Published in Proc Natl Acad Sci U S A on September 12, 1995
CD28 and CTLA-4 coreceptor expression and signal transduction. Immunol Rev (2009) 3.09
Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation. Immunity (2008) 2.42
The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K. Science (2010) 2.26
Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production. Proc Natl Acad Sci U S A (1997) 2.05
Mechanisms of interleukin-10-mediated immune suppression. Immunology (2001) 1.70
Cytoskeleton-membrane interactions in membrane raft structure. Cell Mol Life Sci (2009) 1.59
FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells. Proc Natl Acad Sci U S A (1998) 1.56
Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the Pleckstrin homology domain of inducible T cell kinase. Proc Natl Acad Sci U S A (1997) 1.43
An enigmatic tail of CD28 signaling. Cold Spring Harb Perspect Biol (2010) 1.30
T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes. Immunity (2010) 1.29
Regulation of T-cell responses by PTEN. Immunol Rev (2008) 1.15
A dose-dependent requirement for the proline motif of CD28 in cellular and humoral immunity revealed by a targeted knockin mutant. J Exp Med (2006) 1.15
Targeted knock-in mice expressing mutations of CD28 reveal an essential pathway for costimulation. Mol Cell Biol (2009) 1.14
CD28: a signalling perspective. Biochem J (1996) 1.08
CD28 co-signaling in the adaptive immune response. Self Nonself (2010) 1.08
Differential association of protein tyrosine kinases with the T cell receptor is linked to the induction of anergy and its prevention by B7 family-mediated costimulation. J Exp Med (1996) 1.04
Induction of autoimmune disease in CTLA-4-/- mice depends on a specific CD28 motif that is required for in vivo costimulation. Proc Natl Acad Sci U S A (2007) 1.02
Cross talk between phosphatidylinositol 3-kinase and cyclic AMP (cAMP)-protein kinase a signaling pathways at the level of a protein kinase B/beta-arrestin/cAMP phosphodiesterase 4 complex. Mol Cell Biol (2010) 1.01
PKC-theta-mediated signal delivery from the TCR/CD28 surface receptors. Front Immunol (2012) 0.97
LCK-phosphorylated human killer cell-inhibitory receptors recruit and activate phosphatidylinositol 3-kinase. Proc Natl Acad Sci U S A (1998) 0.95
Itk: the rheostat of the T cell response. J Signal Transduct (2011) 0.91
CD28 Costimulation: From Mechanism to Therapy. Immunity (2016) 0.90
Multiple functions for CD28 and cytotoxic T lymphocyte antigen-4 during different phases of T cell responses: implications for arthritis and autoimmune diseases. Arthritis Res Ther (2004) 0.84
Simian immunodeficiency virus Nef protein delays the progression of CD4+ T cells through G1/S phase of the cell cycle. J Virol (2002) 0.84
The immunoglobulin tail tyrosine motif upgrades memory-type BCRs by incorporating a Grb2-Btk signalling module. Nat Commun (2014) 0.84
Cross talk between CD3 and CD28 is spatially modulated by protein lateral mobility. Mol Cell Biol (2013) 0.83
Cutting edge: A double-mutant knockin of the CD28 YMNM and PYAP motifs reveals a critical role for the YMNM motif in regulation of T cell proliferation and Bcl-xL expression. J Immunol (2014) 0.82
Lack of costimulation by both sphingomyelinase and C2 ceramide in resting human T cells. Immunology (2000) 0.81
The Fyn-ADAP Axis: Cytotoxicity Versus Cytokine Production in Killer Cells. Front Immunol (2015) 0.79
Alloantigen-induced unresponsiveness in cord blood T lymphocytes is associated with defective activation of Ras. Proc Natl Acad Sci U S A (1998) 0.79
Signaling in Effector Lymphocytes: Insights toward Safer Immunotherapy. Front Immunol (2016) 0.76
Costimulation of IL-2 Production through CD28 Is Dependent on the Size of Its Ligand. J Immunol (2015) 0.76
Vav1 Regulates T-Cell Activation through a Feedback Mechanism and Crosstalk between the T-Cell Receptor and CD28. J Proteome Res (2015) 0.75
Cell Type-Specific Regulation of Immunological Synapse Dynamics by B7 Ligand Recognition. Front Immunol (2016) 0.75
Evidence that a kinase distinct from protein kinase C and phosphatidylinositol 3-kinase mediates ligation-dependent serine/threonine phosphorylation of the T-lymphocyte co-stimulatory molecule CD28. Biochem J (1997) 0.75
