Published in Cancer Res on November 15, 1994
Hypoxia alters early gestation human cytotrophoblast differentiation/invasion in vitro and models the placental defects that occur in preeclampsia. J Clin Invest (1996) 2.29
Physical and functional sensitivity of zinc finger transcription factors to redox change. Mol Cell Biol (1996) 1.26
Combined analysis of hypoxia-inducible factor 1 alpha and metallothionein indicates an aggressive subtype of colorectal carcinoma. Int J Colorectal Dis (2009) 0.86
Vascular endothelial growth factor: environmental controls and effects in angiogenesis. Br J Cancer Suppl (1996) 0.75
Role of oxygenation and vascularization in drug resistance. Cytotechnology (1998) 0.75
Growth of multicell spheroids in tissue culture as a model of nodular carcinomas. J Natl Cancer Inst (1971) 2.83
Resistance to adriamycin in multicellular spheroids. Int J Radiat Oncol Biol Phys (1979) 2.78
Radiation response of multicell spheroids--an in vitro tumour model. Curr Top Radiat Res Q (1976) 2.73
Selective chemotherapy of noncycling cells in an in vitro tumor model. Cancer Res (1974) 2.44
Cell-associated ovalbumin is cross-presented much more efficiently than soluble ovalbumin in vivo. J Immunol (2001) 2.41
Oxygen in human tumors: correlations between methods of measurement and response to therapy. Summary of a workshop held November 19-20, 1992, at the National Cancer Institute, Bethesda, Maryland. Radiat Res (1993) 1.99
Erythrocyte membrane sulfhydryl groups and cation permeability. J Cell Physiol (1967) 1.83
Variations in tumor cell growth rates and metabolism with oxygen concentration, glucose concentration, and extracellular pH. J Cell Physiol (1992) 1.77
Effects of intercellular contact on repair of radiation damage. Exp Cell Res (1972) 1.76
Regulation of growth saturation and development of necrosis in EMT6/Ro multicellular spheroids by the glucose and oxygen supply. Cancer Res (1986) 1.59
Induction characteristics of oxygen regulated proteins. Int J Radiat Oncol Biol Phys (1986) 1.58
CD8 T cell ignorance or tolerance to islet antigens depends on antigen dose. Proc Natl Acad Sci U S A (1999) 1.55
Requirement for calcium ions in lymphocyte transformation stimulated by phytohemagglutinin. J Cell Physiol (1972) 1.55
Selective dissociation and characterization of cells from different regions of multicell tumor spheroids. Cancer Res (1980) 1.50
Oxygenation and differentiation in multicellular spheroids of human colon carcinoma. Cancer Res (1986) 1.42
Placenta growth factor gene expression is induced by hypoxia in fibroblasts: a central role for metal transcription factor-1. Cancer Res (2001) 1.42
Enhanced uptake of calcium by transforming lymphocytes. Cell Immunol (1972) 1.42
Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression. Cancer Res (1996) 1.38
The interaction between bleomycin and radiation on cell survival and DNA damage in mammalian cell cultures. Int J Radiat Oncol Biol Phys (1985) 1.36
Glucose diffusivity in multicellular tumor spheroids. Cancer Res (1988) 1.33
In vivo response of KHT sarcomas to combination chemotherapy with radiosensitizers and BCNU. Br J Cancer (1981) 1.32
Oxygen diffusion distance and development of necrosis in multicell spheroids. Radiat Res (1979) 1.28
Letter: Hypoxic radiosensitizers and cellular respiration. Br J Radiol (1976) 1.27
A reduction in the in situ rates of oxygen and glucose consumption of cells in EMT6/Ro spheroids during growth. J Cell Physiol (1985) 1.26
Enhanced synthesis of stress proteins caused by hypoxia and relation to altered cell growth and metabolism. Br J Cancer (1990) 1.23
Activation of metallothionein gene expression by hypoxia involves metal response elements and metal transcription factor-1. Cancer Res (1999) 1.18
Influence of convection in the growth medium on oxygen tensions in multicellular tumor spheroids. Cancer Res (1982) 1.18
In situ oxygen consumption rates of cells in V-79 multicellular spheroids during growth. J Cell Physiol (1984) 1.17
Mathematical modelling of microenvironment and growth in EMT6/Ro multicellular tumour spheroids. Cell Prolif (1992) 1.17
