Published in J Gen Physiol on March 01, 1978
Estimating kinetic constants from single channel data. Biophys J (1983) 6.14
Effect of N-bromoacetamide on single sodium channel currents in excised membrane patches. J Gen Physiol (1982) 3.65
Some kinetic and steady-state properties of sodium channels after removal of inactivation. J Gen Physiol (1981) 3.57
Statistical analysis of single sodium channels. Effects of N-bromoacetamide. Biophys J (1984) 3.01
Gating of Na channels. Inactivation modifiers discriminate among models. J Gen Physiol (1987) 2.53
Sodium channel activation in the squid giant axon. Steady state properties. J Gen Physiol (1985) 2.35
Batrachotoxin modifies the gating kinetics of sodium channels in internally perfused neuroblastoma cells. Proc Natl Acad Sci U S A (1982) 1.53
Interactions of monovalent cations with sodium channels in squid axon. I. Modification of physiological inactivation gating. J Gen Physiol (1985) 1.51
Simulation of Na channel inactivation by thiazine dyes. J Gen Physiol (1982) 1.44
Irreversible modification of sodium channel inactivation in toad myelinated nerve fibres by the oxidant chloramine-T. J Physiol (1984) 1.42
Kinetics of veratridine action on Na channels of skeletal muscle. J Gen Physiol (1986) 1.38
Burst kinetics of sodium channels which lack fast inactivation in mouse neuroblastoma cells. J Physiol (1987) 1.30
The inactivating K+ current in GH3 pituitary cells and its modification by chemical reagents. J Physiol (1989) 1.26
n-Alkanols potentiate sodium channel inactivation in squid giant axons. Biophys J (1979) 1.22
Kinetics of 9-aminoacridine block of single Na channels. J Gen Physiol (1984) 1.19
Saxitoxin and tetrodotoxin. Electrostatic effects on sodium channel gating current in crayfish axons. Biophys J (1986) 1.11
Voltage-dependent removal of sodium inactivation by N-bromoacetamide and pronase. Biophys J (1985) 1.07
Batrachotoxin uncouples gating charge immobilization from fast Na inactivation in squid giant axons. Biophys J (1988) 1.04
BTX modification of Na channels in squid axons. I. State dependence of BTX action. J Gen Physiol (1991) 1.04
Effects of some chemical reagents on sodium current inactivation in myelinated nerve fibers of the frog. Biophys J (1986) 1.03
Effects of the dipolar form of phloretin on potassium conductance in squid giant axons. Biophys J (1980) 1.02
Interactions of monovalent cations with sodium channels in squid axon. II. Modification of pharmacological inactivation gating. J Gen Physiol (1985) 1.00
Modification of potassium channel kinetics by histidine-specific reagents. J Gen Physiol (1990) 0.95
Intracellular pH and ionic channels in the Loligo vulgaris giant axon. Biophys J (1981) 0.94
Modification of K channel inactivation by papain and N-bromoacetamide. Biophys J (1988) 0.93
Effect of sea anemone toxins on the sodium inactivation process in crayfish axons. J Gen Physiol (1983) 0.93
Effects of channel cytoplasmic regions on the activation mechanisms of cardiac versus skeletal muscle Na(+) channels. Biophys J (1999) 0.92
Removal of sodium inactivation and block of sodium channels by chloramine-T in crayfish and squid giant axons. Biophys J (1987) 0.91
The effect of temperature on the nerve-blocking action of benzyl alcohol on the squid giant axon. J Physiol (1983) 0.89
Transient outward currents and changes of their gating properties after cell activation in thrombocytes of the newt. J Physiol (1987) 0.88
Saxitoxin blocks batrachotoxin-modified sodium channels in the node of Ranvier in a voltage-dependent manner. Biophys J (1986) 0.88
Faster voltage-dependent activation of Na+ channels in growth cones versus somata of neuroblastoma N1E-115 cells. Biophys J (1996) 0.88
Glutamine substitution at alanine1649 in the S4-S5 cytoplasmic loop of domain 4 removes the voltage sensitivity of fast inactivation in the human heart sodium channel. J Gen Physiol (1998) 0.86
Internal cations, membrane current, and sodium inactivation gate closure in Myxicola giant axons. Biophys J (1988) 0.86
Modification of potassium channel kinetics by amino group reagents. J Gen Physiol (1992) 0.85
Propagation of action potentials in squid giant axons. Repetitive firing at regions of membrane inhomogeneities. J Gen Physiol (1979) 0.85
Modification of sodium channel inactivation in single myelinated nerve fibers by methionine-reactive chemicals. Biophys J (1984) 0.84
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Purified, modified eel sodium channels are active in planar bilayers in the absence of activating neurotoxins. Proc Natl Acad Sci U S A (1989) 0.83
Dynamics of strychnine block of single sodium channels in bovine chromaffin cells. J Physiol (1986) 0.82
