Published in Proc Natl Acad Sci U S A on September 01, 1981
SOS chromotest, a direct assay of induction of an SOS function in Escherichia coli K-12 to measure genotoxicity. Proc Natl Acad Sci U S A (1982) 1.99
Design and antimicrobial action of purine analogues that bind Guanine riboswitches. ACS Chem Biol (2009) 1.29
YcbX and yiiM, two novel determinants for resistance of Escherichia coli to N-hydroxylated base analogues. Mol Microbiol (2008) 1.08
Biochemical characterization of a novel hypoxanthine/xanthine dNTP pyrophosphatase from Methanococcus jannaschii. Nucleic Acids Res (2001) 1.00
Molybdenum cofactor-dependent resistance to N-hydroxylated base analogs in Escherichia coli is independent of MobA function. Mutat Res (2007) 0.98
Pivotal role of inosine triphosphate pyrophosphatase in maintaining genome stability and the prevention of apoptosis in human cells. PLoS One (2012) 0.89
Induction of mutation in mouse FM3A cells by N4-aminocytidine-mediated replicational errors. Mol Cell Biol (1988) 0.86
Role for CysJ flavin reductase in molybdenum cofactor-dependent resistance of Escherichia coli to 6-N-hydroxylaminopurine. J Bacteriol (2010) 0.83
[Genetic control of metabolism of mutagenic purine base analogs 6-hydroxylaminopurine and 2-amino-6-hydroxylaminopurine in yeast Saccharomyces cerevisiae]. Genetika (2009) 0.81
Elevated Levels of DNA Strand Breaks Induced by a Base Analog in the Human Cell Line with the P32T ITPA Variant. J Nucleic Acids (2010) 0.80
The pivotal role of the mitochondrial amidoxime reducing component 2 in protecting human cells against apoptotic effects of the base analog N6-hydroxylaminopurine. J Biol Chem (2015) 0.79
A critical role for the putative NCS2 nucleobase permease YjcD in the sensitivity of Escherichia coli to cytotoxic and mutagenic purine analogs. MBio (2013) 0.79
Mechanism of 2-aminopurine mutagenesis in mouse T-lymphosarcoma cells. Mol Cell Biol (1982) 0.79
The twists and turns of enzyme function. J Bacteriol (2010) 0.77
TusA (YhhP) and IscS are required for molybdenum cofactor-dependent base-analog detoxification. Microbiologyopen (2013) 0.76
Mouse transgenes in human cells detect specific base substitutions. Proc Natl Acad Sci U S A (1990) 0.75
Antibacterial and antivirulence effect of 6-N-hydroxylaminopurine in Listeria monocytogenes. Nucleic Acids Res (2017) 0.75
Mutagenicity testing of 9-N-substituted adenines and their N-oxidation products. Environ Health Perspect (1993) 0.75
Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals: discussion. Proc Natl Acad Sci U S A (1976) 3.46
The origin of human cancers. Nature (1981) 3.24
Evidence for the progressive nature of neoplastic transformation in vitro. Proc Natl Acad Sci U S A (1978) 2.00
2-Aminopurine. Mutat Res (1980) 1.82
Validation and characterization of the L5178Y/TK+/- mouse lymphoma mutagen assay system. Mutat Res (1979) 1.39
Induction of ad-3 Mutants of Neurospora Crassa by 2-Aminopurine. Genetics (1963) 1.36
Identification of the chromosomes that control malignancy. Nat New Biol (1973) 1.22
Relationship between somatic mutation and neoplastic transformation. Proc Natl Acad Sci U S A (1978) 1.09
The efficiency and extent of mutagenic activity of some new mutagens of base-analogue type. Mutat Res (1978) 1.08
A mammalian cellular system for the concomitant study of neoplastic transformation and somatic mutation. Mutat Res (1978) 1.07
Diethylstilbestrol induces neoplastic transformation without measurable gene mutation at two loci. Science (1981) 1.06
Genes which increase chromosomal instability in somatic cells and predispose to cancer. Prog Med Genet (1972) 1.06
The mutagenic effect of hydroxyaminopurine derivatives on phage T4. Mutat Res (1968) 0.97
INFLUENCE OF MUTAGENS ON THE INITIATION OF SKIN CARCINOGENESIS. Biochem Pharmacol (1964) 0.95
Early changes in chromosomal number and structure after treatment of fetal hamster cultures with transforming doses of polycyclic hydrocarbons. J Natl Cancer Inst (1972) 0.91
Problems associated with the application of short-term tests for mutagenicity in mass-screening programs. Environ Mutagen (1979) 0.84