Influence of glucose and oxygen supply conditions on the oxygenation of multicellular spheroids. Br J Cancer (1986) 1.14
Drug resistance in Chinese hamster ovary cells during recovery from severe hypoxia. J Natl Cancer Inst (1989) 1.11
Oxygen tensions in multicell spheroids of two cell lines. Br J Cancer (1982) 1.10
The AMPK stress response pathway mediates anoikis resistance through inhibition of mTOR and suppression of protein synthesis. Cell Death Differ (2011) 1.10
31P nuclear magnetic resonance spectroscopy studies of tumor energy metabolism and its relationship to intracapillary oxyhemoglobin saturation status and tumor hypoxia. Cancer Res (1988) 1.09
Mapping of the vascular endothelial growth factor-producing hypoxic cells in multicellular tumor spheroids using a hypoxia-specific marker. Cancer Res (1995) 1.08
The identification of heme oxygenase as a major hypoxic stress protein in Chinese hamster ovary cells. Br J Cancer (1991) 1.08
Growth and cellular characteristics of multicell spheroids. Recent Results Cancer Res (1984) 1.07
Isolation of quiescent cells from multicellular tumor spheroids using centrifugal elutriation. Cancer Res (1982) 1.04
Hypoxic cells in an in vitro tumour model. Int J Radiat Biol Relat Stud Phys Chem Med (1973) 1.02
Radiation survival of cells from spheroids grown in different oxygen concentrations. Radiat Res (1979) 1.01
Proliferative and clonogenic heterogeneity of cells from EMT6/Ro multicellular spheroids induced by the glucose and oxygen supply. Cancer Res (1986) 1.01
Phytohemagglutinin (PHA)-induced transformation of lymphocytes from patients with cancer. Cancer (1971) 1.00
Misonidazole neurotoxicity in the mouse: evaluation of functional, pharmacokinetic, electrophysiologic and morphologic parameters. Int J Radiat Oncol Biol Phys (1979) 1.00
Hypoxia-induced drug resistance: comparison to P-glycoprotein-associated drug resistance. Br J Cancer (1991) 1.00
Misonidazole cytotoxicity in vivo: a comparison of large single doses with smaller doses and extended contact of the drug with tumor cells. Radiat Res (1980) 1.00
Cytokine mediated effects in mucosal immunity. Immunol Cell Biol (1995) 1.00
Assessment of tumor energy and oxygenation status by bioluminescence, nuclear magnetic resonance spectroscopy, and cryospectrophotometry. Cancer Res (1990) 1.00
Repair of radiation damage to erythrocyte membranes. The reduction of radiation-induced disulfide groups. Radiat Res (1968) 0.99
Optical detection of antibody-antigen reactions at a glass-liquid interface. Clin Chem (1984) 0.99
Differences in growth and morphology between the spontaneous C3H mammary carcinoma in the mouse and its syngeneic transplants. Cancer (1971) 0.99
Effect of postoperative radiotherapy on peripheral blood lymphocytes in patients with carcinoma of the breast. Cancer (1972) 0.98
A multi-component radiation survival curve using an in vitro tumour model. Int J Radiat Biol Relat Stud Phys Chem Med (1970) 0.98
CD4 help-independent induction of cytotoxic CD8 cells to allogeneic P815 tumor cells is absolutely dependent on costimulation. J Immunol (2000) 0.97
Rate of death of hypoxic cells in multicell spheroids. Radiat Res (1978) 0.97
In vivo tumor response to single and multiple exposures of adriamycin. Eur J Cancer (1980) 0.96
Regulation of c-jun expression during hypoxic and low-glucose stress. Mol Cell Biol (1994) 0.96
Inhibition of human bladder cancer cell motility by genistein is dependent on epidermal growth factor receptor but not p21ras gene expression. Int J Cancer (1998) 0.96
Growth of nodular carcinomas in rodents compared with multi-cell spheroids in tissue culture. Growth (1970) 0.96
Nonperturbing test for cytotoxicity in isolated cells and spheroids, using electron paramagnetic resonance. Magn Reson Med (1991) 0.96
Enhancement of sensitivity of human squamous carcinoma cells to radiation by epidermal growth factor. J Natl Cancer Inst (1989) 0.95
Enhancement of transforming growth factor-alpha synthesis in multicellular tumour spheroids of A431 squamous carcinoma cells. Br J Cancer (1992) 0.95
Evidence for a major role of glucose in controlling development of necrosis in EMT6/Ro multicell tumor spheroids. Adv Exp Med Biol (1983) 0.95