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Quantification of exponential Na+ current activation in N-bromoacetamide-treated cardiac myocytes of guinea-pig. J Physiol (1993) 0.79
Reconstituted voltage-sensitive sodium channel from Electrophorus electricus: chemical modifications that alter regulation of ion permeability. Proc Natl Acad Sci U S A (1987) 0.78
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A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol (1952) 160.83
The action of calcium on the electrical properties of squid axons. J Physiol (1957) 35.98
Interaction of tetraethylammonium ion derivatives with the potassium channels of giant axons. J Gen Physiol (1971) 14.23
Inactivation of the sodium channel. I. Sodium current experiments. J Gen Physiol (1977) 12.35
Charges and potentials at the nerve surface. Divalent ions and pH. J Gen Physiol (1968) 9.73
Destruction of sodium conductance inactivation in squid axons perfused with pronase. J Gen Physiol (1973) 8.53
An improved vaseline gap voltage clamp for skeletal muscle fibers. J Gen Physiol (1976) 5.57
The effects of external potassium and long duration voltage conditioning on the amplitude of sodium currents in the giant axon of the squid, Loligo pealei. J Gen Physiol (1969) 5.32
Chemicals as tools in the study of excitable membranes. Physiol Rev (1974) 5.27
Nonenzymatic cleavage of peptide bonds: the methionine residues in bovine pancreatic ribonuclease. J Biol Chem (1962) 5.10
Mechanism of frequency-dependent inhibition of sodium currents in frog myelinated nerve by the lidocaine derivative GEA. J Pharmacol Exp Ther (1975) 5.07
Replacement of the protoplasm of a giant nerve fibre with artificial solutions. Nature (1961) 4.32
Destruction of the sodium conductance inactivation by a specific protease in perfused nerve fibres from Loligo. J Physiol (1976) 4.18
Slow changes in membrane permeability and long-lasting action potentials in axons perfused with fluoride solutions. J Physiol (1970) 3.45
EFFECTS OF VARIOUS POTASSIUM SALTS AND PROTEASES UPON EXCITABILITY OF INTRACELLULARLY PERFUSED SQUID GIANT AXONS. Proc Natl Acad Sci U S A (1964) 3.22
The influence of external potassium on the inactivation of sodium currents in the giant axon of the squid, Loligo pealei. J Gen Physiol (1969) 3.13
Currents associated with the ionic gating structures in nerve membrane. Ann N Y Acad Sci (1975) 3.02
Sodium conductance activation without inactivation in pronase-perfused axons. Nat New Biol (1971) 2.78
Ionic conductance changes in voltage clamped crayfish axons at low pH. J Gen Physiol (1974) 2.69
Ultra-slow inactivation of the ionic currents through the membrane of myelinated nerve. Biochim Biophys Acta (1976) 2.27
Mechanism of negative temperature coefficient of nerve blocking action of allethrin. J Pharmacol Exp Ther (1972) 2.16
Conductance of the sodium channel in myelinated nerve fibres with modified sodium inactivation. J Physiol (1976) 2.15
Mechanism of action of propranolol on squid axon membranes. J Pharmacol Exp Ther (1973) 2.08
Slow sodium inactivation in Myxicola axons. Evidence for a second inactive state. Biophys J (1976) 2.01
The interactions of calcium with mpyxicola giant axons and a description in terms of a simple surface charge model. J Physiol (1975) 1.73
Condylactis toxin: interaction with nerve membrane ionic conductances. Science (1969) 1.55
Morphology and electrophysiological properties of squid giant axons perfused intracellularly with protease solution. J Gen Physiol (1969) 1.44
Slow sodium inactivation in nerve after exposure to sulhydryl blocking reagents. J Gen Physiol (1977) 1.43
Selective modification of sodium channel gating in lobster axons by 2, 4, 6-trinitrophenol: Evidence for two inactivation mechanisms. J Gen Physiol (1975) 1.42
Sulfenyl halides as modifying reagents for polypeptides and proteins. I. Modification of tryptophan residues. Biochemistry (1968) 1.41
Effects of redox and sulfhydryl reagents on the bioelectric properties of the giant axon of the squid. Biophys J (1966) 1.34
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Effects of sulfhydryl blockade on axonal function. J Cell Physiol (1958) 1.15
Ultraviolet photoalteration of ion channels in voltage-clamped lobster giant axons. J Membr Biol (1975) 1.08
Effects of proteolytic enzymes on ionic conductances of squid axon membranes. J Membr Biol (1975) 1.07
Internal perfusion of crayfish, giant axons: action of tannic acid, DDT, and TEA. J Cell Physiol (1969) 1.02
Depolarization-induced change in the enzymatic radio-iodination of a protein of the internal surface of the squid giant, axon membrane. Comp Biochem Physiol A Comp Physiol (1974) 1.00
Release of proteins from the inner surface of squid axon membrane labeled with tritiated N-ethylmaleimide. J Gen Physiol (1976) 0.95
Letter: pronase and models for the sodium conductance. J Gen Physiol (1975) 0.94
