Crystalline arrays of membrane-bound acetylcholine receptor.

Mammalian nicotinic acetylcholine receptors: from structure to function. Physiol Rev (2009) 5.64

Structure and function of an acetylcholine receptor. Biophys J (1982) 2.92

How pore mouth charge distributions alter the permeability of transmembrane ionic channels. Biophys J (1987) 1.87

Three-dimensional structure of the acetylcholine receptor by cryoelectron microscopy and helical image reconstruction. J Cell Biol (1990) 1.25

Effect of pore structure on energy barriers and applied voltage profiles. I. Symmetrical channels. Biophys J (1984) 1.18

Three-dimensional structure of the nicotinic acetylcholine receptor and location of the major associated 43-kD cytoskeletal protein, determined at 22 A by low dose electron microscopy and x-ray diffraction to 12.5 A. J Cell Biol (1989) 1.17

Improved secondary structure predictions for a nicotinic receptor subunit: incorporation of solvent accessibility and experimental data into a two-dimensional representation. Biophys J (1999) 1.08

Tubular crystals of acetylcholine receptor. J Cell Biol (1984) 1.06

End-plate acetylcholine receptor: structure, mechanism, pharmacology, and disease. Physiol Rev (2012) 1.06

Electron microscopic evidence for nucleation and growth of 3D acetylcholine receptor microcrystals in structured lipid-detergent matrices. Proc Natl Acad Sci U S A (2003) 1.03

Effect of pore structure on energy barriers and applied voltage profiles. II. Unsymmetrical channels. Biophys J (1984) 0.96

Concerted vs. sequential. Two activation patterns of vast arrays of intracellular Ca2+ channels in muscle. J Gen Physiol (2005) 0.94

Structural answers and persistent questions about how nicotinic receptors work. Front Biosci (2008) 0.93

Nicotinic acetylcholine receptor and the structural basis of neuromuscular transmission: insights from Torpedo postsynaptic membranes. Q Rev Biophys (2013) 0.91

Dimeric arrangement and structure of the membrane-bound acetylcholine receptor studied by electron microscopy. EMBO J (1982) 0.89

Present and future of membrane protein structure determination by electron crystallography. Adv Protein Chem Struct Biol (2010) 0.85

Evolution and comparative genomics of subcellular specializations: EST sequencing of Torpedo electric organ. Mar Genomics (2011) 0.81

Allosteric regulation of pentameric ligand-gated ion channels: an emerging mechanistic perspective. Channels (Austin) (2014) 0.80

Alpha-bungarotoxin binding to acetylcholine receptor membranes studied by low angle X-ray diffraction. Biophys J (2003) 0.79

Agonists binding nicotinic receptors elicit specific channel-opening patterns at αγ and αδ sites. J Physiol (2014) 0.78

The concept of allosteric interaction and its consequences for the chemistry of the brain. J Biol Chem (2013) 0.77

Subcellular neuronal quasicrystals: Implications for consciousness. Commun Integr Biol (2015) 0.75

Subcellular neuronal quasicrystals: Implications for consciousness. Commun Integr Biol (2015) 0.75

New biophysical techniques and their application to the study of membranes. Biochem J (1985) 0.75

Acetylcholine receptor: complex of homologous subunits. Science (1980) 3.45

Structural studies of a membrane-bound acetylcholine receptor from Torpedo californica. J Mol Biol (1977) 2.17

Molecular weight in detergent solution of acetylcholine receptor from Torpedo californica. Biochemistry (1978) 2.08

Presence of a lattice structure in membrane fragments rich in nicotinic receptor protein from the electric organ of Torpedo marmorata. FEBS Lett (1973) 2.03

Biochemical properties of acteylcholine receptor subunits from Torpedo californica. Biochemistry (1979) 1.94

Immunospecific identification and three-dimensional structure of a membrane-bound acetylcholine receptor from Torpedo californica. J Mol Biol (1979) 1.82

Structure determination of asymmetric membrane profiles using an iterative Fourier method. Biophys J (1979) 1.75

Ultrastructure of isolated membranes of Torpedo electric tissue. Brain Res (1973) 1.68

A morphological study of the cholinergic receptor protein from Torpedo marmorata in its membrane environment and in its detergent-extracted purified form. J Cell Sci (1978) 1.59

Formation of disulfide-linked oligomers of acetylcholine receptor in membrane from torpedo electric tissue. Biochemistry (1979) 1.27

Membranes rich in acetylcholine receptor: characterization and reconstitution to excitable membranes from exogenous lipids. Eur J Biochem (1978) 1.25

