Induction of a DNA adduct detectable by 32P-postlabeling in the dorsolateral prostate of NBL/Cr rats treated with estradiol-17 beta and testosterone.

PubWeight™: 0.91‹?›

🔗 View Article (PMID 7728979)

Published in Carcinogenesis on April 01, 1995

Authors

X Han1, J G Liehr, M C Bosland

Author Affiliations

1: Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston 77555-1031, USA.

Articles by these authors

Structure of the modified nucleoside Q isolated from Escherichia coli transfer ribonucleic acid. 7-(4,5-cis-Dihydroxy-1-cyclopenten-3-ylaminomethyl)-7-deazaguanosine. Biochemistry (1975) 3.73

Molecular mechanisms of estrogen carcinogenesis. Annu Rev Pharmacol Toxicol (1996) 2.91

Estrogens as endogenous genotoxic agents--DNA adducts and mutations. J Natl Cancer Inst Monogr (2000) 2.55

Carcinogenicity of catechol estrogens in Syrian hamsters. J Steroid Biochem (1986) 1.82

Induction of covalent DNA adducts in rodents by tamoxifen. Cancer Res (1992) 1.78

Arsenite is a cocarcinogen with solar ultraviolet radiation for mouse skin: an animal model for arsenic carcinogenesis. Toxicol Appl Pharmacol (2001) 1.70

Induction of uterine adenocarcinoma in CD-1 mice by catechol estrogens. Cancer Res (2000) 1.61

Tissue-specific synthesis and oxidative metabolism of estrogens. J Natl Cancer Inst Monogr (2000) 1.60

Estrogen, DNA damage and mutations. Mutat Res (1999) 1.27

Microsome-mediated 8-hydroxylation of guanine bases of DNA by steroid estrogens: correlation of DNA damage by free radicals with metabolic activation to quinones. Carcinogenesis (1995) 1.18

Lipid peroxidation-induced putative malondialdehyde-DNA adducts in human breast tissues. Cancer Epidemiol Biomarkers Prev (1996) 1.18

8-Hydroxylation of guanine bases in kidney and liver DNA of hamsters treated with estradiol: role of free radicals in estrogen-induced carcinogenesis. Cancer Res (1994) 1.17

Cytochrome P-450-mediated redox cycling of estrogens. J Biol Chem (1986) 1.09

Estrogen-induced endogenous DNA adduction: possible mechanism of hormonal cancer. Proc Natl Acad Sci U S A (1986) 1.06

Elevated 4-hydroxylation of estradiol by hamster kidney microsomes: a potential pathway of metabolic activation of estrogens. Endocrinology (1992) 1.05

DNA single-strand breaks in kidneys of Syrian hamsters treated with steroidal estrogens: hormone-induced free radical damage preceding renal malignancy. Carcinogenesis (1994) 1.02

Induction by estrogens of lipid peroxidation and lipid peroxide-derived malonaldehyde-DNA adducts in male Syrian hamsters: role of lipid peroxidation in estrogen-induced kidney carcinogenesis. Carcinogenesis (1995) 1.02

Influence of N-methyl-N-nitrosourea, testosterone, and N-(4-hydroxyphenyl)-all-trans-retinamide on prostate cancer induction in Wistar-Unilever rats. Cancer Res (1998) 0.99

2-Fluoroestradiol. Separation of estrogenicity from carcinogenicity. Mol Pharmacol (1983) 0.98

Chemoprevention of rat prostate carcinogenesis by early and delayed administration of dehydroepiandrosterone. Cancer Res (1999) 0.97

Chemoprevention of rat prostate carcinogenesis by 9-cis-retinoic acid. Cancer Res (1999) 0.94

Conversion of estrone to 2- and 4-hydroxyestrone by hamster kidney and liver microsomes: implications for the mechanism of estrogen-induced carcinogenesis. Endocrinology (1994) 0.93

