Published in Clin Pharmacol Ther on January 01, 1994
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Decreased dromotropic response to verapamil despite pronounced increased drug concentration in rheumatoid arthritis. Br J Clin Pharmacol (2000) 0.87
Effect of age, gender, and obesity on midazolam kinetics. Anesthesiology (1984) 2.14
Enantioselective disposition of hydroxychloroquine after a single oral dose of the racemate to healthy subjects. Br J Clin Pharmacol (1995) 1.43
High-risk prescribing and incidence of frailty among older community-dwelling men. Clin Pharmacol Ther (2012) 1.43
In vitro quantitation of benzodiazepine lipophilicity: relation to in vivo distribution. Br J Anaesth (1983) 1.39
Drug therapy. Current status of benzodiazepines. N Engl J Med (1983) 1.39
Pharmacokinetics, central nervous system uptake, and lipid solubility of propranolol, acebutolol, and sotalol. Cardiology (1984) 1.37
Ca(2+) sensors of L-type Ca(2+) channel. FEBS Lett (2000) 1.26
Physical and cognitive performance and burden of anticholinergics, sedatives, and ACE inhibitors in older women. Clin Pharmacol Ther (2007) 1.25
Molecular determinants of L-type Ca2+ channel inactivation. Segment exchange analysis of the carboxyl-terminal cytoplasmic motif encoded by exons 40-42 of the human alpha1C subunit gene. J Biol Chem (1998) 1.24
The effect of pharmaceutical benefits managers: is it being evaluated? Ann Intern Med (1996) 1.21
Antipyrine kinetics in the elderly: prediction of age-related changes in benzodiazepine oxidizing capacity. J Pharmacol Exp Ther (1982) 1.19
High-performance liquid chromatographic determination of acetaminophen in plasma: single-dose pharmacokinetic studies. J Chromatogr (1981) 1.19
Impairment of caffeine clearance by chronic use of low-dose oestrogen-containing oral contraceptives. Eur J Clin Pharmacol (1985) 1.17
Serum protein signatures detect early radiographic osteoarthritis. Osteoarthritis Cartilage (2008) 1.15
Drug therapy. Current status of benzodiazepines. N Engl J Med (1983) 1.14
In vitro correlates of benzodiazepine cerebrospinal fluid uptake, pharmacodynamic action and peripheral distribution. J Pharmacol Exp Ther (1983) 1.14
Automated ligand fishing using human serum albumin-coated magnetic beads. Anal Chem (2007) 1.13
The influence of obesity on the pharmacokinetics of oral alprazolam and triazolam. Clin Pharmacokinet (1984) 1.13
Alterations in drug distribution and clearance due to obesity. J Pharmacol Exp Ther (1981) 1.12
Evidence for a pathogenetic role of xanthine oxidase in the "stunned" myocardium. Am J Physiol (1987) 1.11
Drug disposition in obese humans. An update. Clin Pharmacokinet (1986) 1.09
An investigation of the cause of accumulation of verapamil during regular dosing in patients. Br J Clin Pharmacol (1985) 1.08
Impairment of lidocaine clearance in elderly male subjects. J Cardiovasc Pharmacol (1984) 1.07
Ligand and protein fishing with heat shock protein 90 coated magnetic beads. Anal Chem (2008) 1.06
Pharmacokinetics and clinical effectiveness of methylphenidate. Clin Pharmacokinet (1999) 1.06
Allosteric and competitive displacement of drugs from human serum albumin by octanoic acid, as revealed by high-performance liquid affinity chromatography, on a human serum albumin-based stationary phase. J Chromatogr (1992) 1.06
Reduced clearance of triazolam in old age: relation to antipyrine oxidizing capacity. Br J Clin Pharmacol (1983) 1.05
Pharmacokinetics of drugs in obesity. Clin Pharmacokinet (1982) 1.04
Interactions of racemic mefloquine and its enantiomers with P-glycoprotein in an immortalised rat brain capillary endothelial cell line, GPNT. Biochim Biophys Acta (2000) 1.03
Probenecid impairment of acetaminophen and lorazepam clearance: direct inhibition of ether glucuronide formation. J Pharmacol Exp Ther (1985) 1.03
Proteolysis-inducing factor is expressed in tumours of patients with gastrointestinal cancers and correlates with weight loss. Br J Cancer (2001) 1.03
Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamil. Br J Clin Pharmacol (1999) 1.02
Development and characterization of an immobilized human organic cation transporter based liquid chromatographic stationary phase. J Chromatogr B Analyt Technol Biomed Life Sci (2005) 1.02