Comparison of the structural and chemical composition of giant T-even phage heads. J Supramol Struct (1976) 1.22

Immunological comparison of acetylcholine receptors and their subunits from species of electric ray. Arch Biochem Biophys (1977) 1.22

Protease effects on the structure of acetylcholine receptor membranes from Torpedo californica. J Cell Biol (1980) 1.21

Application of optical diffraction to helical structures in the bacteriophage tail. Philos Trans R Soc Lond B Biol Sci (1971) 1.15

On the conformation of the acetylcholine receptor protein from Torpedo nobiliana. FEBS Lett (1974) 1.15

Demonstration of the transmembrane nature of the acetylcholine receptor by labeling with anti-receptor antibodies. J Cell Biol (1979) 1.09

Topographic studies of Torpedo acetylcholine receptor subunits as a transmembrane complex. Proc Natl Acad Sci U S A (1980) 1.04

Structural changes during the transformation of bacteriophage T4 polyheads: characterization of the initial and final states by freeze-drying and shadowing Fab-fragment-labelled preparations. J Mol Biol (1978) 1.00

Structural details of membrane-bound acetylcholine receptor from Tropedo marmorata. Proc Natl Acad Sci U S A (1980) 0.99

Structure of acetylcholine receptor dimer determined by neutron scattering and electron microscopy. J Biol Chem (1981) 0.89

Structure of a glycerol-conducting channel and the basis for its selectivity. Science (2000) 6.64

Clq: rapid purification method for preparation of monospecific antisera and for biochemical studies. J Immunol (1971) 5.06

Amphipathic analysis and possible formation of the ion channel in an acetylcholine receptor. Proc Natl Acad Sci U S A (1984) 4.70

The signal recognition particle. Annu Rev Biochem (2001) 4.47

Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: a model for viral DNA binding. Proc Natl Acad Sci U S A (2000) 3.26

Structure and function of an acetylcholine receptor. Biophys J (1982) 2.92

Ultrastructure of a periodic protein layer in the outer membrane of Escherichia coli. J Cell Biol (1977) 2.89

Antisera directed against connexin43 peptides react with a 43-kD protein localized to gap junctions in myocardium and other tissues. J Cell Biol (1989) 2.66

Efficiency of signalling through cytokine receptors depends critically on receptor orientation. Nature (1998) 2.65

Site-directed ligand discovery. Proc Natl Acad Sci U S A (2000) 2.58

Crystal structure of colicin Ia. Nature (1997) 2.57

Structure of the conserved GTPase domain of the signal recognition particle. Nature (1997) 2.52

Utility values and age-related macular degeneration. Arch Ophthalmol (2000) 2.48

Atomic structure of thymidylate synthase: target for rational drug design. Science (1987) 2.48

Crystal structure of the signal sequence binding subunit of the signal recognition particle. Cell (1998) 2.44

Mechanism of action of the C3b inactivator: requirement for a high molecular weight cofactor (C3b-C4bINA cofactor) and production of a new C3b derivative (C3b'). Immunochemistry (1978) 2.43

C'2ad, an inactive derivative of C'2 released during decay of EAC'4,2a. Immunochemistry (1966) 2.37

Ultrastructure of the human complement component, Clq (negative staining-glutamine synthetase-biologically active Clq). Proc Natl Acad Sci U S A (1972) 2.32

Cleavage of C2 by C1s into the antigenically distinct fragments C2a and C2b: demonstration of binding of C2b to C4b. Proc Natl Acad Sci U S A (1977) 2.27

Domain structure of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a glycoprotein of the endoplasmic reticulum. J Biol Chem (1985) 2.27

Polymorphic fibrillar assembly of human amylin. J Struct Biol (1997) 2.26

Cleavage products of C4b produced by enzymes in human serum. Immunochemistry (1975) 2.26

Regulation of an enzyme by phosphorylation at the active site. Science (1990) 2.25

Structure of a bacterial enzyme regulated by phosphorylation, isocitrate dehydrogenase. Proc Natl Acad Sci U S A (1989) 2.20

Structural studies of a membrane-bound acetylcholine receptor from Torpedo californica. J Mol Biol (1977) 2.17

Rabbit C1q: purification, functional and structural studies. J Immunol Methods (1972) 2.15

Chemical studies of Clq; a modulator of immunoglobulin biology. Biochem Biophys Res Commun (1971) 2.05

Linking regions between helices in bacteriorhodopsin revealed. Biophys J (1982) 2.03

Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate. Biochemistry (1990) 1.98