Catechol-O-methyltransferase-catalyzed rapid O-methylation of mutagenic flavonoids. Metabolic inactivation as a possible reason for their lack of carcinogenicity in vivo. J Biol Chem (1994) 0.93

Differential effects of diethylstilbestrol and estradiol-17 beta in combination with testosterone on rat prostate lobes. Toxicol Appl Pharmacol (1992) 0.92

Elevated 8-hydroxydeoxyguanosine levels in DNA of diethylstilbestrol-treated Syrian hamsters: covalent DNA damage by free radicals generated by redox cycling of diethylstilbestrol. Cancer Res (1991) 0.92

Frequent activation of the Ki-ras oncogene at codon 12 in N-methyl-N-nitrosourea-induced rat prostate adenocarcinomas and neurogenic sarcomas. Mol Carcinog (1991) 0.91

Modulation of estrogen-induced carcinogenesis by chemical modifications. Arch Toxicol (1984) 0.90

Inhibition of the catechol-O-methyltransferase-catalyzed O-methylation of 2- and 4-hydroxyestradiol by catecholamine: implications for the mechanism of estrogen-induced carcinogenesis. Arch Biochem Biophys (1993) 0.90

Release of iron from ferritin storage by redox cycling of stilbene and steroid estrogen metabolites: a mechanism of induction of free radical damage by estrogen. Arch Biochem Biophys (1997) 0.89

Inhibition of catechol O-methyltransferase-catalyzed O-methylation of 2- and 4-hydroxyestradiol by quercetin. Possible role in estradiol-induced tumorigenesis. J Biol Chem (1996) 0.89

Characterization of semiquinone free radicals formed from stilbene catechol estrogens. An ESR spin stabilization and spin trapping study. J Biol Chem (1989) 0.87

Quercetin increases the severity of estradiol-induced tumorigenesis in hamster kidney. Toxicol Appl Pharmacol (1994) 0.87

Localization of estrogen receptors in interstitial cells of hamster kidney and in estradiol-induced renal tumors as evidence of the mesenchymal origin of this neoplasm. Cancer Res (1993) 0.87

Glutamyl ribose 5-phosphate storage disease. A hereditary defect in the degradation of poly(ADP-ribosylated) proteins. J Biol Chem (1984) 0.87

Identification of fatty acid hydroperoxide cofactors in the cytochrome P450-mediated oxidation of estrogens to quinone metabolites. Role and balance of lipid peroxides during estrogen-induced carcinogenesis. J Biol Chem (1994) 0.87

Enhancement of estrogen-induced renal tumorigenesis in hamsters by dietary iron. Carcinogenesis (1998) 0.86

Carcinogenicity and metabolic activation of hexestrol. Chem Biol Interact (1985) 0.86

Dietary fat, calories, and prostate cancer risk. J Natl Cancer Inst (1999) 0.85

Age-dependent covalent DNA alterations (I-compounds) in rodent tissues: species, tissue and sex specificities. Mutat Res (1989) 0.85

Concentration dependence of prooxidant and antioxidant properties of catecholestrogens. Arch Biochem Biophys (1998) 0.85

Lipid hydroperoxide-induced endogenous DNA adducts in hamsters: possible mechanism of lipid hydroperoxide-mediated carcinogenesis. Arch Biochem Biophys (1995) 0.85

Mechanism of genotoxicity of diethylstilbestrol in vivo. J Biol Chem (1989) 0.84

Target organ-specific inactivation of drug metabolizing enzymes in kidney of hamsters treated with estradiol. Mol Cell Biochem (1992) 0.84

Mechanism of cytochrome P450-catalyzed aromatic hydroxylation of estrogens. Chem Res Toxicol (1997) 0.84

Inhibition of estrogen-induced kidney carcinogenesis in Syrian hamsters by modulators of estrogen metabolism. Carcinogenesis (1990) 0.84

Temporary decrease in renal quinone reductase activity induced by chronic administration of estradiol to male Syrian hamsters. Increased superoxide formation by redox cycling of estrogen. J Biol Chem (1988) 0.84

