Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.

PubWeight™: 8.97‹?› | Rank: Top 0.1%

🔗 View Article (PMC 2191751)

Published in J Exp Med on November 01, 1994

Authors

J J Peschon1, P J Morrissey, K H Grabstein, F J Ramsdell, E Maraskovsky, B C Gliniak, L S Park, S F Ziegler, D E Williams, C B Ware, J D Meyer, B L Davison

Author Affiliations

1: Immunex Research and Development Corporation, Seattle, Washington 98101.

Articles citing this

(truncated to the top 100)

Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J Exp Med (1995) 7.52

Cytokine requirements for acute and Basal homeostatic proliferation of naive and memory CD8+ T cells. J Exp Med (2002) 5.09

miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely. Proc Natl Acad Sci U S A (2007) 4.15

The stem cell niches in bone. J Clin Invest (2006) 4.11

A role for TSLP in the development of inflammation in an asthma model. J Exp Med (2005) 4.08

Interleukin 7 regulates the survival and generation of memory CD4 cells. J Exp Med (2003) 3.76

Transcription factor RORα is critical for nuocyte development. Nat Immunol (2012) 3.72

Stat5a/b are essential for normal lymphoid development and differentiation. Proc Natl Acad Sci U S A (2006) 3.66

Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: Formation of a functional heteromeric complex requires interleukin 7 receptor. J Exp Med (2000) 3.51

Overexpression of interleukin (IL)-7 leads to IL-15-independent generation of memory phenotype CD8+ T cells. J Exp Med (2002) 3.06

Transition of late-stage effector T cells to CD27+ CD28+ tumor-reactive effector memory T cells in humans after adoptive cell transfer therapy. Blood (2004) 3.05

BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia. Blood (2012) 2.91

IL-7 promotes the transition of CD4 effectors to persistent memory cells. J Exp Med (2003) 2.87

IL-7 administration to humans leads to expansion of CD8+ and CD4+ cells but a relative decrease of CD4+ T-regulatory cells. J Immunother (2006) 2.86

The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells. J Exp Med (2007) 2.84

A role for thymic stromal lymphopoietin in CD4(+) T cell development. J Exp Med (2004) 2.81

Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. J Exp Med (2013) 2.79

Cytokine-induced survival of activated T cells in vitro and in vivo. Proc Natl Acad Sci U S A (1998) 2.71

Gain-of-function mutations in interleukin-7 receptor-α (IL7R) in childhood acute lymphoblastic leukemias. J Exp Med (2011) 2.59

The MAR-binding protein SATB1 orchestrates temporal and spatial expression of multiple genes during T-cell development. Genes Dev (2000) 2.49

Retracted Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease. Nat Med (2010) 2.43

Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation. Blood (2006) 2.38

Contingent gene regulatory networks and B cell fate specification. Proc Natl Acad Sci U S A (2005) 2.36

T cell immune reconstitution following lymphodepletion. Semin Immunol (2007) 2.35

Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells. J Exp Med (2004) 2.32

Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia. Nat Genet (2011) 2.32

Molecular cloning and biological characterization of a novel murine lymphoid growth factor. J Exp Med (2000) 2.21

Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7 ligands in lymph node development. J Exp Med (2003) 2.16

Osteoblastic regulation of B lymphopoiesis is mediated by Gs{alpha}-dependent signaling pathways. Proc Natl Acad Sci U S A (2008) 2.15

A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory. Immunity (2011) 2.15

Transcription factor Foxp1 exerts essential cell-intrinsic regulation of the quiescence of naive T cells. Nat Immunol (2011) 2.12

Induction of early B cell factor (EBF) and multiple B lineage genes by the basic helix-loop-helix transcription factor E12. J Exp Med (1998) 2.08

The bone marrow at the crossroads of blood and immunity. Nat Rev Immunol (2011) 2.07

Identification of novel lymphoid tissues in murine intestinal mucosa where clusters of c-kit+ IL-7R+ Thy1+ lympho-hemopoietic progenitors develop. J Exp Med (1996) 2.06

Arrested B lymphopoiesis and persistence of activated B cells in adult interleukin 7(-/)- mice. J Exp Med (2001) 2.06

