Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data.

PubWeight™: 9.59‹?› | Rank: Top 0.1%

🔗 View Article (PMID 6822610)

Published in J Cereb Blood Flow Metab on March 01, 1983

Authors

C S Patlak, R G Blasberg, J D Fenstermacher

Associated clinical trials:

Implications for Management of PET Amyloid Classification Technology in the Imaging Dementia(IDEAS) Trial (IMPACT2) | NCT02781220

Implications for Management of PET Amyloid Classification Technology (IMPACT) | NCT02778971

Articles citing this

(truncated to the top 100)

Cold acclimation recruits human brown fat and increases nonshivering thermogenesis. J Clin Invest (2013) 3.25

Differences between males and females in rates of serotonin synthesis in human brain. Proc Natl Acad Sci U S A (1997) 2.50

Dopamine synthesis capacity before onset of psychosis: a prospective [18F]-DOPA PET imaging study. Am J Psychiatry (2011) 2.37

Imaging in unilateral Wilms tumour. Pediatr Radiol (2007) 2.04

Regional analysis of FDG and PIB-PET images in normal aging, mild cognitive impairment, and Alzheimer's disease. Eur J Nucl Med Mol Imaging (2008) 2.04

Imaging transgene expression with radionuclide imaging technologies. Neoplasia (2000) 2.03

Lung regional metabolic activity and gas volume changes induced by tidal ventilation in patients with acute lung injury. Am J Respir Crit Care Med (2011) 1.84

Measuring drug occupancy in the absence of a reference region: the Lassen plot re-visited. J Cereb Blood Flow Metab (2009) 1.80

Brain monoamine oxidase A inhibition in cigarette smokers. Proc Natl Acad Sci U S A (1996) 1.78

An assessment of the effects of shell cross-linked nanoparticle size, core composition, and surface PEGylation on in vivo biodistribution. Biomacromolecules (2005) 1.70

Reperfusion injury following cerebral ischemia: pathophysiology, MR imaging, and potential therapies. Neuroradiology (2006) 1.70

Neurological diseases in relation to the blood-brain barrier. J Cereb Blood Flow Metab (2012) 1.62

Validation of in vivo magnetic resonance imaging blood-brain barrier permeability measurements by comparison with gold standard histology. Stroke (2011) 1.53

18F-FDG uptake rate is a biomarker of eosinophilic inflammation and airway response in asthma. J Nucl Med (2011) 1.53

On the rate and extent of drug delivery to the brain. Pharm Res (2007) 1.53

Macromolecular permeability across the blood-nerve and blood-brain barriers. Proc Natl Acad Sci U S A (1994) 1.50

Age-related changes in midbrain dopaminergic regulation of the human reward system. Proc Natl Acad Sci U S A (2008) 1.49

Dopaminergic mechanisms of reduced basal ganglia responses to hedonic reward during interferon alfa administration. Arch Gen Psychiatry (2012) 1.48

Modified regression model for the Logan plot. J Cereb Blood Flow Metab (2002) 1.44

Qualitative interpretation of PET scans using a Likert scale to assess neck node response to radiotherapy in head and neck cancer. Eur J Nucl Med Mol Imaging (2015) 1.43

A simple method for determining split renal function from dynamic (99m)Tc-MAG3 scintigraphic data. Eur J Nucl Med Mol Imaging (2015) 1.43

Pre-clinical myocardial metabolic alterations in chronic kidney disease. Cardiology (2010) 1.43

Estimation of the 18F-FDG input function in mice by use of dynamic small-animal PET and minimal blood sample data. J Nucl Med (2007) 1.42

How should we analyse FDG PET studies for monitoring tumour response? Eur J Nucl Med Mol Imaging (2006) 1.41

Minimal penetration of lipopolysaccharide across the murine blood-brain barrier. Brain Behav Immun (2009) 1.41

Clinical and [18F] dopa PET findings in early Parkinson's disease. J Neurol Neurosurg Psychiatry (1995) 1.39

A simplified analysis of [18F]3'-deoxy-3'-fluorothymidine metabolism and retention. Eur J Nucl Med Mol Imaging (2005) 1.34

