Published in Am J Physiol on September 01, 1978
A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease. J Clin Invest (2012) 2.98
Penetration of drugs through the blood-cerebrospinal fluid/blood-brain barrier for treatment of central nervous system infections. Clin Microbiol Rev (2010) 2.66
Osmotic opening of the blood-brain barrier: principles, mechanism, and therapeutic applications. Cell Mol Neurobiol (2000) 1.80
On the rate and extent of drug delivery to the brain. Pharm Res (2007) 1.53
Macromolecular permeability across the blood-nerve and blood-brain barriers. Proc Natl Acad Sci U S A (1994) 1.50
Functional effectiveness of the blood-brain barrier to small water-soluble molecules in developing and adult opossum (Monodelphis domestica). J Comp Neurol (2006) 1.48
Drug metabolism and pharmacokinetics, the blood-brain barrier, and central nervous system drug discovery. NeuroRx (2005) 1.48
Transport of steroid hormones through the rat blood-brain barrier. Primary role of albumin-bound hormone. J Clin Invest (1979) 1.42
Transport into retina measured by short vascular perfusion in the rat. J Physiol (1993) 1.18
The blood-brain barrier: an engineering perspective. Front Neuroeng (2013) 1.09
Effect of synthetic matrix metalloproteinase inhibitors on lipopolysaccharide-induced blood-brain barrier opening in rodents: Differences in response based on strains and solvents. Brain Res (2006) 1.02
Lack of selectivity to small ions in paracellular pathways in cerebral and muscle capillaries of the frog. J Physiol (1984) 0.93
How to measure drug transport across the blood-brain barrier. NeuroRx (2005) 0.93
In vitro models of the blood-brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use. J Cereb Blood Flow Metab (2016) 0.90
Quantitative assessment of the permeability of the rat blood-retinal barrier to small water-soluble non-electrolytes. J Physiol (1987) 0.89
Calcium-activated potassium channels mediated blood-brain tumor barrier opening in a rat metastatic brain tumor model. Mol Cancer (2007) 0.89
P-glycoprotein deficient mouse in situ blood-brain barrier permeability and its prediction using an in combo PAMPA model. Eur J Pharm Sci (2009) 0.88
Enhanced delivery of carboplatin into brain tumours with intravenous Cereport (RMP-7): dramatic differences and insight gained from dosing parameters. Br J Cancer (1999) 0.88
Central nervous system targeting of 2',3'-dideoxyinosine via adenosine deaminase-activated 6-halo-dideoxypurine prodrugs. Antimicrob Agents Chemother (1992) 0.85
Role of organic osmolytes in myelinolysis. A topographic study in rats after rapid correction of hyponatremia. J Clin Invest (1995) 0.83
Glycerol does not reduce neuronal damage in experimental Streptococcus pneumoniae meningitis in rabbits. Inflammopharmacology (1998) 0.83
Failure of hyperthermia to open rat blood-brain barrier: reduced permeation of sucrose. Acta Neuropathol (1982) 0.81
Relative vascular permeability and vascularity across different regions of the rat nasal mucosa: implications for nasal physiology and drug delivery. Sci Rep (2016) 0.81
Tightness of the blood-brain barrier and evidence for brain interstitial fluid flow in the cuttlefish, Sepia officinalis. J Physiol (1985) 0.80
Imaging hemodynamics. Cancer Metastasis Rev (2008) 0.79
Comparative effects of glucose- and mannitol-induced osmolar stress on blood-brain barrier function in ovine fetuses and lambs. J Cereb Blood Flow Metab (2011) 0.78
Anti-IL-6 neutralizing antibody modulates blood-brain barrier function in the ovine fetus. FASEB J (2015) 0.78
A new in situ brain perfusion flow correction method for lipophilic drugs based on the pH-dependent Crone-Renkin equation. Pharm Res (2010) 0.77
Oral TNFα Modulation Alters Neutrophil Infiltration, Improves Cognition and Diminishes Tau and Amyloid Pathology in the 3xTgAD Mouse Model. PLoS One (2015) 0.77
Meta-analysis of studies comparing adjuvant dexamethasone to glycerol to improve clinical outcome of bacterial meningitis. J Res Med Sci (2016) 0.75
Physiologically based pharmacokinetic modelling of drug penetration across the blood-brain barrier--towards a mechanistic IVIVE-based approach. AAPS J (2013) 0.75
The involvement of GABA-transaminase in the blood-brain barrier to radiolabelled GABA. Acta Neuropathol (1984) 0.75
