Published in Ann Intern Med on October 15, 1993
Tumor necrosis factor alpha and interleukin 1beta are responsible for in vitro myocardial cell depression induced by human septic shock serum. J Exp Med (1996) 2.50
Balance of inflammatory cytokines related to severity and mortality of murine sepsis. Infect Immun (1996) 2.43
Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis. Am J Respir Crit Care Med (2008) 2.37
The cell wall components peptidoglycan and lipoteichoic acid from Staphylococcus aureus act in synergy to cause shock and multiple organ failure. Proc Natl Acad Sci U S A (1995) 2.36
Interleukin-6 in the injured patient. Marker of injury or mediator of inflammation? Ann Surg (1996) 2.24
Immunopathologic alterations in murine models of sepsis of increasing severity. Infect Immun (1999) 2.13
FcgammaRIIb balances efficient pathogen clearance and the cytokine-mediated consequences of sepsis. J Exp Med (2004) 1.95
Viral infection augments Nod1/2 signaling to potentiate lethality associated with secondary bacterial infections. Cell Host Microbe (2011) 1.86
Toll-like receptor 2 plays a critical role in cardiac dysfunction during polymicrobial sepsis. Crit Care Med (2010) 1.84
Increased C5a receptor expression in sepsis. J Clin Invest (2002) 1.79
The association between BMI and plasma cytokine levels in patients with acute lung injury. Chest (2010) 1.75
Caspase-1 regulates Escherichia coli sepsis and splenic B cell apoptosis independently of interleukin-1beta and interleukin-18. Am J Respir Crit Care Med (2006) 1.73
Endotoxemia: methods of detection and clinical correlates. Clin Microbiol Rev (1995) 1.73
Cytokine production and monocyte HLA-DR expression as predictors of outcome for patients with community-acquired severe infections. Clin Diagn Lab Immunol (2004) 1.65
Measurement of endotoxin activity in critically ill patients using whole blood neutrophil dependent chemiluminescence. Crit Care (2002) 1.61
Predictive value of nuclear factor kappaB activity and plasma cytokine levels in patients with sepsis. Infect Immun (2000) 1.58
Tumor necrosis factor-alpha gene and protein expression in adult feline myocardium after endotoxin administration. J Clin Invest (1995) 1.55
A functional synonymous coding variant in the IL1RN gene is associated with survival in septic shock. Am J Respir Crit Care Med (2014) 1.53
Chronic kidney disease worsens sepsis and sepsis-induced acute kidney injury by releasing High Mobility Group Box Protein-1. Kidney Int (2011) 1.52
Plasma granulocyte colony-stimulating factor levels correlate with clinical outcomes in patients with acute lung injury. Crit Care Med (2009) 1.47
Coenzyme Q10 levels are low and associated with increased mortality in post-cardiac arrest patients. Resuscitation (2012) 1.47
Internalization of Staphylococcus aureus by endothelial cells induces cytokine gene expression. Infect Immun (1995) 1.45
Elevated levels of macrophage inflammatory protein 2 in severe murine peritonitis increase neutrophil recruitment and mortality. Infect Immun (1997) 1.39
CD40 and CD80/86 act synergistically to regulate inflammation and mortality in polymicrobial sepsis. Am J Respir Crit Care Med (2007) 1.37
Autophagy mediates the delivery of thrombogenic tissue factor to neutrophil extracellular traps in human sepsis. PLoS One (2012) 1.36
High levels of interleukin 10 in serum are associated with fatality in meningococcal disease. Infect Immun (1995) 1.36
Marked elevation of serum interleukin-6 in patients with cholangiocarcinoma: validation of utility as a clinical marker. Ann Surg (1998) 1.32
Dose- and time-related effects of dexmedetomidine on mortality and inflammatory responses to endotoxin-induced shock in rats. J Anesth (2008) 1.29
Sepsis: Something old, something new, and a systems view. J Crit Care (2011) 1.29
