Evidence for cellular heterogeneity in primary cultures of human orbital fibroblasts.

PubWeight™: 1.41‹?› | Rank: Top 5%

🔗 View Article (PMID 7673404)

Published in J Clin Endocrinol Metab on September 01, 1995

Authors

T J Smith1, G D Sempowski, H S Wang, P J Del Vecchio, S D Lippe, R P Phipps

Author Affiliations

1: Department of Medicine, Albany Medical College, New York 12208, USA.

Articles citing this

Fibroblasts as sentinel cells. Synthesis of chemokines and regulation of inflammation. Am J Pathol (1997) 2.47

Increased generation of fibrocytes in thyroid-associated ophthalmopathy. J Clin Endocrinol Metab (2009) 2.10

Loss of fibroblast Thy-1 expression correlates with lung fibrogenesis. Am J Pathol (2005) 1.76

Thy-1 expression in human fibroblast subsets defines myofibroblastic or lipofibroblastic phenotypes. Am J Pathol (2003) 1.75

Host prostaglandin E(2)-EP3 signaling regulates tumor-associated angiogenesis and tumor growth. J Exp Med (2003) 1.69

Isolation and characterization of rheumatoid arthritis synovial fibroblasts from primary culture--primary culture cells markedly differ from fourth-passage cells. Arthritis Res (2000) 1.62

Evidence for an association between thyroid-stimulating hormone and insulin-like growth factor 1 receptors: a tale of two antigens implicated in Graves' disease. J Immunol (2008) 1.45

Insulin-like growth factor-I regulation of immune function: a potential therapeutic target in autoimmune diseases? Pharmacol Rev (2010) 1.39

Activated human T lymphocytes express cyclooxygenase-2 and produce proadipogenic prostaglandins that drive human orbital fibroblast differentiation to adipocytes. Am J Pathol (2006) 1.32

Unique attributes of orbital fibroblasts and global alterations in IGF-1 receptor signaling could explain thyroid-associated ophthalmopathy. Thyroid (2008) 1.21

Fibroblast heterogeneity: existence of functionally distinct Thy 1(+) and Thy 1(-) human female reproductive tract fibroblasts. Am J Pathol (2001) 1.18

Orbital fibroblasts from patients with thyroid-associated ophthalmopathy overexpress CD40: CD154 hyperinduces IL-6, IL-8, and MCP-1. Invest Ophthalmol Vis Sci (2008) 1.10

Insights into the role of fibroblasts in human autoimmune diseases. Clin Exp Immunol (2005) 1.10

Immune mechanisms in thyroid eye disease. Thyroid (2008) 1.05

Fibroblasts expressing the thyrotropin receptor overarch thyroid and orbit in Graves' disease. J Clin Endocrinol Metab (2011) 1.05

Current concepts in the molecular pathogenesis of thyroid-associated ophthalmopathy. Invest Ophthalmol Vis Sci (2014) 1.03

Human fibrocytes coexpress thyroglobulin and thyrotropin receptor. Proc Natl Acad Sci U S A (2012) 0.97

Interleukin-6 production in CD40-engaged fibrocytes in thyroid-associated ophthalmopathy: involvement of Akt and NF-κB. Invest Ophthalmol Vis Sci (2012) 0.94

Thyrotropin regulates IL-6 expression in CD34+ fibrocytes: clear delineation of its cAMP-independent actions. PLoS One (2013) 0.92

Leukoregulin induction of protein expression in human orbital fibroblasts: evidence for anatomical site-restricted cytokine-target cell interactions. Proc Natl Acad Sci U S A (1998) 0.92

Orbital fibroblasts from thyroid eye disease patients differ in proliferative and adipogenic responses depending on disease subtype. Invest Ophthalmol Vis Sci (2013) 0.92

Novel anti-adipogenic activity produced by human fibroblasts. Am J Physiol Cell Physiol (2010) 0.91

