Published in J Exp Med on August 01, 1994
Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A (2001) 132.88
Control of immunity by the TNFR-related molecule OX40 (CD134). Annu Rev Immunol (2010) 2.67
Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus. Nat Genet (2007) 2.38
The T cell-B cell interaction via OX40-OX40L is necessary for the T cell-dependent humoral immune response. J Exp Med (1996) 2.17
Impairment of antigen-presenting cell function in mice lacking expression of OX40 ligand. J Exp Med (2000) 1.73
The significance of OX40 and OX40L to T-cell biology and immune disease. Immunol Rev (2009) 1.70
The human OX40/gp34 system directly mediates adhesion of activated T cells to vascular endothelial cells. J Exp Med (1996) 1.59
Thymic stromal lymphopoietin, OX40-ligand, and interleukin-25 in allergic responses. Clin Exp Allergy (2009) 1.49
4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB. Mol Cell Biol (1998) 1.48
Science gone translational: the OX40 agonist story. Immunol Rev (2011) 1.39
Signaling through OX40 enhances antitumor immunity. Semin Oncol (2010) 1.27
Mechanisms of T-cell activation by human T-cell lymphotropic virus type I. Microbiol Mol Biol Rev (1999) 1.27
OX40 ligand expressed by DCs costimulates NKT and CD4+ Th cell antitumor immunity in mice. J Clin Invest (2007) 1.21
GM-CSF-induced, bone-marrow-derived dendritic cells can expand natural Tregs and induce adaptive Tregs by different mechanisms. J Leukoc Biol (2010) 1.19
The TNFRs OX40, 4-1BB, and CD40 as targets for cancer immunotherapy. Curr Opin Immunol (2013) 1.16
Expansion of activated human naïve T-cells precedes effector function. Clin Exp Immunol (2002) 1.07
OX40-OX40L interactions: a promising therapeutic target for allergic diseases? J Clin Invest (2007) 0.96
Antigen-presenting cell-derived signals determine expression levels of CD70 on primed T cells. Immunology (1997) 0.95
OX40L/Jagged1 cosignaling by GM-CSF-induced bone marrow-derived dendritic cells is required for the expansion of functional regulatory T cells. J Immunol (2013) 0.90
Novel identified receptors on mast cells. Front Immunol (2012) 0.88
Targeting tumor-necrosis factor receptor pathways for tumor immunotherapy. J Immunother Cancer (2014) 0.87
Memory T Cells Mediate Cardiac Allograft Vasculopathy and are Inactivated by Anti-OX40L Monoclonal Antibody. Cardiovasc Drugs Ther (2014) 0.86
OX40 engagement stabilizes Mxd4 and Mnt protein levels in antigen-stimulated T cells leading to an increase in cell survival. Eur J Immunol (2011) 0.85
A common polymorphism in the promoter region of the TNFSF4 gene is associated with lower allele-specific expression and risk of myocardial infarction. PLoS One (2011) 0.83
OX40 stimulation by gp34/OX40 ligand enhances productive human immunodeficiency virus type 1 infection. J Virol (2001) 0.82
TNFA deletion alters apoptosis as well as caspase 3 and 4 expression during otitis media. BMC Immunol (2011) 0.81
Targeting CD8+ T-cell tolerance for cancer immunotherapy. Immunotherapy (2014) 0.81
A diametric role for OX40 in the response of effector/memory CD4+ T cells and regulatory T cells to alloantigen. J Immunol (2013) 0.81
OX40 interactions in gastrointestinal nematode infection. Immunology (2006) 0.81
The role of costimulatory receptors of the tumour necrosis factor receptor family in atherosclerosis. J Biomed Biotechnol (2011) 0.81
Cell surface markers in HTLV-1 pathogenesis. Viruses (2011) 0.80
Altered expression of TNFSF4 and TRAF2 mRNAs in peripheral blood mononuclear cells in patients with systemic lupus erythematosus: association with atherosclerotic symptoms and lupus nephritis. Inflamm Res (2012) 0.79
Genetic variation in the OX40L/OX40 system and plasma lipid and lipoprotein levels in a Chinese hypertriglyceridemic population. Genet Test Mol Biomarkers (2012) 0.77
TNF superfamily protein-protein interactions: feasibility of small- molecule modulation. Curr Drug Targets (2015) 0.77
OX40 ligand expression abrogates the immunosuppressive function of retinal pigment epithelium. J Ophthalmic Inflamm Infect (2013) 0.75
