes. Biochem J (1987) 1.13
Fuel selection and carbon flux during the starved-to-fed transition. Biochem J (1989) 1.10
Role of Ca2+ ions in the regulation of intramitochondrial metabolism in rat epididymal adipose tissue. Evidence against a role for Ca2+ in the activation of pyruvate dehydrogenase by insulin. Biochem J (1984) 1.06
Oxygen uptake on-kinetics in dog gastrocnemius in situ following activation of pyruvate dehydrogenase by dichloroacetate. J Physiol (2002) 1.06
Effect of starvation and exercise on actual and total activity of the branched-chain 2-oxo acid dehydrogenase complex in rat tissues. Biochem J (1984) 1.03
Persistence of the effect of insulin on pyruvate dehydrogenase activity in rat white and brown adipose tissue during the preparation and subsequent incubation of mitochondria. Biochem J (1984) 1.01
Blunted Akt/FOXO signalling and activation of genes controlling atrophy and fuel use in statin myopathy. J Physiol (2008) 1.01
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Evidence for the compartmentation of pyruvate metabolism in perfused rat skeletal muscle. Biochem J (1983) 1.01
Regulation of muscle pyruvate dehydrogenase complex in insulin resistance: effects of exercise and dichloroacetate. Diabetes Metab J (2013) 0.99
Effects of aerobic training on pyruvate dehydrogenase and pyruvate dehydrogenase kinase in human skeletal muscle. J Physiol (2004) 0.99
Dependence of cardiac mitochondrial pyruvate dehydrogenase activity on intramitochondrial free Ca2+ concentration. Biochem J (1988) 0.98
Effects of Ca2+ and Mg2+ on the activity of pyruvate dehydrogenase phosphate phosphatase within toluene-permeabilized mitochondria. Biochem J (1987) 0.98
Relation between cytosolic free Ca2+ concentration and the control of pyruvate dehydrogenase in isolated cardiac myocytes. Biochem J (1987) 0.93
Activation of rat liver branched-chain 2-oxo acid dehydrogenase in vivo by glucagon and adrenaline. Biochem J (1985) 0.93
Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents. J Physiol (2012) 0.91
Concentration of free oxaloacetate in the mitochondrial compartment of isolated liver cells. Biochem J (1984) 0.91
Temporal changes in the involvement of pyruvate dehydrogenase complex in muscle lactate accumulation during lipopolysaccharide infusion in rats. J Physiol (2008) 0.90
Effects of prior contractions on muscle microvascular oxygen pressure at onset of subsequent contractions. J Physiol (2002) 0.90
Adrenaline increases skeletal muscle glycogenolysis, pyruvate dehydrogenase activation and carbohydrate oxidation during moderate exercise in humans. J Physiol (2001) 0.89
Regulation of renal and hepatic pyruvate dehydrogenase complex on carbohydrate re-feeding after starvation. Possible mechanisms and a regulatory role for thyroid hormone. Biochem J (1987) 0.87
Muscle pyruvate availability can limit the flux, but not activation, of the pyruvate dehydrogenase complex during submaximal exercise in humans. J Physiol (2004) 0.84
The glucagon-induced activation of pyruvate dehydrogenase in hepatocytes is diminished by 4 beta-phorbol 12-myristate 13-acetate. A role for cytoplasmic Ca2+ in dehydrogenase regulation. Biochem J (1987) 0.84
Modulation of rat skeletal muscle branched-chain alpha-keto acid dehydrogenase in vivo. Effects of dietary protein and meal consumption. J Clin Invest (1987) 0.83
Inactivation of pyruvate dehydrogenase complex in heart muscle mitochondria of gold-thioglucose-induced obese mice is not due to a stable increase in activity of pyruvate dehydrogenase kinase. Biochem J (1988) 0.83
Insulin regulation of the activity and phosphorylation of branched-chain 2-oxo acid dehydrogenase in adipose tissue. Biochem J (1989) 0.82