Divergent Sp1 protein levels may underlie differential expression of UDP-glucose dehydrogenase by fibroblasts: role in susceptibility to orbital Graves disease. J Biol Chem (2011) 0.91

Thyroid associated ophthalmopathy: evidence for CD4(+) gammadelta T cells; de novo differentiation of RFD7(+) macrophages, but not of RFD1(+) dendritic cells; and loss of gammadelta and alphabeta T cell receptor expression. Br J Ophthalmol (2004) 0.91

Mast cell-derived prostaglandin D2 controls hyaluronan synthesis in human orbital fibroblasts via DP1 activation: implications for thyroid eye disease. J Biol Chem (2010) 0.91

Regulation of Lymphocyte Function by PPARgamma: Relevance to Thyroid Eye Disease-Related Inflammation. PPAR Res (2008) 0.90

Reversible and irreversible differentiation of cardiac fibroblasts. Cardiovasc Res (2013) 0.89

Characterisation of 11beta-hydroxysteroid dehydrogenase 1 in human orbital adipose tissue: a comparison with subcutaneous and omental fat. J Endocrinol (2007) 0.87

Potential role for bone marrow-derived fibrocytes in the orbital fibroblast heterogeneity associated with thyroid-associated ophthalmopathy. Clin Exp Immunol (2010) 0.85

Divergent expression of IL-1 receptor antagonists in CD34⁺ fibrocytes and orbital fibroblasts in thyroid-associated ophthalmopathy: contribution of fibrocytes to orbital inflammation. J Clin Endocrinol Metab (2013) 0.85

Expression of thyrotropin receptor, thyroglobulin, sodium-iodide symporter, and thyroperoxidase by fibrocytes depends on AIRE. J Clin Endocrinol Metab (2014) 0.84

Peroxisome proliferator-activated receptor gamma ligands inhibit transforming growth factor-beta-induced, hyaluronan-dependent, T cell adhesion to orbital fibroblasts. J Biol Chem (2011) 0.82

Locally produced insulin-like growth factor-1 by orbital fibroblasts as implicative pathogenic factor rather than systemically circulated IGF-1 for patients with thyroid-associated ophthalmopathy. Graefes Arch Clin Exp Ophthalmol (2011) 0.82

Human fibrocytes express multiple antigens associated with autoimmune endocrine diseases. J Clin Endocrinol Metab (2014) 0.81

p53/PUMA expression in human pulmonary fibroblasts mediates cell activation and migration in silicosis. Sci Rep (2015) 0.79

TSH-receptor-expressing fibrocytes and thyroid-associated ophthalmopathy. Nat Rev Endocrinol (2015) 0.78

Pentraxin-3 Is a TSH-Inducible Protein in Human Fibrocytes and Orbital Fibroblasts. Endocrinology (2015) 0.76

Thyroid associated orbitopathy following periocular surgery. Korean J Ophthalmol (2006) 0.75

Update on thyroid-associated Ophthalmopathy with a special emphasis on the ocular surface. Clin Diabetes Endocrinol (2016) 0.75

Articles by these authors

Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection. J Exp Med (2001) 3.64

Immunosenescence of ageing. J Pathol (2007) 3.32

Role of the Kv4.3 K+ channel in ventricular muscle. A molecular correlate for the transient outward current. Circ Res (1996) 3.23

Clinical features and risk factors of pulmonary oedema after enterovirus-71-related hand, foot, and mouth disease. Lancet (1999) 3.02

Electrical method for detection of endothelial cell shape change in real time: assessment of endothelial barrier function. Proc Natl Acad Sci U S A (1992) 3.00

The maintenance and regulation of the humoral immune response: persisting antigen and the role of follicular antigen-binding dendritic cells as accessory cells. Immunol Rev (1980) 2.95

The follicular dendritic cell: long term antigen retention during immunity. Immunol Rev (1980) 2.77

The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection. Annu Rev Immunol (2000) 2.52