Elevated serum cyclophilin levels in patients with severe sepsis. J Clin Immunol (1997) 1.28
TNF-alpha and IL-1beta increase Ca2+ leak from the sarcoplasmic reticulum and susceptibility to arrhythmia in rat ventricular myocytes. Cell Calcium (2010) 1.27
Expanded CD14+ CD16+ monocyte subpopulation in patients with acute and chronic infections undergoing hemodialysis. Infect Immun (1998) 1.24
Heat shock protein 90 inhibitors prolong survival, attenuate inflammation, and reduce lung injury in murine sepsis. Am J Respir Crit Care Med (2007) 1.24
Time course of cytokine levels in sepsis. Intensive Care Med (1995) 1.22
Soluble form of the triggering receptor expressed on myeloid cells-1 as a marker of microbial infection. Clin Med Res (2004) 1.22
Emerging role of the interleukin-8 cleaving enzyme SpyCEP in clinical Streptococcus pyogenes infection. J Infect Dis (2009) 1.19
Soluble ST2 plasma concentrations predict mortality in severe sepsis. Intensive Care Med (2010) 1.19
Are serum cytokines early predictors for the outcome of burn patients with inhalation injuries who do not survive? Crit Care (2008) 1.15
Elevated postoperative inflammatory biomarkers are associated with short- and medium-term cognitive dysfunction after coronary artery surgery. J Anesth (2011) 1.13
Monocyte derived microvesicles deliver a cell death message via encapsulated caspase-1. PLoS One (2009) 1.13
Helicobacter pylori and Porphyromonas gingivalis lipopolysaccharides are poorly transferred to recombinant soluble CD14. Infect Immun (1996) 1.12
Prognostic value of phagocytic activity of neutrophils and monocytes in sepsis. Correlation to CD64 and CD14 antigen expression. Clin Exp Immunol (2008) 1.11
Predicting mortality in patients with systemic inflammatory response syndrome: an evaluation of two prognostic models, two soluble receptors, and a macrophage migration inhibitory factor. Eur J Clin Microbiol Infect Dis (2008) 1.11
Circulating immune parameters predicting the progression from hospital-acquired pneumonia to septic shock in surgical patients. Crit Care (2005) 1.09
Interleukin-10 modulates proinflammatory cytokines in the human monocytic cell line THP-1 stimulated with Borrelia burgdorferi lipoproteins. Infect Immun (2000) 1.09
Clinical sepsis and septic shock--definition, diagnosis and management principles. Langenbecks Arch Surg (2008) 1.08
The evolving experience with therapeutic TNF inhibition in sepsis: considering the potential influence of risk of death. Expert Opin Investig Drugs (2011) 1.07
Insulin activation of the phosphatidylinositol 3-kinase/protein kinase B (Akt) pathway reduces lipopolysaccharide-induced inflammation in mice. J Pharmacol Exp Ther (2008) 1.07
The immunopathogenesis of meningococcal disease. J Clin Pathol (2003) 1.07
Rapid diagnosis of sepsis. Virulence (2013) 1.06
Correlation of histopathologic and bacteriologic changes with cytokine expression in an experimental murine model of bacteremic Staphylococcus aureus infection. Infect Immun (1997) 1.06
Cytokine profiles in sepsis have limited relevance for stratifying patients in the emergency department: a prospective observational study. PLoS One (2011) 1.05
Intracellular and extracellular cytokine production by human mixed mononuclear cells in response to group B streptococci. Infect Immun (2000) 1.03
MyD88 and Trif signaling play distinct roles in cardiac dysfunction and mortality during endotoxin shock and polymicrobial sepsis. Anesthesiology (2011) 1.03
Anti-inflammatory role in septic shock of pituitary adenylate cyclase-activating polypeptide receptor. Proc Natl Acad Sci U S A (2002) 1.02
Human schistosomiasis is associated with endotoxemia and Toll-like receptor 2- and 4-bearing B cells. Am J Trop Med Hyg (2011) 1.02
Effect of hemofiltration filter adsorption on circulating IL-6 levels in septic rats. Crit Care (2002) 1.01
