Published in J Biol Chem on October 06, 1995
Life below the gum line: pathogenic mechanisms of Porphyromonas gingivalis. Microbiol Mol Biol Rev (1998) 6.28
Complete genome sequence of the oral pathogenic Bacterium porphyromonas gingivalis strain W83. J Bacteriol (2003) 4.41
Determination of the genome sequence of Porphyromonas gingivalis strain ATCC 33277 and genomic comparison with strain W83 revealed extensive genome rearrangements in P. gingivalis. DNA Res (2008) 2.72
Predominant archaea in marine sediments degrade detrital proteins. Nature (2013) 2.41
A protein secretion system linked to bacteroidete gliding motility and pathogenesis. Proc Natl Acad Sci U S A (2009) 2.02
Purification, gene cloning, gene expression, and mutants of Dps from the obligate anaerobe Porphyromonas gingivalis. Infect Immun (2003) 1.57
Does the importance of the C-terminal residues in the maturation of RgpB from Porphyromonas gingivalis reveal a novel mechanism for protein export in a subgroup of Gram-Negative bacteria? J Bacteriol (2006) 1.56
Role of Porphyromonas gingivalis protease activity in colonization of oral surfaces. Infect Immun (1996) 1.41
Enhanced biofilm formation and loss of capsule synthesis: deletion of a putative glycosyltransferase in Porphyromonas gingivalis. J Bacteriol (2006) 1.40
Porphyromonas gingivalis gingipains and adhesion to epithelial cells. Infect Immun (2001) 1.38
Involvement of arginine-specific cysteine proteinase (Arg-gingipain) in fimbriation of Porphyromonas gingivalis. J Bacteriol (1996) 1.37
Analysis of the prtP gene encoding porphypain, a cysteine proteinase of Porphyromonas gingivalis. J Bacteriol (1996) 1.36
Role of Arg-gingipain A in virulence of Porphyromonas gingivalis. Infect Immun (1998) 1.29
In vitro models of tissue penetration and destruction by Porphyromonas gingivalis. Infect Immun (2004) 1.26
Calprotectin expression in vitro by oral epithelial cells confers resistance to infection by Porphyromonas gingivalis. Infect Immun (2001) 1.23
Biochemical characterization of the arginine-specific proteases of Porphyromonas gingivalis W50 suggests a common precursor. Biochem J (1997) 1.23
Porphyromonas gingivalis galE is involved in lipopolysaccharide O-antigen synthesis and biofilm formation. Infect Immun (2006) 1.17
Formation of methyl mercaptan from L-methionine by Porphyromonas gingivalis. Infect Immun (2000) 1.16
High molecular weight gingipains from Porphyromonas gingivalis induce cytokine responses from human macrophage-like cells via a nonproteolytic mechanism. J Innate Immun (2008) 1.15
A peptide domain on gingipain R which confers immunity against Porphyromonas gingivalis infection in mice. Infect Immun (1998) 1.14
IS195, an insertion sequence-like element associated with protease genes in Porphyromonas gingivalis. Infect Immun (1998) 1.14
The Tla protein of Porphyromonas gingivalis W50: a homolog of the RI protease precursor (PrpRI) is an outer membrane receptor required for growth on low levels of hemin. J Bacteriol (1997) 1.13
Regulation of protease expression in Porphyromonas gingivalis. Infect Immun (1998) 1.09
Effect of inactivation of the Arg- and/or Lys-gingipain gene on selected virulence and physiological properties of Porphyromonas gingivalis. Infect Immun (2003) 1.06
Discrete proteolysis of focal contact and adherens junction components in Porphyromonas gingivalis-infected oral keratinocytes: a strategy for cell adhesion and migration disabling. Infect Immun (2002) 1.06
RgpA-Kgp peptide-based immunogens provide protection against Porphyromonas gingivalis challenge in a murine lesion model. Infect Immun (2000) 1.06
Contact-dependent protein secretion in Porphyromonas gingivalis. Infect Immun (1998) 1.05
Enzymatic properties of dipeptidyl aminopeptidase IV produced by the periodontal pathogen Porphyromonas gingivalis and its participation in virulence. Infect Immun (2000) 1.03
Maturation of the arginine-specific proteases of Porphyromonas gingivalis W50 is dependent on a functional prR2 protease gene. Infect Immun (1998) 1.02
Asp- and Glu-specific novel dipeptidyl peptidase 11 of Porphyromonas gingivalis ensures utilization of proteinaceous energy sources. J Biol Chem (2011) 1.00