Fibroblasts as sentinel cells. Synthesis of chemokines and regulation of inflammation. Am J Pathol (1997) 2.47

Regulation of KChIP2 potassium channel beta subunit gene expression underlies the gradient of transient outward current in canine and human ventricle. J Physiol (2001) 2.37

IL-8 production in human lung fibroblasts and epithelial cells activated by the Pseudomonas autoinducer N-3-oxododecanoyl homoserine lactone is transcriptionally regulated by NF-kappa B and activator protein-2. J Immunol (2001) 2.32

Paclitaxel-induced cell death: where the cell cycle and apoptosis come together. Cancer (2000) 2.29

Direct cytotoxic action of Shiga toxin on human vascular endothelial cells. Infect Immun (1988) 2.12

Thrombin-induced increase in albumin permeability across the endothelium. J Cell Physiol (1986) 2.04

Evaluation of the API 20 c microtube system for the identification of clinically important yeasts. J Clin Microbiol (1976) 2.00

The B/macrophage cell: an elusive link between CD5+ B lymphocytes and macrophages. Immunol Today (1996) 1.94

Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways. J Biol Chem (1998) 1.93

Evaluation of a caffeic acid-ferric citrate test for rapid identification of Cryptococcus neoformans. J Clin Microbiol (1977) 1.91

Regional cerebral blood flow estimated by 133-xenon inhalation. Stroke (1975) 1.87

Evidence of fibroblast heterogeneity and the role of fibroblast subpopulations in fibrosis. Clin Immunol Immunopathol (1994) 1.83

Preeclampsia is associated with reduced serum levels of placenta growth factor. Am J Obstet Gynecol (1998) 1.79

Preoperative carcinoembryonic antigen level as an independent prognostic factor in colorectal cancer: Taiwan experience. Jpn J Clin Oncol (2000) 1.74

Activation of protein kinase C pathway contributes to hydrogen peroxide-induced increase in endothelial permeability. Lab Invest (1992) 1.66

Determination of regional cerebral blood flow by inhalation of 133-Xenon. Circ Res (1967) 1.62

Phenotypic correlations in patients with ring chromosome 22. Clin Genet (1977) 1.54

Role of CXCR2 in cigarette smoke-induced lung inflammation. Am J Physiol Lung Cell Mol Physiol (2005) 1.49

Regional localization of 18 human X-linked DNA sequences. Cytogenet Cell Genet (1986) 1.48

Subsets of murine lung fibroblasts express membrane-bound and soluble IL-4 receptors. Role of IL-4 in enhancing fibroblast proliferation and collagen synthesis. J Immunol (1994) 1.46

Identification of two nervous system-specific members of the erg potassium channel gene family. J Neurosci (1997) 1.46

CD40 expression by human fibroblasts. Clin Immunol Immunopathol (1995) 1.46

Expression of stromal-derived factor-1 is decreased by IL-1 and TNF and in dermal wound healing. J Immunol (2001) 1.43

Microtubule dysfunction induced by paclitaxel initiates apoptosis through both c-Jun N-terminal kinase (JNK)-dependent and -independent pathways in ovarian cancer cells. J Biol Chem (1999) 1.41

Expression of angiotensin-converting enzyme activity in cultured pulmonary artery endothelial cells. J Cell Physiol (1981) 1.38

The nuclear receptor PPAR gamma is expressed by mouse T lymphocytes and PPAR gamma agonists induce apoptosis. Eur J Immunol (2001) 1.37

Analysis of the human thymic perivascular space during aging. J Clin Invest (1999) 1.36

Endothelial monolayer permeability to macromolecules. Fed Proc (1987) 1.36

Activation of human orbital fibroblasts through CD40 engagement results in a dramatic induction of hyaluronan synthesis and prostaglandin endoperoxide H synthase-2 expression. Insights into potential pathogenic mechanisms of thyroid-associated ophthalmopathy. J Biol Chem (1998) 1.34