A comparison of the oncogenicities of 3-hydroxyxanthine, guanine 3-N-oxide, and some related compounds. Cancer Res (1970) 0.84
Nuclear DNA and histologic studies of genital lesions in diethylstilbestrol-exposed progeny. I. Intraepithelial squamous abnormalities. Am J Clin Pathol (1979) 0.81
Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc Natl Acad Sci U S A (1996) 4.33
KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2. Science (1995) 3.97
High-resolution serum proteomic features for ovarian cancer detection. Endocr Relat Cancer (2004) 3.75
Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning? Free Radic Biol Med (2005) 3.13
New IBD genetics: common pathways with other diseases. Gut (2011) 2.95
PTEN/MMAC1 mutations in endometrial cancers. Cancer Res (1997) 2.89
Analysis of the cell population kinetics of transplanted tumours of widely-differing growth rate. Br J Cancer (1966) 2.88
Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase. Nat Genet (1999) 2.81
A mathematical model of the mitotic cycle and its application to the interpretation of percentage labeled mitoses data. J Natl Cancer Inst (1966) 2.36
Microsatellite instability, mismatch repair deficiency, and genetic defects in human cancer cell lines. Cancer Res (1995) 2.35
Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice. Cancer Res (1997) 2.34
Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene. Cancer Res (1999) 2.32
A gene involved in control of human cellular senescence on human chromosome 1q. Mol Cell Biol (1994) 2.26
Microarrays and toxicology: the advent of toxicogenomics. Mol Carcinog (1999) 2.12
Dependence of asbestos- and mineral dust-induced transformation of mammalian cells in culture on fiber dimension. Cancer Res (1984) 2.03
Application of complementary DNA microarray technology to carcinogen identification, toxicology, and drug safety evaluation. Cancer Res (1999) 2.02
Evidence for the progressive nature of neoplastic transformation in vitro. Proc Natl Acad Sci U S A (1978) 2.00
Correction of hypermutability, N-methyl-N'-nitro-N-nitrosoguanidine resistance, and defective DNA mismatch repair by introducing chromosome 2 into human tumor cells with mutations in MSH2 and MSH6. Cancer Res (1997) 1.96
Detection of frequent allelic loss on proximal chromosome 17q in sporadic breast carcinoma using microsatellite length polymorphisms. Cancer Res (1992) 1.93
Age, time and cohort factors in mortality from cancer of the cervix. J Hyg (Lond) (1973) 1.92
DNA methylation analysis of the promoter region of the human telomerase reverse transcriptase (hTERT) gene. Cancer Res (1999) 1.79
Induction of gene amplification by arsenic. Science (1988) 1.72
Functional overlap in mismatch repair by human MSH3 and MSH6. Genetics (1998) 1.70
Transcriptional activation of the telomerase hTERT gene by human papillomavirus type 16 E6 oncoprotein. J Virol (2001) 1.68
optiCall: a robust genotype-calling algorithm for rare, low-frequency and common variants. Bioinformatics (2012) 1.62
A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast cancer. Cancer Res (1998) 1.60
Avoided and avoidable risks of cancer. Carcinogenesis (1997) 1.58
PTEN mutation in endometrial cancers is associated with favorable clinical and pathologic characteristics. Clin Cancer Res (1998) 1.58
Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes. Mol Cell Biol (1999) 1.57
Possible cellular and molecular mechanisms for asbestos carcinogenicity. Am J Ind Med (1992) 1.56
Down-regulation of the KAI1 metastasis suppressor gene during the progression of human prostatic cancer infrequently involves gene mutation or allelic loss. Cancer Res (1996) 1.50
Evidence for a p53-independent pathway for upregulation of SDI1/CIP1/WAF1/p21 RNA in human cells. Mol Carcinog (1994) 1.49
Synthesis of oligodeoxyribonucleotide ethyl phosphotriesters and their specific complex formation with transfer ribonucleic acid. Biochemistry (1974) 1.49
Molecular genetic evidence of the occurrence of breast cancer as an integral tumor in patients with the hereditary nonpolyposis colorectal carcinoma syndrome. Cancer (1996) 1.48
