Long-term culture-initiating cell expansion is dependent on frequent medium exchange combined with stromal and other accessory cell effects.

PubWeight™: 0.79‹?›

🔗 View Article (PMID 7544642)

Published in Blood on September 01, 1995

Authors

M R Koller1, M A Palsson, I Manchel, B O Palsson

Author Affiliations

1: Aastrom Biosciences, Inc, Ann Arbor, MI 48106, USA.

Articles by these authors

In silico predictions of Escherichia coli metabolic capabilities are consistent with experimental data. Nat Biotechnol (2001) 8.88

The Escherichia coli MG1655 in silico metabolic genotype: its definition, characteristics, and capabilities. Proc Natl Acad Sci U S A (2000) 7.70

Stoichiometric flux balance models quantitatively predict growth and metabolic by-product secretion in wild-type Escherichia coli W3110. Appl Environ Microbiol (1994) 6.26

Metabolic modeling of microbial strains in silico. Trends Biochem Sci (2001) 4.29

Theory for the systemic definition of metabolic pathways and their use in interpreting metabolic function from a pathway-oriented perspective. J Theor Biol (2000) 4.23

Robustness analysis of the Escherichia coli metabolic network. Biotechnol Prog (2000) 3.40

Systems properties of the Haemophilus influenzae Rd metabolic genotype. J Biol Chem (1999) 2.92

Metabolic pathway analysis: basic concepts and scientific applications in the post-genomic era. Biotechnol Prog (1999) 2.66

Stoichiometric interpretation of Escherichia coli glucose catabolism under various oxygenation rates. Appl Environ Microbiol (1993) 2.62

Metabolic flux balance analysis and the in silico analysis of Escherichia coli K-12 gene deletions. BMC Bioinformatics (2000) 2.50

Assessment of the metabolic capabilities of Haemophilus influenzae Rd through a genome-scale pathway analysis. J Theor Biol (2000) 2.49

Metabolic capabilities of Escherichia coli: I. synthesis of biosynthetic precursors and cofactors. J Theor Biol (1993) 2.39

Network analysis of intermediary metabolism using linear optimization. I. Development of mathematical formalism. J Theor Biol (1992) 2.21

Characterization of metabolism in the Fe(III)-reducing organism Geobacter sulfurreducens by constraint-based modeling. Appl Environ Microbiol (2006) 2.09

Toward metabolic phenomics: analysis of genomic data using flux balances. Biotechnol Prog (1999) 1.93

Dynamic simulation of the human red blood cell metabolic network. Bioinformatics (2001) 1.92

Biomass as a source of chemical feedstocks: an economic evaluation. Science (1981) 1.78

The underlying pathway structure of biochemical reaction networks. Proc Natl Acad Sci U S A (1998) 1.78

Metabolic dynamics in the human red cell. Part III--Metabolic reaction rates. J Theor Biol (1990) 1.63

Flux-balance analysis of mitochondrial energy metabolism: consequences of systemic stoichiometric constraints. Am J Physiol Regul Integr Comp Physiol (2001) 1.59

Metabolic dynamics in the human red cell. Part I--A comprehensive kinetic model. J Theor Biol (1989) 1.58

Effective intercellular communication distances are determined by the relative time constants for cyto/chemokine secretion and diffusion. Proc Natl Acad Sci U S A (1997) 1.55

Biochemical production capabilities of Escherichia coli. Biotechnol Bioeng (1993) 1.54

Network analysis of intermediary metabolism using linear optimization. II. Interpretation of hybridoma cell metabolism. J Theor Biol (1992) 1.49

Consistent and high rates of gene transfer can be obtained using flow-through transduction over a wide range of retroviral titers. Hum Gene Ther (1996) 1.43

Effect of medium osmolarity on hybridoma growth, metabolism, and antibody production. Biotechnol Bioeng (1991) 1.41

Two new pseudopod morphologies displayed by the human hematopoietic KG1a progenitor cell line and by primary human CD34(+) cells. Blood (1998) 1.40

Reducing complexity in metabolic networks: making metabolic meshes manageable. Fed Proc (1987) 1.31

How will bioinformatics influence metabolic engineering? Biotechnol Bioeng (1999) 1.30

Symmetry of initial cell divisions among primitive hematopoietic progenitors is independent of ontogenic age and regulatory molecules. Blood (1999) 1.29

