Published in Proc Natl Acad Sci U S A on April 26, 1994
Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature (2010) 11.24
CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma. Proc Natl Acad Sci U S A (1996) 5.26
Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure. Nature (2012) 4.46
A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA. Blood (2007) 3.09
Over- and underrepresentation of short DNA words in herpesvirus genomes. J Comput Biol (1996) 2.48
Genome signature comparisons among prokaryote, plasmid, and mitochondrial DNA. Proc Natl Acad Sci U S A (1999) 2.38
Compositional differences within and between eukaryotic genomes. Proc Natl Acad Sci U S A (1997) 2.35
DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria. Proc Natl Acad Sci U S A (2011) 2.21
CpG DNA as a vaccine adjuvant. Expert Rev Vaccines (2011) 2.17
Patterns of evolution and host gene mimicry in influenza and other RNA viruses. PLoS Pathog (2008) 1.96
Virus-host coevolution: common patterns of nucleotide motif usage in Flaviviridae and their hosts. PLoS One (2009) 1.44
Toll-like receptors and corneal innate immunity. Curr Mol Med (2006) 1.44
Complete mitochondrial DNA sequence of the eastern oyster Crassostrea virginica. Mar Biotechnol (NY) (2005) 1.26
Which bacterium is the ancestor of the animal mitochondrial genome? Proc Natl Acad Sci U S A (1994) 1.22
Complete sequence and gene organization of the mitochondrial genome of the land snail Albinaria coerulea. Genetics (1995) 1.20
Effect of aging on 5-hydroxymethylcytosine in brain mitochondria. Neurobiol Aging (2012) 1.15
The control region of mitochondrial DNA shows an unusual CpG and non-CpG methylation pattern. DNA Res (2013) 1.07
Toll-like receptors and the eye. Invest Ophthalmol Vis Sci (2006) 1.04
Pervasive properties of the genomic signature. BMC Genomics (2002) 1.02
A method for selectively enriching microbial DNA from contaminating vertebrate host DNA. PLoS One (2013) 0.98
Intercodon dinucleotides affect codon choice in plant genes. Nucleic Acids Res (2000) 0.95
Mitochondrial DNA: A Blind Spot in Neuroepigenetics. Biomol Concepts (2012) 0.95
Discovery and genomic characterization of a novel bat sapovirus with unusual genomic features and phylogenetic position. PLoS One (2012) 0.92
Signal transduction, gene transcription, and cytokine production triggered in macrophages by exposure to trypanosome DNA. Infect Immun (2006) 0.89
Mitochondria and the lectin pathway of complement. J Biol Chem (2013) 0.86
Complement factor 3 deficiency attenuates hemorrhagic shock-related hepatic injury and systemic inflammatory response syndrome. Am J Physiol Regul Integr Comp Physiol (2010) 0.85
BisQC: an operational pipeline for multiplexed bisulfite sequencing. BMC Genomics (2014) 0.85
Dendritic cell-targeting DNA-based mucosal adjuvants for the development of mucosal vaccines. Expert Rev Vaccines (2009) 0.84
The acceleration of wound healing in primates by the local administration of immunostimulatory CpG oligonucleotides. Biomaterials (2011) 0.83
Oral pretreatment of mice with CpG DNA reduces susceptibility to oral or intraperitoneal challenge with virulent Listeria monocytogenes. Infect Immun (2003) 0.83
DNA methylation and Mycoplasma genomes. J Mol Evol (2003) 0.82
Pathways to Parkinsonism Redux: convergent pathobiological mechanisms in genetics of Parkinson's disease. Hum Mol Genet (2015) 0.82
Cytosine methylation is not the major factor inducing CpG dinucleotide deficiency in bacterial genomes. J Mol Evol (2004) 0.82
Is there an acceleration of the CpG transition rate during the mammalian radiation? Bioinformatics (2008) 0.81
CpG DNA assists the whole inactivated H9N2 influenza virus in crossing the intestinal epithelial barriers via transepithelial uptake of dendritic cell dendrites. Mucosal Immunol (2014) 0.81
GC content increased at CpG flanking positions of fish genes compared with sea squirt orthologs as a mechanism for reducing impact of DNA methylation. PLoS One (2008) 0.81