Neonatal screening for hypothyroidism in Scotland: results of a pilot study. Scott Med J (1981) 0.94
Nitrosourea-misonidazole combination chemotherapy: effect on KHT sarcomas, marrow stem cells and gut. Br J Cancer (1982) 0.94
Cytotoxicity of hypoxic cell sensitizers in multicell spheroids. Cancer Clin Trials (1980) 0.94
Enhanced synthesis of specific proteins, RNA, and DNA caused by hypoxia and reoxygenation. Int J Radiat Oncol Biol Phys (1989) 0.94
In vitro hypoxic cytotoxicity of nitroimidazoles: uptake and cell cycle phase specificity. Int J Radiat Oncol Biol Phys (1982) 0.93
Importance of critical metabolites and cellular interactions in the biology of microregions of tumors. Cancer (1986) 0.93
On the nature of the radiobiologically hypoxic fraction in tumors. Int J Radiat Oncol Biol Phys (1980) 0.92
Differences in EGF related radiosensitisation of human squamous carcinoma cells with high and low numbers of EGF receptors. Br J Cancer (1991) 0.92
Mouse hepatitis virus A59-induced demyelination can occur in the absence of CD8+ T cells. Microb Pathog (1995) 0.92
Adaptation of EGF receptor signal transduction to three-dimensional culture conditions: changes in surface receptor expression and protein tyrosine phosphorylation. J Cell Physiol (1994) 0.92
A comparison of the pharmacokinetics of multiple and single dose administrations of adriamycin. Int J Radiat Oncol Biol Phys (1979) 0.92
Multicellular spheroids: a new model target for in vitro studies of immunity to solid tumor allografts. J Natl Cancer Inst (1977) 0.91
Changes in growth characteristics and macromolecular synthesis on recovery from severe hypoxia. Br J Cancer (1990) 0.91
Regrowth and radiation sensitivity of quiescent cells isolated from EMT6/Ro-fed plateau monolayers. Cancer Res (1985) 0.91
The novel tubulin-binding drug BTO-956 inhibits R3230AC mammary carcinoma growth and angiogenesis in Fischer 344 rats. Clin Cancer Res (2001) 0.91
Shedding of mitotic cells from the surface of multicell spheroids during growth. J Cell Physiol (1981) 0.91
Changes in cellular glutathione content during adriamycin treatment in human ovarian cancer--a possible indicator of chemosensitivity. Br J Cancer (1989) 0.90
Involvement of sulphhydryl groups in radiation damage to the human erythrocyte membrane. Int J Radiat Biol Relat Stud Phys Chem Med (1967) 0.90
Characteristics of calcium accumulation by lymphocytes and alterations in the process induced by phytohemagglutinin. J Cell Physiol (1973) 0.90
Selective down-regulation of integrin receptors in spheroids of squamous cell carcinoma. Cancer Res (1994) 0.90
Effect of duration of breathing 95 percent oxygen plus 5 percent carbon dioxide before x-irradiation on cure of C3H mammary tumor. Cancer (1970) 0.89
Mathematical modelling of oxygen supply and oxygenation in tumor tissues: prognostic, therapeutic, and experimental implications. Int J Radiat Oncol Biol Phys (1988) 0.89
Cryospectrophotometric determination of tumor intravascular oxyhemoglobin saturations: dependence on vascular geometry and tumor growth. J Natl Cancer Inst (1988) 0.89
Determination of diffusion constants for metabolites in multicell tumor spheroids. Adv Exp Med Biol (1983) 0.89
The effect of antigen concentration, antibody valency and size, and tumor architecture on antibody binding in multicell spheroids. Int J Rad Appl Instrum B (1991) 0.89
Heterogeneity of glutathione content in human ovarian cancer. Cancer Res (1989) 0.88
Epidermal growth factor receptor-regulated human bladder cancer motility is in part a phosphatidylinositol 3-kinase-mediated process. Cell Growth Differ (1998) 0.88
Differentiation patterns in two- and three-dimensional culture systems of human squamous carcinoma cell lines. Am J Pathol (1990) 0.88
Oxygen regulated 80 kDa protein and glucose regulated 78kDa protein are identical. Mol Cell Biochem (1991) 0.87
Nutrient modification of proliferation and radiation response in EMT6/Ro spheroids. Int J Radiat Oncol Biol Phys (1987) 0.87
Repair of radiation damage to membrane sulfhydryl groups of human erythrocytes. Biochim Biophys Acta (1967) 0.87