Published in Am J Pathol on February 01, 1994
The role of the choroid plexus in neutrophil invasion after traumatic brain injury. J Cereb Blood Flow Metab (2009) 1.27
In Alzheimer's disease the Golgi apparatus of a population of neurons without neurofibrillary tangles is fragmented and atrophic. Am J Pathol (1996) 1.11
Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's beta-secretase. J Cell Biol (2003) 1.11
Microglia in Alzheimer's disease and transgenic models. How close the fit? Am J Pathol (1999) 1.09
Structure of heparan sulphate from human brain, with special regard to Alzheimer's disease. Biochem J (1995) 0.99
Amyloid beta-protein assembly as a therapeutic target of Alzheimer's disease. Curr Pharm Des (2008) 0.97
Heparan sulfate accumulation with Abeta deposits in Alzheimer's disease and Tg2576 mice is contributed by glial cells. Brain Pathol (2008) 0.97
Acetylcholinesterase-Abeta complexes are more toxic than Abeta fibrils in rat hippocampus: effect on rat beta-amyloid aggregation, laminin expression, reactive astrocytosis, and neuronal cell loss. Am J Pathol (2004) 0.94
Heat shock proteins and amateur chaperones in amyloid-Beta accumulation and clearance in Alzheimer's disease. Mol Neurobiol (2007) 0.92
Agrin is a major heparan sulfate proteoglycan accumulating in Alzheimer's disease brain. Am J Pathol (1999) 0.91
Differences in extracellular matrix production and basic fibroblast growth factor response in skin fibroblasts from sporadic and familial Alzheimer's disease. Mol Med (2007) 0.90
Microglial cells and amyloid beta protein (A beta) deposition; association with A beta 40-containing plaques. Acta Neuropathol (1995) 0.87
Suppression of amyloid beta A11 antibody immunoreactivity by vitamin C: possible role of heparan sulfate oligosaccharides derived from glypican-1 by ascorbate-induced, nitric oxide (NO)-catalyzed degradation. J Biol Chem (2011) 0.85
Neuronal heparan sulfates promote amyloid pathology by modulating brain amyloid-β clearance and aggregation in Alzheimer's disease. Sci Transl Med (2016) 0.81
The carbohydrate deposits detected by histochemical methods in the molecular layer of the dentate gyrus in the hippocampal formation of patients with schizophrenia, Down's syndrome and dementia, and aged person. Glycoconj J (2000) 0.80
In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders. Neural Plast (2015) 0.79
Biological evaluation of a series of 2-acetamido-2-deoxy-D-glucose analogs towards cellular glycosaminoglycan and protein synthesis in vitro. Glycoconj J (2005) 0.78
Sulfated glycosaminoglycans in protein aggregation diseases. Glycoconj J (2017) 0.77
Heparan sulfate proteoglycan induces the production of NO and TNF-alpha by murine microglia. Immun Ageing (2005) 0.75
Chronic Porphyromonas gingivalis infection accelerates the occurrence of age-related granules in ApoE(-)(/)(-) mice brains. J Oral Microbiol (2017) 0.75
Heparan Sulfate and Heparin Promote Faithful Prion Replication in Vitro by Binding to Normal and Abnormal Prion Proteins in Protein Misfolding Cyclic Amplification. J Biol Chem (2016) 0.75
Extracellular matrix proteomics in schizophrenia and Alzheimer's disease. Anal Bioanal Chem (2016) 0.75
Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun (1984) 20.07
Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci U S A (1985) 16.10
Amyloid beta-peptide is produced by cultured cells during normal metabolism. Nature (1992) 7.16
Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiation. Science (1991) 5.64
Differential staining of acid glycosaminoglycans (mucopolysaccharides) by alcian blue in salt solutions. Histochemie (1965) 5.47
Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein. Cell (1989) 4.99
