Distinct patterns of protective antibodies are generated against Borrelia burgdorferi in mice experimentally inoculated with high and low doses of antigen.

PubWeight™: 1.84‹?› | Rank: Top 3%

🔗 View Article (PMID 8349316)

Published in Immunol Lett on May 01, 1993

Authors

U E Schaible1, L Gern, R Wallich, M D Kramer, M Prester, M M Simon

Author Affiliations

1: Max-Planck-Institut für Immunobiologie, Freiburg, Germany.

Articles citing this

Temperature-related differential expression of antigens in the Lyme disease spirochete, Borrelia burgdorferi. Infect Immun (1995) 4.68

Molecular cloning and immunological characterization of a novel linear-plasmid-encoded gene, pG, of Borrelia burgdorferi expressed only in vivo. Infect Immun (1995) 3.00

Circumvention of outer surface protein A immunity by host-adapted Borrelia burgdorferi. Infect Immun (1995) 2.86

Attachment of Borrelia burgdorferi within Ixodes scapularis mediated by outer surface protein A. J Clin Invest (2000) 2.56

A family of genes located on four separate 32-kilobase circular plasmids in Borrelia burgdorferi B31. J Bacteriol (1996) 2.34

Active and passive immunity against Borrelia burgdorferi decorin binding protein A (DbpA) protects against infection. Infect Immun (1998) 2.29

Decorin-binding protein of Borrelia burgdorferi is encoded within a two-gene operon and is protective in the murine model of Lyme borreliosis. Infect Immun (1998) 2.23

DbpA, but not OspA, is expressed by Borrelia burgdorferi during spirochetemia and is a target for protective antibodies. Infect Immun (1998) 1.99

Passive immunizing activity of sera from mice infected with Borrelia burgdorferi. Infect Immun (1993) 1.95

Characterization of outer membranes isolated from Borrelia burgdorferi, the Lyme disease spirochete. Infect Immun (1995) 1.66

Expression and gene sequence of outer surface protein C of Borrelia burgdorferi reisolated from chronically infected mice. Infect Immun (1994) 1.57

Molecular characterization of a 6.6-kilodalton Borrelia burgdorferi outer membrane-associated lipoprotein (lp6.6) which appears to be downregulated during mammalian infection. Infect Immun (1997) 1.57

Borrelia burgdorferi antigens that are targeted by antibody-dependent, complement-mediated killing in the rhesus monkey. Infect Immun (1994) 1.55

Therapeutic passive vaccination against chronic Lyme disease in mice. Proc Natl Acad Sci U S A (1997) 1.50

Borrelia burgdorferi alters its gene expression and antigenic profile in response to CO2 levels. J Bacteriol (2006) 1.32

Antigenic stability of Borrelia burgdorferi during chronic infections of immunocompetent mice. Infect Immun (1993) 1.31

Development of destructive arthritis in vaccinated hamsters challenged with Borrelia burgdorferi. Infect Immun (1994) 1.30

Differential immune responses to Borrelia burgdorferi in European wild rodent species influence spirochete transmission to Ixodes ricinus L. (Acari: Ixodidae). Infect Immun (1994) 1.24

Variation in antigenicity and infectivity of derivatives of Borrelia burgdorferi, strain B31, maintained in the natural, zoonotic cycle compared with maintenance in culture. Infect Immun (1995) 1.21

Quantitative evaluation of ehrlichial burden in horses after experimental transmission of human granulocytic Ehrlichia agent by intravenous inoculation with infected leukocytes and by infected ticks. J Clin Microbiol (1999) 1.14

Specificity of infection-induced immunity among Borrelia burgdorferi sensu lato species. Infect Immun (1999) 1.05

Duration of immunity to reinfection with tick-transmitted Borrelia burgdorferi in naturally infected mice. Infect Immun (1997) 1.01

Acquired resistance to Borrelia burgdorferi infection in the rabbit. Comparison between outer surface protein A vaccine- and infection-derived immunity. J Clin Invest (1997) 0.98

