Published in Cell on November 19, 1993
Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast. Genetics (1996) 24.62
Identification of genes periodically expressed in the human cell cycle and their expression in tumors. Mol Biol Cell (2002) 17.32
The tripartite motif family identifies cell compartments. EMBO J (2001) 9.64
Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing. EMBO J (2002) 5.70
Split ubiquitin as a sensor of protein interactions in vivo. Proc Natl Acad Sci U S A (1994) 5.16
Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions. Mol Cell Biol (1999) 4.98
Reverse two-hybrid and one-hybrid systems to detect dissociation of protein-protein and DNA-protein interactions. Proc Natl Acad Sci U S A (1996) 4.70
Correlation of two-hybrid affinity data with in vitro measurements. Mol Cell Biol (1995) 4.63
Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell (1997) 4.39
Inhibition of Stat1-mediated gene activation by PIAS1. Proc Natl Acad Sci U S A (1998) 4.12
Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc. EMBO J (1995) 4.02
The influenza virus NEP (NS2 protein) mediates the nuclear export of viral ribonucleoproteins. EMBO J (1998) 3.98
HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo. EMBO J (2003) 3.96
A computationally directed screen identifying interacting coiled coils from Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2000) 3.92
Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels. J Cell Biol (2006) 3.87
Identification and characterization of Saccharomyces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2. Proc Natl Acad Sci U S A (1997) 3.66
Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2C. Mol Cell Biol (1997) 3.62
Interaction of NPR1 with basic leucine zipper protein transcription factors that bind sequences required for salicylic acid induction of the PR-1 gene. Proc Natl Acad Sci U S A (1999) 3.56
A septin-based hierarchy of proteins required for localized deposition of chitin in the Saccharomyces cerevisiae cell wall. J Cell Biol (1997) 3.37
Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system. Proc Natl Acad Sci U S A (1994) 3.26
The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase-associated est1 protein. Genes Dev (2000) 3.25
cAMP-mediated inhibition of the epithelial brush border Na+/H+ exchanger, NHE3, requires an associated regulatory protein. Proc Natl Acad Sci U S A (1997) 3.19
Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development. EMBO J (1996) 3.18
Interaction mating reveals binary and ternary connections between Drosophila cell cycle regulators. Proc Natl Acad Sci U S A (1994) 3.18
Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism. Proc Natl Acad Sci U S A (1999) 3.17
Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1. J Cell Biol (1998) 3.11
Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors. Proc Natl Acad Sci U S A (1998) 3.07
Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2. Proc Natl Acad Sci U S A (1997) 3.06
The budding yeast proteins Spc24p and Spc25p interact with Ndc80p and Nuf2p at the kinetochore and are important for kinetochore clustering and checkpoint control. EMBO J (2001) 3.02
E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. Proc Natl Acad Sci U S A (1995) 2.99
A Drosophila protein-interaction map centered on cell-cycle regulators. Genome Biol (2004) 2.95
Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase. Proc Natl Acad Sci U S A (2001) 2.91
Role of polo kinase and Mid1p in determining the site of cell division in fission yeast. J Cell Biol (1998) 2.89
Role of dynein, dynactin, and CLIP-170 interactions in LIS1 kinetochore function. J Cell Biol (2002) 2.89
Direct interaction between the Arabidopsis disease resistance signaling proteins, EDS1 and PAD4. EMBO J (2001) 2.88
The Gfi-1 proto-oncoprotein contains a novel transcriptional repressor domain, SNAG, and inhibits G1 arrest induced by interleukin-2 withdrawal. Mol Cell Biol (1996) 2.87
Rab11 is required for trans-golgi network-to-plasma membrane transport and a preferential target for GDP dissociation inhibitor. Mol Biol Cell (1998) 2.86
Rch1, a protein that specifically interacts with the RAG-1 recombination-activating protein. Proc Natl Acad Sci U S A (1994) 2.86
The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation. Genes Dev (1998) 2.82
Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs. Mol Cell Biol (1995) 2.80
The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutations. Proc Natl Acad Sci U S A (1998) 2.77
Mutations in the RNA polymerase II transcription machinery suppress the hyperrecombination mutant hpr1 delta of Saccharomyces cerevisiae. Genetics (1996) 2.74
