Published in Br J Clin Pharmacol on October 01, 1980
Paracetamol Study in Patients With Low Muscle Mass | NCT03648658
Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism. Proc Natl Acad Sci U S A (2009) 3.01
Inter-subject and ethnic differences in paracetamol metabolism. Br J Clin Pharmacol (1986) 1.48
First-pass metabolism via UDP-glucuronosyltransferase: a barrier to oral bioavailability of phenolics. J Pharm Sci (2011) 1.27
The role of sulphate conjugation in the metabolism and disposition of oral and intravenous paracetamol in man. Br J Clin Pharmacol (1984) 1.14
Drug-dependent clearance of human platelets in the NOD/scid mouse by antibodies from patients with drug-induced immune thrombocytopenia. Blood (2010) 1.11
Feline drug metabolism and disposition: pharmacokinetic evidence for species differences and molecular mechanisms. Vet Clin North Am Small Anim Pract (2013) 1.02
Application of physiologically based pharmacokinetic modeling to predict acetaminophen metabolism and pharmacokinetics in children. CPT Pharmacometrics Syst Pharmacol (2013) 1.01
Paracetamol and phenacetin. Drugs (1986) 0.99
The clinical assessment of analgesic drugs. Br J Clin Pharmacol (1981) 0.96
Paracetamol metabolites in the neonate following maternal overdose. Br J Clin Pharmacol (1984) 0.95
The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model. Theor Biol Med Model (2012) 0.94
Pharmacokinetics and metabolism of rectally administered paracetamol in preterm neonates. Arch Dis Child Fetal Neonatal Ed (1999) 0.91
Inhibition of paracetamol glucuronidation by tyrosine kinase inhibitors. Br J Clin Pharmacol (2011) 0.89
Evidence for the changing regimens of acetylcysteine. Br J Clin Pharmacol (2015) 0.88
Paracetamol: a focus for the general pediatrician. Eur J Pediatr (2013) 0.87
Passage of paracetamol into breast milk and its subsequent metabolism by the neonate. Br J Clin Pharmacol (1987) 0.86
Time of ingestion relative to meal intake determines gastrointestinal responses to a plant sterol-containing yoghurt drink. Eur J Nutr (2012) 0.86
The effect of age on glucuronidation and sulphation of paracetamol by human liver fractions. Br J Clin Pharmacol (1991) 0.86
Effect of migraine attacks on paracetamol absorption. Br J Clin Pharmacol (1984) 0.83
Time course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients and in HepaRG cells. Xenobiotica (2015) 0.83
Target biomarker profile for the clinical management of paracetamol overdose. Br J Clin Pharmacol (2015) 0.82
Paracetamol interaction with oral contraceptive steroids: increased plasma concentrations of ethinyloestradiol. Br J Clin Pharmacol (1987) 0.81
Outcomes from massive paracetamol overdose: a retrospective observational study. Br J Clin Pharmacol (2016) 0.80
Metabolic profiling and population screening of analgesic usage in nuclear magnetic resonance spectroscopy-based large-scale epidemiologic studies. Anal Chem (2009) 0.79
Oral pharmacokinetics of acetaminophen to evaluate gastric emptying profiles of Shiba goats. J Vet Med Sci (2015) 0.78
PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses. Pharmacogenet Genomics (2015) 0.78
Transcriptome association analysis identifies miR-375 as a major determinant of variable acetaminophen glucuronidation by human liver. Biochem Pharmacol (2016) 0.78
Effect of prenatal exposure to fine particulate matter and intake of Paracetamol (Acetaminophen) in pregnancy on eczema occurrence in early childhood. Sci Total Environ (2011) 0.78
Morbidly Obese Patients Exhibit Increased CYP2E1-Mediated Oxidation of Acetaminophen. Clin Pharmacokinet (2016) 0.78
A novel approach for estimating ingested dose associated with paracetamol overdose. Br J Clin Pharmacol (2015) 0.77
Assessment of hepatic detoxification activity: proposal of an improved variant of the (13)c-methacetin breath test. PLoS One (2013) 0.76
A Liver-Centric Multiscale Modeling Framework for Xenobiotics. PLoS One (2016) 0.76
Paracetamol-induced hepatotoxicity: lack of enhancement of the hepatoprotective effect of N-acetylcysteine by sodium sulphate. Inflammopharmacology (1998) 0.76
