Coaxial stacking of helixes enhances binding of oligoribonucleotides and improves predictions of RNA folding.

PubWeight™: 8.06‹?› | Rank: Top 0.1%

🔗 View Article (PMC 44783)

Published in Proc Natl Acad Sci U S A on September 27, 1994

Authors

A E Walter1, D H Turner, J Kim, M H Lyttle, P Müller, D H Mathews, M Zuker

Author Affiliations

1: Department of Chemistry, University of Rochester, NY 14627-0216.

Articles citing this

(truncated to the top 100)

Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res (2003) 77.89

Incorporating chemical modification constraints into a dynamic programming algorithm for prediction of RNA secondary structure. Proc Natl Acad Sci U S A (2004) 10.35

Fast and reliable prediction of noncoding RNAs. Proc Natl Acad Sci U S A (2005) 8.15

DINAMelt web server for nucleic acid melting prediction. Nucleic Acids Res (2005) 6.90

"Well-determined" regions in RNA secondary structure prediction: analysis of small subunit ribosomal RNA. Nucleic Acids Res (1995) 4.87

Pfold: RNA secondary structure prediction using stochastic context-free grammars. Nucleic Acids Res (2003) 4.41

Neutral evolution of mutational robustness. Proc Natl Acad Sci U S A (1999) 4.38

Using reliability information to annotate RNA secondary structures. RNA (1998) 3.75

Evaluation of several lightweight stochastic context-free grammars for RNA secondary structure prediction. BMC Bioinformatics (2004) 3.60

Automatic detection of conserved RNA structure elements in complete RNA virus genomes. Nucleic Acids Res (1998) 3.18

Using an RNA secondary structure partition function to determine confidence in base pairs predicted by free energy minimization. RNA (2004) 2.86

Base-stacking and base-pairing contributions into thermal stability of the DNA double helix. Nucleic Acids Res (2006) 2.78

Evaluation of the suitability of free-energy minimization using nearest-neighbor energy parameters for RNA secondary structure prediction. BMC Bioinformatics (2004) 2.57

Linkage and association of the glutamate receptor 6 gene with autism. Mol Psychiatry (2002) 2.51

Comparative analysis of superintegrons: engineering extensive genetic diversity in the Vibrionaceae. Genome Res (2003) 2.31

Characterization of fully 2'-modified oligoribonucleotide hetero- and homoduplex hybridization and nuclease sensitivity. Nucleic Acids Res (1995) 2.30

Expanded CUG repeat RNAs form hairpins that activate the double-stranded RNA-dependent protein kinase PKR. RNA (2000) 2.25

RNA folding energy landscapes. Proc Natl Acad Sci U S A (2000) 2.12

Statistical prediction of single-stranded regions in RNA secondary structure and application to predicting effective antisense target sites and beyond. Nucleic Acids Res (2001) 2.09

Antisense transcripts of the expanded C9ORF72 hexanucleotide repeat form nuclear RNA foci and undergo repeat-associated non-ATG translation in c9FTD/ALS. Acta Neuropathol (2013) 1.95

Role of alpha/beta interferon in Venezuelan equine encephalitis virus pathogenesis: effect of an attenuating mutation in the 5' untranslated region. J Virol (2001) 1.87

Optimization of probe length and the number of probes per gene for optimal microarray analysis of gene expression. Nucleic Acids Res (2004) 1.87

FOXL2 and BPES: mutational hotspots, phenotypic variability, and revision of the genotype-phenotype correlation. Am J Hum Genet (2003) 1.70

Secondary structure model of the RNA recognized by the reverse transcriptase from the R2 retrotransposable element. RNA (1997) 1.68

A set of nearest neighbor parameters for predicting the enthalpy change of RNA secondary structure formation. Nucleic Acids Res (2006) 1.67

Kinefold web server for RNA/DNA folding path and structure prediction including pseudoknots and knots. Nucleic Acids Res (2005) 1.66

Design of multistable RNA molecules. RNA (2001) 1.65

Integron cassette insertion: a recombination process involving a folded single strand substrate. EMBO J (2005) 1.62

Force-induced denaturation of RNA. Biophys J (2001) 1.62

Effects of RNA secondary structure on cellular antisense activity. Nucleic Acids Res (2000) 1.60

