Published in J Biol Chem on September 10, 1981
Phosphorylation activates the insulin receptor tyrosine protein kinase. Proc Natl Acad Sci U S A (1983) 3.94
Tyrosine-specific protein kinase activity is associated with the purified insulin receptor. Proc Natl Acad Sci U S A (1983) 2.49
Insulin activates a tyrosine-specific protein kinase in extracts of 3T3-L1 adipocytes and human placenta. Proc Natl Acad Sci U S A (1982) 2.40
Monoclonal antibodies to the human insulin receptor block insulin binding and inhibit insulin action. Proc Natl Acad Sci U S A (1982) 1.57
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Isolation of a Drosophila genomic sequence homologous to the kinase domain of the human insulin receptor and detection of the phosphorylated Drosophila receptor with an anti-peptide antibody. Proc Natl Acad Sci U S A (1986) 1.15
An antipeptide antibody that specifically inhibits insulin receptor autophosphorylation and protein kinase activity. Proc Natl Acad Sci U S A (1985) 1.11
Latent insulin receptors and possible receptor precursors in 3T3-L1 adipocytes. Proc Natl Acad Sci U S A (1983) 1.11
Internalization and molecular processing of insulin receptors in isolated rat adipocytes. Proc Natl Acad Sci U S A (1982) 1.02
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Structure of the insulin-like growth factor receptor in chicken embryo fibroblasts. Proc Natl Acad Sci U S A (1982) 0.93
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Cell cycle regulation of mouse H3 histone mRNA metabolism. Mol Cell Biol (1984) 2.97
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Antibodies to purified insulin receptor have insulin-like activity. Science (1978) 2.58
Somatomedin-C stimulates the phosphorylation of the beta-subunit of its own receptor. J Biol Chem (1983) 2.55
Monoclonal antibodies to receptors for insulin and somatomedin-C. J Biol Chem (1983) 2.53
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Phorbol esters stimulate the phosphorylation of receptors for insulin and somatomedin C. Proc Natl Acad Sci U S A (1983) 2.30
Insulin receptor: covalent labeling and identification of subunits. Proc Natl Acad Sci U S A (1979) 2.24
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Fate of immunoprecipitable protein kinase C in GH3 cells treated with phorbol 12-myristate 13-acetate. J Biol Chem (1985) 2.15
Association of phorbol ester-induced hyperphosphorylation and reversible regulation of transferrin membrane receptors in HL60 cells. Proc Natl Acad Sci U S A (1984) 2.14
Insulin-like growth factor-I is an essential regulator of the differentiation of 3T3-L1 adipocytes. J Biol Chem (1988) 2.04
Fluorescent labeling of hormone receptors in viable cells: preparation and properties of highly fluorescent derivatives of epidermal growth factor and insulin. Proc Natl Acad Sci U S A (1978) 2.03
Molecular forms and subunit composition of a cyclic adenosine 3',5'-monophosphate-dependent protein kinase purified from bovine heart muscle. J Biol Chem (1972) 1.99
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Activation of S6 kinase activity in 3T3-L1 cells by insulin and phorbol ester. Proc Natl Acad Sci U S A (1985) 1.89
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Cyclic adenosine 3',5'-monophosphate-dependent protein kinase of human erythrocyte membranes. J Biol Chem (1972) 1.80
Characterization of cDNA for the large subunit of the transcription initiation factor TFIIF. Nature (1992) 1.73
Cyclic 3':5'-adenosine monophosphate in Escherichia coli during transient and catabolite repression. Proc Natl Acad Sci U S A (1974) 1.71
Transformation of rat fibroblasts by FSV rapidly increases glucose transporter gene transcription. Science (1987) 1.70
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The mobile receptor hypothesis and "cooperativity" of hormone binding. Application to insulin. Biochim Biophys Acta (1976) 1.60
Predicting outcome among intensive care unit patients using computerised trend analysis of daily Apache II scores corrected for organ system failure. Intensive Care Med (1988) 1.60
Purified rat brain calcium- and phospholipid-dependent protein kinase phosphorylates ribosomal protein S6. Proc Natl Acad Sci U S A (1983) 1.59
Description of a protein kinase derived from insulin-treated 3T3-L1 cells that catalyzes the phosphorylation of ribosomal protein S6 and casein. J Biol Chem (1983) 1.59
The subunit structure of rat liver insulin receptor. Antibodies directed against the insulin-binding subunit. J Biol Chem (1980) 1.57
Study of the mass and spin-parity of the Higgs boson candidate via its decays to Z boson pairs. Phys Rev Lett (2013) 1.56