T cell metabolism drives immunity. J Exp Med (2015) 2.06

Withdrawal of IL-7 induces Bax translocation from cytosol to mitochondria through a rise in intracellular pH. Proc Natl Acad Sci U S A (1999) 2.02

Interleukin 7 receptor-deficient mice lack gammadelta T cells. Proc Natl Acad Sci U S A (1996) 2.01

Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling. Genes Dev (2005) 1.98

A cell-autonomous requirement for CXCR4 in long-term lymphoid and myeloid reconstitution. Proc Natl Acad Sci U S A (1999) 1.97

Cell competition is a tumour suppressor mechanism in the thymus. Nature (2014) 1.97

The transcriptional repressor Gfi1 affects development of early, uncommitted c-Kit+ T cell progenitors and CD4/CD8 lineage decision in the thymus. J Exp Med (2003) 1.96

The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow. Nat Immunol (2011) 1.96

Absence of an essential role for thymic stromal lymphopoietin receptor in murine B-cell development. Mol Cell Biol (2004) 1.96

IL-2 negatively regulates IL-7 receptor alpha chain expression in activated T lymphocytes. Proc Natl Acad Sci U S A (2002) 1.96

The bHLH gene Hes1 is essential for expansion of early T cell precursors. Genes Dev (1999) 1.95

IL-7 receptor signaling is necessary for stage transition in adult B cell development through up-regulation of EBF. J Exp Med (2005) 1.94

Interleukin-7 induces expression of latent human immunodeficiency virus type 1 with minimal effects on T-cell phenotype. J Virol (2002) 1.93

Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin. PLoS One (2010) 1.92

Thymic involution and immune reconstitution. Trends Immunol (2009) 1.91

Loss of Bim increases T cell production and function in interleukin 7 receptor-deficient mice. J Exp Med (2004) 1.83

T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow. J Exp Med (2014) 1.82

Mapping precursor movement through the postnatal thymus reveals specific microenvironments supporting defined stages of early lymphoid development. J Exp Med (2001) 1.80

IL-7 regulates basal homeostatic proliferation of antiviral CD4+T cell memory. Proc Natl Acad Sci U S A (2004) 1.79

Purified hematopoietic stem cell engraftment of rare niches corrects severe lymphoid deficiencies without host conditioning. J Exp Med (2005) 1.77

Control of B cell development by Ras-mediated activation of Raf. EMBO J (1997) 1.76

HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes. Blood (2012) 1.76

IL-7 promotes T(H)1 development and serum IL-7 predicts clinical response to interferon-β in multiple sclerosis. Sci Transl Med (2011) 1.73

T-cell tolerance and the multi-functional role of IL-2R signaling in T-regulatory cells. Immunol Rev (2011) 1.69

Pax5 is required for recombination of transcribed, acetylated, 5' IgH V gene segments. Genes Dev (2003) 1.69

Core binding factors are necessary for natural killer cell development and cooperate with Notch signaling during T-cell specification. Blood (2008) 1.67

Group 2 innate lymphoid cells and CD4+ T cells cooperate to mediate type 2 immune response in mice. Allergy (2014) 1.66

The earliest step in B lineage differentiation from common lymphoid progenitors is critically dependent upon interleukin 7. J Exp Med (2002) 1.61

Interleukin-22: immunobiology and pathology. Annu Rev Immunol (2015) 1.60

From the cradle to the grave: activities of GATA-3 throughout T-cell development and differentiation. Immunol Rev (2010) 1.60

The interleukin-7 receptor alpha chain transmits distinct signals for proliferation and differentiation during B lymphopoiesis. EMBO J (1996) 1.60

Anti-IL-7 receptor-α reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function. Proc Natl Acad Sci U S A (2012) 1.60

Interleukin-7 is necessary to maintain the B cell potential in common lymphoid progenitors. J Exp Med (2005) 1.59

In vitro evidence that cytokine receptor signals are required for differentiation of double positive thymocytes into functionally mature CD8+ T cells. J Exp Med (2003) 1.58

