Published in Nature on October 28, 1976
Nucleotide sequence of an insertion element, IS1. Proc Natl Acad Sci U S A (1978) 11.43
Molecular and functional analysis of the TOL plasmid pWWO from Pseudomonas putida and cloning of genes for the entire regulated aromatic ring meta cleavage pathway. Proc Natl Acad Sci U S A (1981) 8.20
Molecular model for the transposition and replication of bacteriophage Mu and other transposable elements. Proc Natl Acad Sci U S A (1979) 7.80
Properties of six pesticide degradation plasmids isolated from Alcaligenes paradoxus and Alcaligenes eutrophus. J Bacteriol (1981) 7.57
The RAD52 gene is required for homothallic interconversion of mating types and spontaneous mitotic recombination in yeast. Proc Natl Acad Sci U S A (1980) 6.50
Antimicrobial resistance of Staphylococcus aureus: genetic basis. Microbiol Rev (1987) 6.00
Structure of yeast phenylalanine-tRNA genes: an intervening DNA segment within the region coding for the tRNA. Proc Natl Acad Sci U S A (1978) 5.29
Conjugal transfer system of plasmid RP4: analysis by transposon 7 insertion. J Bacteriol (1978) 4.85
Selected translocation of plasmid genes: frequency and regional specificity of translocation of the Tn3 element. J Bacteriol (1977) 4.08
Plasmid-mediated beta-lactamase production in Neisseria gonorrhoeae. Antimicrob Agents Chemother (1977) 4.02
Molecular characterization of two beta-lactamase-specifying plasmids isolated from Neisseria gonorrhoeae. J Bacteriol (1977) 3.76
Bacteriocin and antibiotic resistance plasmids in Bacillus cereus and Bacillus subtilis. J Bacteriol (1978) 3.69
Determination of the functions of hemolytic plasmid pHly152 of Escherichia coli. J Bacteriol (1981) 2.77
Isolation and characterization of the pesticide-degrading plasmid pJP1 from Alcaligenes paradoxus. J Bacteriol (1978) 2.65
Transposition of plasmid DNA segments specifying hydrocarbon degradation and their expression in various microorganisms. Proc Natl Acad Sci U S A (1978) 2.55
Bacterial resistance to the tetracyclines. Microbiol Rev (1978) 2.52
Transposition of the Escherichia coli insertion element gamma generates a five-base-pair repeat. Proc Natl Acad Sci U S A (1979) 2.47
Plasmid transfer in Haemophilus influenzae. J Bacteriol (1979) 2.44
Use of plasmid profiles in epidemiologic surveillance of disease outbreaks and in tracing the transmission of antibiotic resistance. Clin Microbiol Rev (1988) 2.35
Transposon A-generated mutations in the mercuric resistance genes of plasmid R100-1. J Bacteriol (1979) 2.33
Escherichia coli K-12 mutants hyperproducing chromosomal beta-lactamase by gene repetitions. J Bacteriol (1977) 2.21
Polypeptides expressed in Escherichia coli K-12 minicells by transposition elements Tn1 and Tn3. J Bacteriol (1979) 2.17
Spontaneous deletion of citrate-utilizing ability promoted by insertion sequences. J Bacteriol (1984) 1.86
Transposition of the oxacillin-hydrolyzing penicillinase gene. J Bacteriol (1981) 1.82
Circular Epstein-Barr virus genomes of reduced size in a human lymphoid cell line of infectious mononucleosis origin. J Virol (1977) 1.77
A cDNA clone from Zea mays endosperm sucrose synthetase mRNA. Nucleic Acids Res (1980) 1.67
Direct involvement of IS26 in an antibiotic resistance operon. J Bacteriol (1990) 1.55
Physicochemical characterization of mitochondrial DNA from soybean. Plant Physiol (1978) 1.47
Sequences homologous to ribosomal insertions occur in the Drosophila genome outside the nucleolus organizer. Proc Natl Acad Sci U S A (1977) 1.40
Plasmids coding for heat-labile enterotoxin production isolated from Escherichia coli O78: comparison of properties. J Bacteriol (1980) 1.37
Cloning of deoxyribonucleic acid regions encoding a heat-labile and heat-stable enterotoxin originating from an enterotoxigenic Escherichia coli strain of human origin. J Bacteriol (1980) 1.34
Origins of metabolic diversity: evolutionary divergence by sequence repetition. Proc Natl Acad Sci U S A (1979) 1.33
