Published in Xenobiotica on June 01, 1982
Methods to identify and characterize developmental neurotoxicity for human health risk assessment. III: pharmacokinetic and pharmacodynamic considerations. Environ Health Perspect (2001) 1.05
Changes in maternal liver Cyp2c and Cyp2d expression and activity during rat pregnancy. Biochem Pharmacol (2008) 0.93
Effects of pregnancy on nicotine self-administration and nicotine pharmacokinetics in rats. Psychopharmacology (Berl) (2007) 0.80
N-demethylation of ethylmorphine in pregnant and non-pregnant women and in men: an evaluation of the effects of sex steroids. Br J Clin Pharmacol (1992) 0.77
Urinary metabolites of caffeine in pregnant women. Br J Clin Pharmacol (1986) 0.77
A fluorimetric study of the hydroxylation of biphenyl in vitro by liver preparations of various species. Biochem J (1965) 2.47
Carbenoxolone in the treatment of duodenal ulcer. Practitioner (1967) 1.95
A spectrofluorimetric study of the 7-hydroxylation of coumarin by liver microsomes. Biochem J (1965) 1.76
The effects of some terpenoids and other dietary anutrients on hepatic drug-metabolizing enzymes. Biochem J (1969) 1.37
A prospective toxicity evaluation (COMPACT) on 40 chemicals currently being tested by the National Toxicology Program. Mutagenesis (1990) 1.37
Interactions of imidazole antifungal agents with purified cytochrome P-450 proteins. Biochem Pharmacol (1987) 1.22
The absorption and excretion of carbenoxolone in man. J Pharm Pharmacol (1970) 1.22
Quantitative and qualitative aspects of the plasma protein binding of carbenoxolone, an ulcer-healing drug. Ann N Y Acad Sci (1973) 1.21
The toxicity of benzene and its metabolism and molecular pathology in human risk assessment. Br J Ind Med (1991) 1.16
A retrospective evaluation of COMPACT predictions of the outcome of NTP rodent carcinogenicity testing. Environ Health Perspect (1995) 1.15
Effect of development on the activity of microsomal drug-metabolizing enzymes in rat liver. Biochem J (1971) 1.11
The stimulation of hydroxylation by carcinogenic and non-carcinogenic compounds. Biochem Pharmacol (1966) 1.09
Effects of neomycin on the biliary excretion and enterohepatic circulation of mestranol and 17beta-oestradiol. Biochem Pharmacol (1977) 1.08
The stabilization-lysis action of anti-inflammatory steroids on lysosomes. J Pharm Pharmacol (1970) 1.05
Activation mechanisms to chemical toxicity. Arch Toxicol (1987) 1.05
Stabilising action of anti-inflammatory steroids on lysosomes. Biochem Pharmacol (1969) 1.05
Action of anti-inflammatory steroids on the lytic action of phospholipase C and 2,4,6-trinitrobenzene sulphonic acid on lysosomes. Biochem Pharmacol (1974) 1.03
COMPACT and molecular structure in toxicity assessment: a prospective evaluation of 30 chemicals currently being tested for rodent carcinogenicity by the NCI/NTP. Environ Health Perspect (1996) 1.02
Pharmacology of mucus. Br Med Bull (1978) 1.01
The metabolism of [2-14C] indole in the rat. Biochem J (1966) 1.00
Mechanisms of chemical toxicity--a unifying hypothesis. Regul Toxicol Pharmacol (1982) 0.97
The mechanism of action of phenformin in starved rats. Biochem Pharmacol (1983) 0.95
Single-dose pharmacokinetics of perhexiline administered orally to humans. J Chromatogr (1984) 0.95
Structural origins of the exonuclease resistance of a zwitterionic RNA. Proc Natl Acad Sci U S A (1999) 0.93
Interaction of a series of nitriles with the alcohol-inducible isoform of P450: computer analysis of structure-activity relationships. Xenobiotica (1994) 0.93
In vitro enhancement of hepatic microsomal biphenyl 2-hydroxylation by carcinogens. Nature (1974) 0.92
Effects of preincubation invitro with 3, 4-benzopyrene and phenobarbital on the drug-metabolism systems present in the microsomal and soluble fractions of the avocado pear (Persea americana). Biochem Soc Trans (1975) 0.91