Offline solid-phase extraction for preconcentration of pharmaceuticals and personal care products in environmental water and their simultaneous determination using the reversed phase high-performance liquid chromatography method. Environ Monit Assess (2016) 0.76
The role of oxidative stress, inflammation and acetaminophen exposure from birth to early childhood in the induction of autism. J Int Med Res (2017) 0.75
Pharmacokinetic properties of intramuscular versus oral syrup paracetamol in Plasmodium falciparum malaria. Malar J (2016) 0.75
Serum drug concentrations after oral administration of paracetamol to patients with surgical resection of the gastrointestinal tract. Br J Clin Pharmacol (1995) 0.75
Does a hot drink provide faster absorption of paracetamol than a tablet? A pharmacoscintigraphic study in healthy male volunteers. Pharm Res (2014) 0.75
Is biliary excretion of paracetamol significant in man? Br J Clin Pharmacol (1986) 0.75
Multiscale modeling reveals inhibitory and stimulatory effects of caffeine on acetaminophen-induced toxicity in humans. CPT Pharmacometrics Syst Pharmacol (2017) 0.75
Bioavailability of paracetamol with/without caffeine in Egyptian patients with hepatitis C virus. Eur J Clin Pharmacol (2016) 0.75
Exposure to acetaminophen and all its metabolites upon 10, 15 and 20 mg/kg intravenous acetaminophen in very preterm infants. Pediatr Res (2017) 0.75
Ecotoxicological risk assessment and seasonal variation of some pharmaceuticals and personal care products in the sewage treatment plant and surface water bodies (lakes). Environ Monit Assess (2017) 0.75
Gastric emptying and acetaminophen: lessons learnt from the several co-administered drugs on the experimental design. Eur J Clin Pharmacol (2015) 0.75
Intravenous N-acetylcystine: the treatment of choice for paracetamol poisoning. Br Med J (1979) 6.45
Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism. J Pharmacol Exp Ther (1973) 4.40
Pharmacological modification of gastric emptying: effects of propantheline and metoclopromide on paracetamol absorption. Br Med J (1973) 3.77
The dependence of paracetamol absorption on the rate of gastric emptying. Br J Pharmacol (1973) 3.26
Acetaminophen-induced hepatic injury: protective role of glutathione in man and rationale for therapy. Clin Pharmacol Ther (1974) 2.62
Kinetics of acetaminophen absorption and gastric emptying in man. Clin Pharmacol Ther (1978) 2.41
Acetaminophen elimination kinetics in neonates, children, and adults. Clin Pharmacol Ther (1976) 2.24
Inhibition of gastric emptying and drug absorption by narcotic analgesics. Br J Clin Pharmacol (1975) 2.18
A kinetic study of drug elimination: the excretion of paracetamol and its metabolites in man. Br J Pharmacol Chemother (1967) 1.99
High performance liquid chromatographic estimation of paracetamol metabolites in plasma. Br J Clin Pharmacol (1978) 1.78
Pharmacokinetics of paracetamol (acetaminophen) after intravenous and oral administration. Eur J Clin Pharmacol (1977) 1.76
Pharmacokinetics of acetaminophen in the human neonate: formation of acetaminophen glucuronide and sulfate in relation to plasma bilirubin concentration and D-glucaric acid excretion. Pediatrics (1975) 1.52
Gastrointestinal absorption of drugs. Med Clin North Am (1974) 1.49
Drug biotransformation interactions in man. 3. Acetaminophen and salicylamide. J Pharm Sci (1971) 1.35
Paracetamol disposition in normal subjects and in patients treated with antiepileptic drugs. Br J Clin Pharmacol (1979) 1.30
KINETICS OF THE METABOLISM OF ACETAMINOPHEN BY HUMANS. J Pharm Sci (1963) 1.20
Molecular basis for several drug-induced nephropathies. Am J Med (1977) 1.18
The metabolism of acetophenetidine. Isolation and characterization of S-(1-acetamido-4-hydroxyphenyl)-cysteine, a metabolite of acetophenetidine. Biochem J (1964) 1.13
Some factors affecting the absorption of paracetamol. J Pharm Pharmacol (1972) 1.09
Antipyrine, paracetamol, and lignocaine elimination in chronic liver disease. Br Med J (1977) 1.06
The binding of paracetamol to plasma proteins of man and pig. J Pharm Pharmacol (1973) 1.06
The effects of particle size on the absorption of phenacetin in man. A correlation between plasma concentration of phenacetin and effects on the central nervous system. Clin Pharmacol Ther (1970) 1.05