Blockade of the type I somatomedin receptor inhibits growth of human breast cancer cells in athymic mice. J Clin Invest (1989) 1.56
Purification and properties of insulin receptors from rat liver membranes. Biochem Biophys Res Commun (1977) 1.54
Autophosphorylation of the insulin receptor in vitro. Designation of phosphorylation sites and correlation with receptor kinase activation. J Biol Chem (1986) 1.54
Insulin-treated 3T3-L1 adipocytes and cell-free extracts derived from them incorporate 32P into ribosomal protein S6. Proc Natl Acad Sci U S A (1980) 1.53
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A potential complication associated with percutaneous tracheostomy with an endotracheal tube with a Murphy eye in situ. Anesthesiology (1998) 1.53
Growth factors rapidly induce expression of the glucose transporter gene. J Biol Chem (1988) 1.53
The protein-tyrosine kinase activity of the insulin receptor is necessary for insulin-mediated receptor down-regulation. J Biol Chem (1987) 1.52
Influence of intraoperative opioid on postoperative pain and pulmonary function after laparoscopic gastric banding: remifentanil TCI vs sufentanil TCI in morbid obesity. Br J Anaesth (2007) 1.51
Evidence from monoclonal antibody studies that insulin stimulates deoxyribonucleic acid synthesis through the type I somatomedin receptor. J Clin Endocrinol Metab (1985) 1.49
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Charcot's arthropathy of the shoulder following intraarticular corticosteroid injections. J Rheumatol (1993) 1.47
Characterization of S-AKAP84, a novel developmentally regulated A kinase anchor protein of male germ cells. J Biol Chem (1995) 1.47
Insulin-like growth factor I receptor beta-subunit heterogeneity. Evidence for hybrid tetramers composed of insulin-like growth factor I and insulin receptor heterodimers. J Biol Chem (1989) 1.47
Culture and characterization of normal epithelium from cystoscopic biopsies of human bladder. In Vitro Cell Dev Biol Anim (1993) 1.47
A dose-ranging study of pegylated interferon alfa-2b and ribavirin in chronic hepatitis C. The Hepatitis C Intervention Therapy Group. Hepatology (2000) 1.44
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Characterization of antisera to a synthetic carboxyl-terminal peptide of the glucose transporter protein. J Biol Chem (1988) 1.42
Insulin-stimulated protein phosphorylation in 3T3-L1 preadipocytes. Proc Natl Acad Sci U S A (1979) 1.41
Increasing the cAMP content of IM-9 cells alters the phosphorylation state and protein kinase activity of the insulin receptor. J Biol Chem (1986) 1.41
Monensin blocks the maturation of receptors for insulin and somatomedin C: identification of receptor precursors. Proc Natl Acad Sci U S A (1983) 1.40
Phosphorylation of a cyclic adenosine 3':5'-monophosphate-dependent protein kinase from bovine cardiac muscle. J Biol Chem (1974) 1.40
Pseudomonas aeruginosa outbreak associated with a contaminated blood-gas analyser in a neonatal intensive care unit. J Hosp Infect (1996) 1.40
Reversible autophosphorylation of a cyclic 3':5'-AMP-dependent protein kinase from bovine cardiac muscle. J Biol Chem (1975) 1.40
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Increased rates of donation with laparoscopic donor nephrectomy. Ann Surg (2000) 1.40
Laparoscopic versus open donor nephrectomy: comparing ureteral complications in the recipients and improving the laparoscopic technique. Transplantation (1999) 1.38
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Soluble cyclic AMP-dependent protein kinases: review of the enzyme isolated from bovine cardiac muscle. Curr Top Cell Regul (1977) 1.37
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Purification of IMP:pyrophosphate phosphoribosyltransferases, catalytically incompetent enzymes in Lesch-Nyhan disease. Proc Natl Acad Sci U S A (1971) 1.36
High affinity binding protein for the regulatory subunit of cAMP-dependent protein kinase II-B. Cloning, characterization, and expression of cDNAs for rat brain P150. J Biol Chem (1989) 1.36
Cyclic AMP-dependent protein kinase from bovine heart muscle. Methods Enzymol (1974) 1.35
The novel metallothionein genes of Caenorhabditis elegans. Structural organization and inducible, cell-specific expression. J Biol Chem (1993) 1.35
Regulation of cAMP-mediated signal transduction via interaction of caveolins with the catalytic subunit of protein kinase A. J Biol Chem (1999) 1.34
A monoclonal antibody to human insulin receptor. Biochem Biophys Res Commun (1982) 1.33
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Modulation of binding and bioactivity of insulin by anti-insulin antibody: relation to possible role of receptor self-aggregation in hormone action. Proc Natl Acad Sci U S A (1979) 1.31