Mechanical unfolding of RNA hairpins. Proc Natl Acad Sci U S A (2005) 1.57

Cloning, sequencing, and phenotypic characterization of the rpoS gene from Pseudomonas putida KT2440. J Bacteriol (1998) 1.55

A novel design of whole-genome microarray probes for Saccharomyces cerevisiae which minimizes cross-hybridization. BMC Genomics (2003) 1.51

Unifying evolutionary and thermodynamic information for RNA folding of multiple alignments. Nucleic Acids Res (2008) 1.47

In vitro structure-function studies of the Bacillus subtilis tyrS mRNA antiterminator: evidence for factor-independent tRNA acceptor stem binding specificity. Nucleic Acids Res (2002) 1.43

Forced-unfolding and force-quench refolding of RNA hairpins. Biophys J (2006) 1.42

RNA secondary structure prediction. Curr Protoc Nucleic Acid Chem (2007) 1.40

Predicting helical coaxial stacking in RNA multibranch loops. RNA (2007) 1.40

The relationship between third-codon position nucleotide content, codon bias, mRNA secondary structure and gene expression in the drosophilid alcohol dehydrogenase genes Adh and Adhr. Genetics (2001) 1.39

Design and delivery of antisense oligonucleotides to block microRNA function in cultured Drosophila and human cells. Nat Protoc (2008) 1.38

RNAProfile: an algorithm for finding conserved secondary structure motifs in unaligned RNA sequences. Nucleic Acids Res (2004) 1.38

Novel non-coding RNAs in Dictyostelium discoideum and their expression during development. Nucleic Acids Res (2004) 1.35

Selection of the simplest RNA that binds isoleucine. RNA (2003) 1.35

Sequence variation of MicroRNAs and their binding sites in Arabidopsis. Plant Physiol (2008) 1.35

Downstream sequences influence the choice between a naturally occurring noncanonical and closely positioned upstream canonical heptameric fusion motif during bovine coronavirus subgenomic mRNA synthesis. J Virol (2001) 1.31

Probing RNA structure with chemical reagents and enzymes. Curr Protoc Nucleic Acid Chem (2001) 1.29

Complete probabilistic analysis of RNA shapes. BMC Biol (2006) 1.27

Identification of the nik gene cluster of Brucella suis: regulation and contribution to urease activity. J Bacteriol (2001) 1.27

Inhibition of cell growth and shoot development by a specific nucleotide sequence in a noncoding viroid RNA. Plant Cell (2003) 1.24

Mechanically probing the folding pathway of single RNA molecules. Biophys J (2003) 1.23

A snoRNA that guides the two most conserved pseudouridine modifications within rRNA confers a growth advantage in yeast. RNA (2003) 1.22

The thermodynamic advantage of DNA oligonucleotide 'stacking hybridization' reactions: energetics of a DNA nick. Nucleic Acids Res (1997) 1.22

Rotavirus RNA replication requires a single-stranded 3' end for efficient minus-strand synthesis. J Virol (1998) 1.22

RNA secondary structure prediction from sequence alignments using a network of k-nearest neighbor classifiers. RNA (2006) 1.19

Transcription of all amoC copies is associated with recovery of Nitrosomonas europaea from ammonia starvation. J Bacteriol (2007) 1.18

Predominance of six different hexanucleotide recoding signals 3' of read-through stop codons. Nucleic Acids Res (2002) 1.18

The complete set of H/ACA snoRNAs that guide rRNA pseudouridylations in Saccharomyces cerevisiae. RNA (2005) 1.17

A 5' RNA stem-loop participates in the transcription attenuation mechanism that controls expression of the Bacillus subtilis trpEDCFBA operon. J Bacteriol (1999) 1.17

The robustness of naturally and artificially selected nucleic acid secondary structures. J Mol Evol (2004) 1.17

In vivo analysis of Saccharomyces cerevisiae COX2 mRNA 5'-untranslated leader functions in mitochondrial translation initiation and translational activation. Genetics (1997) 1.15

La autoantigen specifically recognizes a predicted stem-loop in hepatitis B virus RNA. J Virol (1999) 1.15

Analysis of the Bacillus subtilis S10 ribosomal protein gene cluster identifies two promoters that may be responsible for transcription of the entire 15-kilobase S10-spc-alpha cluster. J Bacteriol (1997) 1.13

