PubRank

M F Perutz

Author PubWeight™ 144.98‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Stereochemistry of cooperative effects in haemoglobin. Nature 1970 13.71
2 Three-dimensional Fourier synthesis of horse oxyhaemoglobin at 2.8 A resolution: the atomic model. Nature 1968 5.44
3 Electrostatic effects in proteins. Science 1978 5.02
4 The crystal structure of human deoxyhaemoglobin at 1.74 A resolution. J Mol Biol 1984 4.49
5 Molecular pathology of human haemoglobin. Nature 1968 4.31
6 Regulation of oxygen affinity of hemoglobin: influence of structure of the globin on the heme iron. Annu Rev Biochem 1979 3.47
7 The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13. Proc Natl Acad Sci U S A 1991 3.12
8 Aromatic rings act as hydrogen bond acceptors. J Mol Biol 1988 2.77
9 An x-ray study of azide methaemoglobin. J Mol Biol 1966 2.58
10 Structure and function of haemoglobin. 3. A three-dimensional fourier synthesis of human deoxyhaemoglobin at 5.5 Angstrom resolution. J Mol Biol 1967 2.54
11 Stereochemical basis of heat stability in bacterial ferredoxins and in haemoglobin A2. Nature 1975 2.53
12 Stereochemistry of iron in deoxyhaemoglobin. Nature 1982 2.36
13 Structure of sickled erythrocytes and of sickle-cell hemoglobin fibers. Proc Natl Acad Sci U S A 1973 2.32
14 Binding of carbon monoxide to isolated hemoglobin chains. Biochemistry 1978 2.31
15 Three dimensional fourier synthesis of horse deoxyhaemoglobin at 2.8 Angstrom units resolution. Nature 1970 2.28
16 Stereochemistry of cooperative effects in hemoglobin. Cold Spring Harb Symp Quant Biol 1972 2.16
17 The structure of horse methaemoglobin at 2-0 A resolution. J Mol Biol 1977 2.15
18 Heme-based sensors, exemplified by the kinase FixL, are a new class of heme protein with distinctive ligand binding and autoxidation. Biochemistry 1994 2.01
19 Structure and mechanism of haemoglobin. Br Med Bull 1976 1.98
20 Influence of globin structure on the state of the heme. I. Human deoxyhemoglobin. Biochemistry 1974 1.96
21 The Croonian Lecture, 1968. The haemoglobin molecule. Proc R Soc Lond B Biol Sci 1969 1.79
22 Oxygen binding properties of human mutant hemoglobins synthesized in Escherichia coli. Proc Natl Acad Sci U S A 1985 1.62
23 Influence of globin structures on the state of the heme. Ferrous low spin derivatives. Biochemistry 1976 1.51
24 Identification of residues responsible for the alkaline Bohr effect in haemoglobin. Nature 1969 1.50
25 Structure of horse carbonmonoxyhaemoglobin. J Mol Biol 1976 1.42
26 When to speak. Nature 1994 1.40
27 Moleuclar pathology of human haemoglobin: stereochemical interpretation of abnormal oxygen affinities. Nature 1971 1.40
28 Influence of globin structure on the state of the heme. II. Allosteric transitions in methemoglobin. Biochemistry 1974 1.40
29 Structure of inositol hexaphosphate--human deoxyhaemoglobin complex. Nature 1974 1.39
30 Myoglobin and haemoglobin: role of distal residues in reactions with haem ligands. Trends Biochem Sci 1989 1.39
31 Three-dimensional Fourier synthesis of horse oxyhaemoglobin at 2.8 A resolution: (1) x-ray analysis. Nature 1968 1.37
32 Structure of human foetal deoxyhaemoglobin. J Mol Biol 1977 1.35
33 Equilibrium between six- and five-coordinated hemes in nitrosylhemoglobin: interpretation of electron spin resonance spectra. Biochemistry 1976 1.31
34 The pKa values of two histidine residues in human haemoglobin, the Bohr effect, and the dipole moments of alpha-helices. J Mol Biol 1985 1.25
35 Structure of hemoglobins Zürich [His E7(63)beta replaced by Arg] and Sydney [Val E11(67)beta replaced by Ala] and role of the distal residues in ligand binding. Proc Natl Acad Sci U S A 1978 1.25
36 Stereochemistry of cooperative effects in fish an amphibian haemoglobins. Nature 1982 1.25
37 Influence of globin structure on the state of the heme. 3. Changes in heme spectra accompanying allosteric transitions in methemoglobin and their implications for heme-heme interaction. Biochemistry 1974 1.21
38 Kinase activity of oxygen sensor FixL depends on the spin state of its heme iron. Biochemistry 1995 1.19