The effects of hepatic and renal damage on paracetamol metabolism and excretion following overdosage. A pharmacokinetic study. Br J Pharmacol (1973) 1.04
Dose-dependent change in the pattern of phenacetin metabolism in man and its possible significance in analgesic nephropathy. Klin Wochenschr (1969) 1.03
The gastrointestinal absorption of paracetamol in the rat. J Pharm Pharmacol (1979) 1.03
Acetaminophen kinetics in acutely poisoned patients. Clin Pharmacol Ther (1979) 1.03
Use of isolated kidney cells for study of drug metabolism. Biochem Pharmacol (1979) 1.03
Generation of reactive metabolites of N-hydroxy-phenacetin by glucoronidation and sulfation. Biochem Pharmacol (1977) 1.02
Data point weighting in pharmacokinetic analysis: intravenous paracetamol in man. J Pharm Pharmacol (1976) 1.01
Paracetamol metabolism in chronic liver disease. Eur J Clin Pharmacol (1979) 0.99
Phenacetin metabolism: effect of hydrocarbons and cigarette smoking. Clin Pharmacol Ther (1977) 0.91
The comparative metabolism of phenacetin and N-acetyl-p-aminophenol in man, with particular reference to effects on the kidney. Clin Pharmacol Ther (1968) 0.89
[Studies on the oxidative metabolism of phenacetin in rats]. Biochem Pharmacol (1967) 0.87
Isolation and identification of paracetamol metabolites. J Int Med Res (1976) 0.86
Some new aspects of the metabolism of phenacetin in the rat. Biochem J (1971) 0.85
Conversion of the N-Q-glucuronide and N-O-sulfate conjugates of N-hydroxyphenacetin to reactive intermediates. Biochem Pharmacol (1978) 0.84
Factors affecting the metabolism of phenacetin. I. Influence of dose, chronic dosage, route of administration and species on the metabolism of (1-14C-acetyl)phenacetin. Xenobiotica (1974) 0.82
N-hydroxylation of p-acetophenetidide as a factor in nephrotoxicity. J Med Chem (1973) 0.81
The metabolism of phenacetin in patients with enal diseas. Clin Pharmacol Ther (1969) 0.80
Formation of a thiomethyl metabolite of phenacetin and acetaminophen in dogs and man. Clin Pharmacol Ther (1978) 0.80
Effect of hemodialysis on kinetics of acetaminophen elimination by anephric patients. Clin Pharmacol Ther (1975) 0.79
Glucuronidation of paracetamol, morphine and 1-naphthol in the rat intestinal loop. Biochem Pharmacol (1976) 0.79
Phenacetin: renal tubular transport and intrarenal distribution in the dog. J Pharmacol Exp Ther (1976) 0.78
Effect of sodium sulfate on acetaminophen elimination by rats. J Pharm Sci (1979) 0.78
Renal tubular transport of paracetamol and its conjugates in the dog. Br J Pharmacol (1975) 0.77
Intravenous N-acetylcystine: the treatment of choice for paracetamol poisoning. Br Med J (1979) 6.45
Plasma-paracetamol half-life and hepatic necrosis in patients with paracetamol overdosage. Lancet (1971) 4.40
Successful treatment of severe paracetamol overdosage with cysteamine. Lancet (1974) 3.83
Mefenamic acid nephropathy. Lancet (1980) 3.80
Pharmacological modification of gastric emptying: effects of propantheline and metoclopromide on paracetamol absorption. Br Med J (1973) 3.77
Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning. Lancet (1976) 3.41
Should methionine be added to every paracetamol tablet? BMJ (1997) 3.33
The dependence of paracetamol absorption on the rate of gastric emptying. Br J Pharmacol (1973) 3.26
Treatment of drug overdosage with naloxone, a specific narcotic antagonist. Lancet (1973) 3.16
Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine. Lancet (1977) 3.00
Treatment of salicylate poisoning with repeated oral charcoal. Br Med J (Clin Res Ed) (1985) 2.90
Diuresis or urinary alkalinisation for salicylate poisoning? Br Med J (Clin Res Ed) (1982) 2.90
Liver damage and impaired glucose tolerance after paracetamol overdosage. Br Med J (1966) 2.68
Kinetics of acetaminophen absorption and gastric emptying in man. Clin Pharmacol Ther (1978) 2.41
Rapid gas-liquid chromatographic estimation of antipyrine in plasma. J Pharm Pharmacol (1973) 2.31
Narcotic analgesics and delayed gastric emptying during labour. Lancet (1975) 2.24
Inhibition of gastric emptying and drug absorption by narcotic analgesics. Br J Clin Pharmacol (1975) 2.18