Organic nitrate reductase: reassessment of its subcellular localization and tissue distribution and its relationship to the glutathione transferases. Int J Biochem (1989) 0.91
Induction of cytochrome P4501 as an indicator of potential chemical carcinogenesis. Drug Metab Rev (1993) 0.91
The induction of hepatic microsomal enzymes by safrole. Biochem J (1970) 0.91
Molecular dimensions of the substrate binding site of cytochrome P-448. Biochem Pharmacol (1986) 0.90
Mechanism of induction of hepatic microsomal drug metabolizing enzymes by a series of barbiturates. J Pharm Pharmacol (1975) 0.90
The cytochrome P450 I gene family of microsomal hemoproteins and their role in the metabolic activation of chemicals. Drug Metab Rev (1990) 0.90
Cytochromes P450 and species differences in xenobiotic metabolism and activation of carcinogen. Environ Health Perspect (1998) 0.90
The fate of ( 14 C)carbenoxolone in patients with gastric ulcer. Clin Sci (1972) 0.90
A study of the possible metabolism of trichlorofluoromethane. Biochem J (1972) 0.89
Effects of pregnancy on the metabolism of drugs in the rat and rabbit. Biochem Pharmacol (1973) 0.89
Spectral and kinetic studies of the interaction of imidazole anti-fungal agents with microsomal cytochromes P-450. Xenobiotica (1987) 0.88
Computer modelling in predicting carcinogenicity. Eur J Cancer Prev (1993) 0.87
Effect of protein/energy nutrition on rat plasma corticosteroids and liver microsomal hydroxylase activity. Nutr Metab (1975) 0.87
Melatonin can induce early onset of the breeding season in ewes. J Endocrinol (1983) 0.87
A comparison of the metabolism of HEOD (dieldrin) in the CF1 mouse with that in the CFE rat. Food Cosmet Toxicol (1972) 0.87
Differential effect of benserazide (Ro4-4602) on the concentration of indoleamines in rat pineal and hypothalamus. Br J Pharmacol (1981) 0.86
Proceedings: Interaction of carbenoxolone sodium with other drigs bound to plasma proteins. Br J Pharmacol (1975) 0.86
The cytochromes P-448--a unique family of enzymes involved in chemical toxicity and carcinogenesis. Biochem Pharmacol (1987) 0.86
The absorption of carbenoxolone administered orally as a positioned-release capsule. Gut (1970) 0.85
The effects of benzopyrene and safrole on biphenyl 2-hydroxylase and other drug-metabolizing enzymes. Biochem J (1976) 0.85
Metabolism of toxic substances. Br Med Bull (1969) 0.85
The effects of chronic drug administration on hepatic enzyme induction and folate metabolism. Br J Clin Pharmacol (1978) 0.84
Further studies on the pharmacokinetics of perhexiline maleate in humans. Xenobiotica (1986) 0.84
Eric Boyland--a pioneer in cancer biochemistry. Xenobiotica (1987) 0.84
Aromatization of shikimic acid in the rat and the role of gastrointestinal micro-organisms. Biochem Soc Trans (1976) 0.84
Metabolic oxidation of the ethynyl group in 4-ethynylbiphenyl. Biochem J (1979) 0.84
An interaction between oestradiol and progesterone in aqueous solutions and in a model membrane system. Biochim Biophys Acta (1971) 0.83
The effects of development on the activity of drug-metabolizing enzymes in the liver of the rat. Biochem J (1970) 0.83
Steroids and their interactions with phospholipids: solubility, distribution coefficient and effect on potassium permeability of liposomes. Biochim Biophys Acta (1970) 0.83
Molecular modelling of cytochrome CYP1A1: a putative access channel explains differences in induction potency between the isomers benzo(a)pyrene and benzo(e)pyrene, and 2- and 4-acetylaminofluorene. Toxicol Lett (1994) 0.83
Nitrosamine carcinogenesis: rodent assays, quantitative structure-activity relationships, and human risk assessment. Drug Metab Rev (1997) 0.82
The effects of carbon disulphide on rat liver microsomal mixed-function oxidases, in vivo and in vitro. Biochem J (1980) 0.82
Effect of natural and synthetic glucocorticoids on rat hepatic microsomal drug metabolism. J Steroid Biochem (1976) 0.82
