Paracetamol.

PubWeight™: 0.88‹?›

🔗 View Article (PMC 2425823)

Published in Postgrad Med J on July 01, 1980

Authors

T J Meredith, R Goulding

Articles cited by this

(truncated to the top 100)

Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. J Pharmacol Exp Ther (1973) 5.23

Acute liver necrosis following overdose of paracetamol. Br Med J (1966) 4.75

Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism. J Pharmacol Exp Ther (1973) 4.40

Plasma-paracetamol half-life and hepatic necrosis in patients with paracetamol overdosage. Lancet (1971) 4.40

A method for testing analgesics in rheumatoid arthritis using a sequential procedure. Ann Rheum Dis (1959) 4.19

Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. J Pharmacol Exp Ther (1973) 3.89

Successful treatment of severe paracetamol overdosage with cysteamine. Lancet (1974) 3.83

Liver necrosis from paracetamol. Br J Pharmacol Chemother (1966) 3.77

Pharmacological modification of gastric emptying: effects of propantheline and metoclopromide on paracetamol absorption. Br Med J (1973) 3.77

Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning. Lancet (1976) 3.41

Inhibition of prostaglandin synthetase in brain explains the anti-pyretic activity of paracetamol (4-acetamidophenol). Nature (1972) 3.30

Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine. Lancet (1977) 3.00

Hepatic damage and death from overdose of paracetamol. Lancet (1973) 2.70

Liver damage and impaired glucose tolerance after paracetamol overdosage. Br Med J (1966) 2.68

Fatal dextropropoxyphene poisoning in Northern Ireland. Review of 30 cases. Lancet (1977) 2.67

Acetaminophen-induced hepatic injury: protective role of glutathione in man and rationale for therapy. Clin Pharmacol Ther (1974) 2.62

Acetaminophen elimination kinetics in neonates, children, and adults. Clin Pharmacol Ther (1976) 2.24

Treatment of acute paracetamol poisoning. Lancet (1968) 2.18

Paracetamol poisoning in children. Br Med J (1978) 2.17

Reduction of absorption of paracetamol by activated charcoal and cholestyramine: a possible therapeutic measure. Br Med J (1973) 2.09

Paracetamol metabolism following overdosage: application of high performance liquid chromatography. J Pharm Pharmacol (1977) 2.01

A kinetic study of drug elimination: the excretion of paracetamol and its metabolites in man. Br J Pharmacol Chemother (1967) 1.99

Controlled trial of cysteamine in treatment of acute paracetamol (acetaminophen) poisoning. Lancet (1976) 1.97

Treatment of propoxyphene overdosage with naloxone. Chest (1973) 1.94

Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro. J Pharmacol Exp Ther (1973) 1.90

Methionine toxicity in liver disease and its prevention by chlortetracycline. Clin Sci (Lond) (1956) 1.85

Acetaminophen overdose: incidence, diagnosis, and management in 416 patients. Pediatrics (1978) 1.80

Acetaminophen-induced hepatic necrosis. VI. Metabolic disposition of toxic and nontoxic doses of acetaminophen. Pharmacology (1974) 1.70

Paracetamol and the kidney. Br Med J (1967) 1.68

THE CLINICAL EVALUATION OF MORPHINE AND ITS SUBSTITUTES AS ANALGESICS. Pharmacol Rev (1964) 1.64

Treatment of dextropropoxyphene poisoning. Br Med J (1973) 1.60

Liver necrosis and myocardiopathy following paracetamol overdosage. S Afr Med J (1968) 1.55

EFFECT OF PARACETAMOL (N-ACETYL-P-AMINOPHENOL) ON GASTROINTESTINAL BLEEDING. Gut (1964) 1.54

The spectrum of paracetamol (acetaminophen) overdose: clinical and epidemiological studies. Postgrad Med J (1978) 1.53

The absorption characteristics of paracetamol tablets in man. J Pharm Pharmacol (1963) 1.52

A comparative evaluation of marketed analgesic drugs. N Engl J Med (1972) 1.50

The effect of diet on the toxicity of paracetamol and the safety of paracetamol-methionine mixtures. Biochem Pharmacol (1975) 1.48