Lipopolysaccharide preparation extracted from Porphyromonas gingivalis lipoprotein-deficient mutant shows a marked decrease in toll-like receptor 2-mediated signaling. Infect Immun (2005) 0.97
Porphyromonas gingivalis gingipains trigger a proinflammatory response in human monocyte-derived macrophages through the p38α mitogen-activated protein kinase signal transduction pathway. Toxins (Basel) (2010) 0.96
A functional virulence complex composed of gingipains, adhesins, and lipopolysaccharide shows high affinity to host cells and matrix proteins and escapes recognition by host immune systems. Infect Immun (2005) 0.96
Role of gingipains in growth of Porphyromonas gingivalis in the presence of human serum albumin. Infect Immun (2001) 0.95
Cleavage of protease-activated receptors on an immortalized oral epithelial cell line by Porphyromonas gingivalis gingipains. Microbiology (2009) 0.94
The core genome of the anaerobic oral pathogenic bacterium Porphyromonas gingivalis. BMC Microbiol (2010) 0.94
Porphyromonas gingivalis genes isolated by screening for epithelial cell attachment. Infect Immun (1996) 0.93
Role for gingipains in Porphyromonas gingivalis traffic to phagolysosomes and survival in human aortic endothelial cells. Infect Immun (2007) 0.90
Porphyromonas gingivalis promotes invasion of oral squamous cell carcinoma through induction of proMMP9 and its activation. Cell Microbiol (2013) 0.90
Selection and phenotypic characterization of nonhemagglutinating mutants of Porphyromonas gingivalis. Infect Immun (1996) 0.88
Porphyromonas gingivalis gingipain-R enhances interleukin-8 but decreases gamma interferon-inducible protein 10 production by human gingival fibroblasts in response to T-cell contact. Infect Immun (2001) 0.87
Pathogen-mediated proteolysis of the cell death regulator RIPK1 and the host defense modulator RIPK2 in human aortic endothelial cells. PLoS Pathog (2012) 0.86
Cleavage of human transferrin by Porphyromonas gingivalis gingipains promotes growth and formation of hydroxyl radicals. Infect Immun (2004) 0.86
Arg-gingipain a DNA vaccine induces protective immunity against infection by Porphyromonas gingivalis in a murine model. Infect Immun (2001) 0.86
Gingipains from the Periodontal Pathogen Porphyromonas gingivalis Play a Significant Role in Regulation of Angiopoietin 1 and Angiopoietin 2 in Human Aortic Smooth Muscle Cells. Infect Immun (2015) 0.84
HU protein affects transcription of surface polysaccharide synthesis genes in Porphyromonas gingivalis. J Bacteriol (2010) 0.83
Enhancement of Th2 pathways and direct activation of B cells by the gingipains of Porphyromonas gingivalis. Clin Exp Immunol (2003) 0.83
Role of extracytoplasmic function sigma factors in biofilm formation of Porphyromonas gingivalis. BMC Oral Health (2015) 0.82
Molecular mechanism for the spontaneous generation of pigmentless Porphyromonas gingivalis mutants. Infect Immun (1999) 0.82
Mfa4, an Accessory Protein of Mfa1 Fimbriae, Modulates Fimbrial Biogenesis, Cell Auto-Aggregation, and Biofilm Formation in Porphyromonas gingivalis. PLoS One (2015) 0.81
Cardiovascular disease and the role of oral bacteria. J Oral Microbiol (2010) 0.81
A two-component system regulates gene expression of the type IX secretion component proteins via an ECF sigma factor. Sci Rep (2016) 0.81
Involvement of an Skp-Like Protein, PGN_0300, in the Type IX Secretion System of Porphyromonas gingivalis. Infect Immun (2015) 0.80
The hemoglobin receptor protein of porphyromonas gingivalis inhibits receptor activator NF-kappaB ligand-induced osteoclastogenesis from bone marrow macrophages. Infect Immun (2006) 0.79
Localization of HArep-containing genes on the chromosome of Porphyromonas gingivalis W83. Infect Immun (1999) 0.79
Hemoglobin receptor protein from Porphyromonas gingivalis induces interleukin-8 production in human gingival epithelial cells through stimulation of the mitogen-activated protein kinase and NF-κB signal transduction pathways. Infect Immun (2013) 0.79
Structure of the fimbrial protein Mfa4 from Porphyromonas gingivalis in its precursor form: implications for a donor-strand complementation mechanism. Sci Rep (2016) 0.78
Noncanonical activation of β-catenin by Porphyromonas gingivalis. Infect Immun (2015) 0.78
Role of Mfa5 in Expression of Mfa1 Fimbriae in Porphyromonas gingivalis. J Dent Res (2016) 0.78