Targeting potassium channels for increasing delivery of imaging agents and therapeutics to brain tumors. Front Pharmacol (2013) 0.75
Macromolecular beta-adrenergic antagonists discriminating between receptor and antibody. Proc Natl Acad Sci U S A (1980) 0.75
Effects of hepatic ischemia-reperfusion injury on the blood-brain barrier permeability to [(14)C] and [(13)C]sucrose. Metab Brain Dis (2017) 0.75
The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat. J Neurochem (1977) 11.55
Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis. Science (1997) 6.66
Positron emission tomography in evaluation of dementia: Regional brain metabolism and long-term outcome. JAMA (2001) 5.13
The natural history of homocystinuria due to cystathionine beta-synthase deficiency. Am J Hum Genet (1985) 4.60
Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene. Science (1997) 4.55
Some relations between changes in the linear electrical properties of striated muscle fibers and changes in ultrastructure. J Gen Physiol (1967) 4.53
The effect of white matter hyperintensity volume on brain structure, cognitive performance, and cerebral metabolism of glucose in 51 healthy adults. Neurology (1995) 3.95
Method for quantification of brain, ventricular, and subarachnoid CSF volumes from MR images. J Comput Assist Tomogr (1992) 3.62
Dissociation of object and spatial visual processing pathways in human extrastriate cortex. Proc Natl Acad Sci U S A (1991) 3.15
Mutation of the acetylcholine receptor alpha subunit causes a slow-channel myasthenic syndrome by enhancing agonist binding affinity. Neuron (1995) 2.55
The Niemann-Pick C1 protein resides in a vesicular compartment linked to retrograde transport of multiple lysosomal cargo. J Biol Chem (1999) 2.45
Increasing annual incidence of primary malignant brain tumors in the elderly. J Natl Cancer Inst (1990) 2.34
Peroxisome targeting signal of rat liver acyl-coenzyme A oxidase resides at the carboxy terminus. Mol Cell Biol (1989) 2.33
Nanoscale nuclear magnetic resonance with a nitrogen-vacancy spin sensor. Science (2013) 2.33
Face encoding and recognition in the human brain. Proc Natl Acad Sci U S A (1996) 2.31
Mutation in the M1 domain of the acetylcholine receptor alpha subunit decreases the rate of agonist dissociation. J Gen Physiol (1997) 2.25
Regional glucose metabolic abnormalities are not the result of atrophy in Alzheimer's disease. Neurology (1998) 2.24
Network analysis of cortical visual pathways mapped with PET. J Neurosci (1994) 2.14
Kinetics of neutral amino acid transport across the blood-brain barrier. J Neurochem (1987) 2.09
Altered brain functional connectivity and impaired short-term memory in Alzheimer's disease. Brain (2001) 2.05
Blood-brain barrier transport of kynurenines: implications for brain synthesis and metabolism. J Neurochem (1991) 2.01
Mitochondrial mutation in fatal infantile cardiomyopathy. Lancet (1990) 1.98
X-chromosome effects on female brain: a magnetic resonance imaging study of Turner's syndrome. Lancet (1993) 1.93
Sex differences in human brain morphometry and metabolism: an in vivo quantitative magnetic resonance imaging and positron emission tomography study on the effect of aging. Arch Gen Psychiatry (1996) 1.90
An in situ brain perfusion technique to study cerebrovascular transport in the rat. Am J Physiol (1984) 1.87
The cerebral metabolic landscape in autism. Intercorrelations of regional glucose utilization. Arch Neurol (1988) 1.86
Critical analysis of the use of computer-assisted transverse axial tomography to study human brain in aging and dementia of the Alzheimer type. Neurology (1990) 1.84
[The fecal flora of man. IV. Communication: Comparison of the newly developed method with the old conventional method for the analysis of intestinal flora (author's transl)]. Zentralbl Bakteriol Orig A (1976) 1.79
Anti-MuSK autoantibodies block binding of collagen Q to MuSK. Neurology (2011) 1.77
Osmotic opening of tight junctions in cerebral endothelium. J Comp Neurol (1973) 1.75
Patients with idiopathic cardiomyopathy belong to the same mitochondrial DNA gene family of Parkinson's disease and mitochondrial encephalomyopathy. Biochem Biophys Res Commun (1991) 1.70
Age-related differences in volumes of subcortical nuclei, brain matter, and cerebrospinal fluid in healthy men as measured with magnetic resonance imaging. Arch Neurol (1992) 1.70