Effect of several "specific" chemical reagents on the Na+, K+ and leakage currents in voltage-clamped single nodes of Ranvier. Biochim Biophys Acta (1974) 0.94
Selective blocking of the nodal sodium channels by ultraviolet radiation. I. Phenomenology of the radiation effect. Pflugers Arch (1974) 0.94
The effect of electrical stimulation on the action of sulfhydryl reagents in the giant axon of squid: suggested mechanisms for the role of thiol and disulfide groups in electrically-induced conformational changes. J Membr Biol (1974) 0.94
Isolation and characterization of active fragments obtained by cleavage of immunoglobulin G with cyanogen bromide. J Biol Chem (1966) 0.89
Chemicals as tools in the study of excitable membranes. Physiol Rev (1974) 5.27
Dynamics of aminopyridine block of potassium channels in squid axon membrane. J Gen Physiol (1976) 4.36
An upper limit to the number of sodium channels in nerve membrane? J Physiol (1967) 3.98
The genetics of levamisole resistance in the nematode Caenorhabditis elegans. Genetics (1980) 3.98
Kinetic analysis of pancuronium interaction with sodium channels in squid axon membranes. J Gen Physiol (1977) 3.95
Interactions of aminopyridines with potassium channels of squid axon membranes. Biophys J (1976) 3.69
The site of action and active form of local anesthetics. II. Experiments with quaternary compounds. J Pharmacol Exp Ther (1970) 3.59
Some kinetic and steady-state properties of sodium channels after removal of inactivation. J Gen Physiol (1981) 3.57
Basis of tetrodotoxin's selectivity in blockage of squid axons. J Gen Physiol (1967) 2.97
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Comparison of tetrodotoxin and procaine in internally perfused squid giant axons. J Gen Physiol (1967) 2.90
The role of calcium in the desensitization of capsaicin responses in rat dorsal root ganglion neurons. J Neurosci (1997) 2.73
Tetrodotoxin's highly selective blockage of an ionic channel. Fed Proc (1968) 2.68
Differential properties of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in rat dorsal root ganglion neurons. J Neurosci (1992) 2.61
Voltage-dependent calcium block of normal and tetramethrin-modified single sodium channels. Biophys J (1984) 2.60
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Levamisole-resistant mutants of the nematode Caenorhabditis elegans appear to lack pharmacological acetylcholine receptors. Neuroscience (1980) 2.44
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Receptor-mediated gene delivery and expression in vivo. J Biol Chem (1988) 2.23
Tetrodotoxin does not block excitation from inside the nerve membrane. Science (1966) 2.22
Modulation of calcium channels by norepinephrine in internally dialyzed avian sensory neurons. J Gen Physiol (1985) 2.20
Mechanism of negative temperature coefficient of nerve blocking action of allethrin. J Pharmacol Exp Ther (1972) 2.16
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Effects of procaine on ionic conductances of end-plate membranes. J Pharmacol Exp Ther (1971) 2.14
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Effects of veratrum alkaloids on membrane potential and conductance of squid and crayfish giant axons. J Pharmacol Exp Ther (1973) 1.90
3,4-diaminopyridine. A potent new potassium channel blocker. Biophys J (1978) 1.88
Block of calcium channels by enkephalin and somatostatin in neuroblastoma-glioma hybrid NG108-15 cells. Proc Natl Acad Sci U S A (1986) 1.82
Effects of scorpion venom on squid axon membranes. Am J Physiol (1972) 1.81
Saxitoxin and tetrodotoxin: comparison of nerve blocking mechanism. Science (1967) 1.77
Cation permeation through the voltage-dependent potassium channel in the squid axon. Characteristics and mechanisms. J Gen Physiol (1987) 1.76
Interaction of DDT with the components of lobster nerve membrane conductance. J Gen Physiol (1968) 1.74
Ionic currents in two strains of rat anterior pituitary tumor cells. J Gen Physiol (1984) 1.69
Mechanism of excitation block by the insecticide allethrin applied externally and internally to squid giant axons. Toxicol Appl Pharmacol (1967) 1.69
Three-dimensional solid-state NMR experiment that correlates the chemical shift and dipolar coupling frequencies of two heteronuclei. J Magn Reson B (1995) 1.66
DDT: interaction with nerve membrane conductance changes. Science (1967) 1.65
Arginine-specific reagents remove sodium channel inactivation. Nature (1978) 1.61
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Electrical properties and excitation-contraction coupling in skeletal muscle treated with ethylene glycol. J Gen Physiol (1972) 1.59
Condylactis toxin: interaction with nerve membrane ionic conductances. Science (1969) 1.55
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