Attenuation of the phosphatidylinositol 3-kinase/Akt signaling pathway by Porphyromonas gingivalis gingipains RgpA, RgpB, and Kgp. J Biol Chem (2015) 0.77
Activities of the Porphyromonas gingivalis PrtP proteinase determined by construction of prtP-deficient mutants and expression of the gene in Bacteroides species. J Bacteriol (1999) 0.77
The sinR ortholog PGN_0088 encodes a transcriptional regulator that inhibits polysaccharide synthesis in Porphyromonas gingivalis ATCC 33277 biofilms. PLoS One (2013) 0.77
Crystallization and preliminary X-ray diffraction analysis of gingipain R2 from Porphyromonas gingivalis in complex with H-D-Phe-Phe-Arg-chloromethylketone. Protein Sci (1998) 0.76
The impact of virulence factors of Porphyromonas gingivalis on wound healing in vitro. J Oral Microbiol (2015) 0.76
Inhibitory effects of protamines on proteolytic and adhesive activities of Porphyromonas gingivalis. Infect Immun (1999) 0.76
Diurnal dynamic behavior of microglia in response to infected bacteria through the UDP-P2Y6 receptor system. Sci Rep (2016) 0.75
Structural and mutational analyses of dipeptidyl peptidase 11 from Porphyromonas gingivalis reveal the molecular basis for strict substrate specificity. Sci Rep (2015) 0.75
Mechanisms by which Porphyromonas gingivalis evades innate immunity. PLoS One (2017) 0.75
Effect of extracytoplasmic function sigma factors on autoaggregation, hemagglutination, and cell surface properties of Porphyromonas gingivalis. PLoS One (2017) 0.75
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med (2001) 16.51
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med (2002) 14.15
Toward a protein-protein interaction map of the budding yeast: A comprehensive system to examine two-hybrid interactions in all possible combinations between the yeast proteins. Proc Natl Acad Sci U S A (2000) 10.98
PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol Cell (1999) 7.56
Hd1, a major photoperiod sensitivity quantitative trait locus in rice, is closely related to the Arabidopsis flowering time gene CONSTANS. Plant Cell (2000) 6.93
A high-density rice genetic linkage map with 2275 markers using a single F2 population. Genetics (1998) 6.82
Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev (2001) 6.15
A precise and fast temperature mapping using water proton chemical shift. Magn Reson Med (1995) 5.73
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature (1996) 5.45
Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature (1994) 5.33
Full-length sequence of a hepatitis C virus genome having poor homology to reported isolates: comparative study of four distinct genotypes. Virology (1992) 5.16
A 300 kilobase interval genetic map of rice including 883 expressed sequences. Nat Genet (1994) 5.08
Genetic analysis of blood pressure in spontaneously hypertensive rats. Jpn Circ J (1970) 4.59
Culture conditions for stimulating cholera toxin production by Vibrio cholerae O1 El Tor. Microbiol Immunol (1986) 4.38
Persistent oxidative stress in cancer. FEBS Lett (1995) 3.85
Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. J Clin Invest (1998) 3.76
Experimental transmission of Bartonella henselae by the cat flea. J Clin Microbiol (1996) 3.67
A simple method to estimate populational 24-h urinary sodium and potassium excretion using a casual urine specimen. J Hum Hypertens (2002) 3.67
Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2. Proc Natl Acad Sci U S A (1997) 3.66
Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha. EMBO J (1998) 3.63
Circulating microRNAs in plasma of patients with gastric cancers. Br J Cancer (2010) 3.59
Signaling by the cytokine receptor superfamily: JAKs and STATs. Trends Biochem Sci (1994) 3.36
Production of cholera-like enterotoxin by a Vibrio cholerae non-O1 strain isolated from the environment. Infect Immun (1981) 3.21
Isolation and characterization of non-defective transducing elements of bacteriophage phi-80. Virology (1967) 3.15
Use of polymerase chain reaction catalyzed by Taq DNA polymerase for site-specific mutagenesis. Gene (1989) 3.11
Properties of the defective phage of Bacillus subtilis. J Mol Biol (1968) 3.09
Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia. Diabetes (2000) 3.01
Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B. Blood (1996) 2.98
Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase. Nat Genet (1999) 2.81
Similarity among the Drosophila (6-4)photolyase, a human photolyase homolog, and the DNA photolyase-blue-light photoreceptor family. Science (1996) 2.74
Non-O1 Vibrio cholerae hemolysin: purification, partial characterization, and immunological relatedness to El Tor hemolysin. Infect Immun (1984) 2.72
The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance. J Biol Chem (2001) 2.69
The NPH4 locus encodes the auxin response factor ARF7, a conditional regulator of differential growth in aerial Arabidopsis tissue. Plant Cell (2000) 2.68
Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients. J Clin Invest (1993) 2.64
Purification and some properties of a non-o1 Vibrio cholerae enterotoxin that is identical to cholera enterotoxin. Infect Immun (1983) 2.62
Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha. Mol Cell Biol (2000) 2.61
Signaling through the hematopoietic cytokine receptors. Annu Rev Immunol (1995) 2.61
Outbreak of Burkitt's-like lymphoma in homosexual men. Lancet (1982) 2.58
Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase. Science (1999) 2.56
Purification and partial characterization of heat-stable enterotoxin of enterotoxigenic Escherichia coli. Infect Immun (1979) 2.55
Potential role of protein kinase B in insulin-induced glucose transport, glycogen synthesis, and protein synthesis. J Biol Chem (1998) 2.51
Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population. Diabetologia (2007) 2.48
Enterotoxicity of El Tor-like hemolysin of non-O1 Vibrio cholerae. Infect Immun (1987) 2.46
Association of amino acid substitutions in penicillin-binding protein 3 with beta-lactam resistance in beta-lactamase-negative ampicillin-resistant Haemophilus influenzae. Antimicrob Agents Chemother (2001) 2.46
Complete nucleotide sequences of 93-kb and 3.3-kb plasmids of an enterohemorrhagic Escherichia coli O157:H7 derived from Sakai outbreak. DNA Res (1998) 2.43
Formation and function of Vibrio parahaemolyticus lateral flagella. J Bacteriol (1977) 2.43
New medium for the production of cholera toxin by Vibrio cholerae O1 biotype El Tor. J Clin Microbiol (1985) 2.43
Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction. J Biol Chem (1999) 2.43
Genetic analyses of proteolysis, hemoglobin binding, and hemagglutination of Porphyromonas gingivalis. Construction of mutants with a combination of rgpA, rgpB, kgp, and hagA. J Biol Chem (1999) 2.39
Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. Diabetologia (2011) 2.37
Pravastatin attenuates allergic airway inflammation by suppressing antigen sensitisation, interleukin 17 production and antigen presentation in the lung. Thorax (2008) 2.37
Regulation of pigment synthesis in mammalian cells, as studied by somatic hybridization. Proc Natl Acad Sci U S A (1966) 2.36
The apoptotic v-cyclin-CDK6 complex phosphorylates and inactivates Bcl-2. Nat Cell Biol (2000) 2.36
Involvement of a NF-kappa B-like transcription factor in the activation of the interleukin-6 gene by inflammatory lymphokines. Mol Cell Biol (1990) 2.34
Characterization of the MexC-MexD-OprJ multidrug efflux system in DeltamexA-mexB-oprM mutants of Pseudomonas aeruginosa. Antimicrob Agents Chemother (1998) 2.29
Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: structure-based mechanism of conversion. Proc Natl Acad Sci U S A (2000) 2.28
Longitudinal study of cerebrospinal fluid levels of tau, A beta1-40, and A beta1-42(43) in Alzheimer's disease: a study in Japan. Ann Neurol (1998) 2.25
Effects of propofol on hemodynamic and inflammatory responses to endotoxemia in rats. Crit Care Med (2000) 2.25
Collective review of small carcinomas of the pancreas. Ann Surg (1986) 2.24
Hepatitis C virus antibody and hepatitis C virus replication in chronic hepatitis B patients. J Hepatol (1994) 2.23
Effects of moderate-intensity endurance and high-intensity intermittent training on anaerobic capacity and VO2max. Med Sci Sports Exerc (1996) 2.23
Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons. J Neurosci (2000) 2.21
Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone. Nature (1997) 2.20
Induction of inflammatory arthropathy resembling rheumatoid arthritis in mice transgenic for HTLV-I. Science (1991) 2.18