39 New effectors of human hemoglobin: structure and function. Biochemistry 1990 1.19
40 Identification of residues contributing to the Bohr effect of human haemoglobin. J Mol Biol 1980 1.17
41 Regulation of oxygen affinity of mammalian haemoglobins. J Mol Biol 1980 1.14
42 Structure and subunit interaction of haemoglobin M Milwaukee. Nat New Biol 1972 1.13
43 Formation of two hydrogen bonds from the globin to the heme-linked oxygen molecule in Ascaris hemoglobin. Proc Natl Acad Sci U S A 1994 1.13
44 Hemoglobin structure and respiratory transport. Sci Am 1978 1.13
45 Bezafibrate lowers oxygen affinity of haemoglobin. Lancet 1983 1.12
46 Influence of quaternary structure of the globin on thermal spin equilibria in different methemoglobin derivatives. Biochemistry 1978 1.10
47 Structure and function of haemoglobin. IV. A three-dimensional Fourier synthesis of horse deoxyhaemoglobin at 5.5 A resolution. J Mol Biol 1968 1.08
48 Role of C-terminal histidine in the alkaline Bohr effect of human hemoglobin. Biochemistry 1980 1.08
49 Noncooperativity of the dimer in the reaction of hemoglobin with oxygen (human-dissociation-equilibrium-sulfhydryl-absorption-x-ray analysis). Proc Natl Acad Sci U S A 1972 1.06
50 Interactions between the quaternary structure of the globin and the spin state of the heme in ferric mixed spin derivatives of hemoglobin. Biochemistry 1978 1.03
51 Structure of human fluoromethaemoglobin with inositol hexaphosphate. J Mol Biol 1977 1.01
52 Crystal structure of a dimeric chymotrypsin inhibitor 2 mutant containing an inserted glutamine repeat. Proc Natl Acad Sci U S A 1999 1.00
53 Structure and function of hemoglobin. Harvey Lect 1969 0.99
54 Structure of hemoglobin M Boston, a variant with a five-coordinated ferric heme. Proc Natl Acad Sci U S A 1973 0.97
55 Three dimensional structure of haemoglobin Rainier. Nat New Biol 1971 0.96
56 Physiological and x-ray studies of potential antisickling agents. Proc Natl Acad Sci U S A 1983 0.95
57 Allosteric mechanism of haemoglobin: rupture of salt-bridges raises the oxygen affinity of the T-structure. J Mol Biol 1998 0.93
58 Haemoglobin of the antarctic fish Pagothenia bernacchii. Amino acid sequence, oxygen equilibria and crystal structure of its carbonmonoxy derivative. J Mol Biol 1992 0.93
59 Stereochemical mechanism of oxygen transport by haemoglobin. Proc R Soc Lond B Biol Sci 1980 0.93
60 Haemoglobin Hiroshima and the mechanism of the alkaline Bohr effect. Nat New Biol 1971 0.92
61 Haemoglobin Radcliffe (alpha2beta299(Gi)Ala): a high oxygen-affinity variant causing familial polycythaemia. Br J Haematol 1977 0.92
62 Identity of structure of horse deoxy- and oxyhaemoglobin after reaction with bis(N-maleidomethyl)ether. J Mol Biol 1967 0.92
63 A mutagenic study of the allosteric linkage of His(HC3)146 beta in haemoglobin. J Mol Biol 1993 0.91
64 Allosteric regulation of crocodilian haemoglobin. Nature 1981 0.91
65 The first Sir Hans Krebs lecture. X-ray analysis, structure and function of enzymes. Eur J Biochem 1969 0.91
66 Haemoglobin: structure, function and synthesis. Br Med Bull 1976 0.90
67 LR16, a compound with potent effects on the oxygen affinity of hemoglobin, on blood cholesterol, and on low density lipoprotein. Proc Natl Acad Sci U S A 1988 0.89
68 Structure of deoxyhemoglobin Cowtown [His HC3(146) beta----Leu]: origin of the alkaline Bohr effect and electrostatic interactions in hemoglobin. Proc Natl Acad Sci U S A 1984 0.89
69 Mechanism of denaturation of haemoglobin by alkali. Nature 1974 0.88
70 Structure and function of haemoglobin Philly (Tyr C1 (35) beta replaced by Phe). J Mol Biol 1976 0.87
71 Structure of deoxyhaemoglobin Zürich (HisE7(63 beta) - greater than Arg). J Mol Biol 1981 0.85
72 Some molecular controls in biology. Endeavour 1967 0.85
73 Amyloid fibrils. Mutations make enzyme polymerize. Nature 1997 0.85
74 Species adaptation in a protein molecule. Adv Protein Chem 1984 0.85
75 Structure of human deoxy cobalt haemoglobin. J Mol Biol 1982 0.85
76 Iron distances in hemoglobin: comparison of x-ray crystallographic and extended x-ray absorption fine structure studies. Proc Natl Acad Sci U S A 1987 0.85