Impairment of T cell development in deltaEF1 mutant mice. J Exp Med (1997) 1.56

IL-7 enhances peripheral T cell reconstitution after allogeneic hematopoietic stem cell transplantation. J Clin Invest (2003) 1.56

Massive apoptosis of thymocytes in T-cell-deficient Id1 transgenic mice. Mol Cell Biol (1999) 1.55

Distinct regions of the interleukin-7 receptor regulate different Bcl2 family members. Mol Cell Biol (2004) 1.54

Elevated epidermal thymic stromal lymphopoietin levels establish an antitumor environment in the skin. Cancer Cell (2012) 1.54

Impairment of T and B cell development by treatment with a type I interferon. J Exp Med (1998) 1.54

IL-7 coordinates proliferation, differentiation and Tcra recombination during thymocyte β-selection. Nat Immunol (2015) 1.53

IL-7 receptor signals inhibit expression of transcription factors TCF-1, LEF-1, and RORgammat: impact on thymocyte development. J Exp Med (2004) 1.52

Activated T cells secrete an alternatively spliced form of common γ-chain that inhibits cytokine signaling and exacerbates inflammation. Immunity (2014) 1.51

Increased B-lymphopoiesis by interleukin 7 induces bone loss in mice with intact ovarian function: similarity to estrogen deficiency. Proc Natl Acad Sci U S A (1997) 1.51

Bcl11a is essential for lymphoid development and negatively regulates p53. J Exp Med (2012) 1.51

Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function. J Exp Med (2014) 1.49

The anti-apoptotic Bcl-2 family member Mcl-1 promotes T lymphocyte survival at multiple stages. J Immunol (2008) 1.49

Single-cell analysis of CD4+ T-cell differentiation reveals three major cell states and progressive acceleration of proliferation. Genome Biol (2016) 1.48

Interleukin-7, but not thymic stromal lymphopoietin, plays a key role in the T cell response to influenza A virus. PLoS One (2012) 1.47

CSL-MAML-dependent Notch1 signaling controls T lineage-specific IL-7R{alpha} gene expression in early human thymopoiesis and leukemia. J Exp Med (2009) 1.47

Enforced granulocyte/macrophage colony-stimulating factor signals do not support lymphopoiesis, but instruct lymphoid to myelomonocytic lineage conversion. J Exp Med (2003) 1.45

Identification of the earliest natural killer cell-committed progenitor in murine bone marrow. Blood (2011) 1.45

Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP. Blood (2008) 1.43

Feeding our immune system: impact on metabolism. Clin Dev Immunol (2008) 1.42

Precursor B cell receptor-dependent B cell proliferation and differentiation does not require the bone marrow or fetal liver environment. J Exp Med (2000) 1.41

Complementary signaling through flt3 and interleukin-7 receptor alpha is indispensable for fetal and adult B cell genesis. J Exp Med (2003) 1.39

Notch3 and pre-TCR interaction unveils distinct NF-kappaB pathways in T-cell development and leukemia. EMBO J (2006) 1.37

Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells. J Exp Med (1996) 1.36

The immune response to herpes simplex virus type 1 infection in susceptible mice is a major cause of central nervous system pathology resulting in fatal encephalitis. J Virol (2008) 1.36

Mutations in Igalpha (CD79a) result in a complete block in B-cell development. J Clin Invest (1999) 1.32

Cytokine signal transduction is suppressed in preselection double-positive thymocytes and restored by positive selection. J Exp Med (2006) 1.32

The GTPase Rho has a critical regulatory role in thymus development. EMBO J (1997) 1.32

Evidence implicating Gfi-1 and Pim-1 in pre-T-cell differentiation steps associated with beta-selection. EMBO J (1998) 1.32

CD127 and CD25 expression defines CD4+ T cell subsets that are differentially depleted during HIV infection. J Immunol (2008) 1.31

Involvement of transcription factors TCF-1 and GATA-3 in the initiation of the earliest step of T cell development in the thymus. J Exp Med (1996) 1.31

Articles cited by this

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature (1988) 20.36

Immune response in mice that lack the interferon-gamma receptor. Science (1993) 12.15

