Published in Cell on October 01, 1982
Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex. J Exp Med (1983) 9.23
Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J Exp Med (1987) 5.48
Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway. Proc Natl Acad Sci U S A (1984) 4.78
Antigen-like effects of monoclonal antibodies directed at receptors on human T cell clones. J Exp Med (1983) 4.10
Use of OKT3 with cyclosporin and steroids for reversal of acute kidney and liver allograft rejection. Nephron (1987) 3.26
Comparison of T3-associated 49- and 43-kilodalton cell surface molecules on individual human T-cell clones: evidence for peptide variability in T-cell receptor structures. Proc Natl Acad Sci U S A (1983) 2.93
Generation of monoclonal antibodies to a human natural killer clone. Characterization of two natural killer-associated antigens, NKH1A and NKH2, expressed on subsets of large granular lymphocytes. J Clin Invest (1985) 2.77
Characterization of the human receptor for T-cell growth factor. Proc Natl Acad Sci U S A (1983) 2.76
Lymphokine-activated killer cell phenomenon. II. Precursor phenotype is serologically distinct from peripheral T lymphocytes, memory cytotoxic thymus-derived lymphocytes, and natural killer cells. J Exp Med (1983) 2.67
Perturbation of the T4 molecule transmits a negative signal to T cells. J Exp Med (1985) 2.66
Deficiency of a leukocyte surface glycoprotein (LFA-1) in two patients with Mo1 deficiency. Effects of cell activation on Mo1/LFA-1 surface expression in normal and deficient leukocytes. J Clin Invest (1984) 2.46
A 275 basepair fragment at the 5' end of the interleukin 2 gene enhances expression from a heterologous promoter in response to signals from the T cell antigen receptor. J Exp Med (1987) 2.37
Identification and functional characterization of the human T-cell receptor beta gene transcriptional enhancer: common nuclear proteins interact with the transcriptional regulatory elements of the T-cell receptor alpha and beta genes. Mol Cell Biol (1990) 2.32
Deficiency of a surface membrane glycoprotein (Mo1) in man. J Clin Invest (1984) 2.29
Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand. J Exp Med (1995) 2.24
Idiotype-like molecules on cells of a human T cell leukemia. J Exp Med (1983) 2.19
Activators of protein kinase C down-regulate and phosphorylate the T3/T-cell antigen receptor complex of human T lymphocytes. Proc Natl Acad Sci U S A (1985) 2.10
Triggering of T cell proliferation through AIM, an activation inducer molecule expressed on activated human lymphocytes. J Exp Med (1988) 2.08
Involvement of T44 molecules in an antigen-independent pathway of T cell activation. Analysis of the correlations to the T cell antigen-receptor complex. J Exp Med (1985) 1.92
Single cell analysis reveals regulated hierarchical T cell antigen receptor signaling thresholds and intraclonal heterogeneity for individual cytokine responses of CD4+ T cells. J Exp Med (1997) 1.87
Endocytosis and recycling of the T3-T cell receptor complex. The role of T3 phosphorylation. J Exp Med (1987) 1.80
Atomic structure of an alphabeta T cell receptor (TCR) heterodimer in complex with an anti-TCR fab fragment derived from a mitogenic antibody. EMBO J (1998) 1.74
Fc gamma receptor type III (CD16) is included in the zeta NK receptor complex expressed by human natural killer cells. Proc Natl Acad Sci U S A (1990) 1.66
Identification of a clonally restricted 90 kD heterodimer on two human cloned natural killer cell lines. Its role in cytotoxic effector function. J Exp Med (1983) 1.62
Isolation and characterization of a T-lymphocyte somatic mutant with altered signal transduction by the antigen receptor. Proc Natl Acad Sci U S A (1987) 1.57
CD3 gamma contains a phosphoserine-dependent di-leucine motif involved in down-regulation of the T cell receptor. EMBO J (1994) 1.54
Antigenic stimulation regulates the level of expression of interleukin 2 receptor on human T cells. Proc Natl Acad Sci U S A (1984) 1.51
Delineation of an immunoregulatory amplifier population recognizing autologous Ia molecules. Analysis with human T cell clones. J Exp Med (1984) 1.49
Molecular cloning and expression of T11 cDNAs reveal a receptor-like structure on human T lymphocytes. Proc Natl Acad Sci U S A (1987) 1.49
Spontaneous release of the Leu-2 (T8) molecule from human T cells. J Exp Med (1983) 1.48
Isolation of the gene encoding the human T-lymphocyte differentiation antigen Leu-2 (T8) by gene transfer and cDNA subtraction. Proc Natl Acad Sci U S A (1984) 1.47
Interdependence of CD3-Ti and CD2 activation pathways in human T lymphocytes. EMBO J (1988) 1.47
Identification and characterization of a 100-kD ligand for CD6 on human thymic epithelial cells. J Exp Med (1995) 1.47
The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins. J Exp Med (1991) 1.41