Secondary structure analysis of a minimal avian leukosis-sarcoma virus packaging signal. J Virol (2000) 1.12

Translational recoding signals between gag and pol in diverse LTR retrotransposons. RNA (2003) 1.10

Thermodynamic and kinetic characterization of antisense oligodeoxynucleotide binding to a structured mRNA. Biophys J (2002) 1.08

Phylogenetic analysis of L4-mediated autogenous control of the S10 ribosomal protein operon. J Bacteriol (1999) 1.08

Urea facilitates the translocation of single-stranded DNA and RNA through the alpha-hemolysin nanopore. Biophys J (2010) 1.08

Predicting RNA secondary structures with pseudoknots by MCMC sampling. J Math Biol (2007) 1.08

In vivo selection of Rous sarcoma virus mutants with randomized sequences in the packaging signal. J Virol (1998) 1.07

trp RNA-binding attenuation protein-5' stem-loop RNA interaction is required for proper transcription attenuation control of the Bacillus subtilis trpEDCFBA operon. J Bacteriol (2000) 1.07

Incorporation of influenza A virus genome segments does not absolutely require wild-type sequences. J Gen Virol (2009) 1.07

Tn1546 is part of a larger plasmid-encoded genetic unit horizontally disseminated among clonal Enterococcus faecium lineages. J Antimicrob Chemother (2010) 1.06

Direct role of a viroid RNA motif in mediating directional RNA trafficking across a specific cellular boundary. Plant Cell (2004) 1.06

Heteroplasmy in the mtDNA control region of sturgeon (Acipenser, Huso and Scaphirhynchus). Genetics (2000) 1.05

Isoenergetic penta- and hexanucleotide microarray probing and chemical mapping provide a secondary structure model for an RNA element orchestrating R2 retrotransposon protein function. Nucleic Acids Res (2008) 1.05

RNA secondary structure analysis using RNAstructure. Curr Protoc Bioinformatics (2006) 1.04

Hierarchy of RNA functional dynamics. Annu Rev Biochem (2014) 1.04

Human BLCAP transcript: new editing events in normal and cancerous tissues. Int J Cancer (2010) 1.04

Characterization of nuclear RNases that cleave hepatitis B virus RNA near the La protein binding site. J Virol (2001) 1.04

On the biophysics and kinetics of toehold-mediated DNA strand displacement. Nucleic Acids Res (2013) 1.03

Inverse folding of RNA pseudoknot structures. Algorithms Mol Biol (2010) 1.03

Computing the partition function for kinetically trapped RNA secondary structures. PLoS One (2011) 1.03

Promoter region of the Escherichia coli O7-specific lipopolysaccharide gene cluster: structural and functional characterization of an upstream untranslated mRNA sequence. J Bacteriol (1998) 1.02

Genetic determinants of Sindbis virus neuroinvasiveness. J Virol (1997) 1.01

Lost in folding space? Comparing four variants of the thermodynamic model for RNA secondary structure prediction. BMC Bioinformatics (2011) 1.01

Predicting coaxial helical stacking in RNA junctions. Nucleic Acids Res (2011) 0.99

Non-specific binding of Na+ and Mg2+ to RNA determined by force spectroscopy methods. Nucleic Acids Res (2012) 0.97

Parallel multiplex thermodynamic analysis of coaxial base stacking in DNA duplexes by oligodeoxyribonucleotide microchips. Nucleic Acids Res (2001) 0.97

A viral noncoding RNA generated by cis-element-mediated protection against 5'->3' RNA decay represses both cap-independent and cap-dependent translation. J Virol (2008) 0.97

Computing folding pathways between RNA secondary structures. Nucleic Acids Res (2009) 0.96

Secondary structures in the capsid protein coding sequence and 3' nontranslated region involved in amplification of the tobacco etch virus genome. J Virol (1998) 0.96

On the normalization of RNA equilibrium free energy to the length of the sequence. Nucleic Acids Res (2003) 0.96

Profiled support vector machines for antisense oligonucleotide efficacy prediction. BMC Bioinformatics (2004) 0.96

Coarse grained models reveal essential contributions of topological constraints to the conformational free energy of RNA bulges. J Phys Chem B (2014) 0.95

A human rotavirus with rearranged genes 7 and 11 encodes a modified NSP3 protein and suggests an additional mechanism for gene rearrangement. J Virol (2001) 0.94

