Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor.

PubWeight™: 3.70‹?› | Rank: Top 1%

🔗 View Article (PMID 7935841)

Published in Nature on October 27, 1994

Authors

D Lu1, D Willard, I R Patel, S Kadwell, L Overton, T Kost, M Luther, W Chen, R P Woychik, W O Wilkison

Author Affiliations

1: Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201.

Articles citing this

(truncated to the top 100)

Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat Neurosci (2003) 4.83

BDNF regulates eating behavior and locomotor activity in mice. EMBO J (2000) 3.52

Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice. Mol Cell Biol (2002) 3.14

Sixteen years and counting: an update on leptin in energy balance. J Clin Invest (2011) 2.21

The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology. Endocr Rev (2010) 2.09

A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors. Proc Natl Acad Sci U S A (2000) 2.02

Melanocortin receptor 1 (MC1R) mutations and coat color in pigs. Genetics (1998) 2.00

The 8818G allele of the agouti signaling protein (ASIP) gene is ancestral and is associated with darker skin color in African Americans. Hum Genet (2005) 1.97

High polymorphism at the human melanocortin 1 receptor locus. Genetics (1999) 1.94

Autosomal genomic scan for loci linked to obesity and energy metabolism in Pima Indians. Am J Hum Genet (1998) 1.78

Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur. Proc Natl Acad Sci U S A (1995) 1.69

Pathophysiological role of leptin in obesity-related hypertension. J Clin Invest (2000) 1.68

A polymorphism in the agouti signaling protein gene is associated with human pigmentation. Am J Hum Genet (2002) 1.63

Genome scan for human obesity and linkage to markers in 20q13. Am J Hum Genet (1999) 1.58

Mouse models of the metabolic syndrome. Dis Model Mech (2010) 1.55

Traveling stripes on the skin of a mutant mouse. Proc Natl Acad Sci U S A (2003) 1.53

Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat. Obesity (Silver Spring) (2011) 1.50

Making sense of the sensory regulation of hunger neurons. Bioessays (2016) 1.49

Impact of macrophage toll-like receptor 4 deficiency on macrophage infiltration into adipose tissue and the artery wall in mice. Diabetologia (2008) 1.47

Metabolism and the circadian clock converge. Physiol Rev (2013) 1.47

Genetic factors for resistance to diet-induced obesity and associated metabolic traits on mouse chromosome 17. Mamm Genome (2009) 1.38

A role for the melanocortin 4 receptor in sexual function. Proc Natl Acad Sci U S A (2002) 1.38

Genetic studies of the mouse mutations mahogany and mahoganoid. Genetics (1997) 1.32

Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case-control study. Hum Mol Genet (2008) 1.30

Characterization of the dog Agouti gene and a nonagoutimutation in German Shepherd Dogs. Mamm Genome (2004) 1.28

Pineal-specific agouti protein regulates teleost background adaptation. Proc Natl Acad Sci U S A (2010) 1.27

Molecular basis of the pleiotropic phenotype of mice carrying the hypervariable yellow (Ahvy) mutation at the agouti locus. Genetics (1996) 1.25

Inverse agonism at G protein-coupled receptors: (patho)physiological relevance and implications for drug discovery. Br J Pharmacol (2000) 1.25

Interaction of Agouti protein with the melanocortin 1 receptor in vitro and in vivo. Genes Dev (1998) 1.25

Agouti regulation of intracellular calcium: role in the insulin resistance of viable yellow mice. Proc Natl Acad Sci U S A (1995) 1.18

Blockade of melanocortin transmission inhibits cocaine reward. Eur J Neurosci (2005) 1.17

Chronic leucine supplementation improves glycemic control in etiologically distinct mouse models of obesity and diabetes mellitus. Nutr Metab (Lond) (2010) 1.15

The role of the central melanocortin system in the regulation of food intake and energy homeostasis: lessons from mouse models. Philos Trans R Soc Lond B Biol Sci (2006) 1.14

Relevance of animal models to human eating disorders and obesity. Psychopharmacology (Berl) (2008) 1.13

Selection for complex traits leaves little or no classic signatures of selection. BMC Genomics (2014) 1.13