The controlling role of ATM in homologous recombinational repair of DNA damage. EMBO J (2000) 2.17
Evolutionary molecular engineering by random elongation mutagenesis. Nat Biotechnol (1999) 2.15
Identity of hemolysins produced by Vibrio cholerae non-O1 and V. cholerae O1, biotype El Tor. Infect Immun (1986) 2.15
Long-term safety and efficacy of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): evidence of safety and efficacy in a 5-year extension study. Ann Rheum Dis (2008) 2.11
Involvement of programmed cell death 4 in transforming growth factor-beta1-induced apoptosis in human hepatocellular carcinoma. Oncogene (2006) 2.10
Matrix/integrin interaction activates the mitogen-activated protein kinase, p44erk-1 and p42erk-2. J Biol Chem (1995) 2.09
Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion. Science (1999) 2.06
Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition. Gut (2008) 2.05
Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue. Cancer Res (1997) 2.02
Effect of iodixanol on renal function immediately after abdominal angiography. Clinical comparison with iomeprol and ioxaglate. Acta Radiol (1998) 2.01
Cell cycle-dependent expression of the mouse Rad51 gene in proliferating cells. Mol Gen Genet (1996) 2.00
Risk factors for worsening to diabetes in subjects with impaired glucose tolerance. Diabetologia (1984) 1.99
Trehalose sensitivity in Drosophila correlates with mutations in and expression of the gustatory receptor gene Gr5a. Curr Biol (2001) 1.99
Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes. J Clin Invest (2001) 1.97
Circulating microRNAs in plasma of patients with oesophageal squamous cell carcinoma. Br J Cancer (2011) 1.97
Doxorubicin-loaded poly(ethylene glycol)-poly(beta-benzyl-L-aspartate) copolymer micelles: their pharmaceutical characteristics and biological significance. J Control Release (2000) 1.96
Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice. Mol Cell Biol (1996) 1.95
Identification of calcium-activated neutral protease as a processing enzyme of human interleukin 1 alpha. Proc Natl Acad Sci U S A (1990) 1.94
Evidence that a non-O1 Vibrio cholerae produces enterotoxin that is similar but not identical to cholera enterotoxin. Infect Immun (1983) 1.93
Two mammalian heat shock proteins, HSP90 and HSP100, are actin-binding proteins. Proc Natl Acad Sci U S A (1986) 1.93
Elevated expression of transforming growth factor-beta in adipose tissue from obese mice. Mol Med (1997) 1.92
The Pro12Ala polymorphism in PPAR gamma2 may confer resistance to type 2 diabetes. Biochem Biophys Res Commun (2000) 1.91
Intervention of thymus and activation-regulated chemokine attenuates the development of allergic airway inflammation and hyperresponsiveness in mice. J Immunol (2001) 1.91
Mechanism for the autogenous control of the crp operon: transcriptional inhibition by a divergent RNA transcript. Proc Natl Acad Sci U S A (1986) 1.88
Construction of nondefective adenovirus type 5 bearing a 2.8-kilobase hepatitis B virus DNA near the right end of its genome. J Virol (1985) 1.88
The role of calcium in depolarization-secretion coupling at the motor nerve terminal. J Physiol (1973) 1.88
Semiquantitative grading of severity of mitral regurgitation by real-time two-dimensional Doppler flow imaging technique. J Am Coll Cardiol (1986) 1.86
Adjacent-segment morbidity after Graf ligamentoplasty compared with posterolateral lumbar fusion. J Neurosurg (2001) 1.86
Functions of the high mobility group protein, Abf2p, in mitochondrial DNA segregation, recombination and copy number in Saccharomyces cerevisiae. Genetics (1998) 1.85
Dissociation of phagocytosis from stimulation of the oxidative metabolic burst in macrophages. J Exp Med (1984) 1.85
Apoptosis and functional Fas antigen in rheumatoid arthritis synoviocytes. Arthritis Rheum (1995) 1.85
Clinicopathological features of Churg-Strauss syndrome-associated neuropathy. Brain (1999) 1.84
Bacillus subtilis gtaB encodes UDP-glucose pyrophosphorylase and is controlled by stationary-phase transcription factor sigma B. J Bacteriol (1993) 1.84
mRNA transport in yeast: time to reinvestigate the functions of the nucleolus. Mol Biol Cell (1995) 1.83
A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes. Diabetologia (2002) 1.83