PubRank

R Kimbell

Author PubWeight™ 23.59‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study. Cancer Res 1991 1.94
2 Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines. Br J Cancer 1995 1.12
3 The role of the reduced-folate carrier and metabolism to intracellular polyglutamates for the activity of ICI D1694. Adv Exp Med Biol 1993 1.05
4 ZD1694 (Tomudex): a new thymidylate synthase inhibitor with activity in colorectal cancer. Eur J Cancer 1995 1.02
5 Cellular pharmacology and in vivo activity of a new anticancer agent, ZD9331: a water-soluble, nonpolyglutamatable, quinazoline-based inhibitor of thymidylate synthase. Clin Cancer Res 1997 1.00
6 Kinetic characteristics of ICI D1694: a quinazoline antifolate which inhibits thymidylate synthase. Biochem Pharmacol 1992 0.99
7 Relationships between resistance to cisplatin and antifolates in sensitive and resistant tumour cell lines. Eur J Cancer 1995 0.87
8 Differential control of mRNA levels for Thy-1 antigen and laminin in rat mammary epithelial and myoepithelial-like cells. J Cell Physiol 1987 0.83
9 Control of type IV collagen production in rat mammary epithelial and myoepithelial-like cells. J Cell Physiol 1986 0.83
10 Quinazoline thymidylate synthase inhibitors: methods for assessing the contribution of polyglutamation to their in vitro activity. Anticancer Drug Des 1995 0.83
11 Increased abundance of a normal cell mRNA sequence accompanies the conversion of rat mammary cuboidal epithelial cells to elongated myoepithelial-like cells in culture. Nucleic Acids Res 1984 0.83
12 The antitumour activity of ZD9331, a non-polyglutamatable quinazoline thymidylate synthase inhibitor. Adv Exp Med Biol 1994 0.82
13 A novel class of lipophilic quinazoline-based folic acid analogues: cytotoxic agents with a folate-independent locus. Br J Cancer 1999 0.80
14 Design and synthesis of Cyclopenta[g]quinazoline-based antifolates as inhibitors of thymidylate synthase and potential antitumor agents(,). J Med Chem 2000 0.80
15 Design and synthesis of potent non-polyglutamatable quinazoline antifolate thymidylate synthase inhibitors. J Med Chem 1999 0.78
16 Substituted-2-desamino-2-methyl-quinazolinones. A series of novel antitumour agents. Adv Exp Med Biol 1993 0.78
17 Characterisation of chondroitin/dermatan sulphate proteoglycans synthesised by rat mammary myoepithelial and fibroblastic cell lines. Biochim Biophys Acta 1992 0.78
18 Combination of raltitrexed with other cytotoxic agents: rationale and preclinical observations. Eur J Cancer 1999 0.78
19 Quinazoline antifolate thymidylate synthase inhibitors: gamma-linked L-D, D-D, and D-L dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583). J Med Chem 1996 0.78
20 Thymidylate synthase inhibitors: the in vitro activity of a series of heterocyclic benzoyl ring modified 2-desamino-2-methyl-N10-substituted-5,8-dideazafolates. Adv Enzyme Regul 1991 0.78
21 Quinazoline antifolate thymidylate synthase inhibitors: replacement of glutamic acid in the C2-methyl series. J Med Chem 1995 0.78
22 The influence of drug-exposure conditions on the development of resistance to methotrexate or ZD1694 in cultured human leukaemia cells. Int J Cancer 1996 0.77
23 Biological activity and intracellular metabolism of ZD1694 in human leukemia cell lines with different resistance mechanisms to antifolate drugs. Jpn J Cancer Res 1996 0.77
24 Folate-based inhibitors of thymidylate synthase: synthesis and antitumor activity of gamma-linked sterically hindered dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583). J Med Chem 1997 0.77
25 Gamma-linked dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8- dideazafolate as antitumour agents. Adv Exp Med Biol 1993 0.77
26 Quinazoline antifolates thymidylate synthase inhibitors: lipophilic analogues with modification to the C2-methyl substituent. J Med Chem 1996 0.77
27 Cellular pharmacokinetics of ZD1694 in cultured human leukaemia cells sensitive, or made resistant, to this drug. J Cancer Res Clin Oncol 1996 0.76
28 The identification of a normal rat gene located close to the gene for the potential myoepithelial cell calcium-binding protein, p9Ka. J Biol Chem 1988 0.75
29 Loss of basement membrane deposits and development of invasive potential by virally-transformed rat mammary cells are independent of collagenase production. Int J Cancer 1987 0.75
30 Role of fibronectin in the organisation of the cytoskeleton during the spreading of rat mammary epithelial cells. Cell Biol Int Rep 1992 0.75
31 Dissociation of basement membrane protein deposition and cell spreading in virally transformed rat mammary myoepithelial cells. J Cell Sci 1986 0.75
32 Quinazoline-based thymidylate synthase inhibitors: relationship between structural modifications and polyglutamation. Anticancer Drug Des 1995 0.75