Quantitative analysis of Borrelia burgdorferi gene expression in naturally (tick) infected mouse strains. Med Microbiol Immunol (2005) 0.98

Borrelia burgdorferi binding of host complement regulator factor H is not required for efficient mammalian infection. Infect Immun (2007) 0.95

B7-1 and B7-2 monoclonal antibodies modulate the severity of murine Lyme arthritis. Infect Immun (1997) 0.92

Immunoglobulin-regulated expression of Borrelia burgdorferi outer surface protein A in vivo. Infect Immun (2005) 0.86

Incongruent effects of two isolates of Rickettsia conorii on the survival of Rhipicephalus sanguineus ticks. Exp Appl Acarol (2009) 0.86

Differentiation of borreliacidal activity caused by immune serum or antimicrobial agents by flow cytometry. Clin Diagn Lab Immunol (1994) 0.82

Experimental infection of dogs with Borrelia burgdorferi sensu stricto using Ixodes scapularis ticks artificially infected by capillary feeding. Med Microbiol Immunol (2003) 0.81

The DBA/1 strain is a novel mouse model for experimental Borrelia burgdorferi infection. Clin Vaccine Immunol (2012) 0.78

Follistatin-like protein 1 is a critical mediator of experimental Lyme arthritis and the humoral response to Borrelia burgdorferi infection. Microb Pathog (2014) 0.76

Articles by these authors

Monoclonal antibodies specific for the outer surface protein A (OspA) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficiency (scid) mice. Proc Natl Acad Sci U S A (1990) 4.15

Different genospecies of Borrelia burgdorferi are associated with distinct clinical manifestations of Lyme borreliosis. Clin Infect Dis (1993) 3.92

Recombinant outer surface protein a from Borrelia burgdorferi induces antibodies protective against spirochetal infection in mice. J Infect Dis (1991) 3.58

Specific Lyt 123 cells are involved in protection against Listeria monocytogenes and in delayed-type hypersensitivity to listerial antigens. J Exp Med (1979) 3.31

Molecular cloning and immunological characterization of a novel linear-plasmid-encoded gene, pG, of Borrelia burgdorferi expressed only in vivo. Infect Immun (1995) 3.00

The severe combined immunodeficiency (scid) mouse. A laboratory model for the analysis of Lyme arthritis and carditis. J Exp Med (1989) 2.68

Co-feeding ticks: Epidemiological significance for tick-borne pathogen transmission. Parasitol Today (1996) 2.67

Persistence of a behavioral food-anticipatory circadian rhythm following dorsomedial hypothalamic ablation in rats. Am J Physiol Regul Integr Comp Physiol (2006) 2.54

Abrogation of metastatic properties of tumour cells by de novo expression of H-2K antigens following H-2 gene transfection. Nature (1985) 2.48

Lyme borreliosis in Europe and North America. Parasitology (2004) 2.37

Nucleotide sequence of a gene encoding the Borrelia burgdorferi flagellin. Nucleic Acids Res (1989) 2.21

Lyme borreliosis in the severe combined immunodeficiency (scid) mouse manifests predominantly in the joints, heart, and liver. Am J Pathol (1990) 2.15

Evaluation of genetic divergence among Borrelia burgdorferi isolates by use of OspA, fla, HSP60, and HSP70 gene probes. Infect Immun (1992) 2.10

The Borrelia burgdorferi flagellum-associated 41-kilodalton antigen (flagellin): molecular cloning, expression, and amplification of the gene. Infect Immun (1990) 2.10

The urokinase system of plasminogen activation and prognosis in 2780 breast cancer patients. Cancer Res (2000) 2.09

Mode of inoculation of the Lyme disease agent Borrelia burgdorferi influences infection and immune responses in inbred strains of mice. J Infect Dis (1993) 1.84

Involvement of common and cell type-specific pathways in c-fos gene control: stable induction of cAMP in macrophages. Cell (1987) 1.83