The role of proopiomelanocortin (POMC) neurones in feeding behaviour. Nutr Metab (Lond) (2007) 1.10

Regulation of G protein-coupled receptor signaling: specific dominant-negative effects of melanocortin 2 receptor accessory protein 2. Sci Signal (2010) 1.08

Voluntary exercise prevents the obese and diabetic metabolic syndrome of the melanocortin-4 receptor knockout mouse. FASEB J (2008) 1.06

CXCL14 deficiency in mice attenuates obesity and inhibits feeding behavior in a novel environment. PLoS One (2010) 1.06

Getting biological about the genetics of diabetes. Nat Med (2010) 1.05

Biology of obesity: lessons from animal models of obesity. J Biomed Biotechnol (2011) 1.05

Bone morphogenetic protein 7 (BMP7) reverses obesity and regulates appetite through a central mTOR pathway. FASEB J (2012) 1.04

Obese gene expression: reduction by fasting and stimulation by insulin and glucose in lean mice, and persistent elevation in acquired (diet-induced) and genetic (yellow agouti) obesity. Proc Natl Acad Sci U S A (1996) 1.03

PKA-mediated phosphorylation of ATR promotes recruitment of XPA to UV-induced DNA damage. Mol Cell (2014) 1.03

Molecular and phenotypic analysis of 25 recessive, homozygous-viable alleles at the mouse agouti locus. Genetics (2002) 1.02

Accelerated puberty and late-onset hypothalamic hypogonadism in female transgenic skinny mice overexpressing leptin. J Clin Invest (2000) 1.02

Linkage and association studies between the melanocortin receptors 4 and 5 genes and obesity-related phenotypes in the Québec Family Study. Mol Med (1997) 0.99

Characterization of genes modulated during pheomelanogenesis using differential display. Proc Natl Acad Sci U S A (1998) 0.99

The mutation causing the black-and-tan pigmentation phenotype of Mangalitza pigs maps to the porcine ASIP locus but does not affect its coding sequence. Mamm Genome (2006) 0.98

Oleic acid directly regulates POMC neuron excitability in the hypothalamus. J Neurophysiol (2009) 0.98

Differential effects of insulin on sympathetic nerve activity in agouti obese mice. J Hypertens (2010) 0.98

MC1R, the cAMP pathway, and the response to solar UV: extending the horizon beyond pigmentation. Pigment Cell Melanoma Res (2014) 0.97

Association of an Agouti allele with fawn or sable coat color in domestic dogs. Mamm Genome (2005) 0.97

Modulation of murine melanocyte function in vitro by agouti signal protein. EMBO J (1997) 0.96

In silico mutagenesis: a case study of the melanocortin 4 receptor. FASEB J (2009) 0.96

Integrated control of appetite and fat metabolism by the leptin-proopiomelanocortin pathway. Proc Natl Acad Sci U S A (2001) 0.96

Mechanisms for the pleiotropic effects of the agouti gene. Proc Natl Acad Sci U S A (1995) 0.96

Neural melanocortin receptors in obesity and related metabolic disorders. Biochim Biophys Acta (2013) 0.96

Genetic effects on coat colour in cattle: dilution of eumelanin and phaeomelanin pigments in an F2-Backcross Charolais x Holstein population. BMC Genet (2007) 0.95

Mahogunin ring finger-1 (MGRN1) E3 ubiquitin ligase inhibits signaling from melanocortin receptor by competition with Galphas. J Biol Chem (2009) 0.95

Melanocortin control of energy balance: evidence from rodent models. Cell Mol Life Sci (2011) 0.94

Missense and nonsense mutations in melanocortin 1 receptor (MC1R) gene of different goat breeds: association with red and black coat colour phenotypes but with unexpected evidences. BMC Genet (2009) 0.94

Mahoganoid and mahogany mutations rectify the obesity of the yellow mouse by effects on endosomal traffic of MC4R protein. J Biol Chem (2011) 0.93

Circumventing leptin resistance for weight control. Proc Natl Acad Sci U S A (2001) 0.93

Phenotypes in three pedigrees with autosomal dominant obesity caused by haploinsufficiency mutations in the melanocortin-4 receptor gene. Am J Hum Genet (1999) 0.92