Quantitative techniques in 18FDG PET scanning in oncology. Br J Cancer (2008) 1.33

Lipopolysaccharide alters the blood-brain barrier transport of amyloid beta protein: a mechanism for inflammation in the progression of Alzheimer's disease. Brain Behav Immun (2009) 1.32

Effects of administration route, dietary condition, and blood glucose level on kinetics and uptake of 18F-FDG in mice. J Nucl Med (2011) 1.31

Imaging correlates of differential expression of indoleamine 2,3-dioxygenase in human brain tumors. Mol Imaging Biol (2009) 1.30

In vivo amyloid imaging with PET in frontotemporal dementia. Eur J Nucl Med Mol Imaging (2007) 1.29

Cyclooxygenase inhibition limits blood-brain barrier disruption following intracerebral injection of tumor necrosis factor-alpha in the rat. J Pharmacol Exp Ther (2007) 1.29

Identifying active vascular microcalcification by (18)F-sodium fluoride positron emission tomography. Nat Commun (2015) 1.27

A systems approach for tumor pharmacokinetics. PLoS One (2011) 1.27

An internet-based "kinetic imaging system" (KIS) for MicroPET. Mol Imaging Biol (2006) 1.27

Dynamic and static approaches to quantifying 18F-FDG uptake for measuring cancer response to therapy, including the effect of granulocyte CSF. J Nucl Med (2007) 1.27

Polypeptide point modifications with fatty acid and amphiphilic block copolymers for enhanced brain delivery. Bioconjug Chem (2005) 1.26

Functional analysis in MR urography - made simple. Pediatr Radiol (2009) 1.24

Dynamic single photon emission computed tomography--basic principles and cardiac applications. Phys Med Biol (2010) 1.24

Comparison of methodologies for the in vivo assessment of 18FLT utilisation in colorectal cancer. Eur J Nucl Med Mol Imaging (2004) 1.24

Kinetic analysis of 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) in head and neck cancer patients before and early after initiation of chemoradiation therapy. J Nucl Med (2009) 1.22

Hepatic uptake and metabolism of galactose can be quantified in vivo by 2-[18F]fluoro-2-deoxygalactose positron emission tomography. Am J Physiol Gastrointest Liver Physiol (2008) 1.22

Imaging of opioid receptors in the central nervous system. Brain (2007) 1.19

Epinephrine enhances lysosomal enzyme delivery across the blood brain barrier by up-regulation of the mannose 6-phosphate receptor. Proc Natl Acad Sci U S A (2007) 1.18

Simultaneous imaging of tumor oxygenation and microvascular permeability using Overhauser enhanced MRI. Proc Natl Acad Sci U S A (2009) 1.18

Comparison of myocardial perfusion estimates from dynamic contrast-enhanced magnetic resonance imaging with four quantitative analysis methods. Magn Reson Med (2010) 1.18

Reproducibility of quantitative 18F-3'-deoxy-3'-fluorothymidine measurements using positron emission tomography. Eur J Nucl Med Mol Imaging (2008) 1.17

Positron emission tomography imaging and clinical progression in relation to molecular pathology in the first Pittsburgh Compound B positron emission tomography patient with Alzheimer's disease. Brain (2010) 1.17

Contrast-enhanced computed tomography and ultrasound for the evaluation of tumor blood flow. Invest Radiol (2005) 1.17

Quantification of cerebral glucose metabolic rate in mice using 18F-FDG and small-animal PET. J Nucl Med (2009) 1.17

Assessment of lung inflammation with 18F-FDG PET during acute lung injury. AJR Am J Roentgenol (2010) 1.17

Advanced magnetic resonance imaging of the physical processes in human glioblastoma. Cancer Res (2014) 1.16

Quantifying pulmonary inflammation in cystic fibrosis with positron emission tomography. Am J Respir Crit Care Med (2006) 1.16

Anti-amyloid beta protein antibody passage across the blood-brain barrier in the SAMP8 mouse model of Alzheimer's disease: an age-related selective uptake with reversal of learning impairment. Exp Neurol (2007) 1.16