Circulating Mitochondrial DAMPs Are Not Effective Inducers of Proteinuria and Kidney Injury in Rodents. PLoS One (2015) 0.80
New Insights into Neutrophil Extracellular Traps: Mechanisms of Formation and Role in Inflammation. Front Immunol (2016) 0.79
DNA methyltransferase 1 mutations and mitochondrial pathology: is mtDNA methylated? Front Genet (2015) 0.78
Toll-like receptor agonists induce apoptosis in mouse B-cell lymphoma cells by altering NF-κB activation. Cell Mol Immunol (2013) 0.78
CpG Oligodeoxynucleotides Facilitate Delivery of Whole Inactivated H9N2 Influenza Virus via Transepithelial Dendrites of Dendritic Cells in Nasal Mucosa. J Virol (2015) 0.76
The concerted impact of domestication and transposon insertions on methylation patterns between dogs and grey wolves. Mol Ecol (2016) 0.76
Matrix protein CCN1 induced by bacterial DNA and CpG ODN limits lung inflammation and contributes to innate immune homeostasis. Mucosal Immunol (2014) 0.76
Obesity-associated extracellular mtDNA activates central TGFβ pathway to cause blood pressure increase. Am J Physiol Endocrinol Metab (2016) 0.75
Synonymous codon usage bias in plant mitochondrial genes is associated with intron number and mirrors species evolution. PLoS One (2015) 0.75
Chronic exposure to indoxacarb and pulmonary expression of toll-like receptor-9 in mice. Vet World (2016) 0.75
Synergistic oligodeoxynucleotide strongly promotes CpG-induced interleukin-6 production. BMC Immunol (2017) 0.75
Receptor for advanced glycation end products is targeted by FBXO10 for ubiquitination and degradation. FASEB J (2017) 0.75
Dendritic cell-targeting DNA-based nasal adjuvants for protective mucosal immunity to Streptococcus pneumoniae. Microbiol Immunol (2017) 0.75
Predicting DNA duplex stability from the base sequence. Proc Natl Acad Sci U S A (1986) 21.73
Replication of animal mitochondrial DNA. Cell (1982) 7.79
Over- and under-representation of short oligonucleotides in DNA sequences. Proc Natl Acad Sci U S A (1992) 5.55
Recent evidence for evolution of the genetic code. Microbiol Rev (1992) 4.32
Sequence of introns and flanking exons in wild-type and box3 mutants of cytochrome b reveals an interlaced splicing protein coded by an intron. Cell (1980) 4.26
The endosymbiont hypothesis revisited. Int Rev Cytol (1992) 3.74
Codon recognition patterns as deduced from sequences of the complete set of transfer RNA species in Mycoplasma capricolum. Resemblance to mitochondria. J Mol Biol (1989) 3.17
Stacking energies in DNA. J Biol Chem (1991) 2.75
Involvement of aminoacyl-tRNA synthetases and other proteins in group I and group II intron splicing. Trends Biochem Sci (1990) 2.49
Evolution of the genome and the genetic code: selection at the dinucleotide level by methylation and polyribonucleotide cleavage. Proc Natl Acad Sci U S A (1989) 2.42
Bizarre tRNAs inferred from DNA sequences of mitochondrial genomes of nematode worms. Proc Natl Acad Sci U S A (1987) 2.39
Molecular evolution of herpesviruses: genomic and protein sequence comparisons. J Virol (1994) 2.34
Nearest neighbor nucleotide patterns. Structural and biological implications. J Biol Chem (1981) 2.16
Paracoccus denitrificans and the evolutionary origin of the mitochondrion. Nature (1975) 2.04
Mitochondrial transcription initiation. Variation and conservation. J Biol Chem (1993) 1.74
Organization of ribosomal RNA genes in Mycoplasma capricolum. Mol Gen Genet (1984) 1.67
Methylation pattern of mouse mitochondrial DNA. Nucleic Acids Res (1984) 1.54
Mitochondrial DNA from various organisms does not contain internally methylated cytosine in -CCGG- sequences. Biochim Biophys Acta (1979) 1.34
5-methylcytidylic acid: absence from mitochondrial DNA of frogs and HeLa cells. Science (1974) 1.27
Prediction of complete gene structures in human genomic DNA. J Mol Biol (1997) 58.76
Sequence and gene organization of mouse mitochondrial DNA. Cell (1981) 13.14
Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice. Nat Genet (1998) 7.89
Replication of animal mitochondrial DNA. Cell (1982) 7.79
Finding the genes in genomic DNA. Curr Opin Struct Biol (1998) 7.31
Dinucleotide relative abundance extremes: a genomic signature. Trends Genet (1995) 6.32
Linkage and selection: two locus symmetric viability model. Theor Popul Biol (1970) 5.90
DNA of a human hepatitis B virus candidate. J Virol (1974) 5.90
Over- and under-representation of short oligonucleotides in DNA sequences. Proc Natl Acad Sci U S A (1992) 5.55
General two-locus selection models: some objectives, results and interpretations. Theor Popul Biol (1975) 5.16
Mitochondrial DNA maintenance in vertebrates. Annu Rev Biochem (1997) 4.96
The number of mitochondrial deoxyribonucleic acid genomes in mouse L and human HeLa cells. Quantitative isolation of mitochondrial deoxyribonucleic acid. J Biol Chem (1974) 4.71
Polymorphisms for genetic and ecological systems with weak coupling. Theor Popul Biol (1972) 4.47
Precise localization and nucleotide sequence of the two mouse mitochondrial rRNA genes and three immediately adjacent novel tRNA genes. Cell (1980) 4.41
Transcription of the mammalian mitochondrial genome. Annu Rev Biochem (1984) 4.35
Similarity of human mitochondrial transcription factor 1 to high mobility group proteins. Science (1991) 4.26
Yeast mitochondrial RNA polymerase is homologous to those encoded by bacteriophages T3 and T7. Cell (1987) 3.83
Towards a theory of the evolution of modifier genes. Theor Popul Biol (1974) 3.79
Application of method of small parameters to multi-niche population genetic models. Theor Popul Biol (1972) 3.72
Rates and probabilities of fixation for two locus random mating finite populations without selection. Genetics (1968) 3.64
Methods and algorithms for statistical analysis of protein sequences. Proc Natl Acad Sci U S A (1992) 3.63
The absence of a pyrimidine dimer repair mechanism in mammalian mitochondria. Proc Natl Acad Sci U S A (1974) 3.58
Structure of hepatitis B Dane particle DNA before and after the Dane particle DNA polymerase reaction. J Virol (1977) 3.57
Circular dimer and catenate forms of mitochondrial DNA in human leukaemic leucocytes. Nature (1967) 3.48
Complex mitochondrial DNA. Cold Spring Harb Symp Quant Biol (1968) 3.31
Nuclear RNase MRP is required for correct processing of pre-5.8S rRNA in Saccharomyces cerevisiae. Mol Cell Biol (1993) 3.29
Numerical studies on two-loci selection models with general viabilities. Theor Popul Biol (1975) 3.20
Homology and structural relationships between the dimeric and monomeric circular forms of mitochondrial DNA from human leukemic leukocytes. J Mol Biol (1970) 3.07
Priming of human mitochondrial DNA replication occurs at the light-strand promoter. Proc Natl Acad Sci U S A (1985) 3.05
Sequence and properties of the human KB cell and mouse L cell D-loop regions of mitochondrial DNA. Nucleic Acids Res (1981) 2.90
New approaches for computer analysis of nucleic acid sequences. Proc Natl Acad Sci U S A (1983) 2.85
Molecular genetic aspects of human mitochondrial disorders. Annu Rev Genet (1995) 2.82
Studies of mouse mitochondrial DNA in Escherichia coli: structure and function of the eucaryotic-procaryotic chimeric plasmids. Cell (1975) 2.80
Purification and characterization of human mitochondrial transcription factor 1. Mol Cell Biol (1988) 2.78
Precise identification of individual promoters for transcription of each strand of human mitochondrial DNA. Cell (1984) 2.69
DNA wrapping and bending by a mitochondrial high mobility group-like transcriptional activator protein. J Biol Chem (1992) 2.64
A mammalian mitochondrial RNA processing activity contains nucleus-encoded RNA. Science (1987) 2.63
A novel endoribonuclease cleaves at a priming site of mouse mitochondrial DNA replication. EMBO J (1987) 2.63
Association of charge clusters with functional domains of cellular transcription factors. Proc Natl Acad Sci U S A (1989) 2.58
Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression. Nat Genet (1999) 2.57
On mutation selection balance for two-locus haploid and diploid populations. Theor Popul Biol (1971) 2.57
The transcription map of mouse mitochondrial DNA. Cell (1978) 2.52
Mouse RNAase MRP RNA is encoded by a nuclear gene and contains a decamer sequence complementary to a conserved region of mitochondrial RNA substrate. Cell (1989) 2.49
Replication of mitochondrial DNA in mouse L cells and their thymidine kinase - derivatives: displacement replication on a covalently-closed circular template. Proc Natl Acad Sci U S A (1972) 2.49
Random temporal variation in selection intensities: case of large population size. Theor Popul Biol (1974) 2.46
Promoter selection in human mitochondria involves binding of a transcription factor to orientation-independent upstream regulatory elements. Cell (1987) 2.44
Genome signature comparisons among prokaryote, plasmid, and mitochondrial DNA. Proc Natl Acad Sci U S A (1999) 2.38
Genome-scale compositional comparisons in eukaryotes. Genome Res (2001) 2.32
Why are human G-protein-coupled receptors predominantly intronless? Trends Genet (1999) 2.31
Length heterogeneity of a conserved displacement-loop sequence in human mitochondrial DNA. Nucleic Acids Res (1985) 2.28
Further analysis of negative assortative mating. Genetics (1968) 2.27
A human mitochondrial transcriptional activator can functionally replace a yeast mitochondrial HMG-box protein both in vivo and in vitro. Mol Cell Biol (1993) 2.27
Altered mobility of polydeoxyribonucleotides in high resolution polyacrylamide gels due to removal of terminal phosphates. Nucleic Acids Res (1981) 2.23
Mechanism of replication of human mitochondrial DNA. Localization of the 5' ends of nascent daughter strands. J Biol Chem (1981) 2.20
Occurrence of complex mitochondrial DNA in normal tissues. Nature (1968) 2.18
Addition of a 29 residue carboxyl-terminal tail converts a simple HMG box-containing protein into a transcriptional activator. J Mol Biol (1995) 2.17
LTP leads to rapid surface expression of NMDA but not AMPA receptors in adult rat CA1. Nat Neurosci (2002) 2.14
Mouse L cell mitochondrial DNA molecules are selected randomly for replication throughout the cell cycle. Cell (1977) 2.09
Human cytomegalovirus origin of DNA replication (oriLyt) resides within a highly complex repetitive region. Proc Natl Acad Sci U S A (1992) 2.09
The RNA processing enzyme RNase MRP is identical to the Th RNP and related to RNase P. Science (1989) 2.07
Mitochondrial DNA of chloramphenicol-resistant mouse cells contains a single nucleotide change in the region encoding the 3' end of the large ribosomal RNA. Proc Natl Acad Sci U S A (1981) 2.03
Replication priming and transcription initiate from precisely the same site in mouse mitochondrial DNA. EMBO J (1985) 2.03
Elongation of displacement-loop strands in human and mouse mitochondrial DNA is arrested near specific template sequences. Proc Natl Acad Sci U S A (1981) 2.02
In situ localization of mitochondrial DNA replication in intact mammalian cells. J Cell Biol (1996) 2.01
Statistical analyses of counts and distributions of restriction sites in DNA sequences. Nucleic Acids Res (1992) 1.99
Trinucleotide repeats and long homopeptides in genes and proteins associated with nervous system disease and development. Proc Natl Acad Sci U S A (1996) 1.99
Identification of significant sequence patterns in proteins. Methods Enzymol (1990) 1.99
Statistical methods for assessing linkage disequilibrium at the HLA-A, B, C loci. Ann Hum Genet (1981) 1.93
Analysis of biochemical genetic data on Jewish populations: II. Results and interpretations of heterogeneity indices and distance measures with respect to standards. Am J Hum Genet (1979) 1.91
In vitro transcription of human mitochondrial DNA. Identification of specific light strand transcripts from the displacement loop region. J Biol Chem (1983) 1.89