Orally available selective melanocortin-4 receptor antagonists stimulate food intake and reduce cancer-induced cachexia in mice. PLoS One (2009) 0.92

Ghrelin is an orexigenic peptide and elicits anxiety-like behaviors following administration into discrete regions of the hypothalamus. Behav Brain Res (2011) 0.91

WNIN/GR-Ob - an insulin-resistant obese rat model from inbred WNIN strain. Indian J Med Res (2011) 0.89

Mahogany (mg) stimulates feeding and increases basal metabolic rate independent of its suppression of agouti. Proc Natl Acad Sci U S A (1998) 0.89

Haploinsufficiency of the melanocortin-4 receptor: part of a thrifty genotype? J Clin Invest (2000) 0.89

Melanocortin 1 Receptor: Structure, Function, and Regulation. Front Genet (2016) 0.88

Advances in murine models of diabetic nephropathy. J Diabetes Res (2013) 0.88

The melanocortin receptors and their accessory proteins. Front Endocrinol (Lausanne) (2013) 0.87

Melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH2 modified at the para position of the benzyl side chain (DPhe): importance for mouse melanocortin-3 receptor agonist versus antagonist activity. J Med Chem (2008) 0.86

Gene-diet interactions in childhood obesity. Curr Genomics (2011) 0.86

Mex3c mutation reduces adiposity and increases energy expenditure. Mol Cell Biol (2012) 0.86

A genome-wide scan study identifies a single nucleotide substitution in ASIP associated with white versus non-white coat-colour variation in sheep (Ovis aries). Heredity (Edinb) (2013) 0.85

HS014, a selective melanocortin-4 (MC4) receptor antagonist, modulates the behavioral effects of morphine in mice. Psychopharmacology (Berl) (2005) 0.84

Combined effects of insulin treatment and adipose tissue-specific agouti expression on the development of obesity. Proc Natl Acad Sci U S A (1997) 0.84

Melanocortin-3 receptors and metabolic homeostasis. Prog Mol Biol Transl Sci (2013) 0.84

Strategies for assessment of botanical action on metabolic syndrome in the mouse and evidence for a genotype-specific effect of Russian tarragon in the regulation of insulin sensitivity. Metabolism (2008) 0.83

Structure-activity studies of new melanocortin peptides containing an aromatic amino acid at the N-terminal position. Peptides (2005) 0.83

Phosphodiesterase inhibitor-dependent inverse agonism of agouti-related protein on melanocortin 4 receptor in sea bass (Dicentrarchus labrax). Am J Physiol Regul Integr Comp Physiol (2009) 0.83

Agouti revisited: transcript quantification of the ASIP gene in bovine tissues related to protein expression and localization. PLoS One (2012) 0.81

Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 receptor. J Med Chem (2007) 0.81

Novel binding motif of ACTH analogues at the melanocortin receptors. Biochemistry (2009) 0.81

Characterizing neutral genomic diversity and selection signatures in indigenous populations of Moroccan goats (Capra hircus) using WGS data. Front Genet (2015) 0.81

γ₂-Melanocyte stimulation hormone (γ₂-MSH) truncation studies results in the cautionary note that γ₂-MSH is not selective for the mouse MC3R over the mouse MC5R. Peptides (2010) 0.81

New Zealand Ginger mouse: novel model that associates the tyrp1b pigmentation gene locus with regulation of lean body mass. Physiol Genomics (2009) 0.80

A composite six bp in-frame deletion in the melanocortin 1 receptor (MC1R) gene is associated with the Japanese brindling coat colour in rabbits (Oryctolagus cuniculus). BMC Genet (2010) 0.80

Liver-specific expression of the agouti gene in transgenic mice promotes liver carcinogenesis in the absence of obesity and diabetes. Mol Cancer (2004) 0.80

60 YEARS OF POMC: Regulation of feeding and energy homeostasis by α-MSH. J Mol Endocrinol (2016) 0.79

Solid-phase peptide head-to-side chain cyclodimerization: discovery of C(2)-symmetric cyclic lactam hybrid α-melanocyte-stimulating hormone (MSH)/agouti-signaling protein (ASIP) analogues with potent activities at the human melanocortin receptors. Peptides (2010) 0.79

