Published in J Cell Biol on December 01, 1975
Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322. Proc Natl Acad Sci U S A (1978) 19.34
Transfer of proteins across membranes. II. Reconstitution of functional rough microsomes from heterologous components. J Cell Biol (1975) 15.47
Intracellular protein topogenesis. Proc Natl Acad Sci U S A (1980) 13.40
Compilation of published signal sequences. Nucleic Acids Res (1984) 11.33
A bacterial clone synthesizing proinsulin. Proc Natl Acad Sci U S A (1978) 10.23
Mechanisms for the incorporation of proteins in membranes and organelles. J Cell Biol (1982) 9.67
ampC cephalosporinase of Escherichia coli K-12 has a different evolutionary origin from that of beta-lactamases of the penicillinase type. Proc Natl Acad Sci U S A (1981) 8.21
Post-translational transport into intact chloroplasts of a precursor to the small subunit of ribulose-1,5-bisphosphate carboxylase. Proc Natl Acad Sci U S A (1978) 8.17
Translocation of proteins across the endoplasmic reticulum. I. Signal recognition protein (SRP) binds to in-vitro-assembled polysomes synthesizing secretory protein. J Cell Biol (1981) 7.40
Purification of a membrane-associated protein complex required for protein translocation across the endoplasmic reticulum. Proc Natl Acad Sci U S A (1980) 7.17
Cell fusion by Semliki Forest, influenza, and vesicular stomatitis viruses. J Cell Biol (1981) 7.07
Identification of a consensus motif for retention of transmembrane proteins in the endoplasmic reticulum. EMBO J (1990) 7.03
Sequence of a mouse germ-line gene for a variable region of an immunoglobulin light chain. Proc Natl Acad Sci U S A (1978) 6.80
Amino acid sequence for the peptide extension on the prolipoprotein of the Escherichia coli outer membrane. Proc Natl Acad Sci U S A (1977) 6.22
Mechanisms of protein localization. Microbiol Rev (1983) 6.12
In vitro synthesis and processing of a putative precursor for the small subunit of ribulose-1,5-bisphosphate carboxylase of Chlamydomonas reinhardtii. Proc Natl Acad Sci U S A (1977) 5.89
Myristylation is required for intracellular transport but not for assembly of D-type retrovirus capsids. J Virol (1987) 5.68
Extracellular enzyme synthesis in the genus Bacillus. Bacteriol Rev (1977) 5.67
Membrane assembly in vitro: synthesis, glycosylation, and asymmetric insertion of a transmembrane protein. Proc Natl Acad Sci U S A (1977) 5.51
Cloning and sequence analysis of rat bone sialoprotein (osteopontin) cDNA reveals an Arg-Gly-Asp cell-binding sequence. Proc Natl Acad Sci U S A (1986) 5.34
Synthesis and processing of an Escherichia coli alkaline phosphatase precursor in vitro. Proc Natl Acad Sci U S A (1977) 5.29
Import of proteins into mitochondria: precursor forms of the extramitochondrially made F1-ATPase subunits in yeast. Proc Natl Acad Sci U S A (1979) 5.21
pH-dependent fusion between the Semliki Forest virus membrane and liposomes. Proc Natl Acad Sci U S A (1980) 5.21
Homology in amino-terminal sequence of precursors to pancreatic secretory proteins. Proc Natl Acad Sci U S A (1975) 5.15
Predicting the orientation of eukaryotic membrane-spanning proteins. Proc Natl Acad Sci U S A (1989) 5.15
5' and 3' terminal nucleotide sequences of the RNA genome segments of influenza virus. Nucleic Acids Res (1979) 4.90
Molecular and biotechnological aspects of microbial proteases. Microbiol Mol Biol Rev (1998) 4.84
Translocation of proteins across the endoplasmic reticulum. II. Signal recognition protein (SRP) mediates the selective binding to microsomal membranes of in-vitro-assembled polysomes synthesizing secretory protein. J Cell Biol (1981) 4.80
The dengue viruses. Clin Microbiol Rev (1990) 4.72
Escherichia coli pleiotropic mutant that reduces amounts of several periplasmic and outer membrane proteins. J Bacteriol (1979) 4.69
Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells. Proc Natl Acad Sci U S A (1987) 4.53
A novel in vitro transcription-translation system: accurate and efficient synthesis of single proteins from cloned DNA sequences. EMBO J (1984) 4.50
ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization. Proc Natl Acad Sci U S A (2009) 4.46
A novel secretory pathway for interleukin-1 beta, a protein lacking a signal sequence. EMBO J (1990) 4.43
Cellular origin and ultrastructure of membranes induced during poliovirus infection. J Virol (1996) 4.41
Proteins of rough microsomal membranes related to ribosome binding. I. Identification of ribophorins I and II, membrane proteins characteristics of rough microsomes. J Cell Biol (1978) 4.33
Tryptic dissection and reconstitution of translocation activity for nascent presecretory proteins across microsomal membranes. Proc Natl Acad Sci U S A (1979) 4.22
Mutant defective in processing of an enzyme located in the lysosome-like vacuole of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1981) 4.20
Nascent prehormones are intermediates in the biosynthesis of authentic bovine pituitary growth hormone and prolactin. Proc Natl Acad Sci U S A (1977) 4.14
Multiple genes are required for proper insertion of secretory proteins into the endoplasmic reticulum in yeast. J Cell Biol (1989) 4.13
Messenger RNA for G1 protein of French bean seeds: Cell-free translation and product characterization. Proc Natl Acad Sci U S A (1978) 4.10
Separate pathways of maturation of the major structural proteins of vesicular stomatitis virus. J Virol (1977) 4.03
Cell-free synthesis of leaf protein: Identification of an apparent precursor of the small subunit of ribulose-1,5-bisphosphate carboxylase. Proc Natl Acad Sci U S A (1978) 3.92
Use of gene fusions to study outer membrane protein localization in Escherichia coli. Proc Natl Acad Sci U S A (1977) 3.78
Biogenesis of peroxisomes: intracellular site of synthesis of catalase and uricase. Proc Natl Acad Sci U S A (1978) 3.63
Secretory protein translocation in a yeast cell-free system can occur posttranslationally and requires ATP hydrolysis. J Cell Biol (1986) 3.62
Post-translational cleavage of presecretory proteins with an extract of rough microsomes from dog pancreas containing signal peptidase activity. Proc Natl Acad Sci U S A (1977) 3.54
Nucleotide sequence of the Akv env gene. J Virol (1982) 3.53
What drives the translocation of proteins? Proc Natl Acad Sci U S A (1992) 3.52
Detection of prokaryotic signal peptidase in an Escherichia coli membrane fraction: endoproteolytic cleavage of nascent f1 pre-coat protein. Proc Natl Acad Sci U S A (1978) 3.48
Fusion of Semliki forest virus with the plasma membrane can be induced by low pH. J Cell Biol (1980) 3.47
NH2-terminal amino acid sequences of precursor and mature forms of the ribulose-1,5-bisphosphate carboxylase small subunit from Chlamydomonas reinhardtii. J Cell Biol (1979) 3.47
Role of positive charge on the amino-terminal region of the signal peptide in protein secretion across the membrane. Proc Natl Acad Sci U S A (1982) 3.44
Bacterial toxins: cellular mechanisms of action. Microbiol Rev (1984) 3.42
Cell-free synthesis of rat preproinsulins: characterization and partial amino acid sequence determination. Proc Natl Acad Sci U S A (1976) 3.41
An Escherichia coli mutant with an amino acid alteration within the signal sequence of outer membrane prolipoprotein. Proc Natl Acad Sci U S A (1978) 3.33
Assembly and secretion of heavy chains that do not associate posttranslationally with immunoglobulin heavy chain-binding protein. J Cell Biol (1987) 3.33
Biological activity of cloned Moloney sarcoma virus DNA: Terminally redundant sequences may enhance transformation efficiency. Proc Natl Acad Sci U S A (1980) 3.29
Cell-free translation of the mRNAs for the heavy and light chains of HLA-A and HLA-B antigens. Proc Natl Acad Sci U S A (1979) 3.29
Cell-free synthesis of fish preproinsulin, and processing by heterologous mammalian microsomal membranes. Proc Natl Acad Sci U S A (1977) 3.27
Role of primary structure and disulfide bond formation in beta-lactamase secretion. J Bacteriol (1983) 3.26
Enzymology, genetics, and regulation of membrane phospholipid synthesis in Escherichia coli. Microbiol Rev (1978) 3.26