Mannose 6-phosphate receptor-mediated transport of sulfamidase across the blood-brain barrier in the newborn mouse. Mol Ther (2008) 1.14

Measuring [(18)F]FDG uptake in breast cancer during chemotherapy: comparison of analytical methods. Eur J Nucl Med Mol Imaging (2003) 1.11

Methodological considerations in quantification of oncological FDG PET studies. Eur J Nucl Med Mol Imaging (2009) 1.11

Perfusion measurements by micro-CT using prior image constrained compressed sensing (PICCS): initial phantom results. Phys Med Biol (2010) 1.10

Lung imaging in asthmatic patients: the picture is clearer. J Allergy Clin Immunol (2011) 1.10

Multi-graphical analysis of dynamic PET. Neuroimage (2009) 1.10

Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier. J Cereb Blood Flow Metab (2008) 1.10

Cardiac and skeletal muscle insulin resistance in patients with coronary heart disease. A study with positron emission tomography. J Clin Invest (1996) 1.10

Lipopolysaccharide impairs amyloid β efflux from brain: altered vascular sequestration, cerebrospinal fluid reabsorption, peripheral clearance and transporter function at the blood-brain barrier. J Neuroinflammation (2012) 1.09

Modeling pulmonary kinetics of 2-deoxy-2-[18F]fluoro-D-glucose during acute lung injury. Acad Radiol (2008) 1.09

Dopaminergic function in the psychosis spectrum: an [18F]-DOPA imaging study in healthy individuals with auditory hallucinations. Schizophr Bull (2012) 1.09

Carotid artery atherosclerosis: effect of intensive lipid therapy on the vasa vasorum--evaluation by using dynamic contrast-enhanced MR imaging. Radiology (2011) 1.08

Estimating blood and brain concentrations and blood-to-brain influx by magnetic resonance imaging with step-down infusion of Gd-DTPA in focal transient cerebral ischemia and confirmation by quantitative autoradiography with Gd-[(14)C]DTPA. J Cereb Blood Flow Metab (2009) 1.07

[18F]fluorodeoxyglucose positron emission tomography for lung antiinflammatory response evaluation. Am J Respir Crit Care Med (2009) 1.07

Dynamic contrast enhanced MRI parameters and tumor cellularity in a rat model of cerebral glioma at 7 T. Magn Reson Med (2013) 1.06

Model selection for DCE-T1 studies in glioblastoma. Magn Reson Med (2011) 1.06

Radioluminescence microscopy: measuring the heterogeneous uptake of radiotracers in single living cells. PLoS One (2012) 1.06

The test-retest reliability of 18F-DOPA PET in assessing striatal and extrastriatal presynaptic dopaminergic function. Neuroimage (2009) 1.06

Simplified quantification of small animal [18F]FDG PET studies using a standard arterial input function. Eur J Nucl Med Mol Imaging (2006) 1.05

The metabolic landscape of cortico-basal ganglionic degeneration: regional asymmetries studied with positron emission tomography. J Neurol Neurosurg Psychiatry (1991) 1.05

A consistent and efficient graphical analysis method to improve the quantification of reversible tracer binding in radioligand receptor dynamic PET studies. Neuroimage (2008) 1.05

Starvation and triglycerides reverse the obesity-induced impairment of insulin transport at the blood-brain barrier. Endocrinology (2008) 1.05

MR urography in children. Pediatr Radiol (2006) 1.05

MR urography in children. Part 2: how to use ImageJ MR urography processing software. Pediatr Radiol (2010) 1.05

Comparison of amino acid positron emission tomographic radiotracers for molecular imaging of primary and metastatic brain tumors. Mol Imaging (2014) 1.04

Image-derived input function for assessment of 18F-FDG uptake by the inflamed lung. J Nucl Med (2007) 1.04

Pegylated leptin antagonist is a potent orexigenic agent: preparation and mechanism of activity. Endocrinology (2009) 1.04

Transport of human immunodeficiency virus type 1 pseudoviruses across the blood-brain barrier: role of envelope proteins and adsorptive endocytosis. J Virol (2001) 1.04