Global patterns of diversity and selection in human tyrosinase gene. PLoS One (2013) 0.79

Progressive obesity leads to altered ovarian gene expression in the Lethal Yellow mouse: a microarray study. J Ovarian Res (2009) 0.79

An agouti mutation lacking the basic domain induces yellow pigmentation but not obesity in transgenic mice. Proc Natl Acad Sci U S A (1999) 0.79

Agnostic about in vivo inverse agonism of agouti-related peptide. Endocrinology (2011) 0.79

Transient ectopic overexpression of agouti-signalling protein 1 (asip1) induces pigment anomalies in flatfish. PLoS One (2012) 0.79

Genetic association study of adiposity and melanocortin-4 receptor (MC4R) common variants: replication and functional characterization of non-coding regions. PLoS One (2014) 0.79

The E92K melanocortin 1 receptor mutant induces cAMP production and arrestin recruitment but not ERK activity indicating biased constitutive signaling. PLoS One (2011) 0.79

Articles by these authors

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature (1995) 34.97

An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J Biol Chem (1995) 13.34

Differential regulation and properties of MAPKs. Oncogene (2007) 6.36

Positron emission tomography in evaluation of dementia: Regional brain metabolism and long-term outcome. JAMA (2001) 5.13

Molecular characterization of the mouse agouti locus. Cell (1992) 4.55

Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion. Cell (2000) 4.45

Anesthesiologist direction and patient outcomes. Anesthesiology (2000) 4.31

GPCRDB: an information system for G protein-coupled receptors. Nucleic Acids Res (1998) 3.94

The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determination. Development (2000) 3.74

A large-scale insertional mutagenesis screen in zebrafish. Genes Dev (1999) 3.57

International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders. Leukemia (2008) 3.41

The teacher as observer and experimenter in the modification of disputing and talking-out behaviors. J Appl Behav Anal (1971) 3.36

Candidate gene associated with a mutation causing recessive polycystic kidney disease in mice. Science (1994) 3.31

Distinguishing between mechanisms of eukaryotic transcriptional activation with bacteriophage T7 RNA polymerase. Cell (1987) 3.26

An inherited limb deformity created by insertional mutagenesis in a transgenic mouse. Nature (1985) 3.05

Cloning and nucleotide sequencing of the bovine growth hormone gene. Nucleic Acids Res (1982) 2.91

Yeast mRNA initiation sites are determined primarily by specific sequences, not by the distance from the TATA element. EMBO J (1985) 2.87

Intranasal lidocaine for treatment of migraine: a randomized, double-blind, controlled trial. JAMA (1996) 2.83

The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes. Mol Psychiatry (2006) 2.80

Critical care transport: outcome evaluation after interfacility transfer and hospitalization. Ann Emerg Med (1999) 2.71

Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity. Nat Genet (1999) 2.60

Requirement for the 3' flanking region of the bovine growth hormone gene for accurate polyadenylylation. Proc Natl Acad Sci U S A (1984) 2.58

The mouse Ames waltzer hearing-loss mutant is caused by mutation of Pcdh15, a novel protocadherin gene. Nat Genet (2001) 2.50

Mutations in the novel protocadherin PCDH15 cause Usher syndrome type 1F. Hum Mol Genet (2001) 2.48

Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification. Nat Genet (1999) 2.46

Microstrip RF surface coil design for extremely high-field MRI and spectroscopy. Magn Reson Med (2001) 2.43

Differential expression of a new dominant agouti allele (Aiapy) is correlated with methylation state and is influenced by parental lineage. Genes Dev (1994) 2.41

Genotype-based screen for ENU-induced mutations in mouse embryonic stem cells. Nat Genet (2000) 2.24

CDKN2 gene silencing in lung cancer by DNA hypermethylation and kinetics of p16INK4 protein induction by 5-aza 2'deoxycytidine. Oncogene (1995) 2.23

Transcriptome analysis and molecular signature of human retinal pigment epithelium. Hum Mol Genet (2010) 2.20

Multivariate matching and bias reduction in the surgical outcomes study. Med Care (2001) 2.19