Formic acid pretreatment enhances immunostaining of cerebral and systemic amyloids. Lab Invest (1987) 4.98
Cleavage of amyloid beta peptide during constitutive processing of its precursor. Science (1990) 4.91
Isolation of a heparan sulfate-containing proteoglycan from basement membrane. Proc Natl Acad Sci U S A (1980) 3.57
Neuritic plaques and cerebrovascular amyloid in Alzheimer disease are antigenically related. Proc Natl Acad Sci U S A (1985) 3.54
Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease. Cell (1988) 3.11
Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing. Science (1990) 3.10
A comparative study of modified Bielschowsky, Bodian and thioflavin S stains on Alzheimer's neurofibrillary tangles. Neuropathol Appl Neurobiol (1986) 3.09
Processing of the amyloid protein precursor to potentially amyloidogenic derivatives. Science (1992) 2.82
Identification of the basic fibroblast growth factor binding sequence in fibroblast heparan sulfate. J Biol Chem (1992) 2.20
Potentially amyloidogenic, carboxyl-terminal derivatives of the amyloid protein precursor. Science (1992) 2.12
Alzheimer's disease: amyloid plaques in the cerebellum. J Neurol Sci (1989) 2.08
Diffuse senile plaques occur commonly in the cerebellum in Alzheimer's disease. Am J Pathol (1989) 1.95
The beta-amyloid protein precursor of Alzheimer disease has soluble derivatives found in human brain and cerebrospinal fluid. Proc Natl Acad Sci U S A (1989) 1.73
Isolation and characterization of amyloid P component from Alzheimer's disease and other types of cerebral amyloidosis. Lab Invest (1988) 1.70
The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease. Am J Pathol (1988) 1.65
Chloroquine inhibits intracellular degradation but not secretion of Alzheimer beta/A4 amyloid precursor protein. Proc Natl Acad Sci U S A (1992) 1.40
Characterization of an amyloid beta precursor protein that binds heparin and contains tyrosine sulfate. Proc Natl Acad Sci U S A (1989) 1.36
Diffuse type of senile plaques in the cerebellum of Alzheimer-type dementia demonstrated by beta protein immunostain. Acta Neuropathol (1989) 1.35
Immunolocalization of heparan sulfate proteoglycans to the prion protein amyloid plaques of Gerstmann-Straussler syndrome, Creutzfeldt-Jakob disease and scrapie. Lab Invest (1990) 1.32
Immunoelectron microscopic localization of amyloid beta protein in the diffuse plaques of Alzheimer-type dementia. Brain Res (1990) 1.23
Proteoglycans in the pathogenesis of Alzheimer's disease and other amyloidoses. Neurobiol Aging (1989) 1.19
Effects of sulfate ions on Alzheimer beta/A4 peptide assemblies: implications for amyloid fibril-proteoglycan interactions. J Neurochem (1992) 1.18
Early accumulation of heparan sulfate in neurons and in the beta-amyloid protein-containing lesions of Alzheimer's disease and Down's syndrome. Am J Pathol (1990) 1.17
Circular-dichroism studies on two murine serum amyloid A proteins. Biochem J (1988) 1.13
Localization of heparan sulfate glycosaminoglycan and proteoglycan core protein in aged brain and Alzheimer's disease. Neuroscience (1992) 1.11
Basement membrane proteoglycan in various tissues: characterization using monoclonal antibodies to the Engelbreth-Holm-Swarm mouse tumor low density heparan sulfate proteoglycan. J Cell Biol (1988) 1.11
"Critical electrolyte concentration" method in histochemistry. J Med Lab Technol (1969) 1.08
Nomenclature of amyloid and amyloidosis. WHO-IUIS Nomenclature Sub-Committee. Bull World Health Organ (1993) 1.07
Ultrastructure of diffuse plaques in senile dementia of the Alzheimer type: comparison with primitive plaques. Acta Neuropathol (1991) 1.05
Evidence for lysosomal processing of amyloid beta-protein precursor in cultured cells. Neurochem Res (1989) 1.02