Chronic excessive acetaminophen use and liver damage. Ann Intern Med (1977) 1.46

Controlled trial of cysteamine and dimercaprol after paracetamol overdose. Br Med J (1977) 1.45

The effects of acetaminophen and sodium salicylate on the release and activity of leukocytic pyrogen in the cat. J Pharmacol Exp Ther (1972) 1.45

Pathogenesis of fever in man. N Engl J Med (1978) 1.43

Analgesic abuse and renal disease in North-East Scotland. Lancet (1966) 1.40

Acetaminophen metabolism in man, as determined by high-resolution liquid chromatography. Clin Chem (1974) 1.39

Acute myocardial necrosis in paracetamol poisoning. Br Med J (1971) 1.37

Histopathological changes in the liver following a paracetamol overdose: correlation with clinical and biochemical parameters. J Pathol (1975) 1.30

Reversal of experimental paracetamol toxicosis with N-acetylcysteine. Lancet (1976) 1.29

Potentiation by previous drug therapy of hepatotoxicity following paracetamol overdosage. Scott Med J (1973) 1.25

Late treatment of paracetamol poisoning with mercaptamine. Br Med J (1978) 1.25

Effect of paracetamol on gastric mucosa. Br Med J (1978) 1.24

The pharmacologic effects of a new analgesic alpha-4-dimethylamino-1,2-diphenyl-3-methyl-4-propionyloxybutane. J Am Pharm Assoc Am Pharm Assoc (1955) 1.23

The antidiuretic action of acetaminophen. Am J Med Sci (1966) 1.22

Molecular basis for several drug-induced nephropathies. Am J Med (1977) 1.18

Frequency of arrhythmias and other cardiac abnormalities in fulminant hepatic failure. Br Heart J (1976) 1.17

Activated charcoal hemoperfusion and experimental acetaminophen poisoning. Toxicol Appl Pharmacol (1975) 1.16

Immune thrombocytopenia due to a drug metabolite. N Engl J Med (1972) 1.16

Chronic liver disease and acetaminophen. Ann Intern Med (1977) 1.16

The metabolism of acetophenetidine. Isolation and characterization of S-(1-acetamido-4-hydroxyphenyl)-cysteine, a metabolite of acetophenetidine. Biochem J (1964) 1.13

Clinical comparison of three antipyretic agents. Am J Dis Child (1967) 1.12

Deuterium isotope effects during formation of phenols by hepatic monoxygenases. Evidence for an alternative to arene oxide pathway. Biochemistry (1975) 1.12

Disorderd hemostasis in liver damage from paracetamol overdose. Gastroenterology (1973) 1.10

Pharmacokinetics of acetaminophen elimination by anephric patients. J Pharmacol Exp Ther (1976) 1.09

Potentiation of oral anticoagulant therapy by acetaminophen. Curr Ther Res Clin Exp (1968) 1.09

Paracetamol metabolism and toxicity in isolated hepatocytes from rat and mouse. Biochem Pharmacol (1978) 1.08

Production of endogenous pyrogen. Fed Proc (1979) 1.08

Fatal acetaminophen overdosage in a young child. J Pediatr (1978) 1.08

Early prediction of the outcome of a paracetamol overdose based on an analysis of 163 patients. Postgrad Med J (1977) 1.06

Antipyrine, paracetamol, and lignocaine elimination in chronic liver disease. Br Med J (1977) 1.06

The binding of paracetamol to plasma proteins of man and pig. J Pharm Pharmacol (1973) 1.06

The effects of hepatic and renal damage on paracetamol metabolism and excretion following overdosage. A pharmacokinetic study. Br J Pharmacol (1973) 1.04

Paracetamol overdose in man: relationship between pattern of urinary metabolites and severity of liver damage. Q J Med (1976) 1.03

Massive hemolysis caused by acetaminophen. Positive determination by direct Coombs test. JAMA (1976) 1.03

Acetaminophen kinetics in acutely poisoned patients. Clin Pharmacol Ther (1979) 1.03