Effects of ventilation strategy on distribution of lung inflammatory cell activity. Crit Care (2013) 1.03

Direct inhibition of hexokinase activity by metformin at least partially impairs glucose metabolism and tumor growth in experimental breast cancer. Cell Cycle (2013) 1.03

Transport across the blood-brain barrier of pluronic leptin. J Pharmacol Exp Ther (2010) 1.01

Attenuation of acute stroke injury in rat brain by minocycline promotes blood-brain barrier remodeling and alternative microglia/macrophage activation during recovery. J Neuroinflammation (2015) 1.01

Correlations between magnetic resonance spectroscopy alterations and cerebral ammonia and glucose metabolism in cirrhotic patients with and without hepatic encephalopathy. Gut (2007) 1.01

Dynamic whole-body PET parametric imaging: I. Concept, acquisition protocol optimization and clinical application. Phys Med Biol (2013) 1.00

Midbrain dopamine function in schizophrenia and depression: a post-mortem and positron emission tomographic imaging study. Brain (2013) 1.00

Reduced regional myocardial perfusion reserve is associated with impaired contractile performance in idiopathic dilated cardiomyopathy. Neth Heart J (2009) 1.00

Derivation of a compartmental model for quantifying 64Cu-DOTA-RGD kinetics in tumor-bearing mice. J Nucl Med (2009) 0.99

Quantitative assessment of blood-brain barrier permeability in multiple sclerosis using 68-Ga-EDTA and positron emission tomography. J Neurol Neurosurg Psychiatry (1988) 0.99

Measuring response to chemotherapy in locally advanced breast cancer: methodological considerations. Eur J Nucl Med Mol Imaging (2004) 0.99

Correction of scan time dependence of standard uptake values in oncological PET. EJNMMI Res (2014) 0.99

Hepatic galactose metabolism quantified in humans using 2-18F-fluoro-2-deoxy-D-galactose PET/CT. J Nucl Med (2011) 0.98

Model selection in measures of vascular parameters using dynamic contrast-enhanced MRI: experimental and clinical applications. NMR Biomed (2013) 0.98

Characterization of apolipoprotein A-IV in brain areas involved in energy homeostasis. Physiol Behav (2008) 0.98

Unidirectional Influx and Net Accumulation of PIB. Open Neuroimag J (2008) 0.98

Using 18F-fluorodeoxyglucose positron emission tomography to monitor clinical outcomes in patients treated with neoadjuvant chemo-radiotherapy for locally advanced pancreatic cancer. Am J Clin Oncol (2010) 0.98

Articles by these authors

The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat. J Neurochem (1977) 11.55

Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. Generalizations. J Cereb Blood Flow Metab (1985) 5.99

The flow of solute and solvent across a two-membrane system. J Theor Biol (1963) 4.70

Comparison of bolus and infusion methods for receptor quantitation: application to [18F]cyclofoxy and positron emission tomography. J Cereb Blood Flow Metab (1993) 2.28

Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: a potential method for monitoring clinical gene therapy. Cancer Res (1996) 2.22

Imaging the expression of transfected genes in vivo. Cancer Res (1995) 2.05

Fate of cerebrospinal fluid-borne amyloid beta-peptide: rapid clearance into blood and appreciable accumulation by cerebral arteries. J Neurochem (1996) 1.96

Transport of alpha-aminoisobutyric acid across brain capillary and cellular membranes. J Cereb Blood Flow Metab (1983) 1.80

Differences in vulnerability to permanent focal cerebral ischemia among 3 common mouse strains. Stroke (2000) 1.77

Intrathecal chemotherapy: brain tissue profiles after ventriculocisternal perfusion. J Pharmacol Exp Ther (1975) 1.63

Efflux of radiolabeled polyethylene glycols and albumin from rat brain. Am J Physiol (1981) 1.62

Drainage of interstitial fluid from different regions of rat brain. Am J Physiol (1984) 1.58

Measurements of dog blood-brain transfer constants by ventriculocisternal perfusion. Am J Physiol (1975) 1.56