{Beta}2-adrenergic receptor agonists inhibit the proliferation of 1321N1 astrocytoma cells. J Pharmacol Exp Ther (2010) 1.02
Effect of food on acetaminophen absorption in young and elderly subjects. J Clin Pharmacol (1983) 1.00
Pharmacophore modelling of stereoselective binding to the human organic cation transporter (hOCT1). Br J Pharmacol (2007) 1.00
Acetaminophen kinetics in the elderly. Clin Pharmacol Ther (1982) 0.99
Enhanced glucuronide conjugation of drugs in obesity: studies of lorazepam, oxazepam, and acetaminophen. J Lab Clin Med (1983) 0.98
Impairment of antipyrine metabolism by low-dose oral contraceptive steroids. Clin Pharmacol Ther (1981) 0.97
Differential effect of cimetidine on drug oxidation (antipyrine and diazepam) vs. conjugation (acetaminophen and lorazepam): prevention of acetaminophen toxicity by cimetidine. J Pharmacol Exp Ther (1983) 0.97
Determination of the enantiomers of mefloquine in plasma and whole blood using a coupled achiral-chiral high-performance liquid chromatographic system. J Chromatogr (1990) 0.97
Clinical pharmacokinetics of the newer benzodiazepines. Clin Pharmacokinet (1983) 0.97
Stereoselective pharmacokinetics of mefloquine in healthy Caucasians after multiple doses. J Pharm Sci (1994) 0.96
Plasma protein binding of drugs after severe burn injury. Clin Pharmacol Ther (1984) 0.95
N-acetylation among HIV-positive patients and patients with AIDS: when is fast, fast and slow, slow? Clin Pharmacol Ther (1997) 0.95
Enantioselective binding to the human organic cation transporter-1 (hOCT1) determined using an immobilized hOCT1 liquid chromatographic stationary phase. Chirality (2005) 0.95
Responses to intravenous and oral diltiazem in elderly and younger patients with systemic hypertension. Am J Cardiol (1987) 0.95
Removal of methotrexate, leucovorin, and their metabolites by combined hemodialysis and hemoperfusion. Cancer (1988) 0.94
Absorption and disposition of ibuprofen in the elderly. Arthritis Rheum (1984) 0.94
Needs for an expanded ontology-based classification of adverse drug reactions and related mechanisms. Clin Pharmacol Ther (2012) 0.94
Interaction of cimetidine with the triazolobenzodiazepines alprazolam and triazolam. Psychopharmacology (Berl) (1983) 0.94
Potentially toxic serum lidocaine concentrations following spray anesthesia for bronchoscopy. Klin Wochenschr (1983) 0.94
Characterization of the protein binding of chiral drugs by high-performance affinity chromatography. Interactions of R- and S-ibuprofen with human serum albumin. J Chromatogr A (1995) 0.94
Age does not alter acetaminophen absorption. J Am Geriatr Soc (1982) 0.94
Development and characterization of immobilized cannabinoid receptor (CB1/CB2) open tubular column for on-line screening. Anal Biochem (2011) 0.93
Immobilized nicotinic receptor stationary phase for on-line liquid chromatographic determination of drug-receptor affinities. Anal Biochem (1998) 0.92
Ticlopidine inhibition of phenytoin metabolism mediated by potent inhibition of CYP2C19. Clin Pharmacol Ther (1997) 0.92
Verapamil pharmacodynamics and disposition in young and elderly hypertensive patients. Altered electrocardiographic and hypotensive responses. Ann Intern Med (1986) 0.91
Electromyographic patterns suggest changes in motor unit physiology associated with early osteoarthritis of the knee. Osteoarthritis Cartilage (2007) 0.91
A pilot study of plasma metabolomic patterns from patients treated with ketamine for bipolar depression: evidence for a response-related difference in mitochondrial networks. Br J Pharmacol (2014) 0.91
Ifosfamide stereoselective dichloroethylation and neurotoxicity. Lancet (1994) 0.91
Lorazepam and oxazepam kinetics in women on low-dose oral contraceptives. Clin Pharmacol Ther (1983) 0.91
Effects of inhalational anesthetics on verapamil pharmacokinetics in dogs. Anesthesiology (1986) 0.90
Imipramine and desipramine disposition in the elderly. J Pharmacol Exp Ther (1985) 0.90
Cerebrospinal fluid uptake and peripheral distribution of centrally acting drugs: relation to lipid solubility. J Pharm Pharmacol (1985) 0.90
Pharmacokinetic studies on Ro 15-1788, a benzodiazepine receptor ligand, in the brain of the rat. Brain Res (1984) 0.90