Immunostimulation by OX40 Ligand Transgenic Ewing Sarcoma Cells. Front Oncol (2015) 0.75
Lack of Association Between rs17568 Polymorphism in OX40 Gene and Myocardial Infarction, Southern of Iran. Glob J Health Sci (2015) 0.75
Advances in immunotherapy for melanoma management. Hum Vaccin Immunother (2016) 0.75
Immunotherapy Expands and Maintains the Function of High-Affinity Tumor-Infiltrating CD8 T Cells In Situ. J Immunol (2016) 0.75
A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell (1986) 36.96
Prediction of the secondary structure of proteins from their amino acid sequence. Adv Enzymol Relat Areas Mol Biol (1978) 29.77
Electroporation for the efficient transfection of mammalian cells with DNA. Nucleic Acids Res (1987) 12.80
Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure. Proc Natl Acad Sci U S A (1987) 12.15
CD44 is the principal cell surface receptor for hyaluronate. Cell (1990) 11.01
Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system. Proc Natl Acad Sci U S A (1987) 10.38
The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death. Cell (1994) 9.25
Differential T cell costimulatory requirements in CD28-deficient mice. Science (1993) 6.93
Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. Cell (1992) 5.67
Signals and signs for lymphocyte responses. Cell (1994) 3.66
Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts. Mol Immunol (1987) 3.36
Fas transduces activation signals in normal human T lymphocytes. J Exp Med (1993) 3.04
CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF. Cell (1993) 2.73
Inducible T cell antigen 4-1BB. Analysis of expression and function. J Immunol (1993) 2.40
Characterization of the MRC OX40 antigen of activated CD4 positive T lymphocytes--a molecule related to nerve growth factor receptor. EMBO J (1990) 2.21
Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor. Cell (1993) 2.11
Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor. Eur J Immunol (1993) 1.81
Cloning of mouse Ox40: a T cell activation marker that may mediate T-B cell interactions. J Immunol (1993) 1.51
A new superfamily of cell surface proteins related to the nerve growth factor receptor. Immunol Today (1991) 1.37
T-cell activation molecule 4-1BB binds to extracellular matrix proteins. Proc Natl Acad Sci U S A (1992) 1.36
The human OX40 homolog: cDNA structure, expression and chromosomal assignment of the ACT35 antigen. Eur J Immunol (1994) 1.32
Molecular cloning and characterization of a novel glycoprotein, gp34, that is specifically induced by the human T-cell leukemia virus type I transactivator p40tax. Mol Cell Biol (1991) 1.24
A glycoprotein antigen detected with new monoclonal antibodies on the surface of human lymphocytes infected with human T-cell leukemia virus type-I (HTLV-I). Int J Cancer (1985) 1.23
Electroporation of bacteria: a general approach to genetic transformation. Genet Eng (N Y) (1990) 1.22
Emerging families of cytokines and receptors. Curr Biol (1993) 1.08
Monocytes provide a novel costimulatory signal to T cells that is not mediated by the CD28/B7 interaction. J Immunol (1994) 1.02
Species-dependent antigenicity of the 34-kDa glycoprotein found on the membrane of various primate lymphocytes transformed by human T-cell leukemia virus type-I (HTLV-I) and simian T-cell leukemia virus (STLV-I). Int J Cancer (1988) 1.00
The DNA sequence of human chromosome 22. Nature (1999) 30.88
pH-independent HIV entry into CD4-positive T cells via virus envelope fusion to the plasma membrane. Cell (1987) 9.29
Induction of CD4-dependent cell fusion by the HTLV-III/LAV envelope glycoprotein. Nature (1986) 8.36
The DNA sequence and comparative analysis of human chromosome 20. Nature (2002) 7.40
AIDS retrovirus induced cytopathology: giant cell formation and involvement of CD4 antigen. Science (1986) 5.58
Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells. Nat Med (1996) 4.15
Activation of human T lymphocyte subsets: helper and suppressor/cytotoxic T cells recognize and respond to distinct histocompatibility antigens. J Immunol (1981) 3.69
Studies of a human T lymphocyte antigen recognized by a monoclonal antibody. Proc Natl Acad Sci U S A (1981) 3.63