Influence of saturation deficit and temperature on Ixodes ricinus tick questing activity in a Lyme borreliosis-endemic area (Switzerland). Parasitol Res (2000) 1.79

Plasmid analysis and restriction fragment length polymorphisms of chromosomal DNA allow a distinction between Borrelia burgdorferi strains. Zentralbl Bakteriol (1990) 1.77

The outer surface protein A of the spirochete Borrelia burgdorferi is a plasmin(ogen) receptor. Proc Natl Acad Sci U S A (1994) 1.76

An avian reservoir (Turdus merula) of the Lyme borreliosis spirochetes. Zentralbl Bakteriol (1998) 1.74

Experimental Borrelia burgdorferi infection in inbred mouse strains: antibody response and association of H-2 genes with resistance and susceptibility to development of arthritis. Eur J Immunol (1991) 1.71

PCR detection of granulocytic ehrlichiae in Ixodes ricinus ticks and wild small mammals in western Switzerland. J Clin Microbiol (2000) 1.68

Molecular and immunological characterization of a novel polymorphic lipoprotein of Borrelia burgdorferi. Infect Immun (1993) 1.64

Antigenic variation and strain heterogeneity in Borrelia spp. Res Microbiol (1993) 1.60

Transmission of Borrelia afzelii from Apodemus mice and Clethrionomys voles to Ixodes ricinus ticks: differential transmission pattern and overwintering maintenance. Parasitology (1999) 1.58

Monoclonal antibodies against murine cell surface antigens: anti-H-2, anti-Ia and anti-T cell antibodies. Curr Top Microbiol Immunol (1978) 1.55

Cloning and sequencing of the gene encoding the outer surface protein A (OspA) of a European Borrelia burgdorferi isolate. Nucleic Acids Res (1989) 1.53

Granzyme A-deficient mice retain potent cell-mediated cytotoxicity. EMBO J (1995) 1.52

A mouse model for Borrelia burgdorferi infection: approach to a vaccine against Lyme disease. Immunol Today (1991) 1.52

Molecular and biochemical characterization of a cytokinin oxidase from maize. Plant Physiol (2001) 1.52

Therapeutic passive vaccination against chronic Lyme disease in mice. Proc Natl Acad Sci U S A (1997) 1.50

[Borrelia burgdorferi infection. I. Aspects of basic research, current approach for diagnosis and therapy]. Hautarzt (1990) 1.49

Interleukin 2 induction in Lyt 1+ 23- T cells from Listeria monocytogenes-immune mice. Infect Immun (1982) 1.49

Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes. Proc Natl Acad Sci U S A (1999) 1.46

The immune response of the mouse to lymphocytic choriomeningitis virus. V. High numbers of cytolytic T lymphocytes are generated in the spleen during acute infection. Eur J Immunol (1987) 1.46

Antigenic conservation of an immunodominant invariable region of the VlsE lipoprotein among European pathogenic genospecies of Borrelia burgdorferi SL. J Infect Dis (2000) 1.45

Cellular immune reactivity to recombinant OspA and flagellin from Borrelia burgdorferi in patients with Lyme borreliosis. Complexity of humoral and cellular immune responses. J Clin Invest (1992) 1.45

Regulatory interactions between macrophages and T-cell subsets in Listeria monocytogenes-specific T-cell activation. Infect Immun (1982) 1.43

Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia. Proc Natl Acad Sci U S A (1996) 1.42

Quantitative studies on T cell diversity. I. Determination of the precursor frequencies for two types of streptococcus A-specific helper cells in nonimmune, polyclonally activated splenic T cells. J Exp Med (1980) 1.39

Strain variation of Lyme disease spirochetes isolated from Ixodes ricinus ticks and rodents collected in two endemic areas in Switzerland. J Med Entomol (1995) 1.37