Dexmedetomidine controls systemic cytokine levels through the cholinergic anti-inflammatory pathway. Inflammation (2014) 1.00
Roles of the bacterial cell wall and capsule in induction of tumor necrosis factor alpha by type III group B streptococci. Infect Immun (1996) 0.99
Circulating inflammatory mediators in patients with fever: predicting bloodstream infection. Clin Diagn Lab Immunol (2001) 0.99
Cytokine measurements in septic shock. Ann Intern Med (1993) 0.97
Functional imaging of interleukin 1 beta expression in inflammatory process using bioluminescence imaging in transgenic mice. BMC Immunol (2008) 0.97
Myocardial dysfunction in sepsis: a large, unsolved puzzle. Crit Care Res Pract (2012) 0.97
Cardiac function and the proinflammatory cytokine response after recovery from cardiac arrest in swine. J Interferon Cytokine Res (2009) 0.96
Bench-to-bedside review: Clinical experience with the endotoxin activity assay. Crit Care (2012) 0.95
Negative inotropic effects of tumour necrosis factor-alpha and interleukin-1beta are ameliorated by alfentanil in rat ventricular myocytes. Br J Pharmacol (2007) 0.94
Exogenous cytokine modulation or neutralization of interleukin-10 enhance survival in lipopolysaccharide-hyporesponsive C3H/HeJ mice with Klebsiella infection. Immunology (1999) 0.94
Dexmedetomidine inhibits inflammatory reaction in lung tissues of septic rats by suppressing TLR4/NF-κB pathway. Mediators Inflamm (2013) 0.93
Polymorphonuclear leucocytes selectively produce anti-inflammatory interleukin-1 receptor antagonist and chemokines, but fail to produce pro-inflammatory mediators. Immunology (2006) 0.91
Regulation of pulmonary and systemic bacterial lipopolysaccharide responses in transgenic mice expressing human elafin. Infect Immun (2003) 0.91
Prolonged expression of lipopolysaccharide (LPS)-induced inflammatory genes in whole blood requires continual exposure to LPS. Infect Immun (1995) 0.91
Antimicrobial cathelicidin peptide LL-37 inhibits the LPS/ATP-induced pyroptosis of macrophages by dual mechanism. PLoS One (2014) 0.90
The IL-6 Paradox: Context Dependent Interplay of SOCS3 and AMPK. J Diabetes Metab (2013) 0.90
Proinflammatory cytokines in acute myocardial infarction with and without cardiogenic shock. Clin Res Cardiol (2007) 0.90
Coenzyme Q10 levels are low and may be associated with the inflammatory cascade in septic shock. Crit Care (2011) 0.89
Activation of common antiviral pathways can potentiate inflammatory responses to septic shock. Shock (2006) 0.88
Altered immune parameters in chronic alcoholic patients at the onset of infection and of septic shock. Crit Care (2004) 0.87
Immune depression in musculoskeletal trauma. Inflamm Res (2010) 0.87
Effects of dexmedetomidine on early and late cytokines during polymicrobial sepsis in mice. Inflamm Res (2013) 0.87
Carbon dioxide pneumoperitoneum prevents mortality from sepsis. Surg Endosc (2006) 0.87
Modulation of LPS-stimulated pulmonary inflammation by Borneol in murine acute lung injury model. Inflammation (2014) 0.86
The antiinflammatory effects of propofol in endotoxemic rats during moderate and mild hypothermia. J Anesth (2007) 0.86
Human severe sepsis cytokine mixture increases β2-integrin-dependent polymorphonuclear leukocyte adhesion to cerebral microvascular endothelial cells in vitro. Crit Care (2015) 0.85
Omega-3 fatty acids in critical illness. Nutr Rev (2010) 0.85
Sepsis, septicaemia, sepsis syndrome, and septic shock: the correct definition and use. Postgrad Med J (1996) 0.85
Cytokines and signaling molecules predict clinical outcomes in sepsis. PLoS One (2013) 0.85
Pitfalls in measuring cytokines. Ann Intern Med (1994) 0.84
Patterns of cytokines and soluble cellular receptors in the sera of children with acute chagas' disease. Clin Diagn Lab Immunol (2002) 0.84