Striatal 18F-dopa uptake: absence of an aging effect. J Cereb Blood Flow Metab (1993) 1.52

Transient and permanent resolution of ischemic lesions on diffusion-weighted imaging after brief periods of focal ischemia in rats : correlation with histopathology. Stroke (2000) 1.52

Local cerebral glucose utilization in controlled graded levels of hyperglycemia in the conscious rat. J Cereb Blood Flow Metab (1988) 1.49

Effects of postnatal dexamethasone on blood-brain barrier permeability and brain water content in newborn lambs. Am J Physiol Regul Integr Comp Physiol (2001) 1.44

Characteristics of p-aminohippurate transport in proximal renal tubules. Am J Physiol (1969) 1.43

Specificity of cerebral amino acid transport: a kinetic analysis. Prog Brain Res (1968) 1.38

Filtration and reflection coefficients of the rabbit blood-brain barrier. Am J Physiol (1966) 1.33

Sucrose and inulin space measurements of cerebral cortex in four mammalian species. Am J Physiol (1970) 1.32

Secondary decline in apparent diffusion coefficient and neurological outcomes after a short period of focal brain ischemia in rats. Ann Neurol (2000) 1.27

Noninvasive quantitation of cytosine deaminase transgene expression in human tumor xenografts with in vivo magnetic resonance spectroscopy. Proc Natl Acad Sci U S A (1999) 1.26

Midazolam changes cerebral blood flow in discrete brain regions: an H2(15)O positron emission tomography study. Anesthesiology (1997) 1.25

A general approach to the non-invasive imaging of transgenes using cis-linked herpes simplex virus thymidine kinase. Neoplasia (1999) 1.25

Imaging adenoviral-mediated herpes virus thymidine kinase gene transfer and expression in vivo. Cancer Res (1999) 1.24

Albumin outflow into deep cervical lymph from different regions of rabbit brain. Am J Physiol (1991) 1.23

Tumor-specific transcriptional targeting of suicide gene therapy. Gene Ther (2002) 1.16

A method to obtain infusion schedules for prescribed blood concentration time courses. J Appl Physiol (1976) 1.15

Cerebrospinal fluid production by the choroid plexus and brain. Science (1971) 1.14

A component of fluid absorption linked to passive ion flows in the superficial pars recta. J Gen Physiol (1975) 1.13

Tumor growth modulation by sense and antisense vascular endothelial growth factor gene expression: effects on angiogenesis, vascular permeability, blood volume, blood flow, fluorodeoxyglucose uptake, and proliferation of human melanoma intracerebral xenografts. Cancer Res (1998) 1.12

Positron emission tomography-based imaging of transgene expression mediated by replication-conditional, oncolytic herpes simplex virus type 1 mutant vectors in vivo. Cancer Res (2001) 1.12

Ontogeny of blood-brain barrier function in ovine fetuses, lambs, and adults. Am J Physiol (1996) 1.11

Rapid distribution of intraventricularly administered sucrose into cerebrospinal fluid cisterns via subarachnoid velae in rat. Neuroscience (1996) 1.11

Extracellular volume decreases while cell volume is maintained by ion uptake in rat brain during acute hypernatremia. J Physiol (1991) 1.10

Theoretical analysis of net tracer flux due to volume circulation in a membrane with pores of different sizes. Relation to solute drag model. J Gen Physiol (1971) 1.10

Mutant herpes simplex virus induced regression of tumors growing in immunocompetent rats. J Neurooncol (1994) 1.09

Choroid plexus papilloma. I. Proof of cerebrospinal fluid overproduction. Childs Brain (1976) 1.07

Quantification and pharmacokinetics of blood-brain barrier disruption in humans. J Neurosurg (1996) 1.06

An evaluation of errors in the determination of blood flow by the indicator fractionation and tissue equilibration (Kety) methods. J Cereb Blood Flow Metab (1984) 1.05

Volume absorption in the pars recta. II. Hydraulic conductivity coefficient. Am J Physiol (1978) 1.03

Monoclonal antibody localization in subcutaneous and intracranial human glioma xenografts: paired-label and imaging analysis. Anticancer Res (1984) 1.03