Immune sera to individual Borrelia burgdorferi isolates or recombinant OspA thereof protect SCID mice against infection with homologous strains but only partially or not at all against those of different OspA/OspB genotype. Vaccine (1993) 1.37

Characterization of Borrelia burgdorferi associated antigens by monoclonal antibodies. Immunobiology (1990) 1.37

Plasminogen activator inhibitor-1 and prognosis in primary breast cancer. J Clin Oncol (1994) 1.36

Expression of cytoplasmic granules with T cell-associated serine proteinase-1 activity in Ly-2+(CD8+) T lymphocytes responding to lymphocytic choriomeningitis virus in vivo. Eur J Immunol (1989) 1.36

Infestation of rodents with larval Ixodes ricinus (Acari: Ixodidae) is an important factor in the transmission cycle of Borrelia burgdorferi s.l. in German woodlands. J Med Entomol (1995) 1.36

Borrelia burgdorferi activates nuclear factor-kappa B and is a potent inducer of chemokine and adhesion molecule gene expression in endothelial cells and fibroblasts. J Immunol (1997) 1.35

Coiling phagocytosis is the preferential phagocytic mechanism for Borrelia burgdorferi. Infect Immun (1992) 1.35

Identification of herpes simplex virus type 1 glycoproteins interacting with the cell surface. J Virol (1990) 1.34

Relationship of Borrelia burgdorferi to its arthropod vectors. Scand J Infect Dis Suppl (1991) 1.32

Novel Borrelia burgdorferi isolates from Ixodes scapularis and Ixodes dentatus ticks feeding on humans. J Clin Microbiol (1996) 1.31

In situ expression of interleukin-10 in noninflamed human gut and in inflammatory bowel disease. Am J Pathol (1998) 1.28

Resolution of experimental and tick-borne Borrelia burgdorferi infection in mice by passive, but not active immunization using recombinant OspC. Eur J Immunol (1999) 1.28

Quantitative studies on T cell diversity. II. Determination of the frequencies and Lyt phenotypes of two types of precursor cells for alloreactive cytotoxic T cells in polyclonally and specifically activated splenic T cells. J Exp Med (1981) 1.28

Antibody-mediated target cell lysis by non-immune cells. Characterization of the antibody and effector cell populations. Eur J Immunol (1972) 1.27

Monoclonal antibodies to interferon-gamma inhibit interleukin 2-dependent induction of growth and maturation in lectin/antigen-reactive cytolytic T lymphocyte precursors. J Immunol (1986) 1.27

The prevalence and incidence of clinical and asymptomatic Lyme borreliosis in a population at risk. J Infect Dis (1991) 1.26

Protection against Borrelia burgdorferi infection in SCID mice is conferred by presensitized spleen cells and partially by B but not T cells alone. Int Immunol (1994) 1.24

Differential immune responses to Borrelia burgdorferi in European wild rodent species influence spirochete transmission to Ixodes ricinus L. (Acari: Ixodidae). Infect Immun (1994) 1.24

Demonstration of antigen-specific T cells and histopathological alterations in mice experimentally inoculated with Borrelia burgdorferi. Infect Immun (1989) 1.24

The tetratricopeptide repeat-domain of the PAS10 protein of Saccharomyces cerevisiae is essential for binding the peroxisomal targeting signal-SKL. Biochem Biophys Res Commun (1994) 1.23

Effector T lymphocytes in lymphocytic choriomeningitis virus-infected mice. Cytolytic activity of Lyt-23 spleen cells in vitro does not correlate with elimination of infectious virus from spleens. J Exp Med (1981) 1.22

Perforin is essential for control of ectromelia virus but not related poxviruses in mice. J Virol (1999) 1.20

Differentially regulated malate synthase genes participate in carbon and nitrogen metabolism of S. cerevisiae. Nucleic Acids Res (1992) 1.19

Coinoculation of Borrelia spp. with tick salivary gland lysate enhances spirochete load in mice and is tick species-specific. J Parasitol (2002) 1.19