Novel anti-CD4 monoclonal antibodies separate human immunodeficiency virus infection and fusion of CD4+ cells from virus binding. J Exp Med (1990) 3.01
Control of lymphocyte recirculation in man. I. Differential regulation of the peripheral lymph node homing receptor L-selectin on T cells during the virgin to memory cell transition. J Immunol (1993) 3.01
Antibodies to membrane structures that distinguish suppressor/cytotoxic and helper T lymphocyte subpopulations block the mixed leukocyte reaction in man. J Exp Med (1981) 2.93
Quality of life of people with epilepsy: a European study. Epilepsia (1997) 2.72
Development of CD8alpha-positive dendritic cells from a common myeloid progenitor. Science (2000) 2.71
CD28 interaction with B7 costimulates primary allogeneic proliferative responses and cytotoxicity mediated by small, resting T lymphocytes. J Exp Med (1992) 2.70
Tolerance and withdrawal of immunosuppressive drugs in patients given kidney and hematopoietic cell transplants. Am J Transplant (2012) 2.46
Intracellular processing of the gp160 HIV-1 envelope precursor. Endoproteolytic cleavage occurs in a cis or medial compartment of the Golgi complex. J Biol Chem (1990) 2.35
Dissection of immunoregulatory subpopulations of T lymphocytes within the helper and suppressor sublineages in man. J Immunol (1982) 2.29
Functional characterization of human T lymphocyte subsets distinguished by monoclonal anti-leu-8. J Immunol (1985) 2.22
Message amplification phenotyping (MAPPing): a technique to simultaneously measure multiple mRNAs from small numbers of cells. Biotechniques (1990) 2.22
Recombinant interleukin 2 enhanced natural killer cell-mediated cytotoxicity in human lymphocyte subpopulations expressing the Leu 7 and Leu 11 antigens. J Immunol (1985) 2.20
Evidence that T cell activation is required for HIV-1 entry in CD4+ lymphocytes. J Immunol (1989) 2.13
Dendritic cells in cancer immunotherapy. Annu Rev Immunol (2000) 2.11
Ligneous conjunctivitis involving the cervix. Case report. Br J Obstet Gynaecol (1989) 2.06
Sequence of the human immunoglobulin diversity (D) segment locus: a systematic analysis provides no evidence for the use of DIR segments, inverted D segments, "minor" D segments or D-D recombination. J Mol Biol (1997) 2.03
Selective expression of integrin alpha 4 beta 7 on a subset of human CD4+ memory T cells with Hallmarks of gut-trophism. J Immunol (1993) 1.92
Altered peptide ligand vaccination with Flt3 ligand expanded dendritic cells for tumor immunotherapy. Proc Natl Acad Sci U S A (2001) 1.85
Monoclonal antibody (B27M2) subdividing HLA-B27. Hum Immunol (1982) 1.81
Induction of tissue-specific autoimmune prostatitis with prostatic acid phosphatase immunization: implications for immunotherapy of prostate cancer. J Immunol (1997) 1.80
Functional and quantitative alterations in T lymphocyte subpopulations in acute toxoplasmosis. J Infect Dis (1984) 1.73
Alloantigen-specific cytotoxic and suppressor T lymphocytes are derived from phenotypically distinct precursors. J Immunol (1983) 1.73
Granulocyte-macrophage colony-stimulating factor promotes differentiation and survival of human peripheral blood dendritic cells in vitro. J Clin Invest (1990) 1.72
Treatment of intractable rheumatoid arthritis with total lymphoid irradiation. N Engl J Med (1981) 1.69
Identification of protein intermediates in the processing of the p55 HIV-1 gag precursor in cells infected with recombinant vaccinia virus. J Biol Chem (1989) 1.66
Requirement for interactions of natural killer T cells and myeloid-derived suppressor cells for transplantation tolerance. Am J Transplant (2014) 1.63
Comparative sequence analysis of the human and pufferfish Huntington's disease genes. Nat Genet (1995) 1.55
CTL response to Mycobacterium tuberculosis: identification of an immunogenic epitope in the 19-kDa lipoprotein. J Immunol (1998) 1.52
A suppressor T cell of the mixed lymphocyte reaction in man specific for the stimulating alloantigen. Evidence that identity at HLA-D between suppressor and responder is required for suppression. J Exp Med (1978) 1.49