Quantitative autoradiographic studies of brain edema and a comparison of multi-isotope autoradiographic techniques. Adv Neurol (1980) 1.03

Nigrostriatal function in humans studied with positron emission tomography. Ann Neurol (1989) 1.03

Regional measurements of blood flow in experimental RG-2 rat gliomas. Cancer Res (1983) 1.01

Volume regulatory loss of Na, Cl, and K from rat brain during acute hyponatremia. Am J Physiol (1987) 1.00

Transport of material between brain extracellular fluid, brain cells and blood. Fed Proc (1974) 1.00

Methods for Quantifying the transport of drugs across brain barrier systems. Pharmacol Ther (1981) 0.99

A critical evaluation of the principles governing the advantages of intra-arterial infusions. J Pharmacokinet Biopharm (1974) 0.98

Regional measurements of blood-to-tissue transport in experimental RG-2 rat gliomas. Cancer Res (1983) 0.97

Selection of experimental conditions for the accurate determination of blood--brain transfer constants from single-time experiments: a theoretical analysis. J Cereb Blood Flow Metab (1983) 0.97

Extracellular space of the cerebral cortex of normothermic and hypothermic cats. Exp Neurol (1970) 0.96

Convection of cerebral interstitial fluid and its role in brain volume regulation. Ann N Y Acad Sci (1986) 0.95

Increased blood-brain transfer in a rabbit model of acute liver failure. Gastroenterology (1983) 0.95

Volume regulatory influx of electrolytes from plasma to brain during acute hyperosmolality. Am J Physiol (1987) 0.94

Regional blood flow in RT-9 brain tumors. J Neurosurg (1983) 0.94

Antenatal steroids decrease blood-brain barrier permeability in the ovine fetus. Am J Physiol (1999) 0.94

Effect of intravascular-to-extravascular water exchange on the determination of blood-to-tissue transfer constant by magnetic resonance imaging. Magn Reson Med (2005) 0.93

Chemotherapy of brain tumors: physiological and pharmacokinetic considerations. Semin Oncol (1986) 0.93

Apparent diffusion coefficient of glial neoplasms: correlation with fluorodeoxyglucose-positron-emission tomography and gadolinium-enhanced MR imaging. AJNR Am J Neuroradiol (2010) 0.93

Dexamethasone effects on [125I]albumin distribution in experimental RG-2 gliomas and adjacent brain. J Cereb Blood Flow Metab (1987) 0.93

Regional variations in the apparent diffusion coefficient and the intracellular distribution of water in rat brain during acute focal ischemia. Stroke (2001) 0.93

Susceptibility changes following bolus injections. Magn Reson Med (1993) 0.93

Fluid absorption and active and passive ion flows in the rabbit superficial pars recta. Am J Physiol (1977) 0.91

Intravascular streaming during carotid artery infusions. Demonstration in humans and reduction using diastole-phased pulsatile administration. J Neurosurg (1991) 0.91

Differences in function and structure of the capillary endothelium in gray matter, white matter and a circumventricular organ of rat brain. Blood Vessels (1986) 0.91

Topography of capillary density, glucose metabolism, and microvascular function within the rat inferior colliculus. J Cereb Blood Flow Metab (1987) 0.91

Local cerebral blood flow during the first hour following acute ligation of multiple arterioles in rat whisker barrel cortex. Neurobiol Dis (1998) 0.91

Drug streaming during intra-arterial chemotherapy. J Neurosurg (1986) 0.91

Peritoneal absorption of macromolecules studied by quantitative autoradiography. Am J Physiol (1985) 0.90

Osmosis in cortical collecting tubules. A theoretical and experimental analysis of the osmotic transient phenomenon. J Gen Physiol (1974) 0.89

Quantitative evaluation of the loss of human platelet dense bodies following stimulation by thrombin or A23187. J Physiol (1977) 0.89

Local blood-to-tissue transport in Walker 256 metastatic brain tumors. J Neurooncol (1984) 0.89

Regulation of brain water and electrolytes during acute hyperosmolality in rats. Am J Physiol (1987) 0.88