Metabolic inertia in contracting skeletal muscle: a novel approach for pharmacological intervention in peripheral vascular disease. Br J Clin Pharmacol (2004) 0.82
Insulin stimulation of pyruvate dehydrogenase in adipocytes involves two distinct signalling pathways. Biochem J (2003) 0.80
Pretranslational regulation of pyruvate dehydrogenase complex subunits in white adipose tissue during the suckling-weaning transition in the rat. Biochem J (1995) 0.79
Formation of N-hydroxy-N-arylacetamides from nitroso aromatic compounds by the mammalian pyruvate dehydrogenase complex. Biochem J (1993) 0.79
The temporal relationship between glycogen phosphorylase and activation of the pyruvate dehydrogenase complex during adrenaline infusion in resting canine skeletal muscle. J Physiol (2002) 0.78
Influence of oleate oxidation on pyruvate production and utilization in hepatocytes isolated from fed rats. Effect of 2-[5-(4-chlorophenyl)pentyl]oxiran-2-carboxylate. Biochem J (1984) 0.78
Graded Maximal Exercise Testing to Assess Mouse Cardio-Metabolic Phenotypes. PLoS One (2016) 0.77
Regulation of pyruvate dehydrogenase kinase activity from pig kidney cortex. Biochem J (1992) 0.77
Crystal structures of archaeal 2-oxoacid:ferredoxin oxidoreductases from Sulfolobus tokodaii. Sci Rep (2016) 0.75
Influence of insulin and glucose on pyruvate catabolism in perfused rat hindlimbs. Biochem J (1985) 0.75
The gene for the alpha polypeptide of pyruvate dehydrogenase is X-linked in humans. Am J Hum Genet (1990) 0.75
The expression of genes involved in jejunal lipogenesis and lipoprotein synthesis is altered in morbidly obese subjects with insulin resistance. Lab Invest (2015) 0.75
Molecular effects of sulphonylurea agents in circulating lymphocytes of patients with non-insulin-dependent diabetes mellitus. Br J Clin Pharmacol (1998) 0.75
The effect of an amino acid beverage on glucose response and glycogen replenishment after strenuous exercise. Eur J Appl Physiol (2015) 0.75
Effect of glucagon on metabolite compartmentation in isolated rat liver cells during gluconeogenesis from lactate. Biochem J (1977) 2.34
Active and inactive forms of pyruvate dehydrogenase in rat liver. Effect of starvation and refeeding and of insulin treatment on pyruvate-dehydrogenase interconversion. Eur J Biochem (1972) 1.82
Phosphorylation state of cytosolic and mitochondrial adenine nucleotides and of pyruvate dehydrogenase in isolated rat liver cells. Biochem J (1976) 1.77
Regulation of pyruvate-dehydrogenase interconversion in rat-liver mitochondria as related to the phosphorylation state of intramitochondrial adenine nucleotides. Eur J Biochem (1974) 1.61
Interconversion of pyruvate dehydrogenase in the isolated perfused rat liver. Eur J Biochem (1973) 1.56
Purification and characterization of pyruvate-dehydrogenase phosphatase from pig-heart muscle. Eur J Biochem (1972) 1.43
Distribution of metabolites between the cytosolic and mitochondrial compartments of hepatocytes isolated from fed rats. Hoppe Seylers Z Physiol Chem (1978) 1.39
Active and inactive forms of pyruvatedehydrogenase in skeletal muscle as related to the metabolic and functional state of the muscle cell. FEBS Lett (1975) 1.28
Regulation of the mammalian pyruvate dehydrogenase complex by covalent modification. Symp Soc Exp Biol (1973) 1.24
Neurospora crassa pyruvate dehydrogenase: interconversion by phosphorylation and dephosphorylation. FEBS Lett (1972) 1.22
Subcellular distribution of key metabolites in isolated liver cells from fasted rats. FEBS Lett (1976) 1.17
On the mechanism of irreversible pyruvate dehydrogenase inactivation in liver mitochondrial extracts. FEBS Lett (1975) 1.10
Increased glycosylation of serum albumin in diabetes mellitus. Diabetes (1980) 1.09
Role of free oxaloacetate in ketogenesis. Derivation from the direct measurement of mitochondrial [3-hydroxybutyrate]/[acetoacetate] ratio in hepatocytes. Eur J Biochem (1982) 1.08