Predictors of function among the old-old: a 10-year follow-up. J Gerontol (1985) 1.33

T-Cell recovery in adults and children following umbilical cord blood transplantation. Biol Blood Marrow Transplant (2001) 1.33

Prostaglandin E2 receptors of the EP2 and EP4 subtypes regulate activation and differentiation of mouse B lymphocytes to IgE-secreting cells. Proc Natl Acad Sci U S A (1996) 1.33

Human orbital fibroblasts are activated through CD40 to induce proinflammatory cytokine production. Am J Physiol (1998) 1.32

Molecular sieving characteristics of the cultured endothelial monolayer. J Cell Physiol (1987) 1.31

The human thymus during aging. Immunol Res (2000) 1.31

Measurement of albumin permeability across endothelial monolayers in vitro. J Appl Physiol (1985) (1987) 1.30

Platelet derived CD154 (CD40 ligand) and febrile responses to transfusion. Lancet (2001) 1.29

Cytokine requirements for induction of systemic and mucosal CTL after nasal immunization. J Immunol (2001) 1.28

Blockade of CD40-CD40 ligand interactions protects against radiation-induced pulmonary inflammation and fibrosis. Clin Immunol Immunopathol (1998) 1.28

Peroxisome proliferator activator receptor-gamma agonists and 15-deoxy-Delta(12,14)(12,14)-PGJ(2) induce apoptosis in normal and malignant B-lineage cells. J Immunol (2000) 1.21

Interleukin-4 and interferon-gamma discordantly regulate collagen biosynthesis by functionally distinct lung fibroblast subsets. J Cell Physiol (1996) 1.21

Organization of a repetitive human 1.8 kb KpnI sequence localized in the heterochromatin of chromosome 15. Chromosoma (1985) 1.19

Fibroblast heterogeneity: existence of functionally distinct Thy 1(+) and Thy 1(-) human female reproductive tract fibroblasts. Am J Pathol (2001) 1.18

Tumor necrosis factor-alpha-mediated decrease in glutathione increases the sensitivity of pulmonary vascular endothelial cells to H2O2. J Clin Invest (1992) 1.18

CD40 engagement up-regulates cyclooxygenase-2 expression and prostaglandin E2 production in human lung fibroblasts. J Immunol (1998) 1.18

Differential Thy-1 expression by splenic fibroblasts defines functionally distinct subsets. Cell Immunol (1996) 1.18

The aryl hydrocarbon receptor is a regulator of cigarette smoke induction of the cyclooxygenase and prostaglandin pathways in human lung fibroblasts. Am J Physiol Lung Cell Mol Physiol (2005) 1.17

Bone marrow metastasis in astrocytic gliomata. J Neurooncol (1998) 1.17

Prostaglandin E2 promotes B lymphocyte Ig isotype switching to IgE. J Immunol (1995) 1.14

Differential collagen and fibronectin production by Thy 1+ and Thy 1- lung fibroblast subpopulations. Am J Physiol (1992) 1.14

CD40 is a functional activation antigen and B7-independent T cell costimulatory molecule on normal human lung fibroblasts. J Immunol (1997) 1.12

Pathogenesis of haemolytic uraemic syndrome. Lancet (1987) 1.12

The infrahyoid myocutaneous flap for reconstruction after resection of head and neck cancer. Cancer (1986) 1.11

Release of biologically active CD154 during collection and storage of platelet concentrates prepared for transfusion. J Thromb Haemost (2007) 1.10

The impact of the total motile sperm count on the success of intrauterine insemination with husband's spermatozoa. J Assist Reprod Genet (1996) 1.09

Disruption of the CD40-CD40 ligand system prevents an oxygen-induced respiratory distress syndrome. Am J Pathol (1998) 1.08

Enhancement of intracellular glutathione protects endothelial cells against oxidant damage. Biochem Biophys Res Commun (1985) 1.08

Involvement of Ca2+ in the H2O2-induced increase in endothelial permeability. Am J Physiol (1996) 1.06

