Published in Proc Natl Acad Sci U S A on April 26, 1994
Genome-wide search for loss of heterozygosity in transgenic mouse tumors reveals candidate tumor suppressor genes on chromosomes 9 and 16. Proc Natl Acad Sci U S A (1994) 1.02
Mouse mammary tumor virus/v-Ha-ras transgene-induced mammary tumors exhibit strain-specific allelic loss on mouse chromosome 4. Proc Natl Acad Sci U S A (1997) 0.88
Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression. Carcinogenesis (2015) 0.77
Endogenous Mtv-encoded superantigens are not required for development of murine AIDS. J Virol (1996) 0.76
An AC-repeat adjacent to mouse Cdkn2B allows the detection of specific allelic losses in the p15INK4b and p16INK4a tumor suppressor genes. Mamm Genome (1998) 0.75
Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am J Hum Genet (1980) 75.25
A genetic model for colorectal tumorigenesis. Cell (1990) 44.37
p53 mutations in human cancers. Science (1991) 31.96
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature (1992) 25.54
Mutations in the p53 gene occur in diverse human tumour types. Nature (1989) 13.62
A genetic map of the mouse suitable for typing intraspecific crosses. Genetics (1992) 8.53
Familial breast-ovarian cancer locus on chromosome 17q12-q23. Lancet (1991) 6.61
Tumor suppressor genes. Science (1991) 5.72
Allelotype of colorectal carcinomas. Science (1989) 5.54
Genetic analysis of autoimmune type 1 diabetes mellitus in mice. Nature (1991) 4.27
A genetic linkage map of the mouse: current applications and future prospects. Science (1993) 4.24
Closing in on a breast cancer gene on chromosome 17q. Am J Hum Genet (1992) 3.89
Towards construction of a high resolution map of the mouse genome using PCR-analysed microsatellites. Nucleic Acids Res (1990) 3.59
Identification of the p53 protein domain involved in formation of the simian virus 40 large T-antigen-p53 protein complex. J Virol (1986) 3.04
Assignment of a locus for familial melanoma, MLM, to chromosome 9p13-p22. Science (1992) 2.89
Allelotype of breast cancer: cumulative allele losses promote tumor progression in primary breast cancer. Cancer Res (1990) 2.57
Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7. Cell (1990) 2.16
Isolation and characterization of the beta and epsilon subunit genes of mouse muscle acetylcholine receptor. J Biol Chem (1989) 1.94
Detection of frequent allelic loss on proximal chromosome 17q in sporadic breast carcinoma using microsatellite length polymorphisms. Cancer Res (1992) 1.93
Dissecting multistep tumorigenesis in transgenic mice. Annu Rev Genet (1988) 1.79
Additional microsatellite markers for mouse genome mapping. Mamm Genome (1991) 1.79
Allelotype of human ovarian cancer. Cancer Res (1991) 1.79
Mapping of murine interferon-alpha genes to chromosome 4. Gene (1983) 1.79
Oncogene activation in chemical carcinogenesis. Adv Cancer Res (1988) 1.72
Accumulation of genetic alterations and progression of primary breast cancer. Cancer Res (1991) 1.70
Ecotropic murine leukemia virus DNA content of normal and lymphomatous tissues of BXH-2 recombinant inbred mice. J Virol (1982) 1.65
Homozygous deletions within human chromosome band 9p21 in melanoma. Proc Natl Acad Sci U S A (1992) 1.58
Carcinogenicity of 1,3-butadiene in C57BL/6 x C3H F1 mice at low exposure concentrations. Cancer Res (1990) 1.45
Allelotype of non-small cell lung carcinoma--comparison between loss of heterozygosity in squamous cell carcinoma and adenocarcinoma. Cancer Res (1992) 1.41
The analysis of malignancy by cell fusion: the position in 1988. Cancer Res (1988) 1.38
Loss of heterozygosity and mutational alterations of the p53 gene in skin tumours of interspecific hybrid mice. Oncogene (1991) 1.32
The recombinant congenic strains for analysis of multigenic traits: genetic composition. FASEB J (1992) 1.26
Characterization of p53 mutations in methylene chloride-induced lung tumors from B6C3F1 mice. Carcinogenesis (1993) 1.09