Uncoupling human immunodeficiency virus type 1 Gag and Pol reading frames: role of the transframe protein p6* in viral replication. J Virol (2009) 0.94

A posteriori design of crystal contacts to improve the X-ray diffraction properties of a small RNA enzyme. Acta Crystallogr D Biol Crystallogr (2007) 0.94

Substrate sequence selection by retroviral integrase. J Virol (2001) 0.92

Statistical thermodynamics for chain molecules with simple RNA tertiary contacts. J Chem Phys (2005) 0.91

Entropy-driven one-step formation of Phi29 pRNA 3WJ from three RNA fragments. Biochemistry (2014) 0.91

Articles cited by this

Estimation of secondary structure in ribonucleic acids. Nature (1971) 20.52

On finding all suboptimal foldings of an RNA molecule. Science (1989) 20.36

Improved free-energy parameters for predictions of RNA duplex stability. Proc Natl Acad Sci U S A (1986) 19.52

Comparative anatomy of 16-S-like ribosomal RNA. Prog Nucleic Acid Res Mol Biol (1985) 16.21

Improved predictions of secondary structures for RNA. Proc Natl Acad Sci U S A (1989) 11.52

Three-dimensional tertiary structure of yeast phenylalanine transfer RNA. Science (1974) 11.02

Modelling of the three-dimensional architecture of group I catalytic introns based on comparative sequence analysis. J Mol Biol (1990) 10.85

Structure of yeast phenylalanine tRNA at 3 A resolution. Nature (1974) 10.27

Free energy of imperfect nucleic acid helices. II. Small hairpin loops. J Mol Biol (1973) 10.07

Lessons from an evolving rRNA: 16S and 23S rRNA structures from a comparative perspective. Microbiol Rev (1994) 9.74

Rapid chemical probing of conformation in 16 S ribosomal RNA and 30 S ribosomal subunits using primer extension. J Mol Biol (1986) 7.87

Base-stacking and base-pairing contributions to helix stability: thermodynamics of double-helix formation with CCGG, CCGGp, CCGGAp, ACCGGp, CCGGUp, and ACCGGUp. Biochemistry (1983) 6.81

RNA structure prediction. Annu Rev Biophys Biophys Chem (1988) 5.75

Prediction of RNA secondary structure. Proc Natl Acad Sci U S A (1971) 5.68

Enzymatic oligoribonucleotide synthesis with T4 RNA ligase. Biochemistry (1978) 3.99

A compilation of large subunit (23S-like) ribosomal RNA sequences presented in a secondary structure format. Nucleic Acids Res (1990) 3.23

Polymer-supported RNA synthesis and its application to test the nearest-neighbor model for duplex stability. Biochemistry (1986) 3.21

Characterization of RNA hairpin loop stability. Nucleic Acids Res (1988) 3.10

A comparison of optimal and suboptimal RNA secondary structures predicted by free energy minimization with structures determined by phylogenetic comparison. Nucleic Acids Res (1991) 2.51

Stabilities of consecutive A.C, C.C, G.G, U.C, and U.U mismatches in RNA internal loops: Evidence for stable hydrogen-bonded U.U and C.C.+ pairs. Biochemistry (1991) 2.44

Context dependence of hydrogen bond free energy revealed by substitutions in an RNA hairpin. Science (1992) 2.44

Equimolar addition of oligoribonucleotides with T4 RNA ligase. Nucleic Acids Res (1977) 2.32

Prevention of chain cleavage in the chemical synthesis of 2'-silylated oligoribonucleotides. Nucleic Acids Res (1989) 2.30

The conformational transitions in yeast tRNAPhe as studied with tRNAPhe fragments. Eur J Biochem (1973) 2.26

Phylogenetic comparative analysis of RNA secondary structure. Methods Enzymol (1989) 2.18

RNA pseudoknots. Stability and loop size requirements. J Mol Biol (1990) 2.15

Folding of circularly permuted transfer RNAs. Science (1991) 2.14

Improved parameters for prediction of RNA structure. Cold Spring Harb Symp Quant Biol (1987) 2.08

DNA sequencing by primer walking with strings of contiguous hexamers. Science (1992) 1.85