Signal transduction by lymphocyte antigen receptors. Cell (1994) 10.63
The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck. Cell (1988) 10.47
Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science (1989) 7.78
Differential T cell costimulatory requirements in CD28-deficient mice. Science (1993) 6.93
Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling. Nature (1993) 6.38
The B7 and CD28 receptor families. Immunol Today (1994) 6.38
Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice. Science (1992) 5.94
The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes. Proc Natl Acad Sci U S A (1988) 5.75
Stimulation of p21ras upon T-cell activation. Nature (1990) 5.72
Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. Cell (1992) 5.67
The role of the CD28 receptor during T cell responses to antigen. Annu Rev Immunol (1993) 5.65
Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells. Science (1993) 5.30
Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28. Science (1991) 5.12
Purification and characterization of phosphoinositide 3-kinase from rat liver. J Biol Chem (1990) 4.75
PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase. Nature (1994) 4.67
Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation. Science (1993) 4.45
JNK is involved in signal integration during costimulation of T lymphocytes. Cell (1994) 4.36
Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4. Cell (1992) 4.34
Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem (1993) 4.23
Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. Science (1994) 4.23
B70 antigen is a second ligand for CTLA-4 and CD28. Nature (1993) 3.57
Identification of an alternative CTLA-4 ligand costimulatory for T cell activation. Science (1993) 3.49
An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro. Cell (1993) 3.40
The CD28 ligand B7/BB1 provides costimulatory signal for alloactivation of CD4+ T cells. J Exp Med (1991) 3.35
T cell activation by clustered tyrosine kinases. Cell (1993) 2.79
Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice. Science (1993) 2.78
Binding of phosphatidylinositol-3-OH kinase to CD28 is required for T-cell signalling. Nature (1994) 2.63
Allogeneic non-T spleen cells restore the responsiveness of normal T cell clones stimulated with antigen and chemically modified antigen-presenting cells. J Immunol (1988) 2.48
Extracellular signals and reversible protein phosphorylation: what to Mek of it all. Cell (1993) 2.31
Tyrosine kinases and tyrosine-based activation motifs. Current research on activation via the T cell antigen receptor. J Biol Chem (1992) 2.05
Activated human B lymphocytes express three CTLA-4 counterreceptors that costimulate T-cell activation. Proc Natl Acad Sci U S A (1993) 2.03
T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif. Proc Natl Acad Sci U S A (1994) 1.95
itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2. Proc Natl Acad Sci U S A (1992) 1.93
Constitutive expression of B7 restores immunogenicity of tumor cells expressing truncated major histocompatibility complex class II molecules. Proc Natl Acad Sci U S A (1993) 1.72
CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line. Proc Natl Acad Sci U S A (1994) 1.70
Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells. J Exp Med (1994) 1.64
Activation of p34cdc2 kinase by cyclin A. J Cell Biol (1991) 1.62
Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells. Proc Natl Acad Sci U S A (1993) 1.62
Developmental regulation of a murine T-cell-specific tyrosine kinase gene, Tsk. Proc Natl Acad Sci U S A (1993) 1.53
The role of the T cell costimulator B7-1 in autoimmunity and the induction and maintenance of tolerance to peripheral antigen. Immunity (1994) 1.49
Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness. Proc Natl Acad Sci U S A (1994) 1.43
Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase. Mol Cell Biol (1993) 1.34
Two-step TCR zeta/CD3-CD4 and CD28 signaling in T cells: SH2/SH3 domains, protein-tyrosine and lipid kinases. Immunol Today (1994) 1.32
T cell antigen CD28 binds to the GRB-2/SOS complex, regulators of p21ras. Eur J Immunol (1995) 1.30
Ligation of CD28 receptor by B7 induces formation of D-3 phosphoinositides in T lymphocytes independently of T cell receptor/CD3 activation. Eur J Immunol (1993) 1.30