Possible mechanism of induction of benign prostatic hyperplasia by estradiol and dihydrotestosterone in dogs. Toxicol Appl Pharmacol (1996) 0.83

Catalysis of the oxidation of steroid and stilbene estrogens to estrogen quinone metabolites by the beta-naphthoflavone-inducible cytochrome P450 IA family. Arch Biochem Biophys (1992) 0.83

Specific binding of 4-hydroxyestradiol to mouse uterine protein: evidence of a physiological role for 4-hydroxyestradiol. J Endocrinol (2005) 0.83

Assays for chloramphenicol compared: radioenzymatic, gas chromatographic with electron capture, and gas chromatographic-mass spectrometric. Clin Chem (1979) 0.82

The O-methylation of 4-hydroxyestradiol is inhibited by 2-hydroxyestradiol: implications for estrogen-induced carcinogenesis. Carcinogenesis (1990) 0.82

Nuclear localization of catechol-O-methyltransferase in neoplastic and nonneoplastic mammary epithelial cells. Am J Pathol (2000) 0.82

Changes in activities of free radical detoxifying enzymes in kidneys of male Syrian hamsters treated with estradiol. Cancer Res (1989) 0.82

Induction of monoamine oxidase B by 17 beta-estradiol in the hamster kidney preceding carcinogenesis. Arch Biochem Biophys (1998) 0.82

Inhibition of estrogen-induced renal carcinoma in Syrian hamsters by vitamin C. Cancer Res (1983) 0.82

Control of cell death (apoptosis) by diethylstilbestrol in an estrogen-dependent kidney tumor. Carcinogenesis (1991) 0.82

Long-term intermittent exposure to sulfuric acid aerosol, ozone, and their combination: alterations in tracheobronchial mucociliary clearance and epithelial secretory cells. Exp Lung Res (1992) 0.81

The differentiation of isomeric biological compounds using collision-induced dissociation of ions generated by fast atom bombardment. Biomed Mass Spectrom (1985) 0.81

Histochemical analysis of the development of estradiol-induced kidney tumors in male Syrian hamsters. Cancer Res (1988) 0.81

Cytochrome b5-mediated redox cycling of estrogen. Arch Biochem Biophys (1991) 0.81

Multistage prostate carcinogenesis: the role of hormones. Princess Takamatsu Symp (1991) 0.81

Influence of acid aerosol droplet size on structural changes in the rat lung caused by acute exposure to sulfuric acid and ozone. Toxicol Appl Pharmacol (1997) 0.81

Correlation of aromatic hydroxylation of 11 beta-substituted estrogens with morphological transformation in vitro but not with in vivo tumor induction by these hormones. Cancer Res (1987) 0.81

Phthalate esters in normal and pathological human kidneys. Bull Environ Contam Toxicol (1979) 0.80

Hypomethylation of DNA in estrogen-induced and -dependent hamster kidney tumors. Carcinogenesis (1988) 0.80

Xanthine oxidase-catalyzed reduction of estrogen quinones to semiquinones and hydroquinones. Biochem Pharmacol (1991) 0.80

Cytochrome P450 metabolism of estradiol in hamster liver and kidney. Toxicol Appl Pharmacol (1997) 0.80

The role of stromal cells in prostate cancer development and progression. In Vivo (1999) 0.80

Possible role of 4',4''-diethylstilbestrol quinone in diethylstilbestrol carcinogenesis. J Toxicol Environ Health (1985) 0.79

Diethylstilbestrol (DES) quinone: a reactive intermediate in DES metabolism. Biochem Pharmacol (1983) 0.79

Transplacental genotoxicity of diethylstilbestrol. Carcinogenesis (1991) 0.79

Pathogenesis of blood-filled cavities in estrogen-induced anterior pituitary tumors in male Sprague-Dawley rats. Toxicol Pathol (1992) 0.79