Yeast site-specific ribonucleoprotein endoribonuclease MRP contains an RNA component homologous to mammalian RNase MRP RNA and essential for cell viability. Genes Dev (1992) 1.88
Displacement-loop replication initiation sequence in animal mitochondrial DNA exists as a family of discrete lengths. Proc Natl Acad Sci U S A (1978) 1.86
A transcription factor required for promoter recognition by human mitochondrial RNA polymerase. Accurate initiation at the heavy- and light-strand promoters dissected and reconstituted in vitro. J Biol Chem (1985) 1.86
Mechanism of mitochondrial DNA replication in mouse L-cells: RNA priming during the initiation of heavy-strand synthesis. J Mol Biol (1979) 1.86
Template-directed pausing in in vitro DNA synthesis by DNA polymerase a from Drosophila melanogaster embryos. Proc Natl Acad Sci U S A (1982) 1.86
Strand compositional asymmetry in bacterial and large viral genomes. Proc Natl Acad Sci U S A (1998) 1.84
Initiation of mitochondrial DNA replication by transcription and R-loop processing. J Biol Chem (1998) 1.83
Mechanism of mitochondrial DNA replication in mouse L-cells: asynchronous replication of strands, segregation of circular daughter molecules, aspects of topology and turnover of an initiation sequence. J Mol Biol (1974) 1.80
Detecting alien genes in bacterial genomes. Ann N Y Acad Sci (1999) 1.80
Isolation of mammalian mitochondrial DNA and RNA and cloning of the mitochondrial genome. Methods Enzymol (1983) 1.76
Theoretical models of genetic map functions. Theor Popul Biol (1984) 1.76
Secondary structure of RNase MRP RNA as predicted by phylogenetic comparison. FASEB J (1993) 1.75
Mitochondrial transcription initiation. Variation and conservation. J Biol Chem (1993) 1.74
In vitro replication of human mitochondrial DNA: accurate initiation at the origin of light-strand synthesis. Cell (1985) 1.72
Pulse-labeled components in the replication of mitochondrial deoxyribonucleic acid. J Biol Chem (1973) 1.69
Selective nicking of mammalian mitochondrial DNA in vivo: photosensitization by incorporation of 5-bromodeoxyuridine. J Mol Biol (1975) 1.68
Evolutionary comparisons of RecA-like proteins across all major kingdoms of living organisms. J Mol Evol (1997) 1.67
Similarities and dissimilarities of phage genomes. Proc Natl Acad Sci U S A (1996) 1.67
A genetically distinct thymidine kinase in mammalian mitochondria. Exclusive labeling of mitochondrial deoxyribonucleic acid. J Biol Chem (1973) 1.64
Low levels of mitochondrial transcription factor A in mitochondrial DNA depletion. Biochem Biophys Res Commun (1994) 1.63
Sibling and parent--offspring correlation estimation with variable family size. Proc Natl Acad Sci U S A (1981) 1.63
Impairment of mitochondrial transcription termination by a point mutation associated with the MELAS subgroup of mitochondrial encephalomyopathies. Nature (1991) 1.60
Very long charge runs in systemic lupus erythematosus-associated autoantigens. Proc Natl Acad Sci U S A (1991) 1.58
Characterization of a unique protein component of yeast RNase MRP: an RNA-binding protein with a zinc-cluster domain. Genes Dev (1994) 1.57
DNA primase of human mitochondria is associated with structural RNA that is essential for enzymatic activity. Cell (1986) 1.54
A persistent RNA-DNA hybrid is formed during transcription at a phylogenetically conserved mitochondrial DNA sequence. Mol Cell Biol (1995) 1.53
Complex mitochondrial DNA in leukemic and normal human myeloid cells. Proc Natl Acad Sci U S A (1969) 1.52
Flexible recognition of rapidly evolving promoter sequences by mitochondrial transcription factor 1. Genes Dev (1989) 1.52
Clusters of charged residues in protein three-dimensional structures. Proc Natl Acad Sci U S A (1996) 1.50
Nuclear RNase MRP processes RNA at multiple discrete sites: interaction with an upstream G box is required for subsequent downstream cleavages. Genes Dev (1991) 1.47