Mapping disease genes: family-based association studies.

The TDT and other family-based tests for linkage disequilibrium and association. Am J Hum Genet (1996) 11.61

A unified stepwise regression procedure for evaluating the relative effects of polymorphisms within a gene using case/control or family data: application to HLA in type 1 diabetes. Am J Hum Genet (2001) 8.47

Control of confounding of genetic associations in stratified populations. Am J Hum Genet (2003) 7.99

A log-linear approach to case-parent-triad data: assessing effects of disease genes that act either directly or through maternal effects and that may be subject to parental imprinting. Am J Hum Genet (1998) 7.38

Transmission-disequilibrium tests for quantitative traits. Am J Hum Genet (1997) 7.10

Genetic association mapping based on discordant sib pairs: the discordant-alleles test. Am J Hum Genet (1998) 7.02

Mapping genes underlying ethnic differences in disease risk by linkage disequilibrium in recently admixed populations. Am J Hum Genet (1997) 6.35

HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Diabetes (2008) 4.94

Logistic regression protects against population structure in genetic association studies. Genome Res (2005) 2.94

Tests and estimates of allelic association in complex inheritance. Proc Natl Acad Sci U S A (1998) 2.78

Transmission/disequilibrium tests using multiple tightly linked markers. Am J Hum Genet (2000) 2.45

Linkage analysis of a complex disease through use of admixed populations. Am J Hum Genet (2004) 2.21

Evidence of linkage disequilibrium between schizophrenia and the SCa1 CAG repeat on chromosome 6p23. Am J Hum Genet (1996) 2.19

Human leukocyte antigen class I B and C loci contribute to Type 1 Diabetes (T1D) susceptibility and age at T1D onset. Hum Immunol (2005) 2.14

HLA-DR2 dose effect on susceptibility to multiple sclerosis and influence on disease course. Am J Hum Genet (2003) 2.02

The HLA class I A locus affects susceptibility to type 1 diabetes. Hum Immunol (2002) 1.98

Association of MSX1 and TGFB3 with nonsyndromic clefting in humans. Am J Hum Genet (1998) 1.89

Power studies for the transmission/disequilibrium tests with multiple alleles. Am J Hum Genet (1997) 1.85

Association and linkage of the dopamine transporter gene and attention-deficit hyperactivity disorder in children: heterogeneity owing to diagnostic subtype and severity. Am J Hum Genet (1998) 1.75

Testing for linkage disequilibrium, maternal effects, and imprinting with (In)complete case-parent triads, by use of the computer program LEM. Am J Hum Genet (2000) 1.65

HLA class I and genetic susceptibility to type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium. Diabetes (2010) 1.62

HLA-DR-DQ haplotypes and genotypes in Finnish patients with rheumatoid arthritis. Ann Rheum Dis (2004) 1.61

High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. PLoS Genet (2009) 1.61

A classical likelihood based approach for admixture mapping using EM algorithm. Hum Genet (2006) 1.43

Localization of PSORS1 to a haplotype block harboring HLA-C and distinct from corneodesmosin and HCR. Hum Genet (2005) 1.37

Linkage disequilibrium between an allele at the dopamine D4 receptor locus and Tourette syndrome, by the transmission-disequilibrium test. Am J Hum Genet (1996) 1.29

HLA DPA1, DPB1 alleles and haplotypes contribute to the risk associated with type 1 diabetes: analysis of the type 1 diabetes genetics consortium families. Diabetes (2010) 1.26

Association of specific language impairment (SLI) to the region of 7q31. Am J Hum Genet (2003) 1.26

Absence of linkage of phonological coding dyslexia to chromosome 6p23-p21.3 in a large family data set. Am J Hum Genet (1998) 1.24

HLA related genetic risk for coeliac disease. Gut (2007) 1.16

Defining multiple common "completely" conserved major histocompatibility complex SNP haplotypes. Clin Immunol (2009) 1.14

Association of a common complement receptor 2 haplotype with increased risk of systemic lupus erythematosus. Proc Natl Acad Sci U S A (2007) 1.13

Uncoupling the roles of HLA-DRB1 and HLA-DRB5 genes in multiple sclerosis. J Immunol (2008) 1.13

