Published in J Biol Chem on January 25, 1982
Monoclonal antibodies to the human insulin receptor block insulin binding and inhibit insulin action. Proc Natl Acad Sci U S A (1982) 1.57
The monomeric alpha beta form of the insulin receptor exhibits much higher insulin-dependent tyrosine-specific protein kinase activity than the intact alpha 2 beta 2 form of the receptor. Proc Natl Acad Sci U S A (1985) 1.03
Studies of liver insulin receptors in non-obese and obese human subjects. J Clin Invest (1983) 1.01
Evidence for dimer structure of proton-pumping cytochrome c oxidase, an analysis by radiation inactivation. EMBO J (1986) 0.92
Partial disruption of naturally occurring groups of insulin receptors on adipocyte plasma membranes by dithiothreitol and N-ethylmaleimide: the role of disulfide bonds. Proc Natl Acad Sci U S A (1983) 0.83
Elucidation of the quaternary structure of the insulin receptor. Biochem J (1983) 0.76
Aspects of light production by Photobacterium fischeri. J Bacteriol (1968) 4.09
A physiological role for titin and nebulin in skeletal muscle. Nature (1986) 3.15
Size determination of enzymes by radiation inactivation. Anal Biochem (1979) 2.66
Activation of adenylate cyclase in hepatic membranes involves interactions of the catalytic unit with multimeric complexes of regulatory proteins. J Biol Chem (1979) 1.72
Activation of protein kinase C (alpha, beta, and zeta) by insulin in 3T3/L1 cells. Transfection studies suggest a role for PKC-zeta in glucose transport. J Biol Chem (1997) 1.71
Characterization of the insulin receptor in its membrane environment by radiation inactivation. J Biol Chem (1980) 1.58
Ca(2+)-independent cytosolic phospholipase A2 from macrophage-like P388D1 cells. Isolation and characterization. J Biol Chem (1994) 1.52
Insulin binding to the human lymphocyte receptor. Evaluation of the negative cooperativity model. J Biol Chem (1977) 1.48
Molecular weight determinations from radiation inactivation. Methods Enzymol (1985) 1.48
Evidence for involvement of protein kinase C (PKC)-zeta and noninvolvement of diacylglycerol-sensitive PKCs in insulin-stimulated glucose transport in L6 myotubes. Endocrinology (1997) 1.46
The influence of low temperature on the radiation sensitivity of enzymes. J Biol Chem (1982) 1.35
Insulin increases membrane and cytosolic protein kinase C activity in BC3H-1 myocytes. J Biol Chem (1987) 1.32
Atypical protein kinase C in insulin action and insulin resistance. Biochem Soc Trans (2005) 1.31
Insulin rapidly increases diacylglycerol by activating de novo phosphatidic acid synthesis. Science (1987) 1.30
The de novo phospholipid effect of insulin is associated with increases in diacylglycerol, but not inositol phosphates or cytosolic Ca2+. Biochem J (1985) 1.30
Radiation inactivation of glutamate dehydrogenase hexamer: lack of energy transfer between subunits. Science (1983) 1.28
The development of insulin receptors and responses in the differentiating nonfusing muscle cell line BC3H-1. J Biol Chem (1984) 1.23
Effects of adenoviral gene transfer of wild-type, constitutively active, and kinase-defective protein kinase C-lambda on insulin-stimulated glucose transport in L6 myotubes. Endocrinology (2000) 1.20
The functional and physical form of mammalian cytochrome c oxidase determined by gel filtration, radiation inactivation, and sedimentation equilibrium analysis. J Biol Chem (1984) 1.18
Effects of insulin and protein synthesis inhibitors on phospholipid metabolism, diacylglycerol levels, and pyruvate dehydrogenase activity in BC3H-1 cultured myocytes. J Biol Chem (1984) 1.17
Phorbol ester provokes insulin-like effects on glucose transport, amino acid uptake, and pyruvate dehydrogenase activity in BC3H-1 cultured myocytes. Endocrinology (1985) 1.17
Activation and translocation of Rho (and ADP ribosylation factor) by insulin in rat adipocytes. Apparent involvement of phosphatidylinositol 3-kinase. J Biol Chem (1997) 1.14