Nutrigenomics, beta-cell function and type 2 diabetes. Curr Genomics (2007) 0.84
Priming of neutrophils and differentiated PLB-985 cells by pathophysiological concentrations of TNF-α is partially oxygen dependent. J Innate Immun (2010) 0.83
Delayed Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Inhibition by Trametinib Attenuates Systemic Inflammatory Responses and Multiple Organ Injury in Murine Sepsis. Crit Care Med (2016) 0.82
Alteco endotoxin hemoadsorption in Gram-negative septic shock patients. Indian J Crit Care Med (2014) 0.82
Anti-inflammatory response of IL-4, IL-10 and TGF-beta in patients with systemic inflammatory response syndrome. Mediators Inflamm (2000) 0.82
Polymyxin B hemoperfusion: a mechanistic perspective. Crit Care (2014) 0.82
Pathogenesis of fulminant monkeypox with bacterial sepsis after experimental infection with West African monkeypox virus in a cynomolgus monkey. Int J Clin Exp Pathol (2014) 0.81
Cardiac function and circulating cytokines after endotoxin exposure in neonatal mice. Pediatr Res (2010) 0.81
Acute respiratory distress syndrome in the septic surgical patient. World J Surg (2003) 0.81
Bactericidal/permeability-increasing protein preserves leukocyte functions after major liver resection. Ann Surg (2000) 0.81
Serial monitoring of interleukin-1beta, soluble interleukin-2 receptor and lipopolysaccharide binding protein levels after death A comparative evaluation of potential postmortem markers of sepsis. Int J Legal Med (2004) 0.81
The effects of tumor necrosis factor-alpha on systolic and diastolic function in rat ventricular myocytes. Physiol Rep (2013) 0.80
Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: a randomized controlled trial. JAMA (2001) 5.86
Is it time to pull the pulmonary artery catheter? JAMA (1996) 5.69
Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein. The Soluble TNF Receptor Sepsis Study Group. N Engl J Med (1996) 5.25
Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. The Interleukin-1 Receptor Antagonist Sepsis Investigator Group. Crit Care Med (1997) 4.86
The ACCP-SCCM consensus conference on sepsis and organ failure. Chest (1992) 4.35
A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock. N Engl J Med (1987) 3.89
Sepsis syndrome: a valid clinical entity. Methylprednisolone Severe Sepsis Study Group. Crit Care Med (1989) 3.41
The relation of pneumothorax and other air leaks to mortality in the acute respiratory distress syndrome. N Engl J Med (1998) 3.40
Hypothermia in the sepsis syndrome and clinical outcome. The Methylprednisolone Severe Sepsis Study Group. Crit Care Med (1992) 2.99
Sepsis: a new hypothesis for pathogenesis of the disease process. Chest (1997) 2.84
Definitions for sepsis and organ failure. Crit Care Med (1992) 2.69
Initial evaluation of human recombinant interleukin-1 receptor antagonist in the treatment of sepsis syndrome: a randomized, open-label, placebo-controlled multicenter trial. Crit Care Med (1994) 2.66
A second large controlled clinical study of E5, a monoclonal antibody to endotoxin: results of a prospective, multicenter, randomized, controlled trial. The E5 Sepsis Study Group. Crit Care Med (1995) 2.48
Sepsis, the sepsis syndrome, multi-organ failure: a plea for comparable definitions. Ann Intern Med (1991) 2.28
E5 murine monoclonal antiendotoxin antibody in gram-negative sepsis: a randomized controlled trial. E5 Study Investigators. JAMA (2000) 2.07
Honoring patient preferences and rationing intensive care. Are these compatible goals? Arch Intern Med (1991) 2.03
Introducing Critical Appraisal to studies of animal models investigating novel therapies in sepsis. Crit Care Med (1996) 1.89
T-cell reactivity and its predictive role in immunosuppression after burns. Crit Care Med (1999) 1.76