Additive recombination in bacteria. Bacteriol Rev (1977) 1.26
Comparison of mRNA precursors in plasmacytomas producing closely related kappa chains. Proc Natl Acad Sci U S A (1979) 1.26
Deoxyribonucleic acid sequence homologies among bacterial insertion sequence elements and genomes of various organisms. J Bacteriol (1979) 1.22
Transposition of ampicillin resistance to an enterotoxin plasmid in an Escherichia coli strain of human origin. J Bacteriol (1979) 1.20
Optimization of gene expression through divergent mutational paths. Cell Rep (2012) 1.18
On the location of palindromes in immunoglobulin genes. Proc Natl Acad Sci U S A (1977) 1.17
Viral R plasmid Rphi6P: properties of the penicillinase plasmid prophage and the supercoiled, circular encapsidated genome. J Bacteriol (1978) 1.16
Effect of temperature on translocation frequency of the Tn3 element. J Bacteriol (1979) 1.15
Evolution of Pseudomonas R-plasmids: consequences of Tn1 insertion and resultant partial diploidy to chromosome and Tra- R-plasmid mobilization. J Bacteriol (1978) 1.14
Chloramphenicol acetyltransferase of Bacteroides fragilis. Antimicrob Agents Chemother (1978) 1.13
Unique plasmid-like mitochondrial DNAs from indigenous maize races of Latin America. Proc Natl Acad Sci U S A (1982) 1.10
Genetics of Rhodospirillaceae. Microbiol Rev (1978) 1.05
Location of an ampicillin resistance transposon, Tn1701, in a group of small, nontransferring plasmids. J Bacteriol (1979) 0.98
Inverted repeated sequences in yeast nuclear DNA. Nucleic Acids Res (1980) 0.97
R plasmids in environmental Vibrio cholerae non-O1 strains. Appl Environ Microbiol (1988) 0.95
Selective amplification of genes on the R plasmid, NR1, in Proteus mirabilis: an example of the induction of selective gene amplification. Proc Natl Acad Sci U S A (1977) 0.94
A genetic approach to analysis of transposons. Proc Natl Acad Sci U S A (1979) 0.94
Expression of R-plasmid functions during anaerobic growth of an Escherichia coli K-12 host. J Bacteriol (1977) 0.90
Cell-cycle-associated rearrangement of inverted repeat DNA sequences. Proc Natl Acad Sci U S A (1979) 0.86
IncF plasmid diversity in multi-drug resistant Escherichia coli strains from animals in China. Front Microbiol (2015) 0.86
Genetic changes accompanying increased fitness in evolving populations of Escherichia coli. Genetics (1992) 0.85
Synthesis of R-plasmid-coded beta-lactamase in minicells and in an in vitro system. J Bacteriol (1977) 0.84
Antibiotic resistance in Enterotoxigenic and non-enterotoxigenic Escherichia coli. J Clin Microbiol (1980) 0.82
DNA cloning: a personal view after 40 years. Proc Natl Acad Sci U S A (2013) 0.79
Tn2011, a new transposon encoding oxacillin-hydrolyzing beta-lactamase. Antimicrob Agents Chemother (1983) 0.79
Characterization of inverted repeated sequences in wheat nuclear DNA. Nucleic Acids Res (1978) 0.78
Isolation of the kanamycin resistance region (Tn2350) of plasmid R1drd-19 as an autonomous replicon. J Bacteriol (1982) 0.76
Plasmid ColVBtrp maintenance in Erwinia carotovora. J Bacteriol (1981) 0.75
Chloramphenicol transposons found in Salmonella naestved and Escherichia coli of domestic animal origin. Antimicrob Agents Chemother (1981) 0.75
Characterization of R-plasmids coding for ampicillin resistance from Salmonella species. J Hyg (Lond) (1979) 0.75
Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid. J Bacteriol (1978) 75.38
Nonchromosomal antibiotic resistance in bacteria: genetic transformation of Escherichia coli by R-factor DNA. Proc Natl Acad Sci U S A (1972) 57.06
Analysis of gene control signals by DNA fusion and cloning in Escherichia coli. J Mol Biol (1980) 41.18
Construction of biologically functional bacterial plasmids in vitro. Proc Natl Acad Sci U S A (1973) 25.61
Lactose genes fused to exogenous promoters in one step using a Mu-lac bacteriophage: in vivo probe for transcriptional control sequences. Proc Natl Acad Sci U S A (1979) 22.59
