Published in Hum Mol Genet on June 01, 1993
Proton-dependent multidrug efflux systems. Microbiol Rev (1996) 8.81
Systematic screening of an arrayed cDNA library by PCR. Proc Natl Acad Sci U S A (1995) 0.92
Initial sequencing and analysis of the human genome. Nature (2001) 212.86
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature (1995) 13.80
Molecular basis of myotonic dystrophy: expansion of a trinucleotide (CTG) repeat at the 3' end of a transcript encoding a protein kinase family member. Cell (1992) 12.74
p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell (1993) 12.02
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature (1996) 10.14
Expansion of an unstable DNA region and phenotypic variation in myotonic dystrophy. Nature (1992) 8.85
Expression and identification of hepatitis C virus polyprotein cleavage products. J Virol (1993) 8.47
Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus. Cell (1990) 8.30
The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene. Cell (1988) 7.10
Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila. Nature (2001) 6.76
p53 status and the efficacy of cancer therapy in vivo. Science (1994) 6.72
Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature (1995) 6.62
Targeted integration of adeno-associated virus (AAV) into human chromosome 19. EMBO J (1991) 6.13
A family of cAMP-binding proteins that directly activate Rap1. Science (1998) 6.12
Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia. Cell (1994) 5.96
Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding. Structure (1998) 5.83
The early-onset torsion dystonia gene (DYT1) encodes an ATP-binding protein. Nat Genet (1997) 5.39
Regulation of flowering time by Arabidopsis photoreceptors. Science (1998) 5.11
Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family. Nat Genet (1997) 4.92
Bipolar affective disorders linked to DNA markers on chromosome 11. Nature (1987) 4.64
The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein. Nat Genet (1996) 4.59
Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor. Science (1987) 4.32
Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide. Cell (1996) 4.12
Negative transport & resistance to water flow through plants. Plant Physiol (1961) 4.10
The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription. Proc Natl Acad Sci U S A (2000) 4.01
Isolation and expression of a complementary DNA that confers multidrug resistance. Nature (1986) 3.84
TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice. Nat Med (2001) 3.84
Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science (1998) 3.53
Exon amplification: a strategy to isolate mammalian genes based on RNA splicing. Proc Natl Acad Sci U S A (1991) 3.43
Isolation and chromosomal assignment of 100 highly informative human simple sequence repeat polymorphisms. Genomics (1992) 3.42
Efficacy and safety of abatacept or infliximab vs placebo in ATTEST: a phase III, multi-centre, randomised, double-blind, placebo-controlled study in patients with rheumatoid arthritis and an inadequate response to methotrexate. Ann Rheum Dis (2007) 3.31
Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells. Proc Natl Acad Sci U S A (1986) 3.19
Expansion of a CUG trinucleotide repeat in the 3' untranslated region of myotonic dystrophy protein kinase transcripts results in nuclear retention of transcripts. Proc Natl Acad Sci U S A (1997) 3.18
Alcohol and gambling pathology among U.S. adults: prevalence, demographic patterns and comorbidity. J Stud Alcohol (2001) 3.14
Survey of major genotypes and subtypes of hepatitis C virus using RFLP of sequences amplified from the 5' non-coding region. J Gen Virol (1995) 3.10
Direct analysis and identification of proteins in mixtures by LC/MS/MS and database searching at the low-femtomole level. Anal Chem (1997) 3.09
The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9. Nat Genet (1996) 3.05
Coronin promotes the rapid assembly and cross-linking of actin filaments and may link the actin and microtubule cytoskeletons in yeast. J Cell Biol (1999) 3.03
Mapping the gene for hereditary cutaneous malignant melanoma-dysplastic nevus to chromosome 1p. N Engl J Med (1989) 3.03
An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor. Cell (1990) 3.02
Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21. Nat Genet (1998) 3.00
Implication of a novel multiprotein Dam1p complex in outer kinetochore function. J Cell Biol (2001) 2.98
Functional cooperation between the microtubule and actin cytoskeletons. Curr Opin Cell Biol (2000) 2.95
Identification of a palmitic acid-modified form of human Sonic hedgehog. J Biol Chem (1998) 2.95
Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3. Nat Genet (1995) 2.93
The Huntington's disease candidate region exhibits many different haplotypes. Nat Genet (1992) 2.84
Isolation of polymorphic DNA fragments from human chromosome 4. Nucleic Acids Res (1987) 2.83
Alternative splicing and genomic structure of the Wilms tumor gene WT1. Proc Natl Acad Sci U S A (1991) 2.83
Antagonistic actions of Arabidopsis cryptochromes and phytochrome B in the regulation of floral induction. Development (1999) 2.76