Species differences in hepatic glutathione depletion, covalent binding and hepatic necrosis after acetaminophen. Life Sci (1974) 1.02

Death in an adolescent following an overdose of acetaminophen and phenobarbital. Am J Dis Child (1978) 1.01

Haemodialysis in paracetamol self-poisoning. Lancet (1972) 1.00

Studies on the mechanism of cystamine prevention of several liver structural and biochemical alterations caused by carbon tetrachloride. Toxicol Appl Pharmacol (1973) 1.00

Paracetamol metabolism in chronic liver disease. Eur J Clin Pharmacol (1979) 0.99

Liver function and structure in survivors of acetaminophen poisoning. A follow-up study of serum bile acids and liver histology. Am J Dig Dis (1977) 0.99

Renal necrosis, glutathione depletion, and covalent binding after acetaminophen. Toxicol Appl Pharmacol (1978) 0.98

Paracetamol poisoning. Br Med J (1978) 0.96

Rapid removal of paracetamol by haemoperfusion through coated charcoal. In vivo and in-vitro studies in the pig. Lancet (1973) 0.95

Chronic hepatic inflammation and fibrosis due to low doses of paracetamol. Lancet (1978) 0.95

Letter: Action of cysteamine in paracetamol poisoning. Lancet (1974) 0.94

Paracetamol-induced thrombocytopenia and haemolytic anaemia. Lancet (1978) 0.94

Experimental paracetamol-induced hepatic necrosis: a histopathological study. J Pathol (1971) 0.94

The development of a blood paracetamol estimation kit. J Int Med Res (1976) 0.93

Central mechanisms of fever. Fed Proc (1979) 0.92

Gastrointestinal blood loss. Effect of aspirin, fenoprofen, and acetaminophen in rheumatoid arthritis as determined by sequential gastroscopy and radioactive fecal markers. JAMA (1977) 0.92

Early changes in coagulation following a paracetamol overdose and a controlled trial of fresh frozen plasma therapy. Gut (1975) 0.91

The paracetamol test-kit in practice. J Int Med Res (1976) 0.90

Paracetamol and renal damage. Br Med J (1971) 0.89

Thrombocytopenic reaction to aspirin and acetaminophen. N Engl J Med (1979) 0.88

The fate of acetophenetidin in man and methods for the estimation of acetophenetidin and its metabolites in biological material. J Pharmacol Exp Ther (1949) 0.88

Liver cytosol catalyzed conjugation of reduced glutathione with a reactive metabolite of acetaminophen. Toxicol Appl Pharmacol (1979) 0.86

Purpura and paracetamol. Br Med J (1968) 0.86

Isolation and identification of paracetamol metabolites. J Int Med Res (1976) 0.86

Acetaminophen and hepatic dysfunction in infectious mononucleosis. South Med J (1977) 0.86

Effect of N-acetylcysteine on hepatic covalent binding of paracetamol (acetaminophen) Lancet (1977) 0.84

Protection of rats against the hepatotoxic effect of paracetamol. Br J Exp Pathol (1974) 0.84

Contribution of modern immunological concepts to an understanding of diseases of the skin. Br Med J (1970) 0.83

Articles by these authors

Papers and originals. Br Med J (1976) 5.90

Oral methionine in the treatment of severe paracetamol (Acetaminophen) overdose. Lancet (1976) 3.20

Household products and poisoning. Br Med J (1978) 3.03

Hepatic damage and death from overdose of paracetamol. Lancet (1973) 2.70

Plasma concentration of amitriptyline and clinical response. Lancet (1972) 2.44

Paracetamol poisoning in children. Br Med J (1978) 2.17

Nasopharyngeal angiofibromas: staging and management. Ann Otol Rhinol Laryngol (1984) 1.93

Paraquat poisoning: clinical features and immediate general management. Hum Toxicol (1987) 1.80

Treatment of acetaminophen poisoning. The use of oral methionine. Arch Intern Med (1981) 1.78

