Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes.

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Published in Mol Cell Biol on December 01, 1994

Authors

A B Reynolds1, J Daniel, P D McCrea, M J Wheelock, J Wu, Z Zhang

Author Affiliations

1: Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.

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Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes. Curr Opin Struct Biol (1999) 2.25

Syndecans serve as attachment receptors for human immunodeficiency virus type 1 on macrophages. J Virol (2001) 2.24

Charged amino acid residues of human immunodeficiency virus type 1 nucleocapsid p7 protein involved in RNA packaging and infectivity. J Virol (1996) 2.22

New structural picture of the Ge2Sb2Te5 phase-change alloy. Phys Rev Lett (2011) 2.21

B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40. Nature (1993) 2.14

StuA is required for cell pattern formation in Aspergillus. Genes Dev (1992) 2.14

Tubulin genes of the African trypanosome Trypanosoma brucei rhodesiense:nucleotide sequence of a 3.7-kb fragment containing genes for alpha and beta tubulins. Gene (1985) 2.10

Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases. Nat Commun (2013) 2.10

Myosin conformational states determined by single fluorophore polarization. Proc Natl Acad Sci U S A (1998) 2.07

Intrastriatal transplantation of bone marrow nonhematopoietic cells improves functional recovery after stroke in adult mice. J Cereb Blood Flow Metab (2000) 2.06

Ly-49D and Ly-49H associate with mouse DAP12 and form activating receptors. J Immunol (1998) 2.06

The relationship of respiratory and cardiovascular hospital admissions to the southern California wildfires of 2003. Occup Environ Med (2008) 2.06

A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors. J Biol Chem (1994) 2.06