Ginsenoside-Rd improves outcome of acute ischaemic stroke - a randomized, double-blind, placebo-controlled, multicenter trial. Eur J Neurol (2012) 2.18

A microplate assay for the detection of oxidative products using 2',7'-dichlorofluorescin-diacetate. J Immunol Methods (1992) 2.17

Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta. Proc Natl Acad Sci U S A (2000) 2.15

The number and location of glycans on influenza hemagglutinin determine folding and association with calnexin and calreticulin. J Cell Biol (1997) 2.14

Frequent somatic hypermutation of the 5' noncoding region of the BCL6 gene in B-cell lymphoma. Proc Natl Acad Sci U S A (1995) 2.13

Vascular endothelial growth factor. Regulation by cell differentiation and activated second messenger pathways. J Biol Chem (1992) 2.12

Unloaded heart in vivo replicates fetal gene expression of cardiac hypertrophy. Nat Med (1998) 2.12

The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB. Mol Cell Biol (1999) 2.12

Essential role of growth hormone in ischemia-induced retinal neovascularization. Science (1997) 2.11

Existent T-cell and antibody immunity to HER-2/neu protein in patients with breast cancer. Cancer Res (1994) 2.10

Epidemic of liver disease caused by hydrochlorofluorocarbons used as ozone-sparing substitutes of chlorofluorocarbons. Lancet (1997) 2.09

Falling cholecystectomy thresholds since the introduction of laparoscopic cholecystectomy. JAMA (1995) 2.08

Production of tumor necrosis factor/cachectin by human B cell lines and tonsillar B cells. J Exp Med (1988) 2.07

Molecular analysis of reverse mutations from nonagouti (a) to black-and-tan (a(t)) and white-bellied agouti (Aw) reveals alternative forms of agouti transcripts. Genes Dev (1994) 2.07

Completely diverted tube ileostomy compared with loop ileostomy for protection of low colorectal anastomosis: a pilot study. Colorectal Dis (2014) 2.06

Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2. Nat Genet (1994) 2.06

Refinement of the alpha aminooleic acid bioprosthetic valve anticalcification technique. Ann Thorac Surg (1997) 2.05

Biodegradation of organophosphorus pesticides by surface-expressed organophosphorus hydrolase. Nat Biotechnol (1997) 2.04

Correlation of in vitro azole susceptibility with in vivo response in a murine model of cryptococcal meningitis. J Infect Dis (1993) 2.03

The multidrug resistance gene PDR1 from Saccharomyces cerevisiae. J Biol Chem (1987) 2.02

Reduced serum amino acid concentrations in infants with necrotizing enterocolitis. J Pediatr (2000) 1.97

Extracellular matrix mineralization and osteoblast gene expression by human adipose tissue-derived stromal cells. Tissue Eng (2001) 1.95

Is obesity a high-risk factor for laparoscopic colorectal surgery? Surg Endosc (2002) 1.95

An epidemiological study of lung cancer in Xuan Wei County, China: current progress. Case-control study on lung cancer and cooking fuel. Environ Health Perspect (1991) 1.95

The melanocortin receptors: agonists, antagonists, and the hormonal control of pigmentation. Recent Prog Horm Res (1996) 1.94

Involvement of pp60c-src with two major signaling pathways in human breast cancer. Proc Natl Acad Sci U S A (1994) 1.94

MiR-200b and miR-15b regulate chemotherapy-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting BMI1. Oncogene (2011) 1.94

Molecular cloning, expression, and functional significance of a cytochrome P450 highly expressed in rat heart myocytes. J Biol Chem (1997) 1.92

A novel mechanism of action of tetracyclines: effects on nitric oxide synthases. Proc Natl Acad Sci U S A (1996) 1.90

Mouse BAC ends quality assessment and sequence analyses. Genome Res (2001) 1.89

Cappuccino, a Drosophila maternal effect gene required for polarity of the egg and embryo, is related to the vertebrate limb deformity locus. Genes Dev (1995) 1.87

Infected cell protein (ICP)47 enhances herpes simplex virus neurovirulence by blocking the CD8+ T cell response. J Exp Med (1998) 1.85

Treatment of murine Candida krusei or Candida glabrata infection with L-743,872. Antimicrob Agents Chemother (1997) 1.83