Use of N-acetylcysteine in clinical toxicology. Am J Med (1991) 1.71

Action of Senna. Br Med J (1957) 1.70

Emergency treatment of common poisons: emptying the stomach. Proc R Soc Med (1977) 1.58

Epidemiology of analgesic overdose in England and Wales. Hum Toxicol (1984) 1.44

Intravenous N-acetylcysteine: the treatment of choice in paracetamol poisoning? Br Med J (1979) 1.43

An introduction to the clinical toxicology of volatile substances. Drug Saf (1990) 1.40

Syrup of ipecacuanha: is it really useful? Br Med J (Clin Res Ed) (1986) 1.31

Baclofen overdose. Postgrad Med J (1980) 1.27

Why do patients still die from paracetamol poisoning? Br Med J (Clin Res Ed) (1986) 1.25

Experimental drug intoxication: treatment with charcoal haemoperfusion. Arch Toxicol (1975) 1.20

Use of charcoal haemoperfusion in the management of severely poisoned patients. Br Med J (1975) 1.17

The epidemiology of acute acetaminophen poisoning in England and Wales. Arch Intern Med (1981) 1.13

Extracorporeal treatment of salicylate or acetaminophen poisoning--is there a role? Arch Intern Med (1981) 1.12

Laburnum "poisoning". Br Med J (Clin Res Ed) (1981) 1.07

Early prediction of the outcome of a paracetamol overdose based on an analysis of 163 patients. Postgrad Med J (1977) 1.06

Treatment of paracetamol poisoning. Br Med J (1978) 1.01

Treatment of paraquat poisoning in man: methods to prevent absorption. Hum Toxicol (1987) 0.99

SI, moles, and drugs. Br Med J (1978) 0.98

Letter: Action of cysteamine in paracetamol poisoning. Lancet (1974) 0.94

The treatment of paraquat poisoning using oral sorbents and charcoal haemoperfusion. Acta Pharmacol Toxicol (Copenh) (1977) 0.94

Panel discussion. Management of acetaminophen overdose. Arch Intern Med (1981) 0.94

Retrospective comparison of 'Cheno' and 'Urso' in the medical treatment of gallstones. Gut (1982) 0.93

Pralidoxime for organophosphorus poisoning. Lancet (1992) 0.92

Organochlorine pesticide residues in human fat in Great Britain. Br Med J (1968) 0.92

Organochlorine pesticide residues in human fat in the United Kingdom 1969-71. Br Med J (1972) 0.92

Comparison of haemoperfusion and haemodialysis in the therapy of barbiturate intoxication in dogs. Arch Toxikol (1973) 0.91

Experience with fixed-bred charcoal haemoperfusion in the treatment of severe drug intoxication. Arch Toxicol (1980) 0.91

Acute poisoning due to non-steroidal anti-inflammatory drugs. Clinical features and management. Med Toxicol (1986) 0.90

Immune haemolytic anaemia following T cell-depleted allogeneic bone marrow transplantation for chronic myeloid leukaemia: association with leukaemic relapse and treatment with donor lymphocyte infusions. Bone Marrow Transplant (2001) 0.87

Poisoning due to psychotropic agents. Adverse Drug React Acute Poisoning Rev (1985) 0.84

Alkaline diuresis for acute poisoning with chlorophenoxy herbicides and ioxynil. Lancet (1990) 0.84

Plasma-11-hydroxycorticosteroid levels in drug-induced coma. Lancet (1971) 0.83

Ingestion of household cleaning products. Br Med J (1980) 0.83

Acute pesticide poisoning in England and Wales. Health Trends (1987) 0.82

Letter: Effective dosage of tricyclic antidepressants. Br Med J (1975) 0.82

Organochlorine pesticide residues in human fat in the United Kingdom 1982-1983. Hum Toxicol (1985) 0.82

Chemical hazards in the home. Br Med Bull (1975) 0.81

The use of methionine for acute paracetamol poisoning. J Int Med Res (1976) 0.80

Organochlorine pesticide residues in human fat in the United Kingdom 1976-7. Br Med J (Clin Res Ed) (1981) 0.79