Soluble derivatives of the beta amyloid protein precursor of Alzheimer's disease are labeled by antisera to the beta amyloid protein. Biochem Biophys Res Commun (1989) 1.01
Microangiopathy and the colocalization of heparan sulfate proteoglycan with amyloid in senile plaques of Alzheimer's disease. Brain Res (1990) 1.00
Widespread serum amyloid P immunoreactivity in cortical amyloid deposits and the neurofibrillary pathology of Alzheimer's disease and other degenerative disorders. Neuropathol Appl Neurobiol (1991) 0.99
Acute phase proteins are present in amorphous plaques in the cerebral but not in the cerebellar cortex of patients with Alzheimer's disease. Neurosci Lett (1990) 0.98
Sulfated glycosaminoglycans modify growth factor-induced neurite outgrowth in PC12 cells. J Cell Physiol (1988) 0.98
Alpha 1-antichymotrypsin is present in diffuse senile plaques. A comparative study of beta-protein and alpha 1-antichymotrypsin immunostaining in the Alzheimer brain. Am J Pathol (1991) 0.97
The amyloid P-component (protein AP): an integral part of the amyloid substance? Scand J Immunol (1979) 0.89
The ultrastructural localization of sulfated proteoglycans is identical in the amyloids of Alzheimer's disease and AA, AL, senile cardiac and medullary carcinoma-associated amyloidosis. Acta Neuropathol (1989) 0.89
Cationic dyes reveal proteoglycans structurally integrated within the characteristic lesions of Alzheimer's disease. Acta Neuropathol (1989) 0.85
Heparan sulfate proteoglycan and laminin immunoreactivity on cultured astrocytes: relationship to differentiation and neurite growth. J Neurosci (1988) 0.84
Amyloid P component and other acute-phase proteins associated with cerebellar A beta-deposits in Alzheimer's disease. Brain Res (1993) 0.82
Functional interactions of neuronal heparan sulphate proteoglycans with laminin. Brain Res (1990) 0.80
Changes in glycosaminoglycans during the neuritogenesis in PC12 pheochromocytoma cells induced by nerve growth factor. J Neurochem (1990) 0.79
Effects of nerve growth factor-induced differentiation on the heparan sulfate of PC12 pheochromocytoma cells and comparison with developing brain. Arch Biochem Biophys (1987) 0.79
Reconstituted basement membrane enhances neurite outgrowth in PC12 cells induced by nerve growth factor. Cell Growth Differ (1990) 0.79
Formic acid treatment exposes hidden neurofilament and tau epitopes in abnormal cytoskeletal filaments from patients with progressive supranuclear palsy and Alzheimer's disease. Neurosci Lett (1990) 0.78
Nomenclature of amyloid A4 proteins and their precursors in Alzheimer's disease and Down's syndrome. Neurobiol Aging (1990) 0.78
Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology (2005) 21.67
Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties. J Biol Chem (1999) 3.34
Clinico-neuropathological correlation of Alzheimer's disease in a community-based case series. J Am Geriatr Soc (1999) 2.63
Staging and natural history of cerebrovascular pathology in dementia. Neurology (2012) 2.61
Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism-chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements. Proc Natl Acad Sci U S A (1999) 2.26
The number of trait loci in late-onset Alzheimer disease. Am J Hum Genet (2000) 2.24
Characterization of fibronectin interactions with glycosaminoglycans and identification of active proteolytic fragments. J Biol Chem (1980) 2.24
Mechanism responsible for glucose-lactose diauxie in Escherichia coli: challenge to the cAMP model. Genes Cells (1996) 2.15
Neuropathologic evidence of endothelial changes in cerebral small vessel disease. Neurology (2011) 2.15
Clinical-neuropathologic findings in multi-infarct dementia: a report of six autopsied cases. Neurology (1997) 2.13