The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell (1990) 10.99

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J Exp Med (1991) 10.87

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell (1993) 9.84

Generation and analysis of interleukin-4 deficient mice. Science (1991) 8.80

Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages. Nature (1992) 7.66

Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans. Cell (1993) 6.83

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature (1991) 5.51

Stimulation of B-cell progenitors by cloned murine interleukin-7. Nature (1988) 5.50

Profound block in thymocyte development in mice lacking p56lck. Nature (1992) 5.48

Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor. Science (1993) 5.22

Survival of mononuclear phagocytes depends on a lineage-specific growth factor that the differentiated cells selectively destroy. Cell (1982) 5.19

CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells. J Exp Med (1993) 4.64

Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4. Science (1993) 4.39

Expression and function of the interleukin 7 receptor in murine lymphocytes. Proc Natl Acad Sci U S A (1993) 4.35

Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody. J Exp Med (1993) 3.38

Interleukin 7 production and function in stromal cell-dependent B cell development. J Exp Med (1989) 2.49

The alphas, betas, and kinases of cytokine receptor complexes. Cell (1993) 2.45

Regulation of hemopoiesis by bone marrow stromal cells and their products. Annu Rev Immunol (1990) 2.40

Murine interleukin 7 (IL-7) receptor. Characterization on an IL-7-dependent cell line. J Exp Med (1990) 2.37

Effect of IL-7 on the growth of fetal thymocytes in culture. J Immunol (1989) 2.11

IL-7 is a growth and maintenance factor for mature and immature thymocyte subsets. Int Immunol (1989) 2.10

The development of functionally responsive T cells. Adv Immunol (1992) 2.03

Murine B cell lymphopoiesis in long term culture. J Immunol Methods (1984) 1.98

Murine thymocytes proliferate in direct response to interleukin-7. Blood (1989) 1.86

Differentiation of hematopoietic stem cells in irradiated mouse thymic lobes. Kinetics and phenotype of progeny. J Immunol (1990) 1.80

Cutaneous lymphoproliferation and lymphomas in interleukin 7 transgenic mice. J Exp Med (1993) 1.76

Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoter. Mol Cell Biol (1991) 1.37

Distinctive growth requirements and gene expression patterns distinguish progenitor B cells from pre-B cells. J Exp Med (1993) 1.16

IL 7-induced T cell receptor-gamma gene expression by pre-T cells in murine fetal liver cultures. J Immunol (1992) 1.15

Status of kappa L chain gene rearrangements and c-kit and IL-7 receptor expression in stromal cell-dependent pre-B cells. J Immunol (1992) 1.02

Articles by these authors

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet (2001) 14.15

Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J Exp Med (2000) 9.78

A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature (1997) 8.59

Lymphokine control of in vivo immunoglobulin isotype selection. Annu Rev Immunol (1990) 7.93

Formation of stable preinitiation complexes between eukaryotic class B transcription factors and promoter sequences. Nature (1983) 7.22

Lung cancer mortality in the Mayo Lung Project: impact of extended follow-up. J Natl Cancer Inst (2000) 6.77

RANK is essential for osteoclast and lymph node development. Genes Dev (1999) 5.85

Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15. EMBO J (1994) 5.69

Distinct dendritic cell subsets differentially regulate the class of immune response in vivo. Proc Natl Acad Sci U S A (1999) 5.66

Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor. Science (1993) 5.22

Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells. Blood (2000) 5.06

Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo. Nat Med (1999) 4.92

Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB. Proc Natl Acad Sci U S A (1999) 4.40

TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation. J Immunol (1998) 4.32

Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency. Nat Genet (1998) 4.32

Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation. J Biol Chem (2001) 4.23

Characterization of the virA locus of Agrobacterium tumefaciens: a transcriptional regulator and host range determinant. EMBO J (1987) 4.22

Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily. Cell (1990) 4.15

Identification of a ligand for the c-kit proto-oncogene. Cell (1990) 4.04

Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor. EMBO J (1995) 3.59

Phenotypic and functional characterization of mice that lack the type I receptor for IL-1. J Immunol (1997) 3.56

Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: Formation of a functional heteromeric complex requires interleukin 7 receptor. J Exp Med (2000) 3.51

Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin. Nat Immunol (2000) 3.42

Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody. J Exp Med (1993) 3.38

Interleukin 10 and interferon gamma regulation of experimental Trypanosoma cruzi infection. J Exp Med (1992) 3.34

Humoral immune responses in CD40 ligand-deficient mice. J Exp Med (1994) 3.32

Regulation, linkage, and sequence of mouse metallothionein I and II genes. Mol Cell Biol (1984) 3.25

A new cytokine receptor superfamily. Trends Biochem Sci (1990) 3.24

Fas transduces activation signals in normal human T lymphocytes. J Exp Med (1993) 3.04

Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles. Cell (1990) 2.95

Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces. Neuron (2001) 2.92

Developmental pathways of dendritic cells in vivo: distinct function, phenotype, and localization of dendritic cell subsets in FLT3 ligand-treated mice. J Immunol (1997) 2.89

A thymic stromal cell line supports in vitro development of surface IgM+ B cells and produces a novel growth factor affecting B and T lineage cells. Exp Hematol (1994) 2.87

Induction of macrophage tumoricidal activity by granulocyte-macrophage colony-stimulating factor. Science (1986) 2.84

Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck). Mol Cell Biol (1988) 2.80

B cell precursor growth-promoting activity. Purification and characterization of a growth factor active on lymphocyte precursors. J Exp Med (1988) 2.64

Thymic stromal lymphopoietin: a cytokine that promotes the development of IgM+ B cells in vitro and signals via a novel mechanism. J Immunol (1999) 2.57

Novel protein-tyrosine kinase gene (hck) preferentially expressed in cells of hematopoietic origin. Mol Cell Biol (1987) 2.52

Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death. Development (1995) 2.46

Retained asymptomatic third molars and risk for second molar pathology. J Dent Res (2013) 2.43

Cytokine stimulation of multilineage hematopoiesis from immature human cells engrafted in SCID mice. Science (1992) 2.40

Beta 2-microglobulin-, CD8+ T-cell-deficient mice survive inoculation with high doses of vaccinia virus and exhibit altered IgG responses. Proc Natl Acad Sci U S A (1992) 2.37

Purification of Bacillus subtilis RNA polymerase with heparin-agarose. In vitro transcription of phi 29 DNA. J Biol Chem (1979) 2.35

Recombinant interleukin 7, pre-B cell growth factor, has costimulatory activity on purified mature T cells. J Exp Med (1989) 2.30

Computed tomographic diagnosis of Mycobacterium avium-intracellulare complex in patients with bronchiectasis. Chest (1994) 2.29

Polyglutamine-expanded ataxin-7 antagonizes CRX function and induces cone-rod dystrophy in a mouse model of SCA7. Neuron (2001) 2.29

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice. Nat Med (1999) 2.25

Molecular cloning and biological characterization of a novel murine lymphoid growth factor. J Exp Med (2000) 2.21

Cellular and molecular characterization of the scurfy mouse mutant. J Immunol (1999) 2.19

Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily. J Exp Med (1990) 2.12

Effect of IL-7 on the growth of fetal thymocytes in culture. J Immunol (1989) 2.11

IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation. J Immunol (1995) 2.10

Interleukin (IL)-4 is a major regulatory cytokine governing bioactive IL-12 production by mouse and human dendritic cells. J Exp Med (2000) 2.09

Characterization of human CD8+ T cells reactive with Mycobacterium tuberculosis-infected antigen-presenting cells. J Exp Med (1998) 2.06

Mesenchymal to epithelial conversion in rat metanephros is induced by LIF. Cell (1999) 2.04

Hematologic effects of flt3 ligand in vivo in mice. Blood (1996) 2.02

Granulocyte-macrophage colony-stimulating factor augments the primary antibody response by enhancing the function of antigen-presenting cells. J Immunol (1987) 2.00

Characterization of the human B cell stimulatory factor 1 receptor. J Exp Med (1987) 1.92