Molecular cloning of the common acute lymphoblastic leukemia antigen (CALLA) identifies a type II integral membrane protein. Proc Natl Acad Sci U S A (1988) 1.41
Clonal heterogeneity in the requirement for T3, T4, and T8 molecules in human cytolytic T lymphocyte function. J Exp Med (1984) 1.29
Selective inhibition of interleukin 2 gene function following thymocyte antigen/major histocompatibility complex receptor crosslinking: possible thymic selection mechanism. Proc Natl Acad Sci U S A (1987) 1.27
Regulation of T cell autocrine growth. T4+ cells become refractory to interleukin 2. J Exp Med (1986) 1.26
CD19 is functionally and physically associated with surface immunoglobulin. J Exp Med (1989) 1.24
Human T lymphocyte subsets. Functional heterogeneity and surface recognition structures. J Clin Invest (1984) 1.23
The structural basis of αβ T-lineage immune recognition: TCR docking topologies, mechanotransduction, and co-receptor function. Immunol Rev (2012) 1.20
Purification and characterization of fetal hematopoietic cells that express the common acute lymphoblastic leukemia antigen (CALLA). J Exp Med (1983) 1.16
Selective inhibition of interleukin 2 gene function following thymocyte antigen/major histocompatibility complex receptor crosslinking: possible thymic selection mechanism. Proc Natl Acad Sci U S A (1986) 1.16
One of the CD3epsilon subunits within a T cell receptor complex lies in close proximity to the Cbeta FG loop. J Exp Med (1998) 1.16
Transcriptional and post-transcriptional regulation of TcR, CD4 and CD8 gene expression during activation of normal human T lymphocytes. EMBO J (1990) 1.11
Ethnic differences in the lymphocyte proliferative response induced by a murine IgG1 antibody, Leu-4, to the T3 molecule. J Exp Med (1984) 1.09
Targeted adenovirus-mediated gene delivery to T cells via CD3. J Virol (1997) 1.09
Heteroantibody duplexes target cells for lysis by cytotoxic T lymphocytes. Proc Natl Acad Sci U S A (1985) 1.08
Monoclonal antibodies which react with bovine T-lymphocyte antigens and induce blastogenesis: tissue distribution and functional characteristics of the target antigens. Immunology (1988) 1.07
Analysis of T cell activation with a non-mitogenic anti CD3 antibody and the phorbol ester TPA. Clin Exp Immunol (1985) 1.05
Suppression of interleukin 2-dependent human T cell growth in vitro by prostaglandin E (PGE) and their precursor fatty acids. Evidence for a PGE-independent mechanism of inhibition by the fatty acids. J Clin Invest (1990) 1.05
Triggering T cells by otherwise inert hybrid anti-CD3/antitumor antibodies requires encounter with the specific target cell. J Exp Med (1989) 1.04
Induction of specific nonresponsiveness in unprimed human T cells by anti-CD3 antibody and alloantigen. J Exp Med (1990) 1.04
Costimulatory signal provided by a B-lymphoblastoid cell line and its Ia-negative variant. Proc Natl Acad Sci U S A (1989) 1.03
Deficiency of the adhesive protein complex lymphocyte function antigen 1, complement receptor type 3, glycoprotein p150,95 in a girl with recurrent bacterial infections. Effects on phagocytic cells and lymphocyte functions. J Clin Invest (1985) 1.01
Tyrosine phosphorylation of CD6 by stimulation of CD3: augmentation by the CD4 and CD2 coreceptors. J Exp Med (1993) 1.01
T3 glycoprotein is functional although structurally distinct on human T-cell receptor gamma T lymphocytes. Proc Natl Acad Sci U S A (1987) 1.01
Specific decrease in T3 antigen density in adult T-cell leukaemia cells: I. Flow microfluorometric analysis. Br J Cancer (1984) 0.99
Differentiation and activation phenotypes of lung T lymphocytes differ from those of circulating T lymphocytes. J Clin Invest (1985) 0.97
Negative feedback loop in T-cell activation through MAPK-catalyzed threonine phosphorylation of LAT. EMBO J (2004) 0.97
Discordance between surface and cytoplasmic expression of the Leu-4 (T3) antigen in thymocytes and in blast cells from childhood T lymphoblastic malignancies. J Clin Invest (1985) 0.96
Mitogenicity and down-regulation of high-affinity interleukin 2 receptor by YTA-1 and YTA-2, monoclonal antibodies that recognize 75-kDa molecules on human large granular lymphocytes. Proc Natl Acad Sci U S A (1989) 0.96
Inhibition or activation of human T cell receptor transfectants is controlled by defined, soluble antigen arrays. J Exp Med (1992) 0.92
Effects of platelet-derived growth factor and epidermal growth factor on antigen-induced proliferation of human T-cell lines. Immunology (1985) 0.91
Relationship between HLA-DR expression by normal myeloid progenitor cells and inhibition of colony growth by prostaglandin E. Implications for prostaglandin E resistance in chronic myeloid leukemia. J Clin Invest (1986) 0.90
Functional and phenotypic studies of Japanese adult T cell leukemia cells. J Clin Invest (1985) 0.89