The influence of p-nitrophenyl beta-d-xyloside on the synthesis of proteochondroitin sulfate by slices of embryonic chick cartilage. J Biochem (1973) 2.08
A chondrogenic cell line derived from a differentiating culture of AT805 teratocarcinoma cells. Cell Differ Dev (1990) 2.00
Mouse cartilage matrix deficiency (cmd) caused by a 7 bp deletion in the aggrecan gene. Nat Genet (1994) 1.94
Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes. Am J Pathol (1998) 1.93
Structural analysis of chick-embryo cartilage proteoglycan by selective degradation with chondroitin lyases (chondroitinases) and endo-beta-D-galactosidase (keratanase). Biochem J (1980) 1.86
Frequency of tau gene mutations in familial and sporadic cases of non-Alzheimer dementia. Arch Neurol (2001) 1.84
Phenotypic variability of Gerstmann-Sträussler-Scheinker disease is associated with prion protein heterogeneity. J Neuropathol Exp Neurol (1998) 1.79
An important role of heparan sulfate proteoglycan (Perlecan) in a model system for the deposition and persistence of fibrillar A beta-amyloid in rat brain. Neuron (1994) 1.77
Phenotype of chromosome 14-linked familial Alzheimer's disease in a large kindred. Ann Neurol (1994) 1.73
A novel regulatory role of glucose transporter of Escherichia coli: membrane sequestration of a global repressor Mlc. EMBO J (2000) 1.72
The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease. Am J Pathol (1988) 1.65
Disease-specific patterns of locus coeruleus cell loss. Ann Neurol (1992) 1.64
A large chondroitin sulfate proteoglycan (PG-M) synthesized before chondrogenesis in the limb bud of chick embryo. J Biol Chem (1986) 1.62
Knowledge and perception of stroke amongst hospital workers in an African community. Eur J Neurol (2009) 1.62
Vascular factors and Alzheimer disease. Alzheimer Dis Assoc Disord (2000) 1.60
Isolation of two forms of basement membrane proteoglycans. J Biol Chem (1985) 1.55
Apolipoprotein E-epsilon4 alleles in cerebral amyloid angiopathy and cerebrovascular pathology associated with Alzheimer's disease. Am J Pathol (1996) 1.54
Neuronal nuclear antigen (NeuN): a marker of neuronal maturation in early human fetal nervous system. Brain Dev (1998) 1.53
Roles of aggrecan, a large chondroitin sulfate proteoglycan, in cartilage structure and function. J Biochem (1998) 1.53
A neuropathological study of vascular factors in late-life depression. J Neurol Neurosurg Psychiatry (2001) 1.53
NINDS AIREN neuroimaging criteria do not distinguish stroke patients with and without dementia. Neurology (2004) 1.48
Cerebral amyloid beta protein deposits and other Alzheimer lesions in non-demented elderly east Africans. Brain Pathol (1996) 1.47
The significance of medial temporal lobe atrophy: a postmortem MRI study in the very old. Neurology (2007) 1.46
Absence of linkage of chromosome 21q21 markers to familial Alzheimer's disease. Science (1988) 1.44
Defect in SHAP-hyaluronan complex causes severe female infertility. A study by inactivation of the bikunin gene in mice. J Biol Chem (2001) 1.42
Dwarfism and age-associated spinal degeneration of heterozygote cmd mice defective in aggrecan. Proc Natl Acad Sci U S A (1997) 1.42
Relationship between hyaluronan production and metastatic potential of mouse mammary carcinoma cells. Cancer Res (1999) 1.41
Chondroitin sulfate proteoglycan (PG-M-like proteoglycan) is involved in the binding of hyaluronic acid to cellular fibronectin. J Biol Chem (1986) 1.41
The relationship of amyloid plaques to cerebral capillaries in Alzheimer's disease. Am J Pathol (1990) 1.40
Absence of proteoglycan core protein in cartilage from the cmd/cmd (cartilage matrix deficiency) mouse. J Biol Chem (1981) 1.37