Ligation of B7 with CD28/CTLA-4 on T cells results in CD40 ligand expression, interleukin-4 secretion and efficient help for antibody production by B cells. Eur J Immunol (1993) 1.29
CD28 of T lymphocytes associates with phosphatidylinositol 3-kinase. Int Immunol (1994) 1.28
CD28-induced T cell activation. Evidence for a protein-tyrosine kinase signal transduction pathway. J Immunol (1992) 1.27
The role of p21ras in CD28 signal transduction: triggering of CD28 with antibodies, but not the ligand B7-1, activates p21ras. J Exp Med (1994) 1.09
Identification, cloning, and characterization of a novel human T-cell-specific tyrosine kinase located at the hematopoietin complex on chromosome 5q. Blood (1993) 1.08
The T-cell antigen CD5 acts as a receptor and substrate for the protein-tyrosine kinase p56lck. Mol Cell Biol (1994) 1.06
Simultaneous ligation of CD5 and CD28 on resting T lymphocytes induces T cell activation in the absence of T cell receptor/CD3 occupancy. J Immunol (1993) 0.99
Activation of src family kinase lck following CD28 crosslinking in the Jurkat leukemic cell line. Biochem Biophys Res Commun (1994) 0.99
Activation-dependent phosphorylation of the T-lymphocyte surface receptor CD28 and associated proteins. Proc Natl Acad Sci U S A (1994) 0.96
Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42. Proc Natl Acad Sci U S A (1995) 3.01
Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science (1995) 3.00
The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex. Proc Natl Acad Sci U S A (1989) 2.80
The CD28-related molecule ICOS is required for effective T cell-dependent immune responses. Immunity (2000) 2.70
A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists. Immunity (1996) 2.69
T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells. J Exp Med (1998) 2.66
Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade. J Biol Chem (2000) 2.08
Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation. Mol Cell Biol (2000) 2.06
Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production. Proc Natl Acad Sci U S A (1997) 2.05
1F7, a novel cell surface molecule, involved in helper function of CD4 cells. J Immunol (1989) 2.04
Complementation of a bovine papilloma virus low-copy-number mutant: evidence for a temporal requirement of the complementing gene. Mol Cell Biol (1986) 1.96
T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif. Proc Natl Acad Sci U S A (1994) 1.95
Regulatory intramolecular association in a tyrosine kinase of the Tec family. Nature (1997) 1.95
Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap. Science (2001) 1.87
Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2. Immunity (1997) 1.74
Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells. Proc Natl Acad Sci U S A (1993) 1.62
FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells. Proc Natl Acad Sci U S A (1998) 1.56
Identification of Itk/Tsk Src homology 3 domain ligands. J Biol Chem (1996) 1.54
CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells. J Exp Med (1995) 1.54
Developmental regulation of a murine T-cell-specific tyrosine kinase gene, Tsk. Proc Natl Acad Sci U S A (1993) 1.53
Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity. J Biol Chem (1997) 1.52
SH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55. EMBO J (2000) 1.50
Identification of two SH3-binding motifs in the regulatory subunit of phosphatidylinositol 3-kinase. J Biol Chem (1994) 1.47
Induction of suppression following autologous mixed lymphocyte reaction; role of a novel 2H4 antigen. Eur J Immunol (1987) 1.46
Characterization and functional expression of a rat genomic DNA clone encoding a lymphocyte potassium channel. J Immunol (1990) 1.41
A novel epitope of the LFA-1 antigen which can distinguish killer effector and suppressor cells in human CD8 cells. Nature (1988) 1.36
Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase. Mol Cell Biol (1993) 1.34
Two-step TCR zeta/CD3-CD4 and CD28 signaling in T cells: SH2/SH3 domains, protein-tyrosine and lipid kinases. Immunol Today (1994) 1.32
FYN-T-FYB-SLP-76 interactions define a T-cell receptor zeta/CD3-mediated tyrosine phosphorylation pathway that up-regulates interleukin 2 transcription in T-cells. J Biol Chem (1999) 1.30