Conformational transitions in tRNA Asp (brewer's yeast). Thermodynamic, kinetic, and enzymatic measurements on oligonucleotide fragments and the intact molecule. Biochemistry (1974) 1.82

Three-dimensional model of the active site of the self-splicing rRNA precursor of Tetrahymena. Proc Natl Acad Sci U S A (1987) 1.77

Thermodynamic study of internal loops in oligoribonucleotides: symmetric loops are more stable than asymmetric loops. Biochemistry (1991) 1.71

Nearest-neighbor parameters for G.U mismatches: [formula; see text] is destabilizing in the contexts [formula; see text] and [formula; see text] but stabilizing in [formula; see text]. Biochemistry (1991) 1.70

Pseudo--half-knot formation with RNA. Science (1992) 1.58

Comparison of binding of mixed ribose-deoxyribose analogues of CUCU to a ribozyme and to GGAGAA by equilibrium dialysis: evidence for ribozyme specific interactions with 2' OH groups. Biochemistry (1991) 1.50

Stability and structure of three-way DNA junctions containing unpaired nucleotides. Nucleic Acids Res (1991) 1.43

RNA hairpin loop stability depends on closing base pair. Nucleic Acids Res (1993) 1.40

Enzymatic and NMR analysis of oligoribonucleotides synthesized with 2'-tert-butyldimethylsilyl protected cyanoethylphosphoramidite monomers. Nucleic Acids Res (1990) 1.28

Thermodynamics of DNA branching. J Mol Biol (1992) 1.17

Articles by these authors

Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information. Nucleic Acids Res (1981) 61.59

Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure. J Mol Biol (1999) 41.48

Improved free-energy parameters for predictions of RNA duplex stability. Proc Natl Acad Sci U S A (1986) 19.52

Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature (2000) 19.15

Epigenetic memory in induced pluripotent stem cells. Nature (2010) 14.31

Improved predictions of secondary structures for RNA. Proc Natl Acad Sci U S A (1989) 11.52

Thermodynamic parameters for an expanded nearest-neighbor model for formation of RNA duplexes with Watson-Crick base pairs. Biochemistry (1998) 9.75

Real-time prediction of hand trajectory by ensembles of cortical neurons in primates. Nature (2000) 7.29

Predicting optimal and suboptimal secondary structure for RNA. Methods Enzymol (1990) 7.08

Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II, or III breast cancer. N Engl J Med (2000) 6.98

Base-stacking and base-pairing contributions to helix stability: thermodynamics of double-helix formation with CCGG, CCGGp, CCGGAp, ACCGGp, CCGGUp, and ACCGGUp. Biochemistry (1983) 6.81

Computer prediction of RNA structure. Methods Enzymol (1989) 6.36

A novel family of divergent seven-transmembrane proteins: candidate odorant receptors in Drosophila. Neuron (1999) 6.03

Secondary structure of the Tetrahymena ribosomal RNA intervening sequence: structural homology with fungal mitochondrial intervening sequences. Proc Natl Acad Sci U S A (1983) 4.78

Apg9p/Cvt7p is an integral membrane protein required for transport vesicle formation in the Cvt and autophagy pathways. J Cell Biol (2000) 4.30

Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption. Neoplasia (2001) 4.22

The itinerary of a vesicle component, Aut7p/Cvt5p, terminates in the yeast vacuole via the autophagy/Cvt pathways. J Biol Chem (2000) 3.97

Identification of a novel bacterial sequence associated with Crohn's disease. Gastroenterology (2000) 3.90

Some simple computational methods to improve the folding of large RNAs. Nucleic Acids Res (1984) 3.69

Dissection of autophagosome biogenesis into distinct nucleation and expansion steps. J Cell Biol (2000) 3.64

Relationship between cell shape and type of collagen synthesised as chondrocytes lose their cartilage phenotype in culture. Nature (1977) 3.46

Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution. Science (2001) 3.39

Predicting thermodynamic properties of RNA. Methods Enzymol (1995) 3.38

Thermodynamics of (dG--dC)3 double-helix formation in water and deuterium oxide. Biochemistry (1981) 3.30

Polymer-supported RNA synthesis and its application to test the nearest-neighbor model for duplex stability. Biochemistry (1986) 3.21

Calmodulin target database. J Struct Funct Genomics (2000) 3.20

Cvt19 is a receptor for the cytoplasm-to-vacuole targeting pathway. Mol Cell (2001) 3.12

Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. EMBO J (1999) 3.11

Survey of extended-spectrum beta-lactamases in clinical isolates of Escherichia coli and Klebsiella pneumoniae: prevalence of TEM-52 in Korea. J Clin Microbiol (1999) 3.04

Investigation of the structural basis for thermodynamic stabilities of tandem GU mismatches: solution structure of (rGAGGUCUC)2 by two-dimensional NMR and simulated annealing. Biochemistry (1996) 2.96

Codon-improved Cre recombinase (iCre) expression in the mouse. Genesis (2002) 2.92

Bone-targeted therapy for advanced androgen-independent carcinoma of the prostate: a randomised phase II trial. Lancet (2001) 2.85

Soft tissue cephalometric analysis: diagnosis and treatment planning of dentofacial deformity. Am J Orthod Dentofacial Orthop (1999) 2.81

Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice. Science (1993) 2.78

Thermodynamic studies of RNA stability. J Biomol Struct Dyn (1984) 2.75

Testing the exon theory of genes: the evidence from protein structure. Science (1994) 2.71

Contributions of dangling end stacking and terminal base-pair formation to the stabilities of XGGCCp, XCCGGp, XGGCCYp, and XCCGGYp helixes. Biochemistry (1985) 2.70

Malignant tumours of the heart: a review of tumour type, diagnosis and therapy. Clin Oncol (R Coll Radiol) (2007) 2.67

Predicting oligonucleotide affinity to nucleic acid targets. RNA (1999) 2.67

Surface attachment of Salmonella typhimurium to intestinal epithelia imprints the subepithelial matrix with gradients chemotactic for neutrophils. J Cell Biol (1995) 2.53

A comparison of optimal and suboptimal RNA secondary structures predicted by free energy minimization with structures determined by phylogenetic comparison. Nucleic Acids Res (1991) 2.51

Regional pattern of white matter microstructural changes in normal aging, MCI, and AD. Neurology (2009) 2.47

Measurement in vivo of proliferation rates of slow turnover cells by 2H2O labeling of the deoxyribose moiety of DNA. Proc Natl Acad Sci U S A (2002) 2.46

Stabilities of consecutive A.C, C.C, G.G, U.C, and U.U mismatches in RNA internal loops: Evidence for stable hydrogen-bonded U.U and C.C.+ pairs. Biochemistry (1991) 2.44

Context dependence of hydrogen bond free energy revealed by substitutions in an RNA hairpin. Science (1992) 2.44

Distinct functional phenotypes of cloned Ia-restricted helper T cells. J Exp Med (1985) 2.39

Design of biomimetic fibrillar interfaces: 1. Making contact. J R Soc Interface (2004) 2.38

Thermodynamics of single mismatches in RNA duplexes. Biochemistry (1999) 2.36

Structural organization of the 16S ribosomal RNA from E. coli. Topography and secondary structure. Nucleic Acids Res (1981) 2.32

Stability of XGCGCp, GCGCYp, and XGCGCYp helixes: an empirical estimate of the energetics of hydrogen bonds in nucleic acids. Biochemistry (1986) 2.32

Electron microscope studies of heteroduplex DNA from a deletion mutant of bacteriophage phiX-174. Proc Natl Acad Sci U S A (1972) 2.29

Expanded CUG repeat RNAs form hairpins that activate the double-stranded RNA-dependent protein kinase PKR. RNA (2000) 2.25

Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells. Proc Natl Acad Sci U S A (1995) 2.24

Controlled trial of transdermal nicotine patch in tobacco withdrawal. Lancet (1989) 2.22

Ultrabithorax regulates genes at several levels of the wing-patterning hierarchy to shape the development of the Drosophila haltere. Genes Dev (1998) 2.22

Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients. Br J Cancer (2008) 2.21

A kinase-deficient transcription factor TFIIH is functional in basal and activated transcription. Proc Natl Acad Sci U S A (1995) 2.20

Thermal unfolding of a group I ribozyme: the low-temperature transition is primarily disruption of tertiary structure. Biochemistry (1993) 2.13

Laser temperature-jump, spectroscopic, and thermodynamic study of salt effects on duplex formation by dGCATGC. Biochemistry (1989) 2.13