Glycosylation of serum albumin: elevated glycosyl-albumin in diabetic patients. FEBS Lett (1979) 1.08
Insulin activates phospholipase C in fat cells: similarity with the activation of pyruvate dehydrogenase. Mol Cell Endocrinol (1984) 1.08
Sensitive assay of carnitine palmitoyl transferase activity in tissue homogenates with a modified spectrophotometric method for enzymatic carnitine determination. Clin Chim Acta (1983) 1.08
Evidence that the insulin receptor-associated protein kinase acts as a phosphatidylinositol kinase. FEBS Lett (1984) 1.07
Regulation of pyruvate dehydrogenase interconversion in isolated hepatocytes by the mitochondrial ATP/ADP ratio. FEBS Lett (1975) 1.06
epsilon-Amino-lysine-bound glucose in human tissues obtained at autopsy. Increase in diabetes mellitus. Diabetes (1982) 1.05
Comparative studies on the influence of hormones on metabolite compartmentation in isolated liver cells during gluconeogenesis from lactate. Biochem Soc Trans (1978) 1.04
Evidence that glucagon stabilizes rather than activates mitochondrial functions in rat liver. Hoppe Seylers Z Physiol Chem (1981) 1.02
Metabolism of isolated kidney tubules. Regulation of pyruvate dehydrogenase by metabolic substrates. Eur J Biochem (1974) 1.00
Phosphorylation--dephosphorylation of purified insulin receptor from human placenta. Effect of insulin. FEBS Lett (1982) 0.99
Evaluation of the Bradford method for protein determination in body fluids. J Clin Chem Clin Biochem (1978) 0.97
Glucagon-induced stimulation of 2-oxoglutarate metabolism in mitochondria from rat liver. FEBS Lett (1978) 0.94
Validity of the digitonin method for metabolite compartmentation in isolated hepatocytes. Biochem J (1980) 0.94
Protein glycation: measurement and clinical relevance. J Clin Chem Clin Biochem (1989) 0.92
Nonenzymatic glycation of immunoglobulins leads to an impairment of immunoreactivity. Biol Chem Hoppe Seyler (1985) 0.92
Early kinetics of glucagon action in isolated hepatocytes at the mitochondrial level. Eur J Biochem (1980) 0.92
Concentration of free oxaloacetate in the mitochondrial compartment of isolated liver cells. Biochem J (1984) 0.91
Stimulation of phosphatidylinositol 4-phosphate phosphorylation in human placenta membranes by GTP gamma S. FEBS Lett (1986) 0.91
Kinetic analysis of glycation as a tool for assessing the half-life of proteins. Biochim Biophys Acta (1986) 0.91
Separation of the protein-tyrosine kinase and phosphatidylinositol kinase activities of the human placental insulin receptor. Biochim Biophys Acta (1988) 0.91
Isolated hepatocytes as a model for the study of stable glucagon effects on mitochondrial respiratory functions. FEBS Lett (1979) 0.91
Evidence for phosphorylation of actin by the insulin receptor-associated protein kinase from human placenta. FEBS Lett (1983) 0.91
The influence of insulin on glucose and fatty acid metabolism in the isolated perfused rat hind quarter. Hoppe Seylers Z Physiol Chem (1975) 0.90
Metabolism of isolated kidney tubules. Additive effects of parathyroid hormone and free-fatty acids on renal gluconeogenesis. Eur J Biochem (1972) 0.89
An Mr 180,000 protein is an endogenous substrate for the insulin-receptor-associated tyrosine kinase in human placenta. Biochem J (1987) 0.89
Purification and partial characterization of phosphatidylinositol-4-phosphate kinase from rat liver plasma membranes. Further evidence for a stimulatory G-protein. Biochim Biophys Acta (1990) 0.87
Partial purification and characterization of a pyruvate dehydrogenase-complex-inactivating enzyme from rat liver. Biochem J (1978) 0.87
Possible role of Pi supply in mitochondrial actions of glucagon. Eur J Biochem (1984) 0.87