Evidence for the covalent binding of SHAP, heavy chains of inter-alpha-trypsin inhibitor, to hyaluronan. J Biol Chem (1995) 1.37
Isolation and characterization of a third proteoglycan (PG-Lt) from chick embryo cartilage which contains disulfide-bonded collagenous polypeptide. J Biol Chem (1983) 1.37
Enzyme interactions in heparan sulfate biosynthesis: uronosyl 5-epimerase and 2-O-sulfotransferase interact in vivo. Proc Natl Acad Sci U S A (2001) 1.36
Mitotic activation: a convergent mechanism for a cohort of neurodegenerative diseases. Neurobiol Aging (2001) 1.32
Amyloid beta protein (Abeta) deposition in chromosome 14-linked Alzheimer's disease: predominance of Abeta42(43). Ann Neurol (1996) 1.32
Immunolocalization of heparan sulfate proteoglycans to the prion protein amyloid plaques of Gerstmann-Straussler syndrome, Creutzfeldt-Jakob disease and scrapie. Lab Invest (1990) 1.32
A serum-derived hyaluronan-associated protein (SHAP) is the heavy chain of the inter alpha-trypsin inhibitor. J Biol Chem (1993) 1.32
2B1 antigen characteristically expressed on extracellular matrices of human malignant tumors is a large chondroitin sulfate proteoglycan, PG-M/versican. Cancer Res (1996) 1.28
In vitro synthesis of hyaluronan by a single protein derived from mouse HAS1 gene and characterization of amino acid residues essential for the activity. J Biol Chem (2000) 1.28
cDNA cloning of PG-M, a large chondroitin sulfate proteoglycan expressed during chondrogenesis in chick limb buds. Alternative spliced multiforms of PG-M and their relationships to versican. J Biol Chem (1993) 1.27
Association of heparan sulfate proteoglycan with the neurofibrillary tangles of Alzheimer's disease. J Neurosci (1991) 1.27
Heterogeneity of proteochondroitin sulfates produced by chondrocytes at different stages of cytodifferentiation. J Biol Chem (1974) 1.25
The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine. J Biol Chem (2000) 1.25
Review: cerebral amyloid angiopathy, prion angiopathy, CADASIL and the spectrum of protein elimination failure angiopathies (PEFA) in neurodegenerative disease with a focus on therapy. Neuropathol Appl Neurobiol (2013) 1.24
Multiple forms of mouse PG-M, a large chondroitin sulfate proteoglycan generated by alternative splicing. J Biol Chem (1995) 1.24
A clinical pathological comparison of three families with frontotemporal dementia and identical mutations in the tau gene (P301L) Brain (1999) 1.22
Increased synthesis of hyaluronic acid by mouse mammary carcinoma cell variants with high metastatic potential. Cancer Res (1983) 1.22
Substrate specificity of the heparan sulfate hexuronic acid 2-O-sulfotransferase. Biochemistry (2001) 1.22
Frontal lobe white matter hyperintensities and neurofibrillary pathology in the oldest old. Neurology (2010) 1.22
Structure of a heparan sulphate oligosaccharide that binds to basic fibroblast growth factor. Biochem J (1992) 1.20
Avian neural crest cell migration is diversely regulated by the two major hyaluronan-binding proteoglycans PG-M/versican and aggrecan. Development (2000) 1.19
Proteoglycans in the pathogenesis of Alzheimer's disease and other amyloidoses. Neurobiol Aging (1989) 1.19
Molecular cloning and expression of Chinese hamster ovary cell heparan-sulfate 2-sulfotransferase. J Biol Chem (1997) 1.19
Familial presenile dementia with psychosis associated with cortical neurofibrillary tangles and degeneration of the amygdala. Neurology (1992) 1.18
Early accumulation of heparan sulfate in neurons and in the beta-amyloid protein-containing lesions of Alzheimer's disease and Down's syndrome. Am J Pathol (1990) 1.17
Phenotypic heterogeneity in familial Alzheimer's disease: a study of 24 kindreds. Ann Neurol (1989) 1.17