Cerebral glucose metabolism in childhood-onset obsessive-compulsive disorder. Revisualization during pharmacotherapy. Arch Gen Psychiatry (1992) 1.69
Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients. Mol Psychiatry (2009) 1.64
Altered long-term potentiation in the young and old Ts65Dn mouse, a model for Down Syndrome. Neuropharmacology (1998) 1.63
Longitudinal study of cerebral metabolic asymmetries and associated neuropsychological patterns in early dementia of the Alzheimer type. Arch Neurol (1990) 1.62
Successful separation of depressed, normal, and insomniac subjects by EEG sleep data. Arch Gen Psychiatry (1979) 1.60
Dietary n-3 PUFA deprivation alters expression of enzymes of the arachidonic and docosahexaenoic acid cascades in rat frontal cortex. Mol Psychiatry (2006) 1.60
New mutations in acetylcholine receptor subunit genes reveal heterogeneity in the slow-channel congenital myasthenic syndrome. Hum Mol Genet (1996) 1.60
Slow-channel myasthenic syndrome caused by enhanced activation, desensitization, and agonist binding affinity attributable to mutation in the M2 domain of the acetylcholine receptor alpha subunit. J Neurosci (1997) 1.59
Niemann-Pick C1 disease: the I1061T substitution is a frequent mutant allele in patients of Western European descent and correlates with a classic juvenile phenotype. Am J Hum Genet (1999) 1.57
Cerebral glucose metabolism in childhood-onset obsessive-compulsive disorder. Arch Gen Psychiatry (1989) 1.56
Premutation female carriers of fragile X syndrome: a pilot study on brain anatomy and metabolism. J Am Acad Child Adolesc Psychiatry (1999) 1.55
dE2F2, a novel E2F-family transcription factor in Drosophila melanogaster. Biochem Biophys Res Commun (1998) 1.54
Positron emission tomography in Alzheimer's disease. Neurology (1986) 1.52
A quantitative method for measuring regional in vivo fatty-acid incorporation into and turnover within brain phospholipids: review and critical analysis. Brain Res Brain Res Rev (1993) 1.51
Intercorrelations of glucose metabolic rates between brain regions: application to healthy males in a state of reduced sensory input. J Cereb Blood Flow Metab (1984) 1.51
Distinct clustering of point mutations in mitochondrial DNA among patients with mitochondrial encephalomyopathies and with Parkinson's disease. Biochem Biophys Res Commun (1991) 1.49
Tensile and viscoelastic properties of human patellar tendon. J Orthop Res (1994) 1.49
Mechanical properties of the sarcolemma and myoplasm in frog muscle as a function of sarcomere length. J Gen Physiol (1972) 1.48
Maternal inheritance of deleted mitochondrial DNA in a family with mitochondrial myopathy. Biochem Biophys Res Commun (1988) 1.48
Volumes of medial temporal lobe structures in patients with Alzheimer's disease and mild cognitive impairment (and in healthy controls). Biol Psychiatry (1998) 1.44
Neuroimaging and affective disorder in late life: a review. Can J Psychiatry (1990) 1.44
Quantitative CT analysis of brain morphometry in adult Down's syndrome at different ages. Neurology (1987) 1.43
GM2-gangliosidosis B1 variant: analysis of beta-hexosaminidase alpha gene abnormalities in seven patients. Am J Hum Genet (1990) 1.43
n-3 polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPK-dependent mechanism. Mol Psychiatry (2006) 1.43
Acetylcholine receptor M3 domain: stereochemical and volume contributions to channel gating. Nat Neurosci (1999) 1.42
Model for drug uptake by brain tumors: effects of osmotic treatment and of diffusion in brain. J Cereb Blood Flow Metab (1990) 1.42
Vascular dementia: stroke prevention takes on new urgency. Geriatrics (1993) 1.42
Brain atrophy in hypertension. A volumetric magnetic resonance imaging study. Hypertension (1992) 1.42
Age-related changes in regional cerebral blood flow during working memory for faces. Neuroimage (1998) 1.42
Congenital hydrocephalus due to intrauterine HTLV-I infection. Lancet (1990) 1.40
Longitudinal changes in lateral ventricular volume in patients with dementia of the Alzheimer type. Neurology (1992) 1.39
Metabolic correlates of fatigue and of recovery from fatigue in single frog muscle fibers. J Gen Physiol (1978) 1.37