T cell antigen CD28 binds to the GRB-2/SOS complex, regulators of p21ras. Eur J Immunol (1995) 1.30
YopH dephosphorylates Cas and Fyn-binding protein in macrophages. Microb Pathog (1999) 1.30
Expression and characterization of a human mitochondrial phenylalanyl-tRNA synthetase. J Mol Biol (1999) 1.27
Selective CD28pYMNM mutations implicate phosphatidylinositol 3-kinase in CD86-CD28-mediated costimulation. Immunity (1995) 1.26
The role of the 2H4 molecule in the generation of suppressor function in Con A-activated T cells. J Immunol (1986) 1.22
The association between glycosylphosphatidylinositol-anchored proteins and heterotrimeric G protein alpha subunits in lymphocytes. Proc Natl Acad Sci U S A (1996) 1.21
CD28 signaling via VAV/SLP-76 adaptors: regulation of cytokine transcription independent of TCR ligation. Immunity (2001) 1.21
Cytotoxic T lymphocyte antigen 4 and CD28 modulate cell surface raft expression in their regulation of T cell function. J Exp Med (2001) 1.21
Lymphokine regulation of CD45R expression on human T cell clones. J Exp Med (1989) 1.20
CD5 acts as a tyrosine kinase substrate within a receptor complex comprising T-cell receptor zeta chain/CD3 and protein-tyrosine kinases p56lck and p59fyn. Proc Natl Acad Sci U S A (1992) 1.20
SHPS-1 is a scaffold for assembling distinct adhesion-regulated multi-protein complexes in macrophages. Curr Biol (1999) 1.18
Interleukin 7 receptor control of T cell receptor gamma gene rearrangement: role of receptor-associated chains and locus accessibility. J Exp Med (1998) 1.18
To build a prognostic score model containing indispensible tumour markers for metastatic nasopharyngeal carcinoma in an epidemic area. Eur J Cancer (2011) 1.15
Biochemical identification of a direct physical interaction between the CD4:p56lck and Ti(TcR)/CD3 complexes. Eur J Immunol (1991) 1.15
The role of Jak3 in lymphoid development, activation, and signaling. Curr Opin Immunol (1997) 1.15
Growth factor receptor-bound protein 2 SH2/SH3 domain binding to CD28 and its role in co-signaling. J Biol Chem (1998) 1.15
Mechanisms of inactivation of p14ARF, p15INK4b, and p16INK4a genes in human esophageal squamous cell carcinoma. Clin Cancer Res (1999) 1.15
A peptide antigen antagonist prevents the differentiation of T cell receptor transgenic thymocytes. J Immunol (1994) 1.14
Cutting edge: SLP-76 cooperativity with FYB/FYN-T in the Up-regulation of TCR-driven IL-2 transcription requires SLP-76 binding to FYB at Tyr595 and Tyr651. J Immunol (1999) 1.14
2H1--a novel antigen involved in T lymphocyte triggering. J Immunol (1988) 1.13
A new member of the Eph family of receptors that lacks protein tyrosine kinase activity. Oncogene (1996) 1.12
Function of the LFA-1 and T4 molecules in the direct activation of resting human B lymphocytes by T lymphocytes. Eur J Immunol (1986) 1.12
Peripheral expression of Jak3 is required to maintain T lymphocyte function. J Exp Med (1997) 1.11
T cell receptor zeta/CD3-p59fyn(T)-associated p120/130 binds to the SH2 domain of p59fyn(T). J Exp Med (1993) 1.10
Adaptor FYB (Fyn-binding protein) regulates integrin-mediated adhesion and mediator release: differential involvement of the FYB SH3 domain. Proc Natl Acad Sci U S A (2001) 1.09
The role of cytokine receptor signaling in lymphocyte development. Curr Opin Immunol (1999) 1.07
The T-cell antigen CD5 acts as a receptor and substrate for the protein-tyrosine kinase p56lck. Mol Cell Biol (1994) 1.06
Novel isoform of lymphoid adaptor FYN-T-binding protein (FYB-130) interacts with SLP-76 and up-regulates interleukin 2 production. J Biol Chem (1999) 1.05
Decreased CD8-p56lck activity in peripheral blood T-lymphocytes from patients with hereditary haemochromatosis. Scand J Immunol (1994) 1.04
Homodimerization of interleukin-4 receptor alpha chain can induce intracellular signaling. J Biol Chem (1996) 1.04
Expression and characterization of the human mitochondrial leucyl-tRNA synthetase. Biochim Biophys Acta (2000) 1.03
Cytolytic T lymphocyte-associated antigen-4 and the TCR zeta/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2. J Immunol (1999) 1.01
HLA-D region antigen-associated invariant polypeptides as revealed by two-dimensional gel analysis. Glycosylation and structural inter-relationships. J Biol Chem (1985) 1.01