Protein kinase C-zeta and phosphoinositide-dependent protein kinase-1 are required for insulin-induced activation of ERK in rat adipocytes. J Biol Chem (1999) 1.13
The molecular biology of Euglena gracilis. V. Enzyme localization. Exp Cell Res (1968) 1.11
AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK-, and PDK1-dependent activation of atypical PKC. Am J Physiol Endocrinol Metab (2009) 1.11
The functional unit of polyenzymes. Determination by radiation inactivation. J Biol Chem (1980) 1.10
Insulin-induced activation of glycerol-3-phosphate acyltransferase by a chiro-inositol-containing insulin mediator is defective in adipocytes of insulin-resistant, type II diabetic, Goto-Kakizaki rats. Proc Natl Acad Sci U S A (1994) 1.09
Growth in volume of Euglena gracilis during the division cycle. J Bacteriol (1970) 1.07
The molecular biology of Euglena gracilis. I. Growth conditions and cellular composition. Biochim Biophys Acta (1965) 1.07
The molecular biology of Euglena gracilis. VII. Inorganic requirements for a minimal culture medium. J Protozool (1972) 1.06
Intestinal brush border membrane Na+/glucose cotransporter functions in situ as a homotetramer. Proc Natl Acad Sci U S A (1990) 1.06
Rosiglitazone, insulin treatment, and fasting correct defective activation of protein kinase C-zeta/lambda by insulin in vastus lateralis muscles and adipocytes of diabetic rats. Endocrinology (2001) 1.06
Glucose activates protein kinase C-zeta /lambda through proline-rich tyrosine kinase-2, extracellular signal-regulated kinase, and phospholipase D: a novel mechanism for activating glucose transporter translocation. J Biol Chem (2001) 1.06
Dependence of insulin-stimulated glucose transporter 4 translocation on 3-phosphoinositide-dependent protein kinase-1 and its target threonine-410 in the activation loop of protein kinase C-zeta. Mol Endocrinol (1999) 1.05
Principles of membrane receptor physiology and their application to clinical medicine. Ann Intern Med (1980) 1.05
The mechanism of insulin stimulation of (Na+,K+)-ATPase transport activity in muscle. J Biol Chem (1985) 1.04
Metformin improves atypical protein kinase C activation by insulin and phosphatidylinositol-3,4,5-(PO4)3 in muscle of diabetic subjects. Diabetologia (2006) 1.03
Effects of insulin and phorbol esters on subcellular distribution of protein kinase C isoforms in rat adipocytes. Biochem J (1992) 1.03
The active streptococcal hyaluronan synthases (HASs) contain a single HAS monomer and multiple cardiolipin molecules. J Biol Chem (1998) 1.02
Functional molecular weight of the lac carrier protein from Escherichia coli as studied by radiation inactivation analysis. Proc Natl Acad Sci U S A (1984) 1.02
Radiation target analysis of glycoproteins. Anal Biochem (1986) 1.01
Insulin-induced glycerolipid mediators and the stimulation of glucose transport in BC3H-1 myocytes. J Biol Chem (1988) 1.01
Functional size of the human asialoglycoprotein receptor as determined by radiation inactivation. J Biol Chem (1984) 1.00
The molecular biology of Euglena gracilis. IV. Cellular stratification by centrifuging. Exp Cell Res (1968) 0.98
Oligomeric structure of p21 ras proteins as determined by radiation inactivation. J Biol Chem (1988) 0.98
Equilibrium model for insulin-induced receptor down-regulation. Regulation of insulin receptors in differentiated BC3H-1 myocytes. J Biol Chem (1984) 0.98
Retention of specific protein kinase C isozymes following chronic phorbol ester treatment in BC3H-1 myocytes. Biochem Biophys Res Commun (1989) 0.97
Growth and cell volume of Euglena gracilis in different media. Appl Environ Microbiol (1977) 0.97
Insulin activates glycerol-3-phosphate acyltransferase (de novo phosphatidic acid synthesis) through a phospholipid-derived mediator. Apparent involvement of Gi alpha and activation of a phospholipase C. Biochemistry (1990) 0.96