Synectin, syndecan-4 cytoplasmic domain binding PDZ protein, inhibits cell migration. J Cell Physiol (2000) 1.82

Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat. J Clin Invest (1998) 1.82

Adrenoleukodystrophy: increased plasma content of saturated very long chain fatty acids. Neurology (1981) 1.81

The embryonic lethality of homozygous lethal yellow mice (Ay/Ay) is associated with the disruption of a novel RNA-binding protein. Genes Dev (1993) 1.80

Effects of pioglitazone on adipose tissue remodeling within the setting of obesity and insulin resistance. Diabetes (2001) 1.80

Identification of a methylation imprint mark within the mouse Gnas locus. Mol Cell Biol (2000) 1.78

Negative regulation of the tumor suppressor p53 gene by microRNAs. Oncogene (2010) 1.78

An approach to probe some neural systems interaction by functional MRI at neural time scale down to milliseconds. Proc Natl Acad Sci U S A (2000) 1.75

MUC1 oncoprotein is targeted to mitochondria by heregulin-induced activation of c-Src and the molecular chaperone HSP90. Oncogene (2006) 1.75

Co-translational folding of an alphavirus capsid protein in the cytosol of living cells. Nat Cell Biol (1999) 1.74

Ischemic preconditioning activates phosphatidylinositol-3-kinase upstream of protein kinase C. Circ Res (2000) 1.71

Relation of isovolumic relaxation to left ventricular wall movement in man. Br Heart J (1979) 1.71

Superinduction of cyclooxygenase-2 activity in human osteoarthritis-affected cartilage. Influence of nitric oxide. J Clin Invest (1997) 1.70

Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur. Proc Natl Acad Sci U S A (1995) 1.69

Melanocortin-1 receptor genotype is a risk factor for basal and squamous cell carcinoma. J Invest Dermatol (2001) 1.69

Secreted aspartic proteinase (Sap) activity contributes to tissue damage in a model of human oral candidosis. Mol Microbiol (1999) 1.69

MC1R genotype modifies risk of melanoma in families segregating CDKN2A mutations. Am J Hum Genet (2001) 1.67

Primary structure, neural-specific expression, and dendritic location of human BC200 RNA. J Neurosci (1993) 1.67

A molecular model for the genetic and phenotypic characteristics of the mouse lethal yellow (Ay) mutation. Proc Natl Acad Sci U S A (1994) 1.67

Novel mutations in spastin gene and absence of correlation with age at onset of symptoms. Neurology (2000) 1.67

The contribution of childhood obesity to adult carotid intima-media thickness: the Bogalusa Heart Study. Int J Obes (Lond) (2008) 1.66

Adipogenic potential of human adipose derived stromal cells from multiple donors is heterogeneous. J Cell Biochem (2001) 1.65

Interactions between distinct types of DNA binding proteins enhance binding to ocs element promoter sequences. Plant Cell (1995) 1.65

Quantitation of hepatic glucose fluxes and pathways of hepatic glycogen synthesis in conscious mice. Am J Physiol (1995) 1.64

beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis. J Biol Chem (2001) 1.63

Expression of multiple functional chemokine receptors and monocyte chemoattractant protein-1 in human neurons. Neuroscience (2000) 1.61

Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action. J Biol Chem (1997) 1.61

Quantitation of the interaction of EScherichia coli RNA polymerase holoenzyme with double-helical DNA using a thermodynamically rigorous centrifugation method. Biochemistry (1981) 1.60

Expression of minute virus of mice major nonstructural protein in insect cells: purification and identification of ATPase and helicase activities. Virology (1991) 1.59

Immunity to oncogenic proteins. Immunol Rev (1995) 1.58

The vaccinia virus B1R gene product is a serine/threonine protein kinase. J Virol (1992) 1.57

Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79. J Biol Chem (2001) 1.55

Endothelial mechanotransduction, nitric oxide and vascular inflammation. J Intern Med (2006) 1.53

Structure and expression of a membrane component of the inhibin receptor system. Endocrinology (2000) 1.53

Crystal structure of p38 mitogen-activated protein kinase. J Biol Chem (1996) 1.52