Frequency and molecular analysis of hprt mutations induced by estradiol in Chinese hamster V79 cells. Int J Oncol (2000) 0.79

Metabolic deglucuronidation and demethylation of estrogen conjugates as a source of parent estrogens and catecholestrogen metabolites in Syrian hamster kidney, a target organ of estrogen-induced tumorigenesis. Toxicol Appl Pharmacol (1996) 0.79

Hormonal carcinogenesis: separation of estrogenicity from carcinogenicity. Chem Biol Interact (1986) 0.79

Target organ-specific covalent DNA damage preceding diethylstilbestrol-induced carcinogenesis. Carcinogenesis (1985) 0.79

Microsomal hydroxylation of 2- and 4-fluoroestradiol to catechol metabolites and their conversion to methyl ethers: catechol estrogens as possible mediators of hormonal carcinogenesis. Mol Pharmacol (1993) 0.79

The carcinogenic activity of ethinyl estrogens is determined by both their hormonal characteristics and their conversion to catechol metabolites. Endocrinology (1993) 0.79

Role of estrogen in alcohol promotion of breast cancer and prolactinomas. Alcohol Clin Exp Res (2001) 0.78

Reactivity of 4',4"-diethylstilbestrol quinone, a metabolic intermediate of diethylstilbestrol. Carcinogenesis (1985) 0.78

Characterization of drug metabolism enzymes in estrogen-induced kidney tumors in male Syrian hamsters. Cancer Res (1988) 0.78

Use of the 32P-postlabelling assay to study transplacental carcinogens and transplacental carcinogenesis. IARC Sci Publ (1989) 0.78

Chemical and hormonal induction of prostate cancer in animal models. Urol Oncol (2011) 0.78

Antioxidant and prooxidant properties of estrogens. J Lab Clin Med (1996) 0.78

Multiple pathways of prostate carcinogenesis analyzed by using cultured cells isolated from rats treated with N-methyl-N-nitrosourea and testosterone. Mol Carcinog (1999) 0.78

Estrogen-induced microsatellite DNA alterations are associated with Syrian hamster kidney tumorigenesis. Carcinogenesis (1998) 0.78

Neonatal lethargy due to isovaleric acidemia and hyperammonemia. Tex Med (1984) 0.78

Adenocarcinomas of the prostate induced by N-nitroso-N-methylurea in rats pretreated with cyproterone acetate and testosterone. Cancer Lett (1983) 0.77

Nutritional factors in lung, colon, and prostate carcinogenesis in animal models. Fed Proc (1986) 0.77

Comparison of assays for catechol estrogen synthase activity: product isolation vs radioenzymatic catechol-O-methyltransferase-coupled procedures. J Steroid Biochem (1989) 0.77

Influence of route of administration on [3H]-camptothecin distribution and tumor uptake in CASE-bearing nude mice: whole-body autoradiographic studies. Cancer Chemother Pharmacol (1996) 0.77

Induction of benign prostatic hyperplasia in intact dogs by near-physiological levels of 5 alpha-dihydrotestosterone and 17 beta-estradiol. Prostate (1995) 0.76

Covalent modification of DNA by daunorubicin. Cancer Chemother Pharmacol (1993) 0.76

Interactive effects of dietary wheat bran and lard on N-methyl-N'-nitro-N-nitrosoguanidine-induced colon carcinogenesis in rats. Cancer Res (1990) 0.76

Regulation of the formation of the major diethylstilbestrol-DNA adduct and some evidence of its structure. Carcinogenesis (1994) 0.76

Estrogens with reduced catechol-forming capacity fail to induce implantation in the rat. Proc Soc Exp Biol Med (1986) 0.75

Androgen-induced redox changes in prostate cancer cells: what are causes and effects? J Natl Cancer Inst (1997) 0.75

Papilloma and carcinoma production in DMBA-initiated, onion oil-promoted mouse skin. Nutr Cancer (1990) 0.75