Regulation by insulin of adipose tissue pyruvate dehydrogenase. A mechanism controlling fatty acid synthesis from carbohydrates. Hoppe Seylers Z Physiol Chem (1974) 0.87
Non-enzymatic glycosylation of human serum lipoproteins. Elevated epsilon-lysine glycosylated low density lipoprotein in diabetic patients. FEBS Lett (1981) 0.85
Evidence for a cholera-toxin-sensitive G-protein involved in the regulation of phosphatidylinositol 4-phosphate kinase of rat liver membranes. Biochim Biophys Acta (1988) 0.84
Regulation of pyruvate dehydrogenase in heart mitochondria. Hoppe Seylers Z Physiol Chem (1977) 0.84
Activation of the pyruvate dehydrogenase complex in isolated fat cell mitochondria by hydrogen peroxide and t-butyl hydroperoxide. FEBS Lett (1980) 0.83
Distinctive roles of oleate and glucagen in gluconeogenesis. Eur J Biochem (1980) 0.83
Decrease by glucagon in hepatic succinyl-CoA. Biochem Biophys Res Commun (1980) 0.83
Specific quantitation by HPLC of protein (lysine) bound glucose in human serum albumin and other glycosylated proteins. J Clin Chem Clin Biochem (1981) 0.83
Enzymatic assay of myo-inositol in serum. J Clin Chem Clin Biochem (1987) 0.82
Insulin activates pyruvate dehydrogenase by lowering the mitochondrial acetyl-CoA/CoA ratio as evidenced by digitonin fractionation of isolated fat cells. FEBS Lett (1978) 0.82
Re-evaluation of Sepharose-insulin as a tool for the study of insulin action. Proc Natl Acad Sci U S A (1975) 0.82
The effect of insulin on pyruvate dehydrogenase interconversion in heart muscle of alloxan-diabetic rats. Diabetologia (1978) 0.82
A small G-protein involved in phosphatidylinositol-4-phosphate kinase activation. FEBS Lett (1990) 0.82
Distinctive effects of glucagon on gluconeogenesis and ketogenesis in hepatocytes isolated from normal and biotin-deficient rats. Biochem J (1978) 0.82
A sensitive and simple method for the study of oxaloacetate compartmentation in isolated hepatocytes. FEBS Lett (1976) 0.82
Changes of human glomerular basement membrane in diabetes mellitus. J Clin Chem Clin Biochem (1984) 0.81
Measurement of ketone bodies in subcellular fractions using a spectrophotometric iron-chelate assay. Anal Biochem (1982) 0.81
Insulin-stimulated phosphorylation of actin by human placental insulin receptor preparations. Curr Top Cell Regul (1985) 0.81
Control of pyruvate dehydrogenase interconversion by palmitoyl-coenzyme A as related to adenine nucleotide translocation in isolated fat cell mitochondria. FEBS Lett (1975) 0.81
Inositol trisphosphate activates pyruvate dehydrogenase in isolated fat cells. FEBS Lett (1984) 0.80
Improved response of isolated liver cells to glucagon in the presence of rat serum. Biochem Biophys Res Commun (1975) 0.80
[Muscular carbohydrate and lipid metabolism in the model of hemoglobin-free perfused rat hindlimb]. Verh Dtsch Ges Inn Med (1974) 0.80
Subunit structure of dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex from bovine kidney. Hoppe Seylers Z Physiol Chem (1980) 0.79
Protein modification by non-enzymatic glucosylation: possible role in the development of diabetic complications. Mol Cell Endocrinol (1983) 0.79
In vitro glycosylation of hemoglobins by different sugars and sugar phosphates. FEBS Lett (1978) 0.79
Preparation and biological properties of glycosylated insulin. FEBS Lett (1979) 0.79
Localization of insulin on fat cell ghosts by ferritin labelled insulin antibodies. Diabetologia (1974) 0.79
[Diagnostic significance of muscle biopsies in metabolic myopathies. II. Clinical biochemistry]. Klin Wochenschr (1984) 0.78
Human alkaline phosphatases. I. Purification and some structural properties of the enzyme from human liver. Hoppe Seylers Z Physiol Chem (1977) 0.78
Essential role of coenzyme A in pyruvate dehydrogenase kinase activity. FEBS Lett (1982) 0.77