Heterogeneous distribution and transmembrane signaling properties of lymphocyte function-associated antigen (LFA-1) in human lymphocyte subsets. J Immunol (1989) 1.46
Dendritic cell-based xenoantigen vaccination for prostate cancer immunotherapy. J Immunol (2001) 1.46
Induction of immunity to antigens expressed by recombinant adeno-associated virus depends on the route of administration. Clin Immunol (1999) 1.45
Treatment of NZB/NZW F1 hybrid mice with Mycobacterium bovis strain BCG or type II interferon preparations accelerates autoimmune disease. Arthritis Rheum (1981) 1.41
Production of functional human T-T hybridomas in selection medium lacking aminopterin and thymidine. Proc Natl Acad Sci U S A (1982) 1.41
Admission as a dental student to the former UMDS and its relationship to socio-demographic characteristics. Br Dent J (2003) 1.40
CD34+AC133+ cells isolated from cord blood are highly enriched in long-term culture-initiating cells, NOD/SCID-repopulating cells and dendritic cell progenitors. Stem Cells (1998) 1.40
Idiotype vaccination using dendritic cells after autologous peripheral blood stem cell transplantation for multiple myeloma--a feasibility study. Blood (1999) 1.40
Involvement of CD28 in MHC-unrestricted cytotoxicity mediated by a human natural killer leukemia cell line. J Immunol (1992) 1.39
Discrimination of viable and non-viable cells using propidium iodide in two color immunofluorescence. Cytometry (1987) 1.32
The stigma of epilepsy: a European perspective. Epilepsia (2000) 1.32
Differential effects of fingolimod (FTY720) on immune cells in the CSF and blood of patients with MS. Neurology (2011) 1.31
A region in domain 1 of CD4 distinct from the primary gp120 binding site is involved in HIV infection and virus-mediated fusion. J Biol Chem (1991) 1.30
Immunoregulatory T cell circuits in man. Alloantigen-primed inducer T cells activate alloantigen-specific suppressor T cells in the absence of the initial antigenic stimulus. J Exp Med (1983) 1.30
Distance stereoacuity in intermittent exotropia. Br J Ophthalmol (2006) 1.30
Evidence for an association between CD8 molecules and the T cell receptor complex on cytotoxic T cells. J Immunol (1987) 1.28
Evidence for involvement of the gamma, delta T cell antigen receptor in cytotoxicity mediated by human alloantigen-specific T cell clones. J Immunol (1989) 1.28
Correlation of functional properties of human lymphoid cell subsets and surface marker phenotypes using multiparameter analysis and flow cytometry. Immunol Rev (1983) 1.27
CD4 molecules are associated with the antigen receptor complex on activated but not resting T cells. J Immunol (1988) 1.26
Primary structure of the succinyl-CoA synthetase of Escherichia coli. Biochemistry (1985) 1.23
Human recombinant interleukin-2 partly reconstitutes deficient in-vitro immune responses of lymphocytes from patients with AIDS. Lancet (1984) 1.22
Human T lymphocyte proliferation induced by a pan-T monoclonal antibody (anti-Leu 4): heterogeneity of response is a function of monocytes. J Immunol (1983) 1.21
Generation of antigen-specific CD8+ CTLs from naive precursors. J Immunol (1994) 1.20
Differentiation of myeloid dendritic cells into CD8alpha-positive dendritic cells in vivo. Blood (2000) 1.20
Autologous mixed lymphocyte reaction in patients with Hodgkin's disease. Evidence for a T cell defect. J Clin Invest (1980) 1.19
Dendritic cells injected via different routes induce immunity in cancer patients. J Immunol (2001) 1.19
Induction of immunoglobulin secreting cells in the human autologous mixed leukocyte reaction: regulation by helper and suppressor lymphocyte subsets defined with monoclonal antibodies. J Immunol (1981) 1.17
Anti-DNA antibody production by CD5+ and CD5- B cells of patients with systemic lupus erythematosus. J Clin Invest (1990) 1.17
Attitudes toward women physicians. A study of 500 clinic patients. West J Med (1974) 1.17
Dehydroepiandrosterone enhances IL2 production and cytotoxic effector function of human T cells. Clin Immunol Immunopathol (1991) 1.17