Studies on the cytochrome P-450 of avocado (Persea [corrected] americana) mesocarp microsomal fraction. Xenobiotica (1990) 0.82
Safrole: its metabolism, carcinogenicity and interactions with cytochrome P-450. Food Cosmet Toxicol (1981) 0.82
Stereoselective pharmacokinetics of perhexiline. Xenobiotica (1986) 0.82
Metabolism of endrin in the rat. J Agric Food Chem (1971) 0.81
The metabolism of cyclohexanecarboxylate in the rat. Biochem J (1977) 0.81
The use of computers in the safety evaluation of drugs and other chemicals. Eur J Drug Metab Pharmacokinet (1995) 0.81
Metabolic abnormalities of tryptophan and nicotinic acid in patients with rheumatoid arthritis. Rheumatol Rehabil (1978) 0.81
Drug metabolism, cytochrome P450 spin state, and phospholipid changes during pregnancy in the rat. Biochem Pharmacol (1981) 0.81
Structural requirements for substrates of cytochromes P-450 and P-448. Chem Biol Interact (1987) 0.81
Proceedings: The effect of mucosal damage on gastric glycoprotein synthesis in the rat. Br J Pharmacol (1974) 0.80
Proceedings: The effects of ulcerogenic and ulcer-healing drugs on gastric mucus. Gut (1975) 0.80
The mutagenic and cell transforming properties of shikimic acid and some of its bacterial and mammalian metabolites. Toxicol Lett (1984) 0.80
Studies on the nature of the in vitro enhancement of biphenyl 2-hydroxylation provoked by some chemical carcinogens. Biochem Pharmacol (1976) 0.80
A comparison of the protective effects of N-acetyl-cysteine and S-carboxymethylcysteine against paracetamol-induced hepatotoxicity. Toxicology (1983) 0.80
Long-term studies on chemically induced liver enlargement in the rat. I. Sustained induction of microsomal enzymes with absence of liver damage on feeding phenobarbitone or butylated hydroxytoluene. Toxicology (1977) 0.80
The effect of dietary cadmium on zinc, copper and iron levels in the bone of rats. Toxicol Lett (1980) 0.80
Serum "prealbumin" as an index of liver function in human hepatobiliary disease. Clin Chim Acta (1981) 0.79
Experimental atherosclerosis in the Wistar rat [proceedings]. Br J Pharmacol (1978) 0.79
The role of nutrition in toxicology. Annu Rev Nutr (1981) 0.79
The effect of carbenoxolone on the subcellular distribution of ( 3 H) aldosterone in rat kidney. Biochem J (1972) 0.79
Biliary excretion of mestranol in the female rat: effect of neomycin pretreatment on enterohepatic recirculation. Biochem Soc Trans (1976) 0.79
Glycylprolyl-p-nitroanilidase in hepatobiliary disease. Clin Chim Acta (1981) 0.79
The metabolism of cyclohexanecarboxylic acid in the isolated perfused rat liver. Xenobiotica (1977) 0.79
The biochemical pharmacology of mucus. Adv Exp Med Biol (1977) 0.79
The effects of sodium carbenoxolone on the stability of cellular membranes. Scand J Gastroenterol Suppl (1980) 0.79
Induction of the drug-metabolizing enzymes. Basic Life Sci (1975) 0.79
A retrospective study of the molecular toxicology of benoxaprofen. Toxicology (1990) 0.79
The effects of alcohol on weight gain and the hypothalamic-pituitary-gonadotrophin axis in the maturing male rat. Biochem Pharmacol (1975) 0.79
Prediction of chemical carcinogenicity from molecular and electronic structures: a comparison of MINDO/3 and CNDO/2 molecular orbital methods. Toxicol Lett (1989) 0.79
Activation of benzo(a)pyrene and 2-acetamidofluorene to mutagens by microsomal preparations from different animal species: role of cytochrome P-450 and P-448. Xenobiotica (1981) 0.79
The protective effects of L-ascorbic acid and DL-alpha-tocopherol on cultured rat embryos treated with xanthine/xanthine oxidase. Mutat Res (1989) 0.79
Induction of the cytochrome P450 I and IV families and peroxisomal proliferation in the liver of rats treated with benoxaprofen. Possible implications in its hepatotoxicity. Biochem Pharmacol (1991) 0.78