77 Influence of anions and protons on the Adair coefficients of haemoglobins A and Cowtown (His HC3(146) beta----Leu). J Mol Biol 1987 0.84
78 Hemoglobin Warsaw (Phe beta 42(CD1)----Val), an unstable variant with decreased oxygen affinity. Characterization of its synthesis, functional properties, and structure. J Biol Chem 1990 0.81
79 Allosteric enzymes. Control by phosphorylation. Nature 1988 0.80
80 Blood. Taking the pressure off. Nature 1996 0.80
81 Structure and function of haemoglobin Barcelona Asp FG1(94) beta leads to His. J Mol Biol 1983 0.80
82 Is there a Root effect in Xenopus hemoglobin? FEBS Lett 1987 0.79
83 Stereochemical effects of amino acid substitution in abnormal human haemoglobin. Biochem J 1970 0.79
84 Stereochemistry of ATP and GTP bound to fish haemoglobins. A transferred nuclear overhauser enhancement, 31P-nuclear magnetic resonance, oxygen equilibrium and molecular modelling study. J Mol Biol 1984 0.79
85 Mechanism of charge compensation and impairment of co-operative functions in haemoglobin Tacoma (Arg B12(30)beta leads to Ser). J Mol Biol 1977 0.78
86 Therapeutic agents for sickle cell disease. Nature 1978 0.78
87 Structure-function relationships in the low-affinity mutant haemoglobin Aalborg (Gly74 (E18)beta----Arg). J Mol Biol 1992 0.78
88 Comparison of histidine proton magnetic resonances of human carbonmonoxyhaemoglobin in different buffers. J Mol Biol 1985 0.78
89 Stereochemical interpretation of high oxygen affinity of haemoglobin Little Rock ( 2 2 143His leads to Gln). Nat New Biol 1973 0.78
90 Mechanism of deamidation of haemoglobin providence Asn. J Mol Biol 1980 0.77
91 X-ray crystallographic and functional studies of human haemoglobin mutants produced in Escherichia coli. Acta Haematol 1987 0.76
92 Stereochemical mechanism of cooperative effects in haemoglobin. Biochimie 1972 0.76
93 Nature of the iron-oxygen bond and control of oxygen affinity of the haem by the structure of the globin in haemoglobin. Adv Exp Med Biol 1982 0.75
94 State of methaemoglobin in normal adults and in patients with hereditary methaemoglobinaemia. Biochem J 1981 0.75
95 Protein function below 220 K. Nature 1992 0.75
96 Physics and the riddle of life. Nature 1987 0.75
97 Molecular pathology of human haemoglobin. Biochimie 1972 0.75
98 Fundamental research in molecular biology: relevance to medicine. Nature 1976 0.75
99 Lattice constants of lamprey haemoglobin. J Mol Biol 1966 0.75
100 Stereochemistry of iron in deoxyhaemoglobin. Ultramicroscopy 1982 0.75
101 Site of the amino-acid substitution in haemoglobin Seattle ( 2 A 2 70 Asp ). Nat New Biol 1973 0.75
102 Haemoglobin. Molecular inventiveness. Nature 1990 0.75
103 Suggested interpretation of diminished Bohr effect in haemoglobin Hiroshima. Nature 1969 0.75
104 Structure of haemoglobin M Milwaukee, a mutant form exhibiting interaction between ferrous and ferric subunits. Adv Exp Med Biol 1972 0.75
105 Recognition of ligands by haem proteins. Mol Biol Biochem Biophys 1980 0.75
106 Structure of sickle-cell haemoglobin. Trans R Soc Trop Med Hyg 1974 0.75
107 Haemoglobin as a model of an allosteric protein. Symp Soc Exp Biol 1973 0.75
108 Structure and function of hemoglobin variants at an internal hydrophobic site: consequences of mutations at the beta 27 (B9) position. Biochemistry 1990 0.75
109 Sir Lawrence Bragg. Nature 1971 0.75
110 Structure and function of human hemoglobin covalently labeled with periodate-oxidized adenosine triphosphate. J Biol Chem 1989 0.75
111 The role of bound water in haemoglobin and myoblobin. Biosystems 1977 0.75
112 [Not Available]. Kos 1996 0.75
113 DNA helix. Science 1969 0.75
114 Structure of haemoglobins Zürich (his e7(63)beta leads to arg) and Sydney (val e11(67)beta leads to ala) and the role of the distal residues in ligand binding. Prog Clin Biol Res 1978 0.75
115 Fundamental research in molecular biology: its relevance to medicine. Ciba Found Symp 1976 0.75
116 Molecular adaptation in haemoglobin and thermophile bacteria. Differentiation 1979 0.75
117 The Medical Research Council, laboratory of molecular biology. Mol Med 1996 0.75