The ITGAV rs3738919-C allele is associated with rheumatoid arthritis in the European Caucasian population: a family-based study. Arthritis Res Ther (2007) 1.12

Combined haplotype relative risk (CHRR): a general and simple genetic association test that combines trios and unrelated case-controls. Genet Epidemiol (2009) 1.11

Multiple sclerosis in Sardinia is associated and in linkage disequilibrium with HLA-DR3 and -DR4 alleles. Am J Hum Genet (1997) 1.10

PBAT: a comprehensive software package for genome-wide association analysis of complex family-based studies. Hum Genomics (2005) 1.09

Risk for rheumatic disease in relation to ethnicity and admixture. Arthritis Res (2000) 1.08

Multipoint linkage-disequilibrium-mapping approach based on the case-parent trio design. Am J Hum Genet (2001) 1.05

Assessing genuine parents-offspring trios for genetic association studies. Hum Hered (2008) 1.03

CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis. Hum Mol Genet (2010) 1.01

Linkage disequilibrium with predisposing DR3 haplotypes accounts for apparent effects of tumor necrosis factor and lymphotoxin-alpha polymorphisms on type 1 diabetes susceptibility. Hum Immunol (2006) 1.00

Several loci in the HLA class III region are associated with T1D risk after adjusting for DRB1-DQB1. Diabetes Obes Metab (2009) 0.98

Next generation sequencing reveals the association of DRB3*02:02 with type 1 diabetes. Diabetes (2013) 0.98

Differential gene expression of peripheral blood mononuclear cells from rheumatoid arthritis patients may discriminate immunogenetic, pathogenic and treatment features. Immunology (2008) 0.90

rs2476601 T allele (R620W) defines high-risk PTPN22 type I diabetes-associated haplotypes with preliminary evidence for an additional protective haplotype. Genes Immun (2009) 0.90

Conditional genotype analysis: detecting secondary disease loci in linkage disequilibrium with a primary disease locus. BMC Proc (2007) 0.90

Coeliac disease patients carry conserved HLA-DR3-DQ2 haplotypes revealed by association of TNF alleles. Immunogenetics (2003) 0.90

Utilising family-based designs for detecting rare variant disease associations. Ann Hum Genet (2014) 0.88

Analysis of maternal-offspring HLA compatibility, parent-of-origin and non-inherited maternal effects for the classical HLA loci in type 1 diabetes. Diabetes Obes Metab (2009) 0.87

Genetic variation within the HLA class III influences T1D susceptibility conferred by high-risk HLA haplotypes. Genes Immun (2010) 0.86

Analytical methods for disease association studies with immunogenetic data. Methods Mol Biol (2012) 0.86

The frequent and conserved DR3-B8-A1 extended haplotype confers less diabetes risk than other DR3 haplotypes. Diabetes Obes Metab (2009) 0.86

Improving the estimation of celiac disease sibling risk by non-HLA genes. PLoS One (2011) 0.84

The HLA-B 3906 allele imparts a high risk of diabetes only on specific HLA-DR/DQ haplotypes. Diabetologia (2011) 0.82

Conditional meta-analysis stratifying on detailed HLA genotypes identifies a novel type 1 diabetes locus around TCF19 in the MHC. Hum Genet (2010) 0.82

Susceptibility to relapsing-progressive multiple sclerosis is associated with inheritance of genes linked to the variable region of the TcR beta locus: use of affected family-based controls. Am J Hum Genet (1998) 0.82

Small duct primary sclerosing cholangitis without inflammatory bowel disease is genetically different from large duct disease. Liver Int (2014) 0.81

Association mapping of complex trait loci with context-dependent effects and unknown context variable. Genetics (2006) 0.80

Interaction of loci within the HLA region influences multiple sclerosis course in the Sardinian population. J Neurol (2005) 0.80

Power of the 2-locus TDT for testing the interaction of two susceptibility genes. BMC Proc (2007) 0.80

PTPRC (CD45) C77G mutation does not contribute to multiple sclerosis susceptibility in Sardinian patients. J Neurol (2004) 0.79

Determination of the real effect of genes identified in GWAS: the example of IL2RA in multiple sclerosis. Eur J Hum Genet (2011) 0.78

Replication and further characterization of a Type 1 diabetes-associated locus at the telomeric end of the major histocompatibility complex. J Diabetes (2011) 0.78