Murine JAK3 is preferentially expressed in hematopoietic tissues and lymphocyte precursor cells. Blood (1996) 1.00
Induction of autoimmune disease in mice by germline alteration of the T cell receptor gene expression. J Immunol (1994) 1.00
Tyrosine phosphatase SHP-2 binding to CTLA-4: absence of direct YVKM/YFIP motif recognition. Biochem Biophys Res Commun (2000) 0.99
Isolation and characterization of a human T lymphocyte-associated glycoprotein (gp40). J Immunol (1984) 0.99
CTLA-4 blockade of antigen-induced cell death. Blood (2001) 0.99
Resting lymphocyte kinase (Rlk/Txk) targets lymphoid adaptor SLP-76 in the cooperative activation of interleukin-2 transcription in T-cells. J Biol Chem (2000) 0.98
Engagement of the TcR/CD3 complex stimulates p59fyn(T) activity: detection of associated proteins at 72 and 120-130 kD. Mol Immunol (1992) 0.98
Association of a 70-kDa tyrosine phosphoprotein with the CD16: zeta: gamma complex expressed in human natural killer cells. Eur J Immunol (1993) 0.98
Biochemical analysis of p120/130: a protein-tyrosine kinase substrate restricted to T and myeloid cells. J Immunol (1997) 0.97
Developmental regulation of thymocyte susceptibility to deletion by "self"-peptide. J Exp Med (1992) 0.97
T cell development and activation in Jak3-deficient mice. J Leukoc Biol (1998) 0.97
Structural characterization of CD6: properties of two distinct epitopes involved in T cell activation. Mol Immunol (1989) 0.96
A 32-kD GTP-binding protein associated with the CD4-p56lck and CD8-p56lck T cell receptor complexes. Science (1991) 0.95
Fc gamma RIIIA-mediated signaling involves src-family lck in human natural killer cells. J Immunol (1993) 0.95
The Fes protein-tyrosine kinase phosphorylates a subset of macrophage proteins that are involved in cell adhesion and cell-cell signaling. J Biol Chem (1997) 0.95
T cells from Jak3-deficient mice have intact TCR signaling, but increased apoptosis. J Immunol (1997) 0.94
CD28 receptor endocytosis is targeted by mutations that disrupt phosphatidylinositol 3-kinase binding and costimulation. J Immunol (1998) 0.93
A role for adhesion and degranulation-promoting adapter protein in collagen-induced platelet activation mediated via integrin α(2) β(1). J Thromb Haemost (2012) 0.92
A profound deficiency in thymic progenitor cells in mice lacking Jak3. J Immunol (2000) 0.91
Tec kinase signaling in T cells is regulated by phosphatidylinositol 3-kinase and the Tec pleckstrin homology domain. J Immunol (2001) 0.90
Effects of domain exchanges between Escherichia coli and mammalian mitochondrial EF-Tu on interactions with guanine nucleotides, aminoacyl-tRNA and ribosomes. Biochim Biophys Acta (1999) 0.90
Biosynthesis and post-translational modification of CD6, a T cell signal-transducing molecule. J Biol Chem (1991) 0.90
Characterization of microRNAs in Taenia saginata of zoonotic significance by Solexa deep sequencing and bioinformatics analysis. Parasitol Res (2011) 0.89
A Raf-1-related p110 polypeptide associates with the CD4-p56lck complex in T cells. Mol Cell Biol (1992) 0.88
A 72-kilodalton fyn-related polypeptide (p72fyn-R) binds to the antigen-receptor/CD3 (TcR/CD3) complex. J Biol Chem (1993) 0.88
Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4. Biochem Biophys Res Commun (1998) 0.87
A regulatory role for cytoplasmic YVKM motif in CTLA-4 inhibition of TCR signaling. Eur J Immunol (2001) 0.86
Phosphatidylinositol-3 kinase inhibitors reproduce the selective antiproliferative effects of imatinib on chronic myeloid leukaemia progenitor cells. Br J Haematol (2004) 0.86
Functional characterization of the CD45R (2H4) molecule on CD8 (T8) cells in the autologous mixed lymphocyte reaction system. Eur J Immunol (1989) 0.85
Dysregulated myelopoiesis in mice lacking Jak3. Blood (1999) 0.85
Phosphorylation of src family lck tyrosine kinase following interleukin-12 activation of human natural killer cells. Cell Immunol (1995) 0.85
Cutting edge: two distinct mechanisms lead to impaired T cell homeostasis in Janus kinase 3- and CTLA-4-deficient mice. J Immunol (2001) 0.85
Functional expression, activation and desensitization of opioid receptor-like receptor ORL1 in neuroblastoma x glioma NG108-15 hybrid cells. FEBS Lett (1997) 0.84