Effects of randomized assignment to a smoking cessation intervention and changes in smoking habits on respiratory symptoms in smokers with early chronic obstructive pulmonary disease: the Lung Health Study. Am J Med (1999) 1.91

Role of the major histocompatibility complex in T cell activation of B cell subpopulations Lyb-5+ and Lyb-5- B cell subpopulations differ in their requirement for major histocompatibility complex-restricted T cell recognition. J Exp Med (1981) 1.90

Characterization of the cell surface receptor for granulocyte-macrophage colony-stimulating factor. J Biol Chem (1986) 1.90

Rift Valley fever affecting humans in South Africa: a clinicopathological study. S Afr Med J (1977) 1.89

Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. J Biol Chem (1996) 1.89

Platypnea-orthodeoxia: clinical profile, diagnostic workup, management, and report of seven cases. Mayo Clin Proc (1984) 1.89

Response of the Photosynthetic Apparatus in Dunaliella salina (Green Algae) to Irradiance Stress. Plant Physiol (1990) 1.89

Soluble forms of CD40 inhibit biologic responses of human B cells. J Immunol (1992) 1.88

Molecular characterization of the human interleukin (IL)-17 receptor. Cytokine (1997) 1.87

Murine thymocytes proliferate in direct response to interleukin-7. Blood (1989) 1.86

Recombinant granulocyte/macrophage colony-stimulating factor activates macrophages to inhibit Trypanosoma cruzi and release hydrogen peroxide. Comparison with interferon gamma. J Exp Med (1987) 1.85

Interleukin-15: a novel anabolic cytokine for skeletal muscle. Endocrinology (1995) 1.85

cMpl ligand is a humoral regulator of megakaryocytopoiesis. Nature (1994) 1.85

The suppressive influences of human tumor necrosis factors on bone marrow hematopoietic progenitor cells from normal donors and patients with leukemia: synergism of tumor necrosis factor and interferon-gamma. J Immunol (1986) 1.85

IL-15, a novel T cell growth factor that shares activities and receptor components with IL-2. J Leukoc Biol (1995) 1.84

Requirement for stat5 in thymic stromal lymphopoietin-mediated signal transduction. J Immunol (1999) 1.84

A test of crystal structure prediction of small organic molecules. Acta Crystallogr B (2000) 1.84

Regulation of cytolytic cell populations from human peripheral blood by B cell stimulatory factor 1 (interleukin 4). J Exp Med (1987) 1.84

Characterization of the high-affinity cell-surface receptor for murine B-cell-stimulating factor 1. Proc Natl Acad Sci U S A (1987) 1.83

Developmental regulation of lck gene expression in T lymphocytes. J Exp Med (1991) 1.82

Characterization of thymic stromal-derived lymphopoietin (TSLP) in murine B cell development in vitro. Eur J Immunol (1996) 1.82

Interleukin 7 induces cytokine secretion and tumoricidal activity by human peripheral blood monocytes. J Exp Med (1991) 1.81

Development and characterization of antiserum to murine granulocyte-macrophage colony-stimulating factor. J Immunol (1986) 1.80

The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor. Mol Cell Biol (1991) 1.76

Impaired survival and proliferation in IL-7 receptor-deficient peripheral T cells. J Immunol (1996) 1.76

Regulation of cytolytic T-lymphocyte generation by B-cell stimulatory factor. Nature (1987) 1.75

Prospective evaluation of Roux-en-Y gastric bypass as primary operation for medically complicated obesity. Mayo Clin Proc (2000) 1.74

Disruption of thymocyte development and lymphomagenesis induced by SV40 T-antigen. Int Immunol (1990) 1.72

Specialized protein tyrosine kinase proto-oncogenes in hematopoietic cells. Biochim Biophys Acta (1989) 1.71

Mouse thymus dendritic cells: kinetics of development and changes in surface markers during maturation. Eur J Immunol (1995) 1.71

Growth inhibition of Francisella tularensis live vaccine strain by IFN-gamma-activated macrophages is mediated by reactive nitrogen intermediates derived from L-arginine metabolism. J Immunol (1992) 1.70

IL-10 mediates susceptibility to Trypanosoma cruzi infection. J Immunol (1994) 1.70