Gas-liquid chromatographic estimation of paracetamol. J Pharm Pharmacol (1971) 2.16
Pharmacokinetic drug interactions. Lancet (1969) 2.07
Effect of gel fibre on gastric emptying and absorption of glucose and paracetamol. Lancet (1979) 2.06
Treatment of ventricular arrhythmias with mexiletine (Kö 1173). Lancet (1973) 2.04
Henry Matthew: the father of modern clinical toxicology. J R Coll Physicians Edinb (2009) 2.04
The chief scientist reports ... prevention of hepatic necrosis following paracetamol overdosage. Health Bull (Edinb) (1978) 2.03
Paracetamol metabolism following overdosage: application of high performance liquid chromatography. J Pharm Pharmacol (1977) 2.01
Acute haemolysis and renal failure after nomifensine overdosage. Br Med J (1980) 2.00
Opioid-induced delay in gastric emptying: a peripheral mechanism in humans. Anesthesiology (1997) 1.87
High performance liquid chromatographic estimation of paracetamol metabolites in plasma. Br J Clin Pharmacol (1978) 1.78
Absorption, distribution and elimination of mexiletine. Postgrad Med J (1977) 1.74
Paracetamol overdosage. Pharmacological considerations and clinical management. Drugs (1983) 1.70
Pharmacokinetics and clinical toxicity of quinine overdosage: lack of efficacy of techniques intended to enhance elimination. Q J Med (1985) 1.65
Paracetamol (acetaminophen) poisoning. No need to change current guidelines to accident departments. BMJ (1998) 1.57
Generic inequivalence--clinical observations. Acta Pharmacol Toxicol (Copenh) (1971) 1.55
Clinical pharmacokinetics of paracetamol. Clin Pharmacokinet (1982) 1.54
Effects of non-narcotic analgesics on the liver. Drugs (1986) 1.50
Gastrointestinal absorption of drugs. Med Clin North Am (1974) 1.49
Inter-subject and ethnic differences in paracetamol metabolism. Br J Clin Pharmacol (1986) 1.48
Drugs prescribed for self poisoners. Br Med J (Clin Res Ed) (1985) 1.44
Analgesic abuse and renal disease in North-East Scotland. Lancet (1966) 1.40
Paracetamol and aspirin absorption from Safapryn and Safapryn-Co. Br J Clin Pharmacol (1979) 1.39
Renal papillary necrosis and aspirin. Scott Med J (1969) 1.38
Spectrophotofluorometric and gas-liquid chromatographic methods for the estimation of mexiletine (Kö 1173) in plasma and urine. J Pharm Pharmacol (1973) 1.36
Long-term treatment of ventricular arrhythmias with oral mexiletine. Am Heart J (1976) 1.36
The gas-liquid chromatographic estimation of phenacetin and paracetamol in plasma and urine. J Pharm Pharmacol (1971) 1.29
Treatment of phenobarbitone poisoning with repeated oral administration of activated charcoal. Q J Med (1986) 1.26
Death and blindness due to overdose of quinine. Br Med J (Clin Res Ed) (1985) 1.25
Comparison of procainamide and mexiletine in prevention of ventricular arrhythmias after acute myocardial infarction. Lancet (1975) 1.25
Potentiation by previous drug therapy of hepatotoxicity following paracetamol overdosage. Scott Med J (1973) 1.25
Why do patients still die from paracetamol poisoning? Br Med J (Clin Res Ed) (1986) 1.25
The treatment of acetaminophen poisoning. Annu Rev Pharmacol Toxicol (1983) 1.24
Fatal pulmonary aspiration of oral activated charcoal. BMJ (1988) 1.24
A pharmacokinetic study of doxapram in patients and volunteers. Br J Clin Pharmacol (1979) 1.22
Impaired Lignocaine metabolism in patients with myocardial infarction and cardiac failure. Br Med J (1976) 1.20
Treatment of severe 2,4-D and mecoprop intoxication with alkaline diuresis. Br J Clin Pharmacol (1979) 1.19
New approaches in managing drug overdosage and poisoning. Br Med J (Clin Res Ed) (1983) 1.15
Fulminant hyperkalaemia and multiple complications following ibuprofen overdose. Med Toxicol Adverse Drug Exp (1990) 1.15
The role of sulphate conjugation in the metabolism and disposition of oral and intravenous paracetamol in man. Br J Clin Pharmacol (1984) 1.14
Rapid gas--liquid chromatographic estimation of doxapram in plasma. J Chromatogr (1977) 1.14
Analgesic nephropathy: a reassessment of the role of phenacetin and other analgesics. Drugs (1982) 1.14
Effects of microsomal enzyme induction on paracetamol metabolism in man. Br J Clin Pharmacol (1981) 1.12
