Morphological effects of lipopeptides against Aspergillus fumigatus correlate with activities against (1,3)-beta-D-glucan synthase.

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Published in Antimicrob Agents Chemother on July 01, 1994

Authors

M B Kurtz1, I B Heath, J Marrinan, S Dreikorn, J Onishi, C Douglas

Author Affiliations

1: Merck Research Laboratories, Rahway, New Jersey 07065.

Associated clinical trials:

Acetato de Caspofungin (Cancidas®) in the Treatment of Fungal Infection | NCT00388167

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Restricticin, a novel glycine-containing antifungal agent. J Antibiot (Tokyo) (1991) 0.78

Long-term respiratory support in children with giant omphalocele. Anaesth Intensive Care (2007) 0.78

Tillage, crop rotation, and organic amendment effect on changes in soil organic matter. Environ Pollut (2002) 0.78

Development of a Portable Acceleration Monitor Device and its clinical application for the Quantitative Gait Assessment of the Elderly. Conf Proc IEEE Eng Med Biol Soc (2005) 0.77

Ca(2+) shuttling in vesicles during tip growth in Neurospora crassa. Fungal Genet Biol (2001) 0.77

Nitric oxide levels and ciliary beat frequency in indigenous New Zealand children. Pediatr Pulmonol (2005) 0.77

[Effect of fat-controlled nutrition on patients with coronary diseases]. Med Welt (1965) 0.76

A tip-high gradient of a putative plasma membrane SNARE approximates the exocytotic gradient in hyphal apices of the fungus Neurospora crassa. Fungal Genet Biol (2000) 0.76

Novel ion channels in the protists, Mougeotia and Saprolegnia, using sub-gigaseals. FEBS Lett (1992) 0.76

Mycoplasma-like structures in the aquatic fungus Aphanomyces astaci. Science (1974) 0.76

Temporal analysis of the nuclear cycle by serial section electron microscopy of the fungus, Saprolegnia ferax. Eur J Cell Biol (1980) 0.76

[Radioimmunoassay for parathyroid hormone and its clinical application (author's transl)]. Horumon To Rinsho (1981) 0.75

[Studies of caries prevention in school health program. 2. Concentration of urinary fluoride following the use of fluoride mouth rinsing]. Gifu Shika Gakkai Zasshi (1979) 0.75

[Studies of caries prevention in school health program. 3. Application of caries activity test: improved Snyder test (author's transl)]. Gifu Shika Gakkai Zasshi (1980) 0.75

A comparison of techniques for localizing actin and tubulin in hyphae of Saprolegnia ferax. J Histochem Cytochem (1994) 0.75

Chytridiomycetous gut fungi, oft overlooked contributors to herbivore digestion. Can J Microbiol (1993) 0.75

[Studies of caries prevention in school health program. 1. Multiple caries-preventive procedure and effects in small scale school]. Gifu Shika Gakkai Zasshi (1979) 0.75

Ca(2+)-dependent polarization of axis establishment in the tip-growing organism, Saprolegnia ferax, by gradients of the ionophore A23187. Eur J Cell Biol (1995) 0.75

Managing a patient with an infected pacemaker site. Nurs Times (2001) 0.75

[Thyroid cancer and calcospherites: report on the detection of minute cancer of the thyroid gland. 1]. Iryo (1967) 0.75