Topology analysis of the SecY protein, an integral membrane protein involved in protein export in Escherichia coli. EMBO J (1987) 3.24
Nucleotide sequence of the feline retroviral oncogene v-fms shows unexpected homology with oncogenes encoding tyrosine-specific protein kinases. Proc Natl Acad Sci U S A (1984) 3.21
Transcriptome-wide regulation of pre-mRNA splicing and mRNA localization by muscleblind proteins. Cell (2012) 3.20
Elongation arrest is not a prerequisite for secretory protein translocation across the microsomal membrane. J Cell Biol (1985) 3.19
Extracellular labeling of nascent polypeptides traversing the membrane of Escherichia coli. Proc Natl Acad Sci U S A (1977) 3.16
Binding of different dimeric forms of PDGF to human fibroblasts: evidence for two separate receptor types. EMBO J (1988) 3.16
Membrane biogenesis: cotranslational integration of the bacteriophage f1 coat protein into an Escherichia coli membrane fraction. Proc Natl Acad Sci U S A (1979) 3.15
Sequence-specific antibodies show that maturation of Moloney leukemia virus envelope polyprotein involves removal of a COOH-terminal peptide. Proc Natl Acad Sci U S A (1981) 3.13
Coupled cell-free synthesis, segregation, and core glycosylation of a secretory protein. Proc Natl Acad Sci U S A (1978) 3.11
A membrane component essential for vectorial translocation of nascent proteins across the endoplasmic reticulum: requirements for its extraction and reassociation with the membrane. J Cell Biol (1980) 3.09
Mouse histocompatibility genes: structure and organisation of a Kd gene. EMBO J (1983) 3.07
Deletion mutants of Moloney murine leukemia virus which lack glycosylated gag protein are replication competent. J Virol (1983) 3.04
Nucleotide and deduced amino acid sequences of Torpedo californica acetylcholine receptor gamma subunit. Proc Natl Acad Sci U S A (1983) 3.01
Effect of tunicamycin on herpes simplex virus glycoproteins and infectious virus production. J Virol (1980) 2.99
pH-induced alterations in the fusogenic spike protein of Semliki Forest virus. J Cell Biol (1985) 2.98
Complete mRNA coding sequence of the acetylcholine binding alpha-subunit of Torpedo marmorata acetylcholine receptor: a model for the transmembrane organization of the polypeptide chain. Proc Natl Acad Sci U S A (1983) 2.98
Membrane fusion activity of influenza virus. EMBO J (1982) 2.97
A mechanism of protein localization: the signal hypothesis and bacteria. J Cell Biol (1980) 2.91
Precursors of three exported proteins in Escherichia coli. Proc Natl Acad Sci U S A (1978) 2.91
The DNA sequence of the gene and genetic control sites for the excreted B. subtilis enzyme beta-glucanase. Nucleic Acids Res (1984) 2.90
cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules. Mol Cell Biol (1988) 2.88
Fibril in senile systemic amyloidosis is derived from normal transthyretin. Proc Natl Acad Sci U S A (1990) 2.87
Vesicular stomatitis virus glycoprotein is anchored in the viral membrane by a hydrophobic domain near the COOH terminus. Proc Natl Acad Sci U S A (1980) 2.87
The nucleotide sequence of the yeast PHO5 gene: a putative precursor of repressible acid phosphatase contains a signal peptide. Nucleic Acids Res (1983) 2.83
Channels formed by botulinum, tetanus, and diphtheria toxins in planar lipid bilayers: relevance to translocation of proteins across membranes. Proc Natl Acad Sci U S A (1985) 2.80
mRNA-dependent synthesis of authentic precursor to human placental lactogen: conversion to its mature hormone form in ascites cell-free extracts. Proc Natl Acad Sci U S A (1976) 2.80
Eukaryotic signal sequence transports insulin antigen in Escherichia coli. Proc Natl Acad Sci U S A (1980) 2.79
Identification of peroxisomal targeting signals located at the carboxy terminus of four peroxisomal proteins. J Cell Biol (1988) 2.77
The c-sis gene encodes a precursor of the B chain of platelet-derived growth factor. EMBO J (1984) 2.77