Characterization of a multiple ligand-gated ion channel cellular membrane affinity chromatography column and identification of endogenously expressed receptors in astrocytoma cell lines. Anal Chem (2008) 0.90
High-performance liquid chromatography assay for simultaneous determination of dextromethorphan and its main metabolites in urine and in microsomal preparations. J Chromatogr B Biomed Sci Appl (2001) 0.90
Absolute and relative bioavailability of oral acetaminophen preparations. J Pharm Sci (1983) 0.90
Evidence of renal metabolism of ifosfamide to nephrotoxic metabolites. Life Sci (2000) 0.89
Aging is associated with endothelial dysfunction in the human forearm vasculature. J Am Geriatr Soc (2000) 0.89
Direct stereochemical resolution of aspartame stereoisomers and their degradation products by high-performance liquid chromatography on a chiral crown ether based stationary phase. J Chromatogr (1990) 0.89
Simultaneous determination of lidocaine and its deethylated metabolites using gas-liquid chromatography with nitrogen-phosphorus detection. J Chromatogr (1984) 0.89
Increased metabolic clearance of acetaminophen with oral contraceptive use. Obstet Gynecol (1982) 0.88
Pharmacokinetics and metabolism of (R,R)-methoxyfenoterol in rat. Xenobiotica (2010) 0.88
Benzodiazepine kinetics: implications for therapeutics and pharmacogeriatrics. Drug Metab Rev (1983) 0.88
Prolonged accumulation of diazepam in obesity. J Clin Pharmacol (1983) 0.88
Thalidomide does not alter the pharmacokinetics of ethinyl estradiol and norethindrone. Clin Pharmacol Ther (1998) 0.87
Differential effects of isoniazid and oral contraceptive steroids on antipyrine oxidation and acetaminophen conjugation. Pharmacology (1984) 0.87
Determination of the enantiomers of albuterol in human and canine plasma by enantioselective high-performance liquid chromatography on a teicoplanin-based chiral stationary phase. Chirality (1998) 0.87
Prolongation of drug half-life due to obesity: studies of desmethyldiazepam (clorazepate). J Pharm Sci (1982) 0.87
The synthesis and characterization of a nuclear membrane affinity chromatography column for the study of human breast cancer resistant protein (BCRP) using nuclear membranes obtained from the LN-229 cells. J Pharm Biomed Anal (2012) 0.87
Effects of wild versus cultivated garlic on blood pressure and other parameters in hypertensive rats. Heart Dis (2001) 0.87
Plasma concentrations of the enantiomers of halofantrine and its main metabolite in malaria patients. Eur J Clin Pharmacol (1994) 0.86
The pharmacokinetics of midazolam in chronic renal failure patients. Anesthesiology (1983) 0.86
Kinetics of low-dose intravenous antipyrine: use of liquid chromatography. Int J Clin Pharmacol Ther Toxicol (1983) 0.86
Stereoselective distribution of hydroxychloroquine in the rabbit following single and multiple oral doses of the racemate and the separate enantiomers. Chirality (1994) 0.86
Impaired endothelial-dependent forearm vascular relaxation in black Americans. Clin Pharmacol Ther (1999) 0.86
The stereochemical resolution of the enantiomers of aspartame on an immobilized alpha-chymotrypsin HPLC chiral stationary phase: the effect of mobile-phase composition and enzyme activity. Chirality (1990) 0.86
Verapamil stereoisomers during racemic verapamil administration: effects of aging and comparisons to administration of individual stereoisomers. Clin Pharmacol Ther (1994) 0.86
The clinical pharmacology of meperidine--comparison of routes of administration. J Clin Pharmacol (1976) 0.85
Competitive and allosteric interactions in ligand binding to P-glycoprotein as observed on an immobilized P-glycoprotein liquid chromatographic stationary phase. Mol Pharmacol (2001) 0.85
Role of CYP2B6 and CYP3A4 in the in vitro N-dechloroethylation of (R)- and (S)-ifosfamide in human liver microsomes. Drug Metab Dispos (1999) 0.85
Liver injury due to verapamil. Hepatogastroenterology (1988) 0.85
Measurement of underivatized propranolol enantiomers in serum using a cellulose-tris(3,5-dimethylphenylcarbamate) high-performance liquid chromatographic (HPLC) chiral stationary phase. Pharm Res (1988) 0.85
Calcium antagonists in geriatric patients: diltiazem in elderly persons with hypertension. Clin Pharmacol Ther (1989) 0.84
Pharmacokinetic aspects of drug therapy in the elderly. Ther Drug Monit (1986) 0.84