Lipoprotein lipase: size of the functional unit determined by radiation inactivation. J Lipid Res (1983) 0.95
Interaction of insulin-like growth factors with a nonfusing mouse muscle cell line: binding, action, and receptor down-regulation. Endocrinology (1984) 0.95
Molecular size of the hepatic receptor for asialoglycoproteins determined in situ by radiation inactivation. J Biol Chem (1981) 0.95
The role of protein kinase C in insulin action. Cell Signal (1992) 0.94
Functional size of acyl coenzyme A:diacylglycerol acyltransferase by radiation inactivation. J Lipid Res (1989) 0.94
Radiation inactivation of membrane components and molecular mass determination by target analysis. Methods Enzymol (1989) 0.93
Glucose activates mitogen-activated protein kinase (extracellular signal-regulated kinase) through proline-rich tyrosine kinase-2 and the Glut1 glucose transporter. J Biol Chem (2000) 0.93
Contrasting insulin dose-dependent defects in activation of atypical protein kinase C and protein kinase B/Akt in muscles of obese diabetic humans. Diabetologia (2006) 0.93
Thiazolidinedione treatment enhances insulin effects on protein kinase C-zeta /lambda activation and glucose transport in adipocytes of nondiabetic and Goto-Kakizaki type II diabetic rats. J Biol Chem (2000) 0.92
Demonstration by radiation inactivation that insulin alters the structure of the insulin receptor in rat liver membranes. J Biol Chem (1981) 0.91
The functional size of ferrochelatase determined in situ by radiation inactivation. J Biol Chem (1991) 0.90
Effects of insulin and phorbol esters on diacylglycerol generation and synthesis and hydrolysis of phosphatidylcholine in BC3H-1 myocytes. Biochem Biophys Res Commun (1988) 0.90
Radiation inactivation studies of the dopamine reuptake transporter protein. Mol Pharmacol (1994) 0.90
Regulation of glucose transport by pioglitazone in cultured muscle cells. Metabolism (1994) 0.89
Functional size of rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase as determined by radiation inactivation. J Biol Chem (1985) 0.89
Mechanisms whereby insulin increases diacylglycerol in BC3H-1 myocytes. Biochem J (1988) 0.89
Macromolecular characterization by sedimentation equilibrium in the preparative ultracentrifuge. J Biol Chem (1979) 0.88
Molecular weight of the functional unit of human leukocyte, fibroblast, and immune interferons. J Biol Chem (1983) 0.88
Insulin but not phorbol ester treatment increases phosphorylation of vinculin by protein kinase C in BC3H-1 myocytes. FEBS Lett (1987) 0.88
Target sizes of galactosyltransferase, sialyltransferase, and uridine diphosphatase in Golgi apparatus of rat liver. Biochemistry (1993) 0.87
Functional unit of the low density lipoprotein receptor of fibroblasts: a 100,000-dalton structure with multiple binding sites. Proc Natl Acad Sci U S A (1981) 0.87
Insulin increases mRNA levels of protein kinase C-alpha and -beta in rat adipocytes and protein kinase C-alpha, -beta and -theta in rat skeletal muscle. Biochem J (1995) 0.87
Functional molecular mass of a vertebrate hyaluronan synthase as determined by radiation inactivation analysis. J Biol Chem (2001) 0.87
Effects of insulin on the translocation of protein kinase C-theta and other protein kinase C isoforms in rat skeletal muscles. Biochem J (1995) 0.87
Role of protein kinase C in insulin's regulation of c-fos transcription. J Biol Chem (1992) 0.87
Radiation inactivation studies of the renal brush-border membrane phlorizin-binding protein. J Biol Chem (1982) 0.87
The functional unit of the arom conjugate in Neurospora. J Biol Chem (1982) 0.86
Radiation inactivation of ricin occurs with transfer of destructive energy across a disulfide bridge. Proc Natl Acad Sci U S A (1985) 0.86
Radiation inactivation probe of membrane-bound enzymes: gamma-glutamyltranspeptidase, aminopeptidase N, and sucrase. Anal Biochem (1986) 0.86