Homozygous loss of the interferon genes defines the critical region on 9p that is deleted in lung cancers. Cancer Res (1993) 1.08
Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. Genomics (1992) 1.03
Alterations of the p53 tumor suppressor gene during mouse skin tumor progression. Cancer Res (1991) 1.02
Expression from the transferrin gene promoter in transgenic mice. Mol Cell Biol (1989) 0.99
Segregation patterns of endogenous mouse mammary tumor viruses in five recombinant inbred strain sets. J Virol (1990) 0.93
Genetic and epigenetic losses of heterozygosity in cancer predisposition and progression. Adv Cancer Res (1990) 0.93
Mouse chromosome 4. Mamm Genome (1992) 0.90
Overlapping loss of heterozygosity by mitotic recombination on mouse chromosome 7F1-ter in skin carcinogenesis. Proc Natl Acad Sci U S A (1991) 0.89
The murine retinoblastoma homolog maps to chromosome 14 near Es-10. Genomics (1989) 0.87
Activation of K-ras by codon 13 mutations in C57BL/6 X C3H F1 mouse tumors induced by exposure to 1,3-butadiene. Cancer Res (1990) 0.87
Murine p53 intron sequences 5-8 and their use in polymerase chain reaction/direct sequencing analysis of p53 mutations in CD-1 mouse liver and lung tumors. Mol Carcinog (1992) 0.84
A family of type I keratin genes and the homeobox-2 gene complex are closely linked to the rex locus on mouse chromosome 11. Genomics (1989) 0.84
Mouse chromosome 14. Mamm Genome (1992) 0.83
Mapping of the mouse atrial natriuretic factor gene. Evidence for tight linkage to the Fv-1 locus. Hypertension (1987) 0.82
Mouse chromosome 9. Mamm Genome (1992) 0.82
The Mos proto-oncogene maps near the centromere on mouse chromosome 4. Genomics (1989) 0.81
Mouse chromosome 11. Mamm Genome (1992) 0.76
Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science (1999) 83.27
A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature (2001) 42.18
Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet (1996) 39.80
Interpreting patterns of gene expression with self-organizing maps: methods and application to hematopoietic differentiation. Proc Natl Acad Sci U S A (1999) 39.79
A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science (1994) 36.53
Construction of multilocus genetic linkage maps in humans. Proc Natl Acad Sci U S A (1987) 35.83
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature (2002) 28.79
Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. Proc Natl Acad Sci U S A (2001) 24.34
Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat Genet (1999) 24.24
Dissecting the regulatory circuitry of a eukaryotic genome. Cell (1998) 23.62
Resolution of quantitative traits into Mendelian factors by using a complete linkage map of restriction fragment length polymorphisms. Nature (1988) 23.48
High-resolution haplotype structure in the human genome. Nat Genet (2001) 20.51
Multiclass cancer diagnosis using tumor gene expression signatures. Proc Natl Acad Sci U S A (2001) 19.30
An SNP map of the human genome generated by reduced representation shotgun sequencing. Nature (2000) 19.19
Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome. Science (1998) 18.23
An STS-based map of the human genome. Science (1995) 17.72
Mendelian factors underlying quantitative traits in tomato: comparison across species, generations, and environments. Genetics (1991) 17.40
Linkage disequilibrium in the human genome. Nature (2001) 17.24
On the allelic spectrum of human disease. Trends Genet (2001) 16.26
The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet (2000) 15.19
A gene map of the human genome. Science (1996) 14.32
Restriction fragment length polymorphism linkage map for Arabidopsis thaliana. Proc Natl Acad Sci U S A (1988) 13.85
Identification of genetic factors contributing to heterosis in a hybrid from two elite maize inbred lines using molecular markers. Genetics (1992) 13.63
A genetic linkage map of the human genome. Cell (1987) 13.37
Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am J Hum Genet (1995) 12.78