Spc98p and Spc97p of the yeast gamma-tubulin complex mediate binding to the spindle pole body via their interaction with Spc110p. EMBO J (1997) 2.71
Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes. Mol Biol Cell (2000) 2.69
NoRC--a novel member of mammalian ISWI-containing chromatin remodeling machines. EMBO J (2001) 2.67
H2O2 sensing through oxidation of the Yap1 transcription factor. EMBO J (2000) 2.67
Role of the yeast Gin4p protein kinase in septin assembly and the relationship between septin assembly and septin function. J Cell Biol (1998) 2.63
LIS1, CLIP-170's key to the dynein/dynactin pathway. Mol Cell Biol (2002) 2.61
Ribonuclease E organizes the protein interactions in the Escherichia coli RNA degradosome. Genes Dev (1998) 2.60
Nucleocytoplasmic transport of macromolecules. Microbiol Mol Biol Rev (1997) 2.51
The NPI-1/NPI-3 (karyopherin alpha) binding site on the influenza a virus nucleoprotein NP is a nonconventional nuclear localization signal. J Virol (1997) 2.51
Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis. Proc Natl Acad Sci U S A (1997) 2.50
Receptors determine the cellular localization of a gamma-tubulin complex and thereby the site of microtubule formation. EMBO J (1998) 2.48
Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cells. Genes Dev (2005) 2.40
RAM: a conserved signaling network that regulates Ace2p transcriptional activity and polarized morphogenesis. Mol Biol Cell (2003) 2.40
A positive feedback loop stabilizes the guanine-nucleotide exchange factor Cdc24 at sites of polarization. EMBO J (2002) 2.39
The spindle pole body component Spc98p interacts with the gamma-tubulin-like Tub4p of Saccharomyces cerevisiae at the sites of microtubule attachment. EMBO J (1996) 2.39
Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor. Mol Cell Biol (1997) 2.37
The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains. Proc Natl Acad Sci U S A (1996) 2.32
Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5. Mol Cell Biol (1996) 2.30
Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting protein, is expressed early in neuronal development. Proc Natl Acad Sci U S A (1996) 2.29
Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt. Mol Cell Biol (1998) 2.28
Oncogenic capacity of the E2F1 gene. Proc Natl Acad Sci U S A (1994) 2.24
Pseudorabies virus UL36 tegument protein physically interacts with the UL37 protein. J Virol (2002) 2.24
INCENP centromere and spindle targeting: identification of essential conserved motifs and involvement of heterochromatin protein HP1. J Cell Biol (1998) 2.23
The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions. EMBO J (1995) 2.22
Physical interaction between envelope glycoproteins E and M of pseudorabies virus and the major tegument protein UL49. J Virol (2002) 2.19
A maize zinc-finger protein binds the prolamin box in zein gene promoters and interacts with the basic leucine zipper transcriptional activator Opaque2. Proc Natl Acad Sci U S A (1997) 2.19
Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex. Proc Natl Acad Sci U S A (2002) 2.16
Rho3 of Saccharomyces cerevisiae, which regulates the actin cytoskeleton and exocytosis, is a GTPase which interacts with Myo2 and Exo70. Mol Cell Biol (1999) 2.15
Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity. EMBO J (2000) 2.15
The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase. J Cell Biol (1999) 2.14
A proteome-wide protein interaction map for Campylobacter jejuni. Genome Biol (2007) 2.13
Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. Nucleic Acids Res (2000) 2.13
A role for myosin-I in actin assembly through interactions with Vrp1p, Bee1p, and the Arp2/3 complex. J Cell Biol (2000) 2.13
Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae. Mol Cell Biol (1996) 2.12
Novel Cdc42-binding proteins Gic1 and Gic2 control cell polarity in yeast. Genes Dev (1997) 2.12
A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells. Mol Cell Biol (1994) 2.11
An inhibitor of yeast cyclin-dependent protein kinase plays an important role in ensuring the genomic integrity of daughter cells. Mol Cell Biol (1994) 2.10
The Drosophila esc and E(z) proteins are direct partners in polycomb group-mediated repression. Mol Cell Biol (1998) 2.10
Translation elongation factor 1-alpha interacts specifically with the human immunodeficiency virus type 1 Gag polyprotein. J Virol (1999) 2.08
Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction. Proc Natl Acad Sci U S A (1994) 2.06
Involvement of 14-3-3 proteins in nuclear localization of telomerase. EMBO J (2000) 2.05
Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4. Mol Cell Biol (1997) 2.05
The Saccharomyces cerevisiae SPT8 gene encodes a very acidic protein that is functionally related to SPT3 and TATA-binding protein. Genetics (1994) 2.04
AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation. Mol Cell Biol (1995) 2.03
Human CUL1 forms an evolutionarily conserved ubiquitin ligase complex (SCF) with SKP1 and an F-box protein. Proc Natl Acad Sci U S A (1998) 2.02
Crm1p mediates regulated nuclear export of a yeast AP-1-like transcription factor. EMBO J (1998) 2.01
Fission yeast pak1+ encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating. EMBO J (1995) 2.00
Sir proteins, Rif proteins, and Cdc13p bind Saccharomyces telomeres in vivo. Mol Cell Biol (1998) 2.00
Phosphorylation regulates in vivo interaction and molecular targeting of serine/arginine-rich pre-mRNA splicing factors. J Cell Biol (1999) 2.00
An activator binding module of yeast RNA polymerase II holoenzyme. Mol Cell Biol (1999) 2.00
Human protein Sam68 relocalization and interaction with poliovirus RNA polymerase in infected cells. Proc Natl Acad Sci U S A (1996) 1.99
Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation. Mol Cell Biol (1996) 1.98
RAR1 positively controls steady state levels of barley MLA resistance proteins and enables sufficient MLA6 accumulation for effective resistance. Plant Cell (2004) 1.98
Cooperative DNA-binding by Bicoid provides a mechanism for threshold-dependent gene activation in the Drosophila embryo. EMBO J (1998) 1.97
LIM protein KyoT2 negatively regulates transcription by association with the RBP-J DNA-binding protein. Mol Cell Biol (1998) 1.96
Cloning and characterization of a novel hepatitis B virus x binding protein that inhibits viral replication. J Virol (1998) 1.96
A eukaryotic transcriptional activator bearing the DNA specificity of a prokaryotic repressor. Cell (1985) 8.30
Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites. Cell (1993) 6.40
Mechanism of action of the lexA gene product. Proc Natl Acad Sci U S A (1981) 6.13
DNA specificity of the bicoid activator protein is determined by homeodomain recognition helix residue 9. Cell (1989) 5.89
Modelling cellular behaviour. Nature (2001) 5.85
Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins. Cell (1994) 4.95
Correlation of two-hybrid affinity data with in vitro measurements. Mol Cell Biol (1995) 4.63
A bacterial repressor protein or a yeast transcriptional terminator can block upstream activation of a yeast gene. Nature (1985) 4.08
APC binds to the novel protein EB1. Cancer Res (1995) 3.98
Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. Mol Endocrinol (1995) 3.59
Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system. Proc Natl Acad Sci U S A (1994) 3.26
DNA-bound Fos proteins activate transcription in yeast. Cell (1988) 3.22
Interaction mating reveals binary and ternary connections between Drosophila cell cycle regulators. Proc Natl Acad Sci U S A (1994) 3.18
The lexA gene product represses its own promoter. Proc Natl Acad Sci U S A (1980) 3.03
Fused protein domains inhibit DNA binding by LexA. Mol Cell Biol (1992) 3.01
Rch1, a protein that specifically interacts with the RAG-1 recombination-activating protein. Proc Natl Acad Sci U S A (1994) 2.86
Yeast Cbk1 and Mob2 activate daughter-specific genetic programs to induce asymmetric cell fates. Cell (2001) 2.76
Mutation of the core or adjacent LVb elements of the Moloney murine leukemia virus enhancer alters disease specificity. Genes Dev (1990) 2.75
Disease specificity of nondefective Friend and Moloney murine leukemia viruses is controlled by a small number of nucleotides. J Virol (1987) 2.53
Protein interaction methods--toward an endgame. Science (1999) 2.48
Genetic selection of peptide aptamers that recognize and inhibit cyclin-dependent kinase 2. Nature (1996) 2.34
LexA protein is a repressor of the colicin E1 gene. J Biol Chem (1983) 2.24
Oncogenic transformation by vrel requires an amino-terminal activation domain. Mol Cell Biol (1990) 2.15
A genetic model for interaction of the homeodomain recognition helix with DNA. Science (1991) 2.09
Regulation of damage-inducible genes in Escherichia coli. J Mol Biol (1982) 1.63
Repression of transcription in yeast. Cell (1985) 1.53
Gene activation and DNA binding by Drosophila Ubx and abd-A proteins. Cell (1989) 1.53
Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylates Max protein. Proc Natl Acad Sci U S A (1995) 1.37
Human RNA polymerase II subunit hsRPB7 functions in yeast and influences stress survival and cell morphology. Mol Biol Cell (1995) 1.32
Isolation of Drosophila cyclin D, a protein expressed in the morphogenetic furrow before entry into S phase. Proc Natl Acad Sci U S A (1996) 1.30
Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway? Oncogene (2000) 1.26
Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor. EMBO J (1997) 1.25