The diagnostic significance of liver cell inhomogeneity: serum enzymes in patients with central liver necrosis and the distribution of glutamate dehydrogenase in normal human liver. Z Klin Chem Klin Biochem (1975) 0.77
[Adult form of acid maltase deficiency presenting as progressive spinal muscular atrophy]. Dtsch Med Wochenschr (1984) 0.77
Kinetic and regulatory properties of pyruvate dehydrogenase from Ehrlich ascites tumor cells. Cancer Res (1976) 0.77
Subcellular distribution of guanine and uracil nucleotides and of succinate in normal and glucagon-stimulated hepatocytes. Hoppe Seylers Z Physiol Chem (1979) 0.77
[Clinical and biochemical studies on the significance and formation of hemoglobins AIc and AIa+b in diabetes mellitus]. Klin Wochenschr (1977) 0.77
Limited nonenzymatic glucosylation of low-density lipoprotein does not alter its catabolism in tissue culture. Biochim Biophys Acta (1985) 0.77
Ultrastructural localization of pyruvate dehydrogenase in rat heart muscle. Histochemie (1973) 0.76
Brain specific proteins: creatine kinase BB isoenzyme is cochromatographed during preparation of neuron-specific enolase from human brain. Clin Chim Acta (1983) 0.76
Activation of pyruvate dehydrogenase by insulin in isolated brown fat cells. Horm Metab Res (1979) 0.76
Endothelial plasma membrane is a glucocorticoid-regulated barrier for the uptake of glucose into the cell. Mol Cell Endocrinol (1985) 0.76
Improvement of the thiobarbituric acid assay for serum glycosylprotein determination. Clin Chim Acta (1981) 0.76
[Mitigated adult forms of acid maltase deficiency (Pompe's disease). Morphologic and pathobiochemical studies]. Klin Wochenschr (1983) 0.75
Pyruvate dehydrogenase and ATP citrate (pro-3S)-lyase activities in adipose tissue and liver of the young lean and the older obese rat. Hoppe Seylers Z Physiol Chem (1979) 0.75
[Pathobiochemistry of the late-onset diabetic syndrome]. Ther Ggw (1974) 0.75
[Hyperglycemia as a cause of diabetic complications]. Verh Dtsch Ges Inn Med (1987) 0.75
Evidence that (a) serine specific protein kinase(s) different from protein kinase C is responsible for the insulin-stimulated actin phosphorylation by placental membrane. FEBS Lett (1986) 0.75
Measurement of ATP citrate-lyase and acetyl-CoA synthetase activity using arylamine acetyltransferase. Anal Biochem (1978) 0.75
[Iodine deficiency, congenital goiter and congenital hypothyroidism. Results of TSH screening in southern Bavaria]. Dtsch Med Wochenschr (1984) 0.75
Evidence for two-domain subunit structure of kidney lipoate acetyltransferase. FEBS Lett (1980) 0.75
[Extracellular cyclic nucleotides: occurrence, analysis and diagnostic significance (author's transl)]. Z Klin Chem Klin Biochem (1973) 0.75
[Deuterium transfer of (1,1-2H2) ethanol to acids of the citric acid cycle and related hydroxy acids of intermediary metabolism in the rat liver in vivo]. Verh Dtsch Ges Inn Med (1974) 0.75
Clinical utility of nonenzymatically glycosylated blood proteins as an index of glucose control. Diabetes Care (1985) 0.75
Different effects of reductive and nonreductive glucosylation on LDL-catabolism. Horm Metab Res Suppl (1985) 0.75
[Pathobiochemistry of the late-onset diabetic syndrome]. Med Klin (1974) 0.75
[Neurospora crassa pyruvate dehydrogenase: interconversion due to phosphorylation and dephosphorylation]. Hoppe Seylers Z Physiol Chem (1972) 0.75
On the nature of the glucose tolerance factor from yeast. Horm Metab Res (1984) 0.75
Enzymatic synthesis of 32P-labeled coenzyme A. Anal Biochem (1974) 0.75
Free insulin, bound insulin, C-peptide and the metabolic control in juvenile onset diabetics: comparison of C-peptide secretors and non-secretors during 24 hours conventional insulin therapy. Eur J Clin Invest (1979) 0.75