Published in Am J Physiol on September 01, 1993
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Synaptic control of motoneuronal excitability. Physiol Rev (2000) 2.93
Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy. Proc Natl Acad Sci U S A (1994) 2.48
Kinetics of cell lysis, dye uptake and permeability changes in cells expressing the rat P2X7 receptor. J Physiol (1999) 2.37
Subcellular imaging of intramitochondrial Ca2+ with recombinant targeted aequorin: significance for the regulation of pyruvate dehydrogenase activity. Proc Natl Acad Sci U S A (1996) 2.33
Type III InsP3 receptor channel stays open in the presence of increased calcium. Nature (1998) 2.26
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Receptor-mediated control of regulatory volume decrease (RVD) and apoptotic volume decrease (AVD). J Physiol (2001) 2.08
Specific features of glycogen metabolism in the liver. Biochem J (1998) 1.99
P2X4: an ATP-activated ionotropic receptor cloned from rat brain. Proc Natl Acad Sci U S A (1996) 1.98
Pharmacological selectivity of the cloned human P2U-purinoceptor: potent activation by diadenosine tetraphosphate. Br J Pharmacol (1995) 1.81
Ca2+ influx is an essential component of the positive-feedback loop that maintains leading-edge structure and activity in macrophages. Proc Natl Acad Sci U S A (2007) 1.81
An angiogenic switch in macrophages involving synergy between Toll-like receptors 2, 4, 7, and 9 and adenosine A(2A) receptors. Am J Pathol (2003) 1.80
Volume-dependent ATP-conductive large-conductance anion channel as a pathway for swelling-induced ATP release. J Gen Physiol (2001) 1.78
Differential effects of P2-purinoceptor antagonists on phospholipase C- and adenylyl cyclase-coupled P2Y-purinoceptors. Br J Pharmacol (1994) 1.77
The purinergic P2Z receptor of human macrophage cells. Characterization and possible physiological role. J Clin Invest (1995) 1.73
Isolated rat hepatocytes can signal to other hepatocytes and bile duct cells by release of nucleotides. Proc Natl Acad Sci U S A (1996) 1.69
A release mechanism for stored ATP in ocular ciliary epithelial cells. Proc Natl Acad Sci U S A (1998) 1.66
Extracellular ATP in plants. Visualization, localization, and analysis of physiological significance in growth and signaling. Plant Physiol (2006) 1.64
Quantitation of extracellular UTP using a sensitive enzymatic assay. Br J Pharmacol (1999) 1.61
P2 receptor subtypes in the cardiovascular system. Biochem J (1998) 1.60
Extracellular ATP induces the accumulation of superoxide via NADPH oxidases in Arabidopsis. Plant Physiol (2006) 1.58
Synergistic up-regulation of vascular endothelial growth factor expression in murine macrophages by adenosine A(2A) receptor agonists and endotoxin. Am J Pathol (2002) 1.53
Characterization of P2-purinoceptors in the smooth muscle of the rat tail artery: a comparison between contractile and electrophysiological responses. Br J Pharmacol (1994) 1.53
2-Chloro N(6)-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate is a selective high affinity P2Y(1) receptor antagonist. Br J Pharmacol (2002) 1.52
Voltage-dependent anion channel-1 (VDAC-1) contributes to ATP release and cell volume regulation in murine cells. J Gen Physiol (2004) 1.49
Quantitation of the P2Y(1) receptor with a high affinity radiolabeled antagonist. Mol Pharmacol (2002) 1.49
Switching from simple to complex oscillations in calcium signaling. Biophys J (2000) 1.48
P2 receptors: intracellular signaling. Pflugers Arch (2006) 1.48
Extracellular ATP activates transcription factor NF-kappaB through the P2Z purinoreceptor by selectively targeting NF-kappaB p65. J Cell Biol (1997) 1.48
Nuclear and cytosolic calcium are regulated independently. Proc Natl Acad Sci U S A (2003) 1.46
Evidence of a novel cell signaling role for extracellular adenosine triphosphates and diphosphates in Arabidopsis. Plant Cell (2004) 1.44
ATP release via anion channels. Purinergic Signal (2005) 1.43
NTPDase1 (CD39) controls nucleotide-dependent vasoconstriction in mouse. Cardiovasc Res (2010) 1.41
Swelling-induced, CFTR-independent ATP release from a human epithelial cell line: lack of correlation with volume-sensitive cl(-) channels. J Gen Physiol (1999) 1.40
Modulation of endothelial cell migration by extracellular nucleotides: involvement of focal adhesion kinase and phosphatidylinositol 3-kinase-mediated pathways. Thromb Haemost (2005) 1.38