Structural and functional conservation between yeast and human 3-hydroxy-3-methylglutaryl coenzyme A reductases, the rate-limiting enzyme of sterol biosynthesis. Mol Cell Biol (1988) 1.97

Amyloid fibril formation from full-length and fragments of amylin. J Struct Biol (2000) 1.95

Cleavage of C4b by C3b inactivator: production of a nicked form of C4b, C4b', as an intermediate cleavage product of C4b by C3b inactivator. J Immunol (1980) 1.94

Catalytic mechanism of NADP(+)-dependent isocitrate dehydrogenase: implications from the structures of magnesium-isocitrate and NADP+ complexes. Biochemistry (1991) 1.91

The three-dimensional structure of Asn102 mutant of trypsin: role of Asp102 in serine protease catalysis. Science (1987) 1.87

Structural studies on human Clq: non-covalent and covalent subunits. Immunochemistry (1972) 1.83

Structure of Cry2Aa suggests an unexpected receptor binding epitope. Structure (2001) 1.82

Watching amyloid fibrils grow by time-lapse atomic force microscopy. J Mol Biol (1999) 1.82

Immunospecific identification and three-dimensional structure of a membrane-bound acetylcholine receptor from Torpedo californica. J Mol Biol (1979) 1.82

Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility from a unique substrate channel. Proc Natl Acad Sci U S A (2001) 1.80

Utility values associated with blindness in an adult population. Br J Ophthalmol (2001) 1.79

Structure at 2.5 A of a designed peptide that maintains solubility of membrane proteins. Science (1993) 1.76

Family of G protein alpha chains: amphipathic analysis and predicted structure of functional domains. Protein Eng (1989) 1.76

Domain flexibility in retroviral proteases: structural implications for drug resistant mutations. Biochemistry (1998) 1.75

Structure determination of asymmetric membrane profiles using an iterative Fourier method. Biophys J (1979) 1.75

Plastic adaptation toward mutations in proteins: structural comparison of thymidylate synthases. Proteins (1990) 1.75

Attachment site(s) of retinal in bacteriorhodopsin. Proc Natl Acad Sci U S A (1981) 1.73

Projected structure of purple membrane determined to 3.7 A resolution by low temperature electron microscopy. J Mol Biol (1981) 1.71

Identification of a 70,000-D protein in lens membrane junctional domains. J Cell Biol (1985) 1.66

Structure and specific binding of trypsin: comparison of inhibited derivatives and a model for substrate binding. J Mol Biol (1974) 1.62

Molecular solutions to mammalian lens transparency. News Physiol Sci (2001) 1.62

Structure-based discovery of inhibitors of thymidylate synthase. Science (1993) 1.61

The structure of bovine trypsin: electron density maps of the inhibited enzyme at 5 Angstrom and at 2-7 Angstron resolution. J Mol Biol (1974) 1.55

Mechanisms of zymogen activation. Annu Rev Biophys Bioeng (1977) 1.51

The molecular neurobiology of the acetylcholine receptor. Annu Rev Neurosci (1986) 1.50

Functional changes in the structure of the SRP GTPase on binding GDP and Mg2+GDP. Nat Struct Biol (1999) 1.47

The crystal and molecular structure of DIP-inhibited bovine trypsin at2.7Angstrom resolution. Cold Spring Harb Symp Quant Biol (1972) 1.45

Atomic force microscopy reveals defects within mica supported lipid bilayers induced by the amyloidogenic human amylin peptide. J Mol Biol (2004) 1.44

Epidermal growth factor (EGF) induces oligomerization of soluble, extracellular, ligand-binding domain of EGF receptor. A low resolution projection structure of the ligand-binding domain. J Biol Chem (1991) 1.41

Reversible adsorption of C'2 by EAC'4: role of Mg2+, enumeration of competent SAC'4, two-step nature of C'2a fixation and estimation of its efficiency. Immunochemistry (1966) 1.41

The structural basis for tRNA recognition and pseudouridine formation by pseudouridine synthase I. Nat Struct Biol (2000) 1.41

Immunolocalization of MP70 in lens fiber 16-17-nm intercellular junctions. J Cell Biol (1987) 1.39

Deficiency of C1r in human serum. Effects on the structure and function of macromolecular C1. J Exp Med (1970) 1.36

Structure of bovine trypsinogen at 1.9 A resolution. Biochemistry (1977) 1.36

Human factor D of the alternative complement pathway: purification and characterization. J Immunol (1977) 1.33

Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site. Biochemistry (1995) 1.32

Surface tongue-and-groove contours on lens MIP facilitate cell-to-cell adherence. J Mol Biol (2000) 1.32