Expression of simian virus 40-rat preproinsulin recombinants in monkey kidney cells: use of preproinsulin RNA processing signals. Proc Natl Acad Sci U S A (1981) 2.76
Cloning structural gene sacB, which codes for exoenzyme levansucrase of Bacillus subtilis: expression of the gene in Escherichia coli. J Bacteriol (1983) 2.73
A role of the latent TGF-beta 1-binding protein in the assembly and secretion of TGF-beta 1. EMBO J (1991) 2.73
Yeast secretory mutants that block the formation of active cell surface enzymes. J Cell Biol (1984) 2.71
An oligomeric protein is imported into peroxisomes in vivo. J Cell Biol (1994) 2.71
A signal sequence is not required for protein export in prlA mutants of Escherichia coli. EMBO J (1993) 2.70
Complete amino acid sequence of human vitronectin deduced from cDNA. Similarity of cell attachment sites in vitronectin and fibronectin. EMBO J (1985) 2.69
gag-Related polyproteins of Moloney murine leukemia virus: evidence for independent synthesis of glycosylated and unglycosylated forms. J Virol (1979) 2.68
Purification of microsomal signal peptidase as a complex. Proc Natl Acad Sci U S A (1986) 2.67
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A possible precursor of immunoglobulin light chains. Nat New Biol (1972) 11.03
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Dissociation of mammalian polyribosomes into subunits by puromycin. Proc Natl Acad Sci U S A (1971) 6.77
Ribosomal-membrane interaction: in vitro binding of ribosomes to microsomal membranes. J Mol Biol (1974) 5.75
Controlled proteolysis of nascent polypeptides in rat liver cell fractions. II. Location of the polypeptides in rough microsomes. J Cell Biol (1970) 5.72
Vectorial discharge of peptides released by puromycin from attached ribosomes. Proc Natl Acad Sci U S A (1966) 5.69
Purification and properties of biologically active messenger RNA for a myeloma light chain. Proc Natl Acad Sci U S A (1972) 5.28
Synthesis and transfer of amylase in pigeon pancreatic micromosomes. J Biol Chem (1966) 5.28
Controlled proteolysis of nascent polypeptides in rat liver cell fractions. I. Location of the polypeptides within ribosomes. J Cell Biol (1970) 5.08
Studies on free and membrane-bound ribosomes in rat liver. I. Distribution as related to total cellular RNA. J Mol Biol (1967) 4.71
Biologically and chemically pure mRNA coding for a mouse immunoglobulin L-chain prepared with the aid of antibodies and immobilized oligothymidine. Proc Natl Acad Sci U S A (1973) 4.02
Cytoplasmic type 80S ribosomes associated with yeast mitochondria. IV. Attachment of ribosomes to the outer membrane of isolated mitochondria. J Cell Biol (1975) 3.82
Initiation of hemoglobin synthesis. Specific inhibition by antibiotics and bacteriophage ribonucleic acid. Biochemistry (1971) 3.50
Purification of 14S messenger RNA of immunoglobulin light chain that codes for a possible light-chain precursor. Proc Natl Acad Sci U S A (1973) 3.25
Electrophoretically homogeneous myeloma light chain mRNA and its translation in vitro. Biochem Biophys Res Commun (1973) 2.42
Cell-free translation of immunoglobulin messenger RNA from MOPC-315 plasmacytoma and MOPC-315 NR, a variant synthesizing only light chain. Proc Natl Acad Sci U S A (1975) 2.37
Use of eukaryotic native small ribosomal subunits for the translation of globin messenger RNA. Proc Natl Acad Sci U S A (1974) 2.27
In vitro exchange of ribosomal subunits between free and membrane-bound ribosomes. J Mol Biol (1973) 2.22
Translation of immunoglobulin mRNAs in a wheat germ cell-free system. Mol Biol Rep (1974) 2.11
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Differences in the ribosomal protein of free and membrane bound polysomes of chick embryo cells. Biochem Biophys Res Commun (1970) 1.93
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Evidence for heterogeneity of ribosomes within the HeLa cell. J Biol Chem (1975) 1.82
The submicrosomal distribution of radioactive proteins released by puromycin from the bound ribosomes of rat liver microsomes labelled in vitro. Biochim Biophys Acta (1972) 1.80