Identification of 28 DNA fragments that detect RFLPs in 13 distinct physical regions of the short arm of chromosome 5. Nucleic Acids Res (1987) 2.72
Tissue specific expression of FMR-1 provides evidence for a functional role in fragile X syndrome. Nat Genet (1993) 2.69
Direct haplotyping of kilobase-size DNA using carbon nanotube probes. Nat Biotechnol (2000) 2.61
Constitutive expression of the cold-regulated Arabidopsis thaliana COR15a gene affects both chloroplast and protoplast freezing tolerance. Proc Natl Acad Sci U S A (1996) 2.58
Molecular approach to analyzing the human 5p deletion syndrome, cri du chat. Somat Cell Mol Genet (1985) 2.56
Development of retrovirus vectors useful for expressing genes in cultured murine embryonal cells and hematopoietic cells in vivo. J Virol (1988) 2.55
A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia. Proc Natl Acad Sci U S A (1998) 2.47
Determinants that contribute to cytoplasmic stability of human c-fos and beta-globin mRNAs are located at several sites in each mRNA. Mol Cell Biol (1988) 2.46
Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome. Proc Natl Acad Sci U S A (1998) 2.46
Cryptosporidiosis in hospital patients with gastroenteritis. Am J Trop Med Hyg (1983) 2.45
Amplification of specific DNA sequences correlates with multi-drug resistance in Chinese hamster cells. Nature (1984) 2.39
Molecular basis of myotonic dystrophy: expansion of a trinucleotide (CTG) repeat at the 3' end of a transcript encoding a protein kinase family member. Cell (1992) 2.38
Mitotic spindle integrity and kinetochore function linked by the Duo1p/Dam1p complex. J Cell Biol (2001) 2.38
Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells. Proc Natl Acad Sci U S A (1994) 2.37
Saccharomyces cerevisiae Duo1p and Dam1p, novel proteins involved in mitotic spindle function. J Cell Biol (1998) 2.35
Mutations in the alpha 1 subunit of the inhibitory glycine receptor cause the dominant neurologic disorder, hyperekplexia. Nat Genet (1993) 2.35
The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues. Mol Cell Biol (1989) 2.35
Clinical signs of dehydration in children. Lancet (1989) 2.34
Human erythroid burst-forming unit: T-cell requirement for proliferation in vitro. J Exp Med (1978) 2.33
Isolation of genes from complex sources of mammalian genomic DNA using exon amplification. Nat Genet (1994) 2.33
Functional cooperation of Dam1, Ipl1, and the inner centromere protein (INCENP)-related protein Sli15 during chromosome segregation. J Cell Biol (2001) 2.31
Loss of heterozygosity for the short arm of chromosome 1 in human neuroblastomas: correlation with N-myc amplification. Proc Natl Acad Sci U S A (1989) 2.25
Using the confluence model of sexual aggression to predict men's conflict with women: a 10-year follow-up study. J Pers Soc Psychol (1995) 2.24
Effects of divalent cations, protons and calmidazolium at the rat P2X7 receptor. Neuropharmacology (1997) 2.24
Huntington disease-linked locus D4S111 exposed as the alpha-L-iduronidase gene. Somat Cell Mol Genet (1991) 2.23
Expression of the Wilms' tumor gene WT1 in the murine urogenital system. Genes Dev (1991) 2.20
Isolation and characterization of DNA sequences amplified in multidrug-resistant hamster cells. Proc Natl Acad Sci U S A (1986) 2.19
A novel cDNA detects homozygous microdeletions in greater than 50% of type I spinal muscular atrophy patients. Nat Genet (1995) 2.17
Isolation of DNA markers in the direction of the Huntington disease gene from the G8 locus. Am J Hum Genet (1988) 2.11
Completely diverted tube ileostomy compared with loop ileostomy for protection of low colorectal anastomosis: a pilot study. Colorectal Dis (2014) 2.06
Interaction of an NF-kappa B-like factor with a site upstream of the c-myc promoter. Proc Natl Acad Sci U S A (1990) 2.06
Linkage disequilibrium in Huntington's disease: an improved localisation for the gene. J Med Genet (1989) 2.05
Isolation and characterization of human cDNA clones encoding a high mobility group box protein that recognizes structural distortions to DNA caused by binding of the anticancer agent cisplatin. Proc Natl Acad Sci U S A (1992) 2.04
An association between the common hereditary hemochromatosis mutation and the factor V Leiden allele in a population with thrombosis. Blood (1998) 2.03
Human chromosome 12 is required for elevated HIV-1 expression in human-hamster hybrid cells. Science (1989) 2.03
De novo expansion of a (CAG)n repeat in sporadic Huntington's disease. Nat Genet (1993) 2.02
Immunogenicity and safety of PRP-T conjugate vaccine given according to the British accelerated immunisation schedule. Arch Dis Child (1992) 2.02
Bovine viral diarrhea virus NS3 serine proteinase: polyprotein cleavage sites, cofactor requirements, and molecular model of an enzyme essential for pestivirus replication. J Virol (1997) 2.00
Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease. Nature (1997) 1.99
The complex pathology of trinucleotide repeats. Curr Opin Cell Biol (1997) 1.98
Genetic demonstration of mitotic recombination in cultured Chinese hamster cell hybrids. Cell (1984) 1.97
Selective linkage disruption in human-Chinese hamster cell hybrids: deletion mapping of the leuS, hexB, emtB, and chr genes on human chromosome 5. Mol Cell Biol (1982) 1.97