Genetic ablation of parathyroid glands reveals another source of parathyroid hormone. Nature (2000) 2.13

Laser temperature-jump study of stacking in adenylic acid polymers. Biochemistry (1979) 2.12

Evolution of HIV-1 coreceptor usage through interactions with distinct CCR5 and CXCR4 domains. Proc Natl Acad Sci U S A (1997) 2.11

An association study of asthma and total serum immunoglobin E levels for Toll-like receptor polymorphisms in a Japanese population. Clin Exp Allergy (2004) 2.10

Unique and shared functions of different connexins in mice. Curr Biol (2000) 2.10

Expression of chemokine receptors by subsets of neurons in the central nervous system. J Immunol (1997) 2.10

Stroke mechanism in patients with non-valvular atrial fibrillation according to the CHADS2 and CHA2 DS2 -VASc scores. Eur J Neurol (2011) 2.09

Low prevalence of valvular heart disease in 226 phentermine-fenfluramine protocol subjects prospectively followed for up to 30 months. J Am Coll Cardiol (1999) 2.09

Structure-function relationship of Rous sarcoma virus leader RNA. Nucleic Acids Res (1982) 2.08

Concentration of ofloxacin in canine prostate tissue and prostate fluid after intraprostatic injection of biodegradable sustained-releasing microspheres containing ofloxacin. J Urol (2000) 2.07

Effects of exercise during long-term support with a left ventricular assist device. Results of the experience with left ventricular assist device with exercise (EVADE) pilot trial. Circulation (1997) 2.06

Melasma: histopathological characteristics in 56 Korean patients. Br J Dermatol (2002) 2.05

alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure. Biochemistry (1990) 2.03

Capacity of multidrug-resistant clinical isolates of Acinetobacter baumannii to form biofilm and adhere to epithelial cell surfaces. Clin Microbiol Infect (2007) 2.00

An outbreak of Campylobacter jejuni infections associated with food handler contamination: the use of pulsed-field gel electrophoresis. J Infect Dis (2000) 1.99

Apg2 is a novel protein required for the cytoplasm to vacuole targeting, autophagy, and pexophagy pathways. J Biol Chem (2001) 1.99

The Vestigial and Scalloped proteins act together to directly regulate wing-specific gene expression in Drosophila. Genes Dev (1998) 1.99

Vascular and metabolic response to isolated small muscle mass exercise: effect of age. Am J Physiol Heart Circ Physiol (2003) 1.97

Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: a model of glioblastoma multiforme pathophysiology. Mol Biol Cell (1993) 1.97

Sequence dependence for the energetics of dangling ends and terminal base pairs in ribonucleic acid. Biochemistry (1987) 1.95

Energetics of internal GU mismatches in ribooligonucleotide helixes. Biochemistry (1986) 1.92

Analysis of hepatitis C virus capsid, E1, and E2/NS1 proteins expressed in insect cells. Virology (1993) 1.92

Free energy contributions of G.U and other terminal mismatches to helix stability. Biochemistry (1986) 1.92

Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signaling. Curr Biol (2000) 1.90

Transforming growth factor-beta1 induces desmoplasia in an experimental model of human pancreatic carcinoma. Cancer Res (2001) 1.88

Structural analysis by energy dot plot of a large mRNA. J Mol Biol (1993) 1.86

Localization of psoriasis-susceptibility locus PSORS1 to a 60-kb interval telomeric to HLA-C. Am J Hum Genet (2000) 1.86

Correlated errors in biased surrogates: study designs and methods for measurement error correction. Stat Med (2005) 1.85

The regulation of AMP-activated protein kinase by H(2)O(2). Biochem Biophys Res Commun (2001) 1.84

Localization of the Vpx packaging signal within the C terminus of the human immunodeficiency virus type 2 Gag precursor protein. J Virol (1994) 1.81

Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production. J Exp Med (1993) 1.81

Carbapenem resistance mechanisms in Pseudomonas aeruginosa clinical isolates. Antimicrob Agents Chemother (2001) 1.81

Influence of age and hemodynamics on myocardial blood flow and flow reserve. Circulation (1993) 1.81

Gastric carcinoma risk index in patients infected with Helicobacter pylori. Virchows Arch (1998) 1.79

Thermodynamics of three-way multibranch loops in RNA. Biochemistry (2001) 1.78