Induction by asbestos fibers of anaphase abnormalities: mechanism for aneuploidy induction and possibly carcinogenesis. Carcinogenesis (1985) 1.46
Mutation of the PTEN tumor suppressor gene in endometrial hyperplasias. Cancer Res (1998) 1.46
Comparison of spontaneous mutation rates of normal and chemically transformed human skin fibroblasts. Cancer Res (1983) 1.45
Apoptosis and altered redox state induced by caffeic acid phenethyl ester (CAPE) in transformed rat fibroblast cells. Cancer Res (1995) 1.44
Biomarkers of oxidative stress study III. Effects of the nonsteroidal anti-inflammatory agents indomethacin and meclofenamic acid on measurements of oxidative products of lipids in CCl4 poisoning. Free Radic Biol Med (2005) 1.42
Mutational analysis of the PTEN gene in human uterine sarcomas. Am J Obstet Gynecol (2001) 1.41
Methylene chloride. Science (1996) 1.40
The role of hMLH1, hMSH3, and hMSH6 defects in cisplatin and oxaliplatin resistance: correlation with replicative bypass of platinum-DNA adducts. Cancer Res (1998) 1.39
Nonrandom loss of chromosome 15 in Syrian hamster tumours induced by v-Ha-ras plus v-myc oncogenes. Nature (1985) 1.39
Comparison of arsenic-induced cell transformation, cytotoxicity, mutation and cytogenetic effects in Syrian hamster embryo cells in culture. Carcinogenesis (1985) 1.37
Homozygous deletions at chromosome 9p21 and mutation analysis of p16 and p15 in microdissected primary non-small cell lung cancers. Clin Cancer Res (1995) 1.37
Reactive oxygen species as double-edged swords in cellular processes: low-dose cell signaling versus high-dose toxicity. Hum Exp Toxicol (2002) 1.37
Breast cancer and environmental risk factors: epidemiological and experimental findings. Annu Rev Pharmacol Toxicol (1996) 1.35
Senescence of nickel-transformed cells by an X chromosome: possible epigenetic control. Science (1991) 1.35
Induction of cellular senescence in immortalized cells by human chromosome 1. Science (1990) 1.31
Temporal acquistion of enhanced fibrinolytic activity by syrian hamster embryo cells following treatment with benzo(a)pyrene. Cancer Res (1977) 1.31
Direct isolation of human BRCA2 gene by transformation-associated recombination in yeast. Proc Natl Acad Sci U S A (1997) 1.30
Chromosome 5 suppresses tumorigenicity of PC3 prostate cancer cells: correlation with re-expression of alpha-catenin and restoration of E-cadherin function. Cancer Res (1995) 1.28
Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair. Nat Genet (1996) 1.28
Induction of apoptosis by c-Fos protein. Mol Cell Biol (1996) 1.26
Insulin-like growth factor-I: a key regulator of human cancer risk? J Natl Cancer Inst (1999) 1.24
Normal human chromosome 11 suppresses tumorigenicity of human cervical tumor cell line SiHa. Mol Carcinog (1989) 1.23
Genomic organization of the human KAI1 metastasis-suppressor gene. Genomics (1997) 1.23
Correlation of asbestos-induced cytogenetic effects with cell transformation of Syrian hamster embryo cells in culture. Cancer Res (1984) 1.21
Insulin-like growth factor 1 (IGF-1) alters drug sensitivity of HBL100 human breast cancer cells by inhibition of apoptosis induced by diverse anticancer drugs. Cancer Res (1997) 1.19
Biomarkers of oxidative stress study: are plasma antioxidants markers of CCl(4) poisoning? Free Radic Biol Med (2000) 1.19
Regulation of microfilament organization and anchorage-independent growth by tropomyosin 1. Proc Natl Acad Sci U S A (1995) 1.16
An Alu polymorphism intragenic to the TP53 gene. Nucleic Acids Res (1991) 1.15
Functional copies of a human gene can be directly isolated by transformation-associated recombination cloning with a small 3' end target sequence. Proc Natl Acad Sci U S A (1998) 1.14
Neoplastic transformation induced by a direct perturbation of DNA. Nature (1978) 1.14
Frequent loss of KAI1 expression in squamous and lymphoid neoplasms. An immunohistochemical study of archival tissues. Am J Pathol (1999) 1.13
Loss of KAI1 expression in the progression of colorectal cancer. Cancer Res (1999) 1.13