Positive natural selection in the human lineage. Science (2006) 12.55
A physical map of 30,000 human genes. Science (1998) 12.43
Homozygosity mapping: a way to map human recessive traits with the DNA of inbred children. Science (1987) 12.20
Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease. Nat Genet (2001) 11.12
Genomic analysis of metastasis reveals an essential role for RhoC. Nature (2000) 10.11
Systematic detection of errors in genetic linkage data. Genomics (1992) 10.06
Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat. Cell (1991) 9.99
Ploidy regulation of gene expression. Science (1999) 9.98
Recognition of related proteins by iterative template refinement (ITR). Protein Sci (1994) 9.67
Remodeling of yeast genome expression in response to environmental changes. Mol Biol Cell (2001) 9.63
Strategies for studying heterogeneous genetic traits in humans by using a linkage map of restriction fragment length polymorphisms. Proc Natl Acad Sci U S A (1986) 9.51
A genetic map of the mouse suitable for typing intraspecific crosses. Genetics (1992) 8.53
Human and mouse gene structure: comparative analysis and application to exon prediction. Genome Res (2000) 8.28
Mapping complex genetic traits in humans: new methods using a complete RFLP linkage map. Cold Spring Harb Symp Quant Biol (1986) 8.22
Chemosensitivity prediction by transcriptional profiling. Proc Natl Acad Sci U S A (2001) 7.51
BRCA1 mutations in primary breast and ovarian carcinomas. Science (1994) 6.81
Rapid multipoint linkage analysis of recessive traits in nuclear families, including homozygosity mapping. Am J Hum Genet (1995) 6.51
Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion. Proc Natl Acad Sci U S A (2000) 6.30
The plasticity of dendritic cell responses to pathogens and their components. Science (2001) 5.58
Research on DNA typing catching up with courtroom application. Am J Hum Genet (1991) 5.28
Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes. Cell (1999) 4.97
Determination of ancestral alleles for human single-nucleotide polymorphisms using high-density oligonucleotide arrays. Nat Genet (1999) 4.79
Chromosomal landscape of nucleosome-dependent gene expression and silencing in yeast. Nature (1999) 4.71
Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse. Cell (1993) 4.66
Large-scale discovery and genotyping of single-nucleotide polymorphisms in the mouse. Nat Genet (2000) 4.66
A nonparametric approach for mapping quantitative trait loci. Genetics (1995) 4.49
A high frequency of sequence alterations is due to formalin fixation of archival specimens. Am J Pathol (1999) 4.43
Genome sequence, comparative analysis, and population genetics of the domestic horse. Science (2009) 4.41
Loss-of-heterozygosity analysis of small-cell lung carcinomas using single-nucleotide polymorphism arrays. Nat Biotechnol (2000) 4.10
Analysing complex genetic traits with chromosome substitution strains. Nat Genet (2000) 3.92
Genetic analysis of the fungus, Bremia lactucae, using restriction fragment length polymorphisms. Genetics (1988) 3.92
Faster multipoint linkage analysis using Fourier transforms. J Comput Biol (1998) 3.87
Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor. Mol Psychiatry (2002) 3.78
Distinct physiological states of Plasmodium falciparum in malaria-infected patients. Nature (2007) 3.69
Mutation analysis of the BRCA2 gene in 49 site-specific breast cancer families. Nat Genet (1996) 3.56
Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci. Am J Hum Genet (2000) 3.52
ARSACS, a spastic ataxia common in northeastern Québec, is caused by mutations in a new gene encoding an 11.5-kb ORF. Nat Genet (2000) 3.17
BRCA2 mutations in primary breast and ovarian cancers. Nat Genet (1996) 2.91
Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis. Nat Genet (1997) 2.91
High-resolution genetic mapping of complex traits. Am J Hum Genet (1995) 2.89
Differential expression of cyclooxygenase 2 in human colorectal cancer. Gut (1999) 2.62