Activation pathways of synovial T lymphocytes. Expression and function of the UM4D4/CDw60 antigen. J Clin Invest (1990) 0.88
Most parasite-specific CD8+ cells in Trypanosoma cruzi-infected chronic mice are down-regulated for T-cell receptor-alphabeta and CD8 molecules. Immunology (2001) 0.87
Human natural killer cells, activated lymphocyte killer cells, and monocytes possess similar cytotoxic mechanisms. Proc Natl Acad Sci U S A (1983) 0.86
Downregulation of T cell receptor expression by CD8(+) lymphocytes in kidney allografts. J Clin Invest (1998) 0.86
Human thymocytes bind to autologous and allogeneic thymic epithelial cells in vitro. Proc Natl Acad Sci U S A (1986) 0.85
T-lymphocyte activation pathways in alcoholic liver disease. Immunology (1991) 0.85
Generation of cytotoxic T cells in the rat mixed lymphocyte reaction is blocked by monoclonal antibody MRC OX-8. Immunology (1984) 0.85
Monoclonal antibody therapy with ciclosporin and steroids in nonmatched cadaveric renal transplants. Nephron (1987) 0.85
Immunological studies of ageing. X. Impaired T lymphocytes and normal monocyte response from elderly humans to the mitogenic antibodies OKT3 and Leu 4. Immunology (1985) 0.85
Relative expression of surface IgM, IgD and the Ig-associating alpha(mb-1) and beta(B-29) polypeptide chains. Immunology (1992) 0.83
Flow microfluorometry analysis of alterations in T-lymphocyte subsets during murine listeriosis. Infect Immun (1984) 0.83
A cloned human T cell line cytotoxic for autologous and allogeneic B lymphoma cells. J Exp Med (1984) 0.82
Generation and characterization of two human alpha/beta T cell clones. Recognizing autologous breast tumor cells through an HLA- and TCR/CD3-independent pathway. J Clin Invest (1994) 0.82
Ion channels activated by specific Ti or T3 antibodies in plasma membranes of human T cells. EMBO J (1987) 0.80
Comparison of phorbol myristate acetate and phytohaemagglutinin as stimulators of in vitro T lymphocyte colony formation of human peripheral blood lymphocytes. I. Surface markers of colony cells. Immunology (1984) 0.79
Constitutively oxidized CXXC motifs within the CD3 heterodimeric ectodomains of the T cell receptor complex enforce the conformation of juxtaposed segments. J Biol Chem (2014) 0.79
Flow cytometry resonance energy transfer suggests an association between low-affinity interleukin 2 binding sites and HLA class I molecules. Biochem J (1990) 0.78
Simultaneous cross-linking of CD6 and CD28 induces cell proliferation in resting T cells. Immunology (1998) 0.78
αβ TCR-mediated recognition: relevance to tumor-antigen discovery and cancer immunotherapy. Cancer Immunol Res (2015) 0.78
Induction of cytolytic activity by anti-T3 monoclonal antibody. Activation of alloimmune memory cells and natural killer cells from normal and immunodeficient individuals. J Clin Invest (1984) 0.78
Defective signal transduction by the CD2 molecule in immature T-cell receptor/CD3- thymocytes. Proc Natl Acad Sci U S A (1992) 0.78
Molecular T cell biology -- basic and translational challenges in the twenty-first century. Front Immunol (2011) 0.77
Revisiting the Discovery of the αβ TCR Complex and Its Co-Receptors. Front Immunol (2014) 0.76
Regulation of the in vitro monoclonal immunoglobulin production in cultures of peripheral blood mononuclear cells and bone marrow cells from myeloma patients mediated by T cell dependent mitogens. Clin Exp Immunol (1986) 0.75
Commentary: "The Role of T3 Surface Molecules in the Activation of Human Cells: A Two-Stimulus Requirement for IL-2 Production Reflects Events Occurring at a Pretranslational Level". Front Immunol (2015) 0.75
OKT3 monoclonal antibody in cardiac transplantation. Experience with 102 patients. Ann Surg (1988) 0.75
In Vivo Activation of Invariant Natural Killer T Cells Induces Systemic and Local Alterations in T-Cell Subsets Prior to Preterm Birth. Clin Exp Immunol (2017) 0.75
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Separation of functional subsets of human T cells by a monoclonal antibody. Proc Natl Acad Sci U S A (1979) 10.28
Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex. J Exp Med (1983) 9.23
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A monoclonal antibody with selective reactivity with functionally mature human thymocytes and all peripheral human T cells. J Immunol (1979) 6.08
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The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes. Proc Natl Acad Sci U S A (1988) 5.75
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Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway. Proc Natl Acad Sci U S A (1984) 4.78
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A soluble CD4 protein selectively inhibits HIV replication and syncytium formation. Nature (1988) 4.15
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