High frequency transformation of Bacillus subtilis protoplasts by plasmid DNA. Mol Gen Genet (1979) 17.16
Transformation of Salmonella typhimurium by plasmid deoxyribonucleic acid. J Bacteriol (1974) 15.89
Recircularization and autonomous replication of a sheared R-factor DNA segment in Escherichia coli transformants. Proc Natl Acad Sci U S A (1973) 13.45
Uniform nomenclature for bacterial plasmids: a proposal. Bacteriol Rev (1976) 12.28
Non-chromosomal antibiotic resistance in bacteria. II. Molecular nature of R-factors isolated from Proteus mirabilis and Escherichia coli. J Mol Biol (1970) 11.86
Electron microscope heteroduplex studies of sequence relations among plasmids of Escherichia coli. II. Structure of drug resistance (R) factors and F factors. J Mol Biol (1973) 11.40
Replication and transcription of eukaryotic DNA in Escherichia coli. Proc Natl Acad Sci U S A (1974) 10.51
Multiple molecular species of circular R-factor DNA isolated from Escherichia coli. Nature (1969) 9.02
Cloning, isolation, and characterization of replication regions of complex plasmid genomes. Proc Natl Acad Sci U S A (1975) 8.85
Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase. Nature (1978) 8.76
Site specific recA--independent recombination between bacterial plasmids: involvement of palindromes at the recombinational loci. Proc Natl Acad Sci U S A (1975) 7.60
Decay of mRNA in Escherichia coli: investigation of the fate of specific segments of transcripts. Proc Natl Acad Sci U S A (1983) 6.79
Nucleotide sequence of cloned cDNA for bovine corticotropin-beta-lipotropin precursor. Nature (1979) 6.56
Identification and characterization of recD, a gene affecting plasmid maintenance and recombination in Escherichia coli. J Bacteriol (1986) 6.06
Gene expression in Streptomyces: construction and application of promoter-probe plasmid vectors in Streptomyces lividans. Mol Gen Genet (1982) 5.99
Replication control in a composite plasmid constructed by in vitro linkage of two distinct replicons. Nature (1976) 5.73
Revised interpretation of the origin of the pSC101 plasmid. J Bacteriol (1977) 5.51
Genome construction between bacterial species in vitro: replication and expression of Staphylococcus plasmid genes in Escherichia coli. Proc Natl Acad Sci U S A (1974) 5.47
Occurrence of insertion sequence (IS) regions on plasmid deoxyribonucleic acid as direct and inverted nucleotide sequence duplications. J Bacteriol (1975) 5.35
Nonchromosomal antibiotic resistance in bacteria. V. Isolation and characterization of R factor mutants exhibiting temperature-sensitive repression of fertility. J Bacteriol (1972) 4.85
Molecular and genetic studies of an R factor system consisting of independent transfer and drug resistance plasmids. J Bacteriol (1973) 4.81
Are chlamydial infections the most prevalent venereal disease? JAMA (1975) 4.79
Alignment of genetic and restriction maps of the photosynthesis region of the Rhodopseudomonas capsulata chromosome by a conjugation-mediated marker rescue technique. J Bacteriol (1983) 4.56
Dengue and chikungunya virus infection in man in Thailand, 1962-1964. I. Observations on hospitalized patients with hemorrhagic fever. Am J Trop Med Hyg (1969) 4.41
Cloning and characterization of EcoRI and HindIII restriction endonuclease-generated fragments of antibiotic resistance plasmids R6-5 and R6. Mol Gen Genet (1978) 4.33
Observations related to pathogenesis of dengue hemorrhagic fever. IV. Relation of disease severity to antibody response and virus recovered. Yale J Biol Med (1970) 4.30
Utilization of two distinct modes of replication by a hybrid plasmid constructed in vitro from separate replicons. Proc Natl Acad Sci U S A (1974) 4.27
Structure and genomic organization of the mouse dihydrofolate reductase gene. Cell (1980) 4.25
3'-end labeling of DNA with [alpha-32P]cordycepin-5'-triphosphate. Gene (1980) 4.22