Dosage transmission disequilibrium test (dTDT) for linkage and association detection. PLoS One (2013) 0.75

Modeling of PTPN22 and HLA-DRB1 susceptibility to rheumatoid arthritis. BMC Proc (2007) 0.75

Congruence as a measurement of extended haplotype structure across the genome. J Transl Med (2012) 0.75

Where is the causal variant? On the advantage of the family design over the case-control design in genetic association studies. Eur J Hum Genet (2015) 0.75

Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet (1993) 51.42

Haplotype relative risks: an easy reliable way to construct a proper control sample for risk calculations. Ann Hum Genet (1987) 13.98

A haplotype-based 'haplotype relative risk' approach to detecting allelic associations. Hum Hered (1992) 8.71

Monte Carlo tests for associations between disease and alleles at highly polymorphic loci. Ann Hum Genet (1995) 8.09

Mapping by admixture linkage disequilibrium in human populations: limits and guidelines. Am J Hum Genet (1994) 7.16

A genome-wide search for human type 1 diabetes susceptibility genes. Nature (1994) 7.13

Statistical properties of the haplotype relative risk. Genet Epidemiol (1989) 7.07

HLA and insulin gene associations with IDDM. Genet Epidemiol (1989) 6.53

Genotype relative risks: methods for design and analysis of candidate-gene association studies. Am J Hum Genet (1993) 6.02

Maximum-likelihood estimation of gene location by linkage disequilibrium. Am J Hum Genet (1994) 5.71

HLA-DR effects in a large German IDDM dataset. Genet Epidemiol Suppl (1986) 5.41

Linkage disequilibrium in subdivided populations. Genetics (1973) 5.22

Genetic analysis of IDDM: summary of GAW5 IDDM results. Genet Epidemiol (1989) 5.06

Insulin-gene sharing in sib pairs with insulin-dependent diabetes mellitus: no evidence for linkage. Am J Hum Genet (1988) 4.86

The effect of a selected locus on linked neutral loci. Genetics (1977) 4.53

HL-A antigens and disease. Statistical and genetical considerations. Tissue Antigens (1974) 4.41

MHC class-II molecules and autoimmunity. Annu Rev Immunol (1991) 3.41

The haplotype-relative-risk (HRR) method for analysis of association in nuclear families. Am J Hum Genet (1993) 2.96

Genes predisposing to IDDM in multiplex families. Genet Epidemiol (1989) 2.92

Genetic heterogeneity, modes of inheritance, and risk estimates for a joint study of Caucasians with insulin-dependent diabetes mellitus. Am J Hum Genet (1988) 2.88

Comparing the classification of subjects by two independent judges. Br J Psychiatry (1970) 2.78

Linkage disequilibrium predicts physical distance in the adenomatous polyposis coli region. Am J Hum Genet (1994) 2.65

Measuring the strength of associations between HLA antigens and diseases. Tissue Antigens (1981) 2.63

Polymorphic admixture typing in human ethnic populations. Am J Hum Genet (1994) 2.37

Relative predispositional effects (RPEs) of marker alleles with disease: HLA-DR alleles and Graves disease. Am J Hum Genet (1989) 2.03

Linkage analysis versus association analysis: distinguishing between two models that explain disease-marker associations. Am J Hum Genet (1993) 1.61

The affected sib method. I. Statistical features of the affected sib-pair method. Genetics (1985) 1.49

Case-parental control method in the search for disease-susceptibility genes. Am J Hum Genet (1994) 1.38

Three-allele synergistic mixed model for insulin-dependent diabetes mellitus. Diabetes (1986) 1.24

Testing for segregation distortion in the HLA complex. Biometrics (1994) 1.11

Linkage and association. Am J Hum Genet (1994) 0.99

Characteristics of a multiplex IDDM sample: unexplained differences with other samples. Genet Epidemiol (1989) 0.90

Inference of the strength of genotype-disease association from studies comparing offspring with and without parental history of disease. Ann Hum Genet (1993) 0.89

Analysis of complex human genetic traits: an ordered-notation method and new tests for mode of inheritance. Am J Hum Genet (1995) 1.61

HLA disease associations: models for the study of complex human genetic disorders. Crit Rev Clin Lab Sci (1995) 0.98