Workforce planning in dentistry: the impact of shorter and more varied career patterns. Community Dent Health (2001) 1.16
Chimerism, graft survival, and withdrawal of immunosuppressive drugs in HLA matched and mismatched patients after living donor kidney and hematopoietic cell transplantation. Am J Transplant (2015) 1.15
Phenotypic and functional characterization of lymphocytes that bind human microvascular endothelial cells in vitro. Evidence for preferential binding of natural killer cells. J Clin Invest (1987) 1.14
Investigation of the factor VIII intron 22 repeated region (int22h) and the associated inversion junctions. Hum Mol Genet (1995) 1.13
Blocking of human T lymphocyte functions by anti-Leu-2 and anti-Leu-3 antibodies: differential inhibition of proliferation and suppression. J Immunol (1983) 1.11
Differences in surface phenotype and mechanism of action between alloantigen-specific CD8+ cytotoxic and suppressor T cell clones. J Immunol (1990) 1.11
Development, validation, and evaluation of the PBC-40, a disease specific health related quality of life measure for primary biliary cirrhosis. Gut (2005) 1.11
Cascade control of E. coli glutamine synthetase. II. Metabolite regulation of the enzymes in the cascade. Arch Biochem Biophys (1978) 1.11
Natural killer lines and clones with apparent antigen specificity. J Exp Med (1990) 1.10
Utility of formaldehyde fixation for flow cytometry and inactivation of the AIDS associated retrovirus. J Immunol Methods (1986) 1.10
Clinical transplantation tolerance twelve years after prospective withdrawal of immunosuppressive drugs: studies of chimerism and anti-donor reactivity. Transplantation (2000) 1.09
Uptake and costs of care for epilepsy: findings from a U.K. regional study. Epilepsia (1998) 1.08
Immune regulation: a critical link between NK cells and CTLs. Immunol Today (1996) 1.08
Introduction of soluble proteins into the MHC class I pathway by conjugation to an HIV tat peptide. J Immunol (1997) 1.08
An open study of dehydroepiandrosterone in systemic lupus erythematosus. Arthritis Rheum (1994) 1.08
Geometry of site alignment during int family recombination: antiparallel synapsis by the Flp recombinase. J Mol Biol (2000) 1.08
Cloning and expression of the succinyl-CoA synthetase genes of Escherichia coli K12. J Gen Microbiol (1986) 1.05
Degradation of CD4 following phorbol-induced internalization in human T lymphocytes. Evidence for distinct endocytic routing of CD4 and CD3. J Biol Chem (1992) 1.05
Beta-adrenergic receptors on human suppressor, helper, and cytolytic lymphocytes. Biochem Pharmacol (1986) 1.04
Effective vaccination of mice against leprosy bacilli with subunits of Mycobacterium leprae. Infect Immun (1990) 1.04
The quality of life of older people with epilepsy: findings from a UK community study. Seizure (2001) 1.04
Early activation events render T cells susceptible to HIV-1-induced syncytia formation. Role of protein kinase C. J Biol Chem (1991) 1.04
Cultured human epidermal cells do not synthesize HLA-DR. J Invest Dermatol (1982) 1.02
Expression and processing of human immunodeficiency virus type 1 gag and pol genes by cells infected with a recombinant vaccinia virus. J Virol (1989) 1.02
Activation of HLA-restricted EBV-specific cytotoxic T cells does not require CD4+ (helper) T cells or exogenous cytokines. J Immunol (1988) 1.02
Mixed lymphocyte reaction in healthy women with rheumatoid factor. Lack of association with HLA-Dw4. Arthritis Rheum (1979) 1.02
A human alloreactive inducer T cell clone that selectively activates antigen-specific suppressor T cells. J Immunol (1984) 1.02
Hodgkin's disease susceptibility: linkage to the HLA locus demonstrated by a new concordance method. Hum Immunol (1983) 1.02
Natural killer (NK)-like cytotoxic activity of allospecific T cell receptor-gamma,delta+ T cell clones. Distinct receptor-ligand interactions mediate NK-like and allospecific cytotoxicity. J Immunol (1989) 1.02
Induction of immunoglobulin-secreting cells in the allogeneic mixed leukocyte reaction: regulation by helper and suppressor lymphocyte subsets in man. J Immunol (1981) 1.02