Disruption of the nuclear hormone receptor RORalpha in staggerer mice. Nature (1996) 2.58
Genome-wide search for asthma susceptibility loci in a founder population. The Collaborative Study on the Genetics of Asthma. Hum Mol Genet (1998) 2.57
Genomewide linkage analysis of stature in multiple populations reveals several regions with evidence of linkage to adult height. Am J Hum Genet (2001) 2.50
Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families. Nat Genet (1996) 2.48
Mutations in the human delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis. Nat Genet (2000) 2.28
A radiation hybrid map of mouse genes. Nat Genet (2001) 2.03
Effects of medical research on health care and economy. Science (1999) 1.99
Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat. Nat Genet (1996) 1.96
The mouse pudgy mutation disrupts Delta homologue Dll3 and initiation of early somite boundaries. Nat Genet (1998) 1.96
Two loci on chromosomes 2 and X for premature coronary heart disease identified in early- and late-settlement populations of Finland. Am J Hum Genet (2000) 1.93
Detection of frequent allelic loss on proximal chromosome 17q in sporadic breast carcinoma using microsatellite length polymorphisms. Cancer Res (1992) 1.93
A genetic linkage map of 27 loci from PND to FY on the short arm of human chromosome I. Am J Hum Genet (1988) 1.92
Effectors of a developmental mitogen-activated protein kinase cascade revealed by expression signatures of signaling mutants. Proc Natl Acad Sci U S A (1999) 1.88
Genetic dissection of autoimmune type I diabetes in the BB rat. Nat Genet (1992) 1.87
Genetic control of serum IgE levels and asthma: linkage and linkage disequilibrium studies in an isolated population. Hum Mol Genet (1997) 1.82
Lower-than-expected linkage disequilibrium between tightly linked markers in humans suggests a role for gene conversion. Am J Hum Genet (2001) 1.80
Ducky mouse phenotype of epilepsy and ataxia is associated with mutations in the Cacna2d2 gene and decreased calcium channel current in cerebellar Purkinje cells. J Neurosci (2001) 1.77
SBE-TAGS: an array-based method for efficient single-nucleotide polymorphism genotyping. Proc Natl Acad Sci U S A (2000) 1.74
The 1.4-Mb CMT1A duplication/HNPP deletion genomic region reveals unique genome architectural features and provides insights into the recent evolution of new genes. Genome Res (2001) 1.72
Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice. Nat Genet (1995) 1.70
Extracerebral organ dysfunction and neurologic outcome after aneurysmal subarachnoid hemorrhage. Crit Care Med (1999) 1.62
Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat. Nat Genet (1996) 1.61
Environmental risk factors for Parkinson's disease and parkinsonism: the Geoparkinson study. Occup Environ Med (2007) 1.60
Direct isolation of polymorphic markers linked to a trait by genetically directed representational difference analysis. Nat Genet (1994) 1.59
CLN5, a novel gene encoding a putative transmembrane protein mutated in Finnish variant late infantile neuronal ceroid lipofuscinosis. Nat Genet (1998) 1.58
Construction of a large-insert yeast artificial chromosome library of the mouse genome. Mamm Genome (1993) 1.58
Genomewide scan of multiple sclerosis in Finnish multiplex families. Am J Hum Genet (1997) 1.57
Genomic mapping by anchoring random clones: a mathematical analysis. Genomics (1991) 1.52
Terminal repetitive sequences in herpesvirus saimiri virion DNA. J Virol (1985) 1.51
Campomelic dysplasia translocation breakpoints are scattered over 1 Mb proximal to SOX9: evidence for an extended control region. Am J Hum Genet (1999) 1.47
Tumor suppressor loci on mouse chromosomes 9 and 16 are lost at distinct stages of tumorigenesis in a transgenic model of islet cell carcinoma. Cancer Res (1995) 1.47
Mom1 is a semi-dominant modifier of intestinal adenoma size and multiplicity in Min/+ mice. Genetics (1996) 1.45