G protein-coupled receptors and the modification of FcepsilonRI-mediated mast cell activation. Immunol Lett (2007) 1.33
Extended pharmacological profiles of rat P2Y2 and rat P2Y4 receptors and their sensitivity to extracellular H+ and Zn2+ ions. Br J Pharmacol (2003) 1.32
Effect of shear stress on the release of soluble ecto-enzymes ATPase and 5'-nucleotidase along with endogenous ATP from vascular endothelial cells. Br J Pharmacol (2000) 1.32
PPADS and suramin as antagonists at cloned P2Y- and P2U-purinoceptors. Br J Pharmacol (1996) 1.32
The P2X(7) receptor-pannexin connection to dye uptake and IL-1beta release. Purinergic Signal (2009) 1.32
Induction of novel agonist selectivity for the ADP-activated P2Y1 receptor versus the ADP-activated P2Y12 and P2Y13 receptors by conformational constraint of an ADP analog. J Pharmacol Exp Ther (2004) 1.31
A truncated P2X7 receptor variant (P2X7-j) endogenously expressed in cervical cancer cells antagonizes the full-length P2X7 receptor through hetero-oligomerization. J Biol Chem (2006) 1.30
Activation of purinergic receptor subtypes modulates odor sensitivity. J Neurosci (2003) 1.30
Identification of potent P2Y-purinoceptor agonists that are derivatives of adenosine 5'-monophosphate. Br J Pharmacol (1996) 1.27
The role of purinergic signaling in the liver and in transplantation: effects of extracellular nucleotides on hepatic graft vascular injury, rejection and metabolism. Front Biosci (2008) 1.24
Swelling-activated, cystic fibrosis transmembrane conductance regulator-augmented ATP release and Cl- conductances in murine C127 cells. J Physiol (2000) 1.23
PPADS: an antagonist at endothelial P2Y-purinoceptors but not P2U-purinoceptors. Br J Pharmacol (1995) 1.23
Purinergic stimulation of rabbit ciliated airway epithelia: control by multiple calcium sources. J Physiol (1996) 1.23
Regulation of CFTR Cl- channel gating by ADP and ATP analogues. J Gen Physiol (1995) 1.21
UDP activates a mucosal-restricted receptor on human nasal epithelial cells that is distinct from the P2Y2 receptor. Proc Natl Acad Sci U S A (1997) 1.20
Role of ATP-conductive anion channel in ATP release from neonatal rat cardiomyocytes in ischaemic or hypoxic conditions. J Physiol (2004) 1.18
Structure activity and molecular modeling analyses of ribose- and base-modified uridine 5'-triphosphate analogues at the human P2Y2 and P2Y4 receptors. Biochem Pharmacol (2005) 1.18
P2 receptors and neuronal injury. Pflugers Arch (2006) 1.18
Extracellular purines are biomarkers of neutrophilic airway inflammation. Eur Respir J (2008) 1.17
Functional evidence of distinct ATP activation sites at the human P2X(7) receptor. J Physiol (2001) 1.16
Mechanism of purinergic activation of endothelial nitric oxide synthase in endothelial cells. Circulation (2009) 1.15
The P2Y purinoceptor in rat brain microvascular endothelial cells couple to inhibition of adenylate cyclase. Br J Pharmacol (1996) 1.14
Expression of P2Y1 receptors in rat taste buds. Histochem Cell Biol (2004) 1.14
The human platelet ADP receptor activates Gi2 proteins. Biochem J (1995) 1.12
Inhibition of neutrophil apoptosis by ATP is mediated by the P2Y11 receptor. J Immunol (2007) 1.12
P2Z-Independent and P2Z receptor-mediated macrophage killing by Pseudomonas aeruginosa isolated from cystic fibrosis patients. Infect Immun (1999) 1.11
P2X7 receptors activate protein kinase D and p42/p44 mitogen-activated protein kinase (MAPK) downstream of protein kinase C. Biochem J (2002) 1.10
Functional expression of a cDNA encoding a human ecto-ATPase. Br J Pharmacol (1999) 1.09
Enzymatic synthesis of UTP gamma S, a potent hydrolysis resistant agonist of P2U-purinoceptors. Br J Pharmacol (1996) 1.09
ATP stimulates GRK-3 phosphorylation and beta-arrestin-2-dependent internalization of P2X7 receptor. Am J Physiol Cell Physiol (2005) 1.08
Platelet-derived growth factor receptor-α-positive cells and not smooth muscle cells mediate purinergic hyperpolarization in murine colonic muscles. Am J Physiol Cell Physiol (2014) 1.08
Extracellular nucleotides and adenosine independently activate AMP-activated protein kinase in endothelial cells: involvement of P2 receptors and adenosine transporters. Circ Res (2006) 1.08