The relationship of the hemolytic activity of active C'1s to its TAMe esterase action: a new method of purification and assay. J Immunol (1969) 1.28

Regulation of isocitrate dehydrogenase by phosphorylation involves no long-range conformational change in the free enzyme. J Biol Chem (1990) 1.27

Complement and host defense against infection. J Pediatr (1977) 1.26

The crystal structure of alpha-bungarotoxin at 2.5 A resolution: relation to solution structure and binding to acetylcholine receptor. Protein Eng (1989) 1.25

Freeze drying and shadowing a two-dimensional periodic specimen. J Ultrastruct Res (1977) 1.24

Comparison of the structural and chemical composition of giant T-even phage heads. J Supramol Struct (1976) 1.22

A family of protein-cutting proteins. Sci Am (1974) 1.22

Protease effects on the structure of acetylcholine receptor membranes from Torpedo californica. J Cell Biol (1980) 1.21

Catalysis of C'2 fixation by C'la. Reaction kinetics, competitive inhibition by TAMe, and transferase hypothesis of the enzymatic action of C'la on C'2, one of its natural substrates. Immunochemistry (1965) 1.20

Mode of interaction of different polyanions with the first (C1, C1), the second (C2) and the fourth (C4) component of complement--III. Inhibition of C4 and C2 binding site(s) on C1s by polyanions. Immunochemistry (1976) 1.20

Acetylcholine receptor structure, function, and evolution. Annu Rev Cell Biol (1985) 1.18

The structural mechanism for half-the-sites reactivity in an enzyme, thymidylate synthase, involves a relay of changes between subunits. Biochemistry (1999) 1.18

Three-dimensional structure of the nicotinic acetylcholine receptor and location of the major associated 43-kD cytoskeletal protein, determined at 22 A by low dose electron microscopy and x-ray diffraction to 12.5 A. J Cell Biol (1989) 1.17

Design of potent selective zinc-mediated serine protease inhibitors. Nature (1998) 1.17

A designed four helix bundle protein with native-like structure. Nat Struct Biol (1997) 1.17

Bacteriorhodopsin D85N: three spectroscopic species in equilibrium. Biochemistry (1993) 1.16

Topological mapping of acetylcholine receptor: evidence for a model with five transmembrane segments and a cytoplasmic COOH-terminal peptide. Proc Natl Acad Sci U S A (1985) 1.16

Assembly of bacteriophage T7. Dimensions of the bacteriophage and its capsids. Biophys J (1981) 1.16

Purification of bacteriorhodopsin and characterization of mature and partially processed forms. J Biol Chem (1989) 1.14

pH dependence of tritium exchange with the C-2 protons of the histidines in bovine trypsin. Biochemistry (1976) 1.13

Interaction of Histoplasma capsulatum with human platelets. J Infect Dis (1980) 1.13

Spatial differences in gap junction gating in the lens are a consequence of connexin cleavage. Eur J Cell Biol (1998) 1.13

Quantitative analysis of electrophoretograms: a mathematical approach to super-resolution. Anal Biochem (1981) 1.13

Functional consequences of the Kaposi's sarcoma-associated herpesvirus protease structure: regulation of activity and dimerization by conserved structural elements. Biochemistry (2000) 1.12

Surface reliefs computed from micrographs of heavy metal-shadowed specimens. J Ultrastruct Res (1977) 1.10

Pairwise specificity and sequential binding in enzyme catalysis: thymidylate synthase. Biochemistry (1990) 1.10

Lens gap junctions and orthogonal arrays are unrelated. FEBS Lett (1980) 1.09

Surface structure of in vitro assembled bacteriophage lambda polyheads. J Mol Biol (1976) 1.09

Mechanism of hydrolysis by serine proteases: direct determination of the pKa's of aspartyl-102 and aspartyl-194 in bovine trypsin using difference infrared spectroscopy. Biochemistry (1976) 1.09

Effects of detergent environments on the photocycle of purified monomeric bacteriorhodopsin. Biochemistry (1991) 1.08

Episelection: novel Ki approximately nanomolar inhibitors of serine proteases selected by binding or chemistry on an enzyme surface. Biochemistry (1995) 1.07

Atomic structure of a glycerol channel and implications for substrate permeation in aqua(glycero)porins. FEBS Lett (2001) 1.07

Mode of interaction of different polyanions with the first (C1, C1), the second (C2) and the fourth (C4) component of complement--II. Effect of polyanions on the binding of C2 to EAC4b. Immunochemistry (1976) 1.07