Paraquat poisoning. Lancet (1986) 0.79

Hepatic damage from overdose of paracetamol. Gut (1972) 0.79

Algorithm for modified alkaline diuresis in salicylate poisoning. Br Med J (Clin Res Ed) (1985) 0.79

Letter: Paracetamol hepatoxicity. Lancet (1976) 0.78

Epidemiology of poisoning. Pharmacol Ther (1993) 0.78

Deaths from paracetamol and dextropropoxyphene (Distalgesic) poisoning in England and Wales in 1979. Hum Toxicol (1984) 0.77

Complete heart block due to chronic chloroquine toxicity managed with permanent pacemaker. Br Med J (1978) 0.76

Haemoperfusion in 'late' paracetamol poisoning. Hum Toxicol (1981) 0.75

Accidental pesticide poisoning: the toll is high. World Health Forum (1988) 0.75

Legal aid. Med Leg J (1998) 0.75

High dose atropine in organophosphorus poisoning. Postgrad Med J (1990) 0.75

Letter: Magnesium depletion and digoxin toxicity. Br Med J (1975) 0.75

Health promotion. J R Soc Med (1994) 0.75

Letter: Activated charcoal in treatment of poisoning. Br Med J (1975) 0.75

The fatal paracetamol dosage--how low can you go? Med Sci Law (1993) 0.75

Experience with cellulose acetate-coated activated charcoal haemoperfusion in the treatment of severe hypnotic drug intoxication. Postgrad Med J (1980) 0.75

Human exposure to organochlorine pesticides. Proc R Soc Med (1967) 0.75

Dangers of dextropropoxyphene. Br Med J (1977) 0.75

Renal function and plasma digoxin levels. Br Med J (1972) 0.75

Health promotion. J R Soc Med (1994) 0.75

Pain and analgesics. Annu Meet Am Inst Oral Biol (1966) 0.75

Acetaminophen poisoning. Pediatrics (1973) 0.75

Statistics of drug addiction. Med Sci Law (1968) 0.75

Toxicological case records. Practitioner (1968) 0.75

Clinical toxicology in the 1990s: the development of clinical toxicology centers--a personal view. J Toxicol Clin Toxicol (1993) 0.75

The treatment of acute poisoning. Trans Med Soc Lond (1967) 0.75

Household products and poisoning. Br Med J (1978) 0.75

Pulmonary disease after amitriptyline overdosage. Br Med J (1973) 0.75

The role of charcoal haemoperfusion in the active management of poisoning. Acta Pharmacol Toxicol (Copenh) (1977) 0.75

Toxicological case records. Practitioner (1968) 0.75

Volatile substance abuse--an overview. Hum Toxicol (1989) 0.75

Antidotal therapy: pharmacokinetic aspects. Dev Toxicol Environ Sci (1986) 0.75

Experience with hemoperfusion in drug abuse. Kidney Int Suppl (1976) 0.75

Crotamiton overdose. Hum Exp Toxicol (1990) 0.75

Methionine in treatment of acetaminophen poisoning. N Engl J Med (1977) 0.75

Self-poisoning. Nurs Mirror Midwives J (1971) 0.75

Poisoning as a fine art. Med Leg J (1978) 0.75

Poisoning due to psychotropic drugs. J Affect Disord (1982) 0.75

Letter: Are PUFA harmful? Br Med J (1973) 0.75

Non-narcotic analgesics. Problems of overdosage. Drugs (1986) 0.75

Cerebellar dysfunction after acute carbon tetrachloride poisoning. Lancet (1983) 0.75

Adsorptive capacities of hemoperfusion devices in clinical use. Artif Organs (1978) 0.75

Letter: Paracetamol test kit. Lancet (1976) 0.75

EFG activation of patients receiving phenothiazines and chlordiazepoxide. J Nerv Ment Dis (1965) 0.75

Toxicological case records. Practitioner (1968) 0.75

Felbamate overdose complicated by massive crystalluria and acute renal failure. J Toxicol Clin Toxicol (2000) 0.75

Letter: Paraquat poisoning. Br Med J (1976) 0.75