Activation of ERK1/2 by extracellular nucleotides in macrophages is mediated by multiple P2 receptors independently of P2X7-associated pore or channel formation. Br J Pharmacol (2006) 1.08
Stimulation of P2 purinergic receptors induces the release of eosinophil cationic protein and interleukin-8 from human eosinophils. Br J Pharmacol (2003) 1.06
IL-1beta: an endosomal exit. Proc Natl Acad Sci U S A (2004) 1.05
Structure Activity Relationships for Derivatives of Adenosine-5'-Triphosphate as Agonists at P(2) Purinoceptors: Heterogeneity Within P(2X) and P(2Y) Subtypes. Drug Dev Res (1994) 1.04
Adenylate kinase as a virulence factor of Pseudomonas aeruginosa. J Bacteriol (2001) 1.03
Chemotactic activity of extracellular nucleotideson human immune cells. Purinergic Signal (2007) 1.02
Critical involvement of extracellular ATP acting on P2RX7 purinergic receptors in photoreceptor cell death. Am J Pathol (2011) 1.02
Wide nanoscopic pore of maxi-anion channel suits its function as an ATP-conductive pathway. Biophys J (2004) 1.01
Implications of purinergic receptor-mediated intracellular calcium transients in neural differentiation. Cell Commun Signal (2013) 1.01
Effects of divalent cations on the potency of ATP and related agonists in the rat isolated vagus nerve: implications for P2 purinoceptor classification. Br J Pharmacol (1994) 1.01
CD39 is incorporated into plasma microparticles where it maintains functional properties and impacts endothelial activation. Br J Haematol (2008) 1.00
P1,P4-dithio-P2,P3-monochloromethylene diadenosine 5',5'''-P1,P4-tetraphosphate: a novel antiplatelet agent. Proc Natl Acad Sci U S A (1997) 1.00
The P2Z-purinoceptor of human lymphocytes: actions of nucleotide agonists and irreversible inhibition by oxidized ATP. Br J Pharmacol (1994) 1.00
A2aR antagonists: Next generation checkpoint blockade for cancer immunotherapy. Comput Struct Biotechnol J (2015) 1.00
P2Y2 receptor-mediated inhibition of ion transport in distal lung epithelial cells. Br J Pharmacol (1999) 0.99
Release of Ca2+ from intracellular store in smooth muscle cells of rat portal vein by ATP-induced Ca2+ entry. Br J Pharmacol (1994) 0.98
Recent patents on novel P2X(7) receptor antagonists and their potential for reducing central nervous system inflammation. Recent Pat CNS Drug Discov (2010) 0.97
Dynamics of ATP-induced calcium signaling in single mouse thymocytes. J Cell Biol (1997) 0.97
Two different ionotropic receptors are activated by ATP in rat microglia. J Physiol (1999) 0.97
Potent agonist action of 2-thioether derivatives of adenine nucleotides at adenylyl cyclase-linked P2Y-purinoceptors. Br J Pharmacol (1995) 0.97
Stimulation of ATP secretion in the liver by therapeutic bile acids. Biochem J (2001) 0.97
Regulation of death and survival in astrocytes by ADP activating P2Y1 and P2Y12 receptors. Biochem Pharmacol (2006) 0.97
Extracellular nucleotides stimulate proliferation in MCF-7 breast cancer cells via P2-purinoceptors. Br J Cancer (1997) 0.97
Adenosine modulates hypoxia-induced responses in rat PC12 cells via the A2A receptor. J Physiol (1998) 0.96
The hepatitis B virus X protein elevates cytosolic calcium signals by modulating mitochondrial calcium uptake. J Virol (2011) 0.96
ATP suppression of interleukin-12 and tumour necrosis factor-alpha release from macrophages. Br J Pharmacol (2000) 0.96
Two subtypes of G protein-coupled nucleotide receptors, P2Y(1) and P2Y(2) are involved in calcium signalling in glioma C6 cells. Br J Pharmacol (2001) 0.96
Quantal transmission at purinergic junctions: stochastic interaction between ATP and its receptors. Biophys J (1995) 0.96
Extracellular ATP induces hyperpolarization and motility stimulation of ciliary cells. Biophys J (1995) 0.96
Biomarkers in exhaled breath condensate: a review of collection, processing and analysis. J Breath Res (2008) 0.95
Purinergic signalling in the gastrointestinal tract and related organs in health and disease. Purinergic Signal (2013) 0.95
Extracellular ATP increases cytosolic free calcium in thymocytes and initiates the blastogenesis of the phorbol 12-myristate 13-acetate-treated medullary population. Biochim Biophys Acta (1987) 0.96
Expression of the pore-forming P2Z purinoreceptor in Xenopus oocytes injected with poly(A)+ RNA from murine macrophages. Mol Pharmacol (1993) 0.92