Differential expression of photosynthesis genes in R. capsulata results from segmental differences in stability within the polycistronic rxcA transcript. Cell (1985) 4.15
Selected translocation of plasmid genes: frequency and regional specificity of translocation of the Tn3 element. J Bacteriol (1977) 4.08
Partitioning of bacterial plasmids during cell division: a cis-acting locus that accomplishes stable plasmid inheritance. Cell (1980) 4.01
Isolation of catenated forms of R factor DNA from minicells. Nat New Biol (1971) 3.99
Indirect selection of bacterial plasmids lacking identifiable phenotypic properties. J Bacteriol (1975) 3.88
Cloning and analysis of strong promoters is made possible by the downstream placement of a RNA termination signal. Proc Natl Acad Sci U S A (1981) 3.77
Isolation of histone genes from unfractionated sea urchin DNA by subculture cloning in E. coli. Nature (1975) 3.70
Involvement of multiple translocating DNA segments and recombinational hotspots in the structural evolution of bacterial plasmids. J Mol Biol (1976) 3.63
Cloning and endonuclease mapping of the hepatitis B viral genome. Nature (1979) 3.62
Letter: Potential biohazards of recombinant DNA molecules. Science (1974) 3.45
Penicillinase-producing Neisseria gonorrhoeae. Lancet (1976) 3.37
A sensitive radioimmunoassay for detecting products translated from cloned DNA fragments. Cell (1978) 3.30
Hemorrhagic fevers of Southeast Asia and South America: a comparative appraisal. Prog Med Virol (1967) 3.22
Growth-rate dependent regulation of mRNA stability in Escherichia coli. Nature (1984) 3.06
Tsg101: a novel tumor susceptibility gene isolated by controlled homozygous functional knockout of allelic loci in mammalian cells. Cell (1996) 2.92
Studies of mouse mitochondrial DNA in Escherichia coli: structure and function of the eucaryotic-procaryotic chimeric plasmids. Cell (1975) 2.80
The stability of E. coli gene transcripts is dependent on determinants localized to specific mRNA segments. Cell (1986) 2.79
Non-chromosomal antibiotic resistance in bacteria. 3. Isolation of the discrete transfer unit of the R-factor R1. Proc Natl Acad Sci U S A (1970) 2.76
In vivo site-specific genetic recombination promoted by the EcoRI restriction endonuclease. Proc Natl Acad Sci U S A (1977) 2.74
Nucleotide sequences encoding and promoting expression of three antibiotic resistance genes indigenous to Streptomyces. Mol Gen Genet (1985) 2.71
Coryneform bacterial endocarditis: difficulties in diagnosis and treatment, presentation of three cases, and review of literature. Mayo Clin Proc (1977) 2.63
The usefulness of preoperative laboratory screening. JAMA (1985) 2.55
An intercistronic stem-loop structure functions as an mRNA decay terminator necessary but insufficient for puf mRNA stability. Cell (1988) 2.53
Global analysis of growth phase responsive gene expression and regulation of antibiotic biosynthetic pathways in Streptomyces coelicolor using DNA microarrays. Genes Dev (2001) 2.49
Shock associated with dengue infection. I. Clinical and physiologic manifestations of dengue hemorrhagic fever in Thailand, 1964. J Pediatr (1966) 2.45
A+U content rather than a particular nucleotide order determines the specificity of RNase E cleavage. J Biol Chem (1994) 2.39
Identification and characterization of a self-regulated repressor of translocation of the Tn3 element. Proc Natl Acad Sci U S A (1979) 2.37
Translocation specificity of the Tn3 element: characterization of sites of multiple insertions. Cell (1980) 2.31
Structural and functional analysis of cloned DNA segments containing the replication and incompatibility regions of a miniplasmid derived from a copy number mutant of NR1. J Bacteriol (1979) 2.29
Complete nucleotide sequence of the Streptomyces lividans plasmid pIJ101 and correlation of the sequence with genetic properties. J Bacteriol (1988) 2.29
The rate of processing and degradation of antisense RNAI regulates the replication of ColE1-type plasmids in vivo. Cell (1991) 2.27
