Published in J Biol Chem on December 10, 1981
Properties of the insulin receptor ectodomain. Proc Natl Acad Sci U S A (1988) 1.08
Stoichiometry of HLA class II-invariant chain oligomers. PLoS One (2011) 0.84
Activation of protein kinase C (alpha, beta, and zeta) by insulin in 3T3/L1 cells. Transfection studies suggest a role for PKC-zeta in glucose transport. J Biol Chem (1997) 1.71
Insulin binding to the human lymphocyte receptor. Evaluation of the negative cooperativity model. J Biol Chem (1977) 1.48
Evidence for involvement of protein kinase C (PKC)-zeta and noninvolvement of diacylglycerol-sensitive PKCs in insulin-stimulated glucose transport in L6 myotubes. Endocrinology (1997) 1.46
Insulin increases membrane and cytosolic protein kinase C activity in BC3H-1 myocytes. J Biol Chem (1987) 1.32
Atypical protein kinase C in insulin action and insulin resistance. Biochem Soc Trans (2005) 1.31
Insulin rapidly increases diacylglycerol by activating de novo phosphatidic acid synthesis. Science (1987) 1.30
The de novo phospholipid effect of insulin is associated with increases in diacylglycerol, but not inositol phosphates or cytosolic Ca2+. Biochem J (1985) 1.30
The development of insulin receptors and responses in the differentiating nonfusing muscle cell line BC3H-1. J Biol Chem (1984) 1.23
Effects of adenoviral gene transfer of wild-type, constitutively active, and kinase-defective protein kinase C-lambda on insulin-stimulated glucose transport in L6 myotubes. Endocrinology (2000) 1.20
Phorbol ester provokes insulin-like effects on glucose transport, amino acid uptake, and pyruvate dehydrogenase activity in BC3H-1 cultured myocytes. Endocrinology (1985) 1.17
Effects of insulin and protein synthesis inhibitors on phospholipid metabolism, diacylglycerol levels, and pyruvate dehydrogenase activity in BC3H-1 cultured myocytes. J Biol Chem (1984) 1.17
Activation and translocation of Rho (and ADP ribosylation factor) by insulin in rat adipocytes. Apparent involvement of phosphatidylinositol 3-kinase. J Biol Chem (1997) 1.14
Protein kinase C-zeta and phosphoinositide-dependent protein kinase-1 are required for insulin-induced activation of ERK in rat adipocytes. J Biol Chem (1999) 1.13
AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK-, and PDK1-dependent activation of atypical PKC. Am J Physiol Endocrinol Metab (2009) 1.11
Insulin-induced activation of glycerol-3-phosphate acyltransferase by a chiro-inositol-containing insulin mediator is defective in adipocytes of insulin-resistant, type II diabetic, Goto-Kakizaki rats. Proc Natl Acad Sci U S A (1994) 1.09
Rosiglitazone, insulin treatment, and fasting correct defective activation of protein kinase C-zeta/lambda by insulin in vastus lateralis muscles and adipocytes of diabetic rats. Endocrinology (2001) 1.06
Glucose activates protein kinase C-zeta /lambda through proline-rich tyrosine kinase-2, extracellular signal-regulated kinase, and phospholipase D: a novel mechanism for activating glucose transporter translocation. J Biol Chem (2001) 1.06
Dependence of insulin-stimulated glucose transporter 4 translocation on 3-phosphoinositide-dependent protein kinase-1 and its target threonine-410 in the activation loop of protein kinase C-zeta. Mol Endocrinol (1999) 1.05
Principles of membrane receptor physiology and their application to clinical medicine. Ann Intern Med (1980) 1.05
The mechanism of insulin stimulation of (Na+,K+)-ATPase transport activity in muscle. J Biol Chem (1985) 1.04
Metformin improves atypical protein kinase C activation by insulin and phosphatidylinositol-3,4,5-(PO4)3 in muscle of diabetic subjects. Diabetologia (2006) 1.03
Effects of insulin and phorbol esters on subcellular distribution of protein kinase C isoforms in rat adipocytes. Biochem J (1992) 1.03
Insulin-induced glycerolipid mediators and the stimulation of glucose transport in BC3H-1 myocytes. J Biol Chem (1988) 1.01
Equilibrium model for insulin-induced receptor down-regulation. Regulation of insulin receptors in differentiated BC3H-1 myocytes. J Biol Chem (1984) 0.98
Retention of specific protein kinase C isozymes following chronic phorbol ester treatment in BC3H-1 myocytes. Biochem Biophys Res Commun (1989) 0.97
Insulin activates glycerol-3-phosphate acyltransferase (de novo phosphatidic acid synthesis) through a phospholipid-derived mediator. Apparent involvement of Gi alpha and activation of a phospholipase C. Biochemistry (1990) 0.96
Interaction of insulin-like growth factors with a nonfusing mouse muscle cell line: binding, action, and receptor down-regulation. Endocrinology (1984) 0.95
The role of protein kinase C in insulin action. Cell Signal (1992) 0.94
Contrasting insulin dose-dependent defects in activation of atypical protein kinase C and protein kinase B/Akt in muscles of obese diabetic humans. Diabetologia (2006) 0.93
Glucose activates mitogen-activated protein kinase (extracellular signal-regulated kinase) through proline-rich tyrosine kinase-2 and the Glut1 glucose transporter. J Biol Chem (2000) 0.93
Thiazolidinedione treatment enhances insulin effects on protein kinase C-zeta /lambda activation and glucose transport in adipocytes of nondiabetic and Goto-Kakizaki type II diabetic rats. J Biol Chem (2000) 0.92