Retroviral infection is limited by Brownian motion. Hum Gene Ther (1996) 1.29

Growth, metabolic, and antibody production kinetics of hybridoma cell culture: 2. Effects of serum concentration, dissolved oxygen concentration, and medium pH in a batch reactor. Biotechnol Prog (1992) 1.24

Effects of ammonia and lactate on hybridoma growth, metabolism, and antibody production. Biotechnol Bioeng (1992) 1.23

Properties of metabolic networks: structure versus function. Biophys J (2004) 1.22

Parametric sensitivity of stoichiometric flux balance models applied to wild-type Escherichia coli metabolism. Biotechnol Bioeng (1995) 1.20

Using the reconstructed genome-scale human metabolic network to study physiology and pathology. J Intern Med (2012) 1.20

Large-scale expansion of human stem and progenitor cells from bone marrow mononuclear cells in continuous perfusion cultures. Blood (1993) 1.18

Cell-cycle-specific F plasmid replication: regulation by cell size control of initiation. J Bacteriol (1991) 1.14

Chemical decomposition of glutamine in cell culture media: effect of media type, pH, and serum concentration. Biotechnol Prog (1990) 1.13

Metabolic dynamics in the human red cell. Part IV--Data prediction and some model computations. J Theor Biol (1990) 1.12

A comprehensive model of human erythrocyte metabolism: extensions to include pH effects. Biomed Biochim Acta (1990) 1.06

Mathematical modelling of dynamics and control in metabolic networks. I. On Michaelis-Menten kinetics. J Theor Biol (1984) 1.06

Optimal selection of metabolic fluxes for in vivo measurement. II. Application to Escherichia coli and hybridoma cell metabolism. J Theor Biol (1992) 1.03

Elemental balancing of biomass and medium composition enhances growth capacity in high-density Chlorella vulgaris cultures. Biotechnol Bioeng (1998) 1.01

Optimal selection of metabolic fluxes for in vivo measurement. I. Development of mathematical methods. J Theor Biol (1992) 1.00

Metabolic dynamics in the human red cell. Part II--Interactions with the environment. J Theor Biol (1989) 0.99

Moloney murine leukemia virus-derived retroviral vectors decay intracellularly with a half-life in the range of 5.5 to 7.5 hours. J Virol (1997) 0.98

Effects of dissolved oxygen on hybridoma cell growth, metabolism, and antibody production kinetics in continuous culture. Biotechnol Prog (1991) 0.98

Clinical-scale human umbilical cord blood cell expansion in a novel automated perfusion culture system. Bone Marrow Transplant (1998) 0.91

Determination of specific oxygen uptake rates in human hematopoietic cultures and implications for bioreactor design. Ann Biomed Eng (1996) 0.90

Growth, metabolic, and antibody production kinetics of hybridoma cell culture: 1. Analysis of data from controlled batch reactors. Biotechnol Prog (1992) 0.90

Kinetics of retroviral production from the amphotropic ΨCRIP murine producer cell line. Cytotechnology (1996) 0.89

Kinetics of retrovirus mediated gene transfer: the importance of intracellular half-life of retroviruses. J Theor Biol (1996) 0.89

Predictions for oxygen supply control to enhance population stability of engineered production strains. Biotechnol Bioeng (1994) 0.89

Production of monoclonal antibody using free-suspended and immobilized hybridoma cells: Effect of serum. Biotechnol Bioeng (1991) 0.88

Quantitative analysis of Escherichia coli metabolic phenotypes within the context of phenotypic phase planes. J Mol Microbiol Biotechnol (2003) 0.88

Review: tissue engineering: reconstitution of human hematopoiesis ex vivo. Biotechnol Bioeng (1993) 0.88

Mathematical modelling of dynamics and control in metabolic networks. V. Static bifurcations in single biochemical control loops. J Theor Biol (1985) 0.87

High-density photoautotrophic algal cultures: design, construction, and operation of a novel photobioreactor system. Biotechnol Bioeng (1991) 0.87

Culture perfusion schedules influence the metabolic activity and granulocyte-macrophage colony-stimulating factor production rates of human bone marrow stromal cells. J Cell Physiol (1991) 0.87

Rapid medium perfusion rate significantly increases the productivity and longevity of human bone marrow cultures. Proc Natl Acad Sci U S A (1991) 0.85