Negative regulation of the pts operon by Mlc: mechanism underlying glucose induction in Escherichia coli. Genes Cells (1999) 1.17
Regulation of cell-substrate adhesion by proteoglycans immobilized on extracellular substrates. J Biol Chem (1989) 1.17
Expression cloning and molecular characterization of HAS protein, a eukaryotic hyaluronan synthase. J Biol Chem (1996) 1.17
Effect of beta-D-xyloside and cycloheximide on the synthesis of two types of proteochondroitin sulfate in chick embryo cartilage. J Biol Chem (1978) 1.16
Purification and characterization of heparan sulfate 2-sulfotransferase from cultured Chinese hamster ovary cells. J Biol Chem (1996) 1.15
The occurrence of low buoyant density proteoglycans in embryonic chick cartilage. Biochem Biophys Res Commun (1978) 1.15
White matter lesions in an unselected cohort of the elderly: astrocytic, microglial and oligodendrocyte precursor cell responses. Neuropathol Appl Neurobiol (2007) 1.14
Comparison of postmortem magnetic resonance imaging and neuropathologic findings in the cerebral white matter. Arch Neurol (1991) 1.14
Proteinase activity in chondroitin lyase (chondroitinase) and endo-beta-D-galactosidase (keratanase) preparations and a method to abolish their proteolytic effect on proteoglycan. Biochem J (1980) 1.14
Degeneration of vascular muscle cells in cerebral amyloid angiopathy of Alzheimer disease. Brain Res (1993) 1.13
Expression of PG-M(V3), an alternatively spliced form of PG-M without a chondroitin sulfate attachment in region in mouse and human tissues. J Biol Chem (1995) 1.13
Molecular cloning of human hyaluronan synthase. Biochem Biophys Res Commun (1996) 1.13
Identification of a stable fragment of the Alzheimer amyloid precursor containing the beta-protein in brain microvessels. Proc Natl Acad Sci U S A (1992) 1.12
Drosophila heparan sulfate 6-O-sulfotransferase (dHS6ST) gene. Structure, expression, and function in the formation of the tracheal system. J Biol Chem (2001) 1.12
Basement membrane proteoglycan in various tissues: characterization using monoclonal antibodies to the Engelbreth-Holm-Swarm mouse tumor low density heparan sulfate proteoglycan. J Cell Biol (1988) 1.11
Chromosome 17 and hereditary dementia: linkage studies in three non-Alzheimer families and kindreds with late-onset FAD. Neurology (1997) 1.10
Multiple forms of heparan sulfate proteoglycans in the Engelbreth-Holm-Swarm mouse tumor. The occurrence of high density forms bearing both heparan sulfate and chondroitin sulfate side chains. J Biol Chem (1987) 1.09
Glomerulosclerosis in mice transgenic for growth hormone. Increased mesangial extracellular matrix is correlated with kidney mRNA levels. J Exp Med (1991) 1.09
Selective distributions of proteoglycans and their ligands in pericellular matrix of cultured fibroblasts. Implications for their roles in cell-substratum adhesion. J Cell Sci (1993) 1.08
Hyaluronan activates cell motility of v-Src-transformed cells via Ras-mitogen-activated protein kinase and phosphoinositide 3-kinase-Akt in a tumor-specific manner. Mol Biol Cell (2001) 1.08
Quantification of Alzheimer pathology in ageing and dementia: age-related accumulation of amyloid-beta(42) peptide in vascular dementia. Neuropathol Appl Neurobiol (2006) 1.08
Heparin modulates the composition of the extracellular matrix domain surrounding arterial smooth muscle cells. Am J Pathol (1990) 1.07
Prion proteins with different conformations accumulate in Gerstmann-Sträussler-Scheinker disease caused by A117V and F198S mutations. Am J Pathol (2001) 1.07
Preparation of lipid-derivatized glycosaminoglycans to probe a regulatory function of the carbohydrate moieties of proteoglycans in cell-matrix interaction. J Biol Chem (1993) 1.07