Effects of insulin and phorbol esters on diacylglycerol generation and synthesis and hydrolysis of phosphatidylcholine in BC3H-1 myocytes. Biochem Biophys Res Commun (1988) 0.90
Structure of the insulin receptor of the cultured human lymphoblastoid cell IM-9. Evidence suggesting that two subunits are required for insulin binding. J Biol Chem (1982) 0.89
Regulation of glucose transport by pioglitazone in cultured muscle cells. Metabolism (1994) 0.89
Mechanisms whereby insulin increases diacylglycerol in BC3H-1 myocytes. Biochem J (1988) 0.89
Insulin but not phorbol ester treatment increases phosphorylation of vinculin by protein kinase C in BC3H-1 myocytes. FEBS Lett (1987) 0.88
Macromolecular characterization by sedimentation equilibrium in the preparative ultracentrifuge. J Biol Chem (1979) 0.88
Effects of insulin on the translocation of protein kinase C-theta and other protein kinase C isoforms in rat skeletal muscles. Biochem J (1995) 0.87
Role of protein kinase C in insulin's regulation of c-fos transcription. J Biol Chem (1992) 0.87
Insulin increases mRNA levels of protein kinase C-alpha and -beta in rat adipocytes and protein kinase C-alpha, -beta and -theta in rat skeletal muscle. Biochem J (1995) 0.87
Differential effects of pertussis toxin on insulin-stimulated phosphatidylcholine hydrolysis and glycerolipid synthesis de novo. Studies in BC3H-1 myocytes and rat adipocytes. Biochemistry (1991) 0.86
Impaired activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5-(PO4)3 in cultured preadipocyte-derived adipocytes and myotubes of obese subjects. J Clin Endocrinol Metab (2004) 0.85
Epidermal growth factor and insulin-like growth factor I stimulate the hydrolysis of the insulin-sensitive phosphatidylinositol-glycan in BC3H-1 myocytes. Biochem Biophys Res Commun (1988) 0.83
Preferential activation of microsomal diacylglycerol/protein kinase C signaling during glucose treatment (De Novo phospholipid synthesis) of rat adipocytes. J Clin Invest (1994) 0.83
Hormone-receptor interactions are noncooperative: application to the beta-adrenergic receptor. Proc Natl Acad Sci U S A (1980) 0.83
Protein kinase C activation patterns are determined by methodological variations. Studies of insulin action in BC3H-1 myocytes and rat adipose tissue. Biochim Biophys Acta (1990) 0.81
Insulin-like effects of sodium orthovanadate on diacylglycerol-protein kinase C signaling in BC3H-1 myocytes. Arch Biochem Biophys (1994) 0.81
Insulin-like effects of epidermal growth factor and insulin-like growth factor-I on [3H]2-deoxyglucose uptake, diacylglycerol generation and protein kinase C activation in BC3H-1 myocytes. Biochem J (1989) 0.81
Direct effects of sulfonylurea agents on glucose transport in the BC3H-1 myocyte. Diabetes (1987) 0.81
Protein kinase C inhibitors block insulin and PMA-stimulated hexose transport in isolated rat adipocytes and BC3H-1 myocytes. Metabolism (1990) 0.80
Immunological evidence that insulin activates protein kinase C in BC3H-1 myocytes. FEBS Lett (1989) 0.80
Characterization of macromolecules by sedimentation equilibrium in the air-turbine ultracentrifuge. Methods Enzymol (1985) 0.80
Insulin provokes co-ordinated increases in the synthesis of phosphatidylinositol, phosphatidylinositol phosphates and the phosphatidylinositol-glycan in BC3H-1 myocytes. Biochem J (1988) 0.80
Regulation of the GLUT1 glucose transporter in cultured myocytes: total number and subcellular distribution as determined by photoaffinity labelling. Biochem J (1994) 0.79
Antisense DNA downregulates protein kinase C isozymes (beta and alpha) and insulin-stimulated 2-deoxyglucose uptake in rat adipocytes. Antisense Res Dev (1991) 0.78
Insulin-glycerolipid mediators and gene expression. FASEB J (1988) 0.78
Protein kinase C downregulation? Nature (1992) 0.78
Studies of in vivo phosphorylated proteins in BC3H-1 myocytes suggest that protein kinase C is involved in insulin action. FEBS Lett (1989) 0.77
Sulfonylureas activate glucose transport and protein kinase C in rat adipocytes. Metabolism (1991) 0.77
Sulfonylurea-stimulated glucose transport association with diacylglycerollike activation of protein kinase C in BC3H1 myocytes. Diabetes (1990) 0.76
Effects of insulin on protein kinase-C (PKC) in HIRC-B cells: specific activation of PKC epsilon and its resistance to phorbol ester-induced down-regulation. Endocrinology (1994) 0.76
Direct evidence for protein kinase C involvement in insulin-stimulated hexose uptake. Biochem Biophys Res Commun (1992) 0.75
Hormone receptors and the liver. Semin Liver Dis (1985) 0.75
Insulin receptors and action in clinical disorders of carbohydrate tolerance. Am J Med (1983) 0.75
Combined hypothalamic hypothyroidism and secondary adrenal insufficiency. Misdiagnosed as primary hypothyroidism. Arch Intern Med (1979) 0.75
Phorbol ester inhibition of insulin-stimulated deoxyribonucleic acid synthesis in BC3H-1 myocytes. Endocrinology (1987) 0.75
The role of diacylglycerol/protein kinase C signaling in insulin-stimulated glucose transport. Trans Assoc Am Physicians (1991) 0.75
Pertussis toxin-sensitive and -insensitive mechanisms for diacylglycerol-protein kinase C signalling during insulin action in BC3H-1 myocytes. Trans Assoc Am Physicians (1990) 0.75