Transfer of proteins across membranes. II. Reconstitution of functional rough microsomes from heterologous components. J Cell Biol (1975) 15.47
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70K heat shock related proteins stimulate protein translocation into microsomes. Nature (1988) 9.60
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The GTP-binding protein Ran/TC4 is required for protein import into the nucleus. Nature (1993) 7.80
Signal recognition particle contains a 7S RNA essential for protein translocation across the endoplasmic reticulum. Nature (1982) 7.80
The nuclear envelope lamina is reversibly depolymerized during mitosis. Cell (1980) 7.67
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Purification of a membrane-associated protein complex required for protein translocation across the endoplasmic reticulum. Proc Natl Acad Sci U S A (1980) 7.17
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Immunocytochemical localization of the major polypeptides of the nuclear pore complex-lamina fraction. Interphase and mitotic distribution. J Cell Biol (1978) 6.29
In vitro synthesis and processing of a putative precursor for the small subunit of ribulose-1,5-bisphosphate carboxylase of Chlamydomonas reinhardtii. Proc Natl Acad Sci U S A (1977) 5.89
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Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha. Cell (1998) 5.27
Import of proteins into mitochondria: precursor forms of the extramitochondrially made F1-ATPase subunits in yeast. Proc Natl Acad Sci U S A (1979) 5.21
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Homology in amino-terminal sequence of precursors to pancreatic secretory proteins. Proc Natl Acad Sci U S A (1975) 5.15
Controlled proteolysis of nascent polypeptides in rat liver cell fractions. I. Location of the polypeptides within ribosomes. J Cell Biol (1970) 5.08
cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins. Proc Natl Acad Sci U S A (1986) 5.07
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The ubiquitin-like protein Smt3p is activated for conjugation to other proteins by an Aos1p/Uba2p heterodimer. EMBO J (1997) 4.80
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Nup358, a cytoplasmically exposed nucleoporin with peptide repeats, Ran-GTP binding sites, zinc fingers, a cyclophilin A homologous domain, and a leucine-rich region. J Biol Chem (1995) 4.50
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A signal sequence for the insertion of a transmembrane glycoprotein. Similarities to the signals of secretory proteins in primary structure and function. J Biol Chem (1978) 4.43
Identification and characterization of a yeast nucleolar protein that is similar to a rat liver nucleolar protein. J Cell Biol (1988) 4.42
Tryptic dissection and reconstitution of translocation activity for nascent presecretory proteins across microsomal membranes. Proc Natl Acad Sci U S A (1979) 4.22
A T5 promoter-based transcription-translation system for the analysis of proteins in vitro and in vivo. Methods Enzymol (1987) 4.21
Nascent prehormones are intermediates in the biosynthesis of authentic bovine pituitary growth hormone and prolactin. Proc Natl Acad Sci U S A (1977) 4.14
Protein translocation across the endoplasmic reticulum. I. Detection in the microsomal membrane of a receptor for the signal recognition particle. J Cell Biol (1982) 4.10
Chicken ovalbumin contains an internal signal sequence. Nature (1979) 4.06
The two steps of nuclear import, targeting to the nuclear envelope and translocation through the nuclear pore, require different cytosolic factors. Cell (1992) 4.05
Homology of 54K protein of signal-recognition particle, docking protein and two E. coli proteins with putative GTP-binding domains. Nature (1989) 4.05
Immunoprecipitation of proteins from cell-free translations. Methods Enzymol (1983) 4.04
Isolation and characterization of a proteinaceous subnuclear fraction composed of nuclear matrix, peripheral lamina, and nuclear pore complexes from embryos of Drosophila melanogaster. J Cell Biol (1982) 4.03