Segmental differentiation of permeability, protein glycosylation, and morphology of cultured bovine lung vascular endothelium. Biochem Biophys Res Commun (1994) 1.05

Leukoregulin is a potent inducer of hyaluronan synthesis in cultured human orbital fibroblasts. Am J Physiol (1995) 1.03

Expression of TGF-beta isoforms by Thy-1+ and Thy-1- pulmonary fibroblast subsets: evidence for TGF-beta as a regulator of IL-1-dependent stimulation of IL-6. Lymphokine Cytokine Res (1994) 1.02

A family with Huntington disease and reciprocal translocation 4;5. Am J Hum Genet (1986) 1.02

Dermoid cyst with dermal sinus tract complicated with spinal subdural abscess. Pediatr Neurol (1999) 1.02

Sexual behavior in aged men and women. I. Observations on 254 community volunteers. Arch Gen Psychiatry (1968) 1.01

Targeting cyclooxygenase-2 in hematological malignancies: rationale and promise. Curr Pharm Des (2008) 0.99

Topical 5-aminolaevulinic acid-photodynamic therapy for the treatment of urethral condylomata acuminata. Br J Dermatol (2004) 0.98

Subregional assignment of the linked marker G8 (D4S10) for Huntington disease to chromosome 4p16.1-16.3. Am J Hum Genet (1986) 0.98

Capillaries of the adrenal cortex possess aminopeptidase A and angiotensin-converting-enzyme activities. Biochem J (1980) 0.98

Some caveats in PCR-based prenatal diagnosis on direct amniotic fluid versus cultured amniocytes. Prenat Diagn (1999) 0.97

Colocalization of NOS and SOD1 in neurofilament accumulation within motor neurons of amyotrophic lateral sclerosis: an immunohistochemical study. J Chem Neuroanat (1996) 0.97

The value of electroencephalography in geriatrics. Geriatrics (1965) 0.97

Prostaglandin E2 promotes IL-4-induced IgE and IgG1 synthesis. J Immunol (1990) 0.97

Calcium dependence of the thrombin-induced increase in endothelial albumin permeability. J Appl Physiol (1985) (1989) 0.97

Assessment of rapid morphological changes associated with elevated cAMP levels in human orbital fibroblasts. Exp Cell Res (1998) 0.96

Sexual behavior in senescence. II. Patterns of sexual activity and interest. Geriatrics (1969) 0.96

Prostaglandin E2 regulation of the immune response. Adv Prostaglandin Thromboxane Leukot Res (1994) 0.96

Endothelin-1 stimulates DNA synthesis and proliferation of pulmonary artery smooth muscle cells. Am J Physiol (1992) 0.95

Endothelial cells of bovine pulmonary artery lack receptors for C3b and for the Fc portion of immunoglobulin G. Science (1980) 0.95

CD40 mediated activation of gingival and periodontal ligament fibroblasts. J Periodontol (1997) 0.95

Thrombin-induced adherence of neutrophils to cultured endothelial monolayers: increased endothelial adhesiveness. J Cell Physiol (1988) 0.95

Platelets adhere to thrombin-treated endothelial cells in vitro. Am J Physiol (1989) 0.95

Large congenital epulis of newborn. J Pediatr Surg (1986) 0.94

Fibroblasts support outgrowth of splenocytes simultaneously expressing B lymphocyte and macrophage characteristics. J Immunol (1995) 0.94

Human epidermal keratinocytes are induced to secrete interleukin-6 and co-stimulate T lymphocyte proliferation by a CD40-dependent mechanism. Eur J Immunol (1996) 0.94

Agents that induce pseudo-allergic reaction. Drug Discov Ther (2011) 0.94

Prostaglandin E2 as a modulator of lymphocyte mediated inflammatory and humoral responses. Adv Exp Med Biol (1999) 0.93

Tissue localization and retention of antigen in relation to the immune response. Am J Anat (1984) 0.93