A defined chromosome 6q fragment (at D6S310) harbors a putative tumor suppressor gene for breast cancer. Oncogene (1996) 1.12
Bisphenol-A induces cellular transformation, aneuploidy and DNA adduct formation in cultured Syrian hamster embryo cells. Int J Cancer (1998) 1.12
Complementation of an hMSH2 defect in human colorectal carcinoma cells by human chromosome 2 transfer. Mol Carcinog (2000) 1.12
Cloning of human centromeres by transformation-associated recombination in yeast and generation of functional human artificial chromosomes. Nucleic Acids Res (2003) 1.11
Defining a common region of deletion at 13q21 in human cancers. Genes Chromosomes Cancer (2001) 1.11
Correlation of in vitro growth properties and tumorigenicity of Syrian hamster cell lines. Cancer Res (1979) 1.10
Relationship between somatic mutation and neoplastic transformation. Proc Natl Acad Sci U S A (1978) 1.09
Mutation of beta-catenin is an early event in chemically induced mouse hepatocellular carcinogenesis. Oncogene (1999) 1.09
Involvement of p85 in p53-dependent apoptotic response to oxidative stress. Nature (1998) 1.07
Roles for insulin-like growth factor-1 in mediating the anti-carcinogenic effects of caloric restriction. J Nutr Health Aging (1999) 1.07
Quantitation of fibrinolytic activity of Syrian hamster fibroblasts using 3H-labeled fibrinogen prepared by reductive alkylation. Cancer Res (1977) 1.07
cis-Activation of the human telomerase gene (hTERT) by the hepatitis B virus genome. J Natl Cancer Inst (2001) 1.07
A mammalian cellular system for the concomitant study of neoplastic transformation and somatic mutation. Mutat Res (1978) 1.07
Genetic and cellular basis of multistep carcinogenesis. Pharmacol Ther (1990) 1.07
Diethylstilbestrol induces neoplastic transformation without measurable gene mutation at two loci. Science (1981) 1.06
Chondrocyte phenotype and cell survival are regulated by culture conditions and by specific cytokines through the expression of Sox-9 transcription factor. Rheumatology (Oxford) (2001) 1.06
Confirmation of the novel association at the BTNL2 locus with ulcerative colitis. Tissue Antigens (2009) 1.06
Restoration of the cellular senescence program and repression of telomerase by human chromosome 3. Jpn J Cancer Res (1995) 1.05
Estrogen upregulation of BRCA1 expression with no effect on localization. Mol Carcinog (1998) 1.05
Insulin-like growth factor-1 inscribes a gene expression profile for angiogenic factors and cancer progression in breast epithelial cells. Neoplasia (2002) 1.04
Gap junction function and cancer. Cancer Res (1993) 1.04
Role of phagocytosis in Syrian hamster cell transformation and cytogenetic effects induced by asbestos and short and long glass fibers. Cancer Res (1986) 1.04
Chemically induced aneuploidy in mammalian cells: mechanisms and biological significance in cancer. Environ Mutagen (1986) 1.04
Regulation of p53 stability and activity in response to genotoxic stress. Mutat Res (2000) 1.04
The carcinogenesis bioassay in perspective: application in identifying human cancer hazards. Environ Health Perspect (1995) 1.03
Growth and differentiation of hamster tracheal epithelial cells in culture. Exp Lung Res (1984) 1.03
Genetic analysis of cellular senescence. Biochim Biophys Acta (1995) 1.03
Up-regulation of urokinase-type plasminogen activator by insulin-like growth factor-I depends upon phosphatidylinositol-3 kinase and mitogen-activated protein kinase kinase. Cancer Res (2001) 1.03
Correction of a genetic defect in multipotent germline stem cells using a human artificial chromosome. Gene Ther (2008) 1.03
An integrated transcript map of human chromosome 1p35-p36. Genomics (1997) 1.03
Protective effect of pregnancy for development of uterine leiomyoma. Carcinogenesis (2001) 1.03
Morphologic and neoplastic transformation of Syrian hamster embryo fibroblasts by diethylstilbestrol and its analogs. Cancer Res (1982) 1.03
A hPMS2 mutant cell line is defective in strand-specific mismatch repair. J Biol Chem (1995) 1.02
Suppression of the tumorigenicity of prostatic cancer cells by gene(s) located on human chromosome 19p13.1-13.2. Prostate (1999) 1.02