Enhanced specific antibody productivity of calcium alginate-entrapped hybridoma is cell line-specific. Cytotechnology (1994) 0.84

Coupled effects of polybrene and calf serum on the efficiency of retroviral transduction and the stability of retroviral vectors. Hum Gene Ther (1997) 0.84

Population balance between producing and nonproducing hybridoma clones is very sensitive to serum level, state of inoculum, and medium composition. Biotechnol Bioeng (1992) 0.83

Cell cycle dependence of retroviral transduction: An issue of overlapping time scales. Biotechnol Bioeng (1999) 0.83

In situ labeling of adherent cells with PKH26. In Vitro Cell Dev Biol Anim (2000) 0.83

Bioreactor expansion of human bone marrow: comparison of unprocessed, density-separated, and CD34-enriched cells. J Hematother (1995) 0.83

Importance of parenchymal:stromal cell ratio for the ex vivo reconstitution of human hematopoiesis. Stem Cells (1997) 0.83

Microencapsulated human bone marrow cultures: a potential culture system for the clonal outgrowth of hematopoietic progenitor cells. Biotechnol Bioeng (1994) 0.82

On the kinetics of plasmid replication. J Theor Biol (1989) 0.82

Application of population balance model to the loss of hybridoma antibody productivity. Biotechnol Prog (1991) 0.82

Dissolution of ionizable drugs in buffered and unbuffered solutions. Pharm Res (1988) 0.82

ColE1 plasmid replication: a simple kinetic description from a structured model. J Theor Biol (1989) 0.81

Flow cytometric analysis of human bone marrow perfusion cultures: erythroid development and relationship with burst-forming units-erythroid. Exp Hematol (1996) 0.81

Replication of the R6K plasmid during the Escherichia coli cell cycle. J Bacteriol (1992) 0.81

Phototoxicity of the fluorescent membrane dyes PKH2 and PKH26 on the human hematopoietic KG1a progenitor cell line. Cytometry (1999) 0.81

Effect of serum concentration on hybridoma cell growth and monoclonal antibody production at various initial cell densities. Hybridoma (1989) 0.81

Multiple steady states in kinetic models of red cell metabolism. J Theor Biol (2000) 0.81

Monoclonal antibody production using free-suspended and entrapped hybridoma cells. Biotechnol Genet Eng Rev (1994) 0.81

Replication of mini-F plasmids during the bacterial division cycle. Res Microbiol (1993) 0.80

Control of interspecies electron transfer flow during anaerobic digestion: dynamic diffusion reaction models for hydrogen gas transfer in microbial flocs. Biotechnol Bioeng (1989) 0.80

Donor-to-donor variability in the expansion potential of human bone marrow cells is reduced by accessory cells but not by soluble growth factors. Exp Hematol (1996) 0.80

In vitro myelopoiesis stimulated by rapid medium exchange and supplementation with hematopoietic growth factors. Blood (1991) 0.80

Cell Culture conditions determine the enhancement of specific monoclonal antibody productivity of calcium alginate-entrapped S3H5/gamma2bA2 hybridoma cells. Biotechnol Bioeng (1993) 0.80

Effect of initial cell density on hybridoma growth, metabolism, and monoclonal antibody production. J Biotechnol (1990) 0.80

Tissue culture surface characteristics influence the expansion of human bone marrow cells. Biomaterials (1998) 0.79

Physiological changes during the adaptation of hybridoma cells to low serum and serum-free media. Biotechnol Bioeng (1991) 0.79

Immobilization can improve the stability of hybridoma antibody productivity in serum-free media. Biotechnol Bioeng (1990) 0.79

Preface: Tissue engineering and cell therapies: II. Biotechnol Bioeng (1994) 0.79

Influence of medium exchange schedules on metabolic, growth, and GM-CSF secretion rates of genetically engineered NIH-3T3 cells. Biotechnol Prog (1991) 0.79

Quantitative long-term culture-initiating cell assays require accessory cell depletion that can be achieved by CD34-enrichment or 5-fluorouracil exposure. Blood (1998) 0.78

Key adhesion molecules are present on long podia extended by hematopoietic cells. Cytometry (1999) 0.78

Different measures of human hematopoietic cell culture performance are optimized under vastly different conditions. Biotechnol Bioeng (1996) 0.78

Kinetics of release from enteric-coated tablets. Pharm Res (1988) 0.78