Carotid endarterectomy--an evidence-based review: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology (2005) 2.26
RNA degradation in Escherichia coli regulated by 3' adenylation and 5' phosphorylation. Nature (1995) 2.26
Transposition protein of Tn3: identification and characterisation of an essential repressor-controlled gene product. Nature (1980) 2.24
Effect of premature termination of translation on mRNA stability depends on the site of ribosome release. Proc Natl Acad Sci U S A (1987) 2.24
Prior antiplatelet use does not affect hemorrhage growth or outcome after ICH. Neurology (2009) 2.23
Bovine papilloma virus plasmids replicate randomly in mouse fibroblasts throughout S phase of the cell cycle. Cell (1987) 2.22
Genetic recombination through protoplast fusion in Streptomyces. Nature (1977) 2.14
Characterization of the structural gene and putative 5'-regulatory sequences for human proopiomelanocortin. Nature (1982) 2.04
The TSG101 tumor susceptibility gene is located in chromosome 11 band p15 and is mutated in human breast cancer. Cell (1997) 2.02
The Escherichia coli pcnB gene promotes adenylylation of antisense RNAI of ColE1-type plasmids in vivo and degradation of RNAI decay intermediates. Proc Natl Acad Sci U S A (1993) 1.99
Structural and functional analysis of the par region of the pSC 10 1 plasmid. Cell (1984) 1.98
A DNA cloning system for interspecies gene transfer in antibiotic-producing Streptomyces. Nature (1980) 1.95
Structural and functional analysis of transcriptional control of the Rhodobacter capsulatus puf operon. J Bacteriol (1989) 1.92
The N-terminal domain of the rne gene product has RNase E activity and is non-overlapping with the arginine-rich RNA-binding site. J Mol Biol (1996) 1.92
Replication timing of DNA sequences associated with human centromeres and telomeres. Mol Cell Biol (1990) 1.89
A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control. Proc Natl Acad Sci U S A (2001) 1.88
Excision of chromosomal DNA sequences from Streptomyces coelicolor forms a novel family of plasmids detectable in Streptomyces lividans. Mol Gen Genet (1981) 1.88
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A simple method for quantitative urine culture. N Engl J Med (1967) 1.85
Transcription of complementary strands of phage lambda-DNA in vivo and in vitro. Proc Natl Acad Sci U S A (1967) 1.80
Site-specific RNase E cleavage of oligonucleotides and inhibition by stem-loops. Nature (1995) 1.79
Genetic analysis of the inter-relationship between plasmid replication and incompatibility. Mol Gen Genet (1979) 1.79
Covalently closed circular DNA molecules of low superhelix density as intermediate forms in plasmid replication. Nature (1976) 1.77
Site-specific DNA deletions occurring adjacent to the termini of a transposable ampicillin resistance element (Tn3). J Mol Biol (1977) 1.74
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Cell cycle-dependent subcellular localization of the TSG101 protein and mitotic and nuclear abnormalities associated with TSG101 deficiency. Proc Natl Acad Sci U S A (1998) 1.70
Inhibition of DNA and RNA polymerase reactions by chloroquine. Proc Natl Acad Sci U S A (1965) 1.70
An artificial intelligence program to advise physicians regarding antimicrobial therapy. Comput Biomed Res (1973) 1.69
The ams-1 and rne-3071 temperature-sensitive mutations in the ams gene are in close proximity to each other and cause substitutions within a domain that resembles a product of the Escherichia coli mre locus. J Bacteriol (1993) 1.67
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Tumor susceptibility gene 101 protein represses androgen receptor transactivation and interacts with p300. Cancer (1999) 1.65
RNA degradosomes exist in vivo in Escherichia coli as multicomponent complexes associated with the cytoplasmic membrane via the N-terminal region of ribonuclease E. Proc Natl Acad Sci U S A (2001) 1.62