Loss of proteins regulating synaptic plasticity in normal aging of the human brain and in Alzheimer disease. J Neuropathol Exp Neurol (1999) 1.37
Brain metabolite concentration and dementia severity in Alzheimer's disease: a (1)H MRS study. Neurology (2001) 1.35
Niemann-Pick C1 disease: correlations between NPC1 mutations, levels of NPC1 protein, and phenotypes emphasize the functional significance of the putative sterol-sensing domain and of the cysteine-rich luminal loop. Am J Hum Genet (2001) 1.34
Mitochondrial DNA mutations in mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS). Biochem Biophys Res Commun (1991) 1.34
Chronological changes of perihematomal edema of human intracerebral hematoma. Acta Neurochir Suppl (2003) 1.33
Quantitative aspects of reversible osmotic opening of the blood-brain barrier. Am J Physiol (1980) 1.33
Progression in acute stroke: value of the initial NIH stroke scale score on patient stratification in future trials. Stroke (1999) 1.33
Bartonella henselae infection from a dog. Lancet (1998) 1.32
Epigenetic modifications in frontal cortex from Alzheimer's disease and bipolar disorder patients. Transl Psychiatry (2012) 1.31
Swelling of the transverse tubular system in frog sartorius. J Gen Physiol (1969) 1.31
Cerebrospinal fluid production is reduced in healthy aging. Neurology (1990) 1.31
The differential expression patterns of messenger RNAs encoding K-Cl cotransporters (KCC1,2) and Na-K-2Cl cotransporter (NKCC1) in the rat nervous system. Neuroscience (2001) 1.30
Effect of light-adaptation on the photoreaction of bacteriorhodopsin from Halobacterium halobium. Biochim Biophys Acta (1977) 1.30
A method for predicting postoperative lung function and its relation to postoperative complications in patients with lung cancer. Ann Thorac Surg (1985) 1.29
Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome. Neuropharmacology (1999) 1.29
Determination of diamines and polyamines in tissues by high-pressure liquid chromatography. J Chromatogr (1976) 1.29
Accumulation of cholera toxin and GM1 ganglioside in the early endosome of Niemann-Pick C1-deficient cells. Proc Natl Acad Sci U S A (2001) 1.28
Relations between neuropsychological and cerebral metabolic asymmetries in early Alzheimer's disease. J Cereb Blood Flow Metab (1985) 1.26
Modification of the blood-brain barrier in the chemotherapy of malignant brain tumors. Fed Proc (1984) 1.25
Corpus callosum atrophy is a possible indicator of region- and cell type-specific neuronal degeneration in Alzheimer disease: a magnetic resonance imaging analysis. Arch Neurol (1998) 1.25
Testing of a hypothesis for osmotic opening of the blood-brain barrier. Am J Physiol (1972) 1.25
Sugar chains of serum transferrin from patients with carbohydrate deficient glycoprotein syndrome. Evidence of asparagine-N-linked oligosaccharide transfer deficiency. J Biol Chem (1993) 1.24
NPC1 gene mutations in Japanese patients with Niemann-Pick disease type C. Hum Genet (1999) 1.23
Visual cortical dysfunction in Alzheimer's disease evaluated with a temporally graded "stress test" during PET. Am J Psychiatry (1996) 1.23
A fixed charge model of the transverse tubular system of frog sartorius. J Gen Physiol (1969) 1.22
A two-dimensional, finite element analysis of vasogenic brain edema. Neurol Med Chir (Tokyo) (1990) 1.21
Mode of action of mood stabilizers: is the arachidonic acid cascade a common target? Mol Psychiatry (2008) 1.21
Separation of the Dns derivatives of polyamines and related compounds by thin-layer and high-pressure liquid chromatography. J Chromatogr (1975) 1.21
Longitudinal study of the early neuropsychological and cerebral metabolic changes in dementia of the Alzheimer type. J Clin Exp Neuropsychol (1988) 1.20
Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer disease. Brain Res Mol Brain Res (1994) 1.18
Effect of task difficulty on cerebral blood flow during perceptual matching of faces. Hum Brain Mapp (1996) 1.18
Heterogeneous anterior-posterior metabolic patterns in dementia of the Alzheimer type. Neurology (1988) 1.18
Fundamental gating mechanism of nicotinic receptor channel revealed by mutation causing a congenital myasthenic syndrome. J Gen Physiol (2000) 1.18
Isolation and quantitation of long-chain acyl-coenzyme A esters in brain tissue by solid-phase extraction. Anal Biochem (1994) 1.17