roughex down-regulates G2 cyclins in G1. Genes Dev (1997) 1.19
"Mutagenesis" by peptide aptamers identifies genetic network members and pathway connections. Proc Natl Acad Sci U S A (1999) 1.18
Specific DNA recognition and intersite spacing are critical for action of the bicoid morphogen. Mol Cell Biol (1994) 1.17
DNA binding is not sufficient for nuclear localization of regulatory proteins in Saccharomyces cerevisiae. Mol Cell Biol (1986) 1.15
An artificial cell-cycle inhibitor isolated from a combinatorial library. Proc Natl Acad Sci U S A (1998) 1.15
p16 proteins from melanoma-prone families are deficient in binding to Cdk4. Oncogene (1995) 1.14
A yeast transcription assay defines distinct rel and dorsal DNA recognition sequences. New Biol (1991) 1.12
Computational and experimental analyses reveal previously undetected coding exons of the KRIT1 (CCM1) gene. Genomics (2001) 1.08
Applications of interaction traps/two-hybrid systems to biotechnology research. Curr Opin Biotechnol (1994) 1.05
The impact of two-hybrid and related methods on biotechnology. Trends Biotechnol (1998) 1.02
Inhibition of mammalian cell proliferation by genetically selected peptide aptamers that functionally antagonize E2F activity. Oncogene (1999) 1.00
Cells that register logical relationships among proteins. Proc Natl Acad Sci U S A (1997) 0.99
Regulation and autoregulation by lexA protein. Biochimie (1983) 0.98
Dimerization of the human papillomavirus E7 oncoprotein in vivo. Virology (1995) 0.96
LCK-phosphorylated human killer cell-inhibitory receptors recruit and activate phosphatidylinositol 3-kinase. Proc Natl Acad Sci U S A (1998) 0.95
Assessing borderline personality disorder with self-report, clinical interview, or semistructured interview. Am J Psychiatry (1984) 0.92
Selection of genetic agents from random peptide aptamer expression libraries. Methods Enzymol (2000) 0.91
The ankyrin repeat-containing adaptor protein Tvl-1 is a novel substrate and regulator of Raf-1. J Biol Chem (1999) 0.91
Targeted localized degradation of Paired protein in Drosophila development. Curr Biol (2000) 0.89
Targeted modification and transportation of cellular proteins. Proc Natl Acad Sci U S A (2000) 0.86
Large-scale preparation of plasmid DNA. Curr Protoc Mol Biol (2001) 0.86
Murine chromosomal location of five bHLH-Zip transcription factor genes. Genomics (1995) 0.82
Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites. Cell (1994) 0.82
Introduction to vectors derived from filamentous phages. Curr Protoc Mol Biol (2001) 0.81
The Alpha Project: a model system for systems biology research. IET Syst Biol (2008) 0.80
A bacterial repressor protein or a yeast transcriptional terminator can block upstream activation of a yeast gene. Nature (1985) 0.80
Minipreps of plasmid DNA. Curr Protoc Mol Biol (2001) 0.78
Interaction trap/two-hybrid system to identify interacting proteins. Curr Protoc Mol Biol (2001) 0.78
Plating lambda phage to generate plaques. Curr Protoc Mol Biol (2001) 0.77
Ventilatory and circulatory changes during cold exposure in the Pekin duck Anas platyrhynchos. Respir Physiol (1984) 0.77
Media preparation and bacteriological tools. Curr Protoc Protein Sci (2001) 0.77
Looms to weave genomic nets. Nat Genet (1997) 0.77
Interaction trap/two-hybrid system to identify interacting proteins. Curr Protoc Protein Sci (2001) 0.76
Interaction trap/two-hybrid system to identify interacting proteins. Curr Protoc Cell Biol (2001) 0.76
Inhibition of X-ray-induced exencephaly by protease inhibitors. Radiat Res (1990) 0.76
Growth in liquid or solid media. Curr Protoc Protein Sci (2001) 0.76
Backward bicoid? Structure (1994) 0.75
Double-stranded DNA arrays: next steps in the surface campaign. Nat Biotechnol (1999) 0.75
Rat trophoblastic cell antigenicity. Placenta Suppl (1981) 0.75
Techniques for bacterial cell culture: media preparation and bacteriological tools. Curr Protoc Cytom (2001) 0.75
Preparation of bacterial plasmid DNA. Curr Protoc Immunol (2001) 0.75
Introduction to lambda phages. Curr Protoc Mol Biol (2001) 0.75
Growing bacteria in liquid media. Curr Protoc Cytom (2001) 0.75
Getting doctors to underserviced areas. Can Doct (1982) 0.75
Interaction trap/two-hybrid system to identify interacting proteins. Curr Protoc Neurosci (2001) 0.75
Preparation of bacterial plasmid DNA. Curr Protoc Neurosci (2001) 0.75
Fluphenazine resistant psychosis. Can J Psychiatry (1981) 0.75
Preparation of plasmid DNA. Curr Protoc Protein Sci (2001) 0.75
Postgenomic protein analysis: the next bend in the river. Nat Biotechnol (1998) 0.75
Growing bacteria on solid media. Curr Protoc Cytom (2001) 0.75
Lambda as a cloning vector. Curr Protoc Mol Biol (2001) 0.75