A nuclear pore complex protein that contains zinc finger motifs, binds DNA, and faces the nucleoplasm. Cell (1993) 3.98
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Nuclear pore complex contains a family of glycoproteins that includes p62: glycosylation through a previously unidentified cellular pathway. Proc Natl Acad Sci U S A (1987) 3.95
MHC class II-associated invariant chain contains a sorting signal for endosomal compartments. Cell (1990) 3.85
Efficient cleavage and segregation of nascent presecretory proteins in a reticulocyte lysate supplemented with microsomal membranes. J Biol Chem (1978) 3.80
Ubc9p is the conjugating enzyme for the ubiquitin-like protein Smt3p. J Biol Chem (1997) 3.76
Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins. Proc Natl Acad Sci U S A (1995) 3.73
Kap104p: a karyopherin involved in the nuclear transport of messenger RNA binding proteins. Science (1996) 3.70
A distinct nuclear import pathway used by ribosomal proteins. Cell (1997) 3.66
SUMO-1 modification and its role in targeting the Ran GTPase-activating protein, RanGAP1, to the nuclear pore complex. J Cell Biol (1998) 3.65
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Biogenesis of peroxisomes: intracellular site of synthesis of catalase and uricase. Proc Natl Acad Sci U S A (1978) 3.63
Secretory protein translocation in a yeast cell-free system can occur posttranslationally and requires ATP hydrolysis. J Cell Biol (1986) 3.62
A new family of yeast nuclear pore complex proteins. J Cell Biol (1992) 3.60
Post-translational cleavage of presecretory proteins with an extract of rough microsomes from dog pancreas containing signal peptidase activity. Proc Natl Acad Sci U S A (1977) 3.54
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Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes. Proc Natl Acad Sci U S A (1995) 3.52
Isolation and characterization of the intracellular MHC class II compartment. Nature (1994) 3.50
Translocation of secretory proteins across the microsomal membrane occurs through an environment accessible to aqueous perturbants. Cell (1985) 3.50
Detection of prokaryotic signal peptidase in an Escherichia coli membrane fraction: endoproteolytic cleavage of nascent f1 pre-coat protein. Proc Natl Acad Sci U S A (1978) 3.48
NH2-terminal amino acid sequences of precursor and mature forms of the ribulose-1,5-bisphosphate carboxylase small subunit from Chlamydomonas reinhardtii. J Cell Biol (1979) 3.47
Disassembly and reconstitution of signal recognition particle. Cell (1983) 3.45
Protein transfer across microsomal membranes reassembled from separated membrane components. Nature (1978) 3.39
A protein of molecular weight 78,000 bound to the polyadenylate region of eukaryotic messenger RNAs. Proc Natl Acad Sci U S A (1973) 3.38
Membrane insertion and oligomeric assembly of HLA-DR histocompatibility antigens. Cell (1982) 3.36
The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains. Nature (1984) 3.33
A lamin B receptor in the nuclear envelope. Proc Natl Acad Sci U S A (1988) 3.28
Cell-free synthesis of fish preproinsulin, and processing by heterologous mammalian microsomal membranes. Proc Natl Acad Sci U S A (1977) 3.27
Isolation of the yeast nuclear pore complex. J Cell Biol (1993) 3.27
Isolation of components of the chloroplast protein import machinery. Science (1994) 3.24
The human CAN protein, a putative oncogene product associated with myeloid leukemogenesis, is a nuclear pore complex protein that faces the cytoplasm. Proc Natl Acad Sci U S A (1994) 3.19
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Assembly of the Semliki Forest virus membrane glycoproteins in the membrane of the endoplasmic reticulum in vitro. J Mol Biol (1978) 3.16
Membrane biogenesis: cotranslational integration of the bacteriophage f1 coat protein into an Escherichia coli membrane fraction. Proc Natl Acad Sci U S A (1979) 3.15
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