Treatment of severe acetaminophen poisoning with intravenous acetylcysteine. Arch Intern Med (1981) 1.11
SI, moles, and drugs. Br Med J (1978) 1.09
Mefenamic acid overdosage. Lancet (1981) 1.09
The effects of repeated administration of mercuric chloride on exfoliation of renal tubular cells and urinary glutamic-oxaloacetic transaminase activity in the rat. Toxicol Appl Pharmacol (1969) 1.09
Who needs molar units for drugs? Lancet (1987) 1.07
The ventilatory effects of doxapram in normal man. Clin Sci (Lond) (1983) 1.07
Antipyrine, paracetamol, and lignocaine elimination in chronic liver disease. Br Med J (1977) 1.06
Inadequate information about drug overdosage in manufacturers' data sheets. Br Med J (1980) 1.05
The effects of particle size on the absorption of phenacetin in man. A correlation between plasma concentration of phenacetin and effects on the central nervous system. Clin Pharmacol Ther (1970) 1.05
The effects of hepatic and renal damage on paracetamol metabolism and excretion following overdosage. A pharmacokinetic study. Br J Pharmacol (1973) 1.04
Changes in cardiorespiratory function during gastric lavage for drug overdose. Hum Toxicol (1987) 1.03
Inappropriate methods for the emergency determination of plasma paracetamol. Ann Clin Biochem (1979) 1.02
Data point weighting in pharmacokinetic analysis: intravenous paracetamol in man. J Pharm Pharmacol (1976) 1.01
Paracetamol metabolism in chronic liver disease. Eur J Clin Pharmacol (1979) 0.99
Clinically important drug interactions. Drugs (1973) 0.99
Americans retreat on SI units. BMJ (1992) 0.98
The nephrotoxicity of analgesics. J Pharm Pharmacol (1966) 0.97
Gastric emptying and drug absorption. Br J Clin Pharmacol (1974) 0.97
Impaired absorption and metabolism of oral lignocaine in patients undergoing laparoscopy. Br J Anaesth (1973) 0.96
Paracetamol metabolites in the neonate following maternal overdose. Br J Clin Pharmacol (1984) 0.95
Gas-liquid chromatographic estimation of tolbutamide and chlorpropamide in plasma. J Pharm Pharmacol (1972) 0.94
Is there a place for cimetidine or ethanol in the treatment of paracetamol poisoning? Lancet (1983) 0.94
Panel discussion. Management of acetaminophen overdose. Arch Intern Med (1981) 0.94
Experimental paracetamol-induced hepatic necrosis: a histopathological study. J Pathol (1971) 0.94
Premedication for upper gastrointestinal endoscopy: a comparative study of flunitrazepam, diazepam and neuroleptanalgesia. Endoscopy (1978) 0.93
Intravenous N-acetylcysteine: still the treatment of choice for paracetamol poisoning. Br Med J (1980) 0.92
The absorption of aspirin and paracetamol in patients with achlorhydria. J Pharm Pharmacol (1974) 0.92
Drug interactions affecting analgesic toxicity. Am J Med (1983) 0.92
Gross impairment of hepatic drug metabolism in a patient with chronic liver disease. Br Med J (1974) 0.91
Combined clinical and metabolic study of the effects of alpha-methyldopa on hypertensive patients. Circulation (1966) 0.91
Hepatotoxicity of mild analgesics. Br J Clin Pharmacol (1980) 0.90
The disposition of intravenous doxapram in man. Eur J Clin Pharmacol (1979) 0.90
The comparative metabolism of phenacetin and N-acetyl-p-aminophenol in man, with particular reference to effects on the kidney. Clin Pharmacol Ther (1968) 0.89
Gas-liquid chromatographic estimation of lignocaine, ethylglycylxylidide, glycylxylidide and 4-hydroxyxylidine in plasma and urine. J Pharm Pharmacol (1974) 0.89
Abnormal drug metabolism after barbiturate and paracetamol overdose. Br Med J (1974) 0.88
Dose-dependent absorption and elimination of cefadroxil in man. Eur J Clin Pharmacol (1991) 0.88
Paracetamol-induced acute renal failure in the absence of fulminant liver damage. Br Med J (Clin Res Ed) (1982) 0.88
Paracetamol pharmacokinetics in thyroid disease. Eur J Clin Pharmacol (1980) 0.88
Effect of food on the absorption of frusemide and bumetanide in man. Br J Clin Pharmacol (1996) 0.87
Long term treatment of ventricular arrhythmias with oral mexiletine. Postgrad Med J (1977) 0.87
Acetaminophen absorption and metabolism in celiac disease and Crohn's disease. Clin Pharmacol Ther (1981) 0.87