Primary Sjogren syndrome: clinical and immunopathologic features. Semin Arthritis Rheum (1984) 1.75
Safety and potential efficacy of an aerosolized surfactant in human sepsis-induced adult respiratory distress syndrome. JAMA (1994) 1.64
Role of tumor necrosis factor-alpha in disease states and inflammation. Crit Care Med (1993) 1.61
The noninvasive respiratory care unit. Patterns of use and financial implications. Chest (1991) 1.56
Medical effectiveness of esophageal balloon pressure manometry in weaning patients from mechanical ventilation. Crit Care Med (1995) 1.43
Sleep apnea and the Arnold-Chiari malformation. Am Rev Respir Dis (1985) 1.42
A word of caution regarding a new long-acting bronchodilator. JAMA (1994) 1.41
Prognostic factors in sepsis: the cold facts. Crit Care Med (1992) 1.40
Selective digestive decontamination in critically ill patients. Crit Care Med (1993) 1.39
A piece of my mind. Lemonade: the last refreshing taste. JAMA (1996) 1.39
Intracavitary amphotereicin B in the treatment of symptomatic pulmonary aspergillomas. Am J Med (1980) 1.33
Sepsis, sepsis syndrome, and the systemic inflammatory response syndrome (SIRS). Gulliver in Laputa. JAMA (1995) 1.32
Intravascular coagulation associated with the adult respiratory distress syndrome. Am J Med (1976) 1.26
Evaluation and correction of dysphagia-producing cervical osteophytosis. Laryngoscope (1974) 1.20
An experiment in medical education. A critical analysis using traditional criteria. JAMA (1991) 1.14
Controlled oxygen administration in acute respiratory failure in chronic obstructive pulmonary disease: a reappraisal. Am J Med (1978) 1.13
Quantitative deposition of ultrafine stable particles in the human respiratory tract. J Appl Physiol (1985) (1985) 1.11
Ibuprofen in canine endotoxin shock. J Clin Invest (1982) 1.10
Measurements of medicine. Crit Care Med (1995) 1.10
The bottom line in asthma management is patient education. Am J Med (1993) 1.08
Neural phase-locking properties in the absence of cochlear outer hair cells. Hear Res (1981) 1.07
Interferon gamma-1b in the treatment of compensatory anti-inflammatory response syndrome. A new approach: proof of principle. Arch Intern Med (1997) 1.06
High-tech predicament: pulmonary artery catheter. JAMA (1990) 1.05
Acoustic characteristics of speech following uvulopalatopharyngoplasty. Laryngoscope (1989) 1.03
Pneumothorax detection using computerised analysis of breath sounds. Med Biol Eng Comput (2002) 1.03
Pneumothorax detection using pulmonary acoustic transmission measurements. Med Biol Eng Comput (2002) 1.00
Indwelling small pleural catheter needle thoracentesis in the management of large pleural effusions. Chest (1997) 0.99
Desquamative interstitial pneumonia following long-term nitrofurantoin therapy. Am J Med (1976) 0.96
Effects of corticosteroids in the treatment of patients with gastric aspiration. Am J Med (1977) 0.96
Incidence of aspiration in tracheally intubated adults. Heart Lung (1987) 0.93
Laryngeal edema. An experimental study. Ann Otol Rhinol Laryngol (1970) 0.93
Technology under Medicare diagnosis-related groups prospective payment. Implications for medical intensive care. Chest (1985) 0.92
Why new definitions of sepsis and organ failure are needed. Am J Med (1993) 0.92
The septic syndrome. Definition and clinical implications. Crit Care Clin (1989) 0.92
Sepsis and controlled clinical trials: the odyssey continues. Crit Care Med (1995) 0.91
A piece of my mind. Maumee: my Walden pond. JAMA (1996) 0.91
Comparison of students' encounters with patients in university and community hospitals. J Med Educ (1986) 0.91
Long-term outcomes for elderly survivors of prolonged ventilator assistance. Chest (1989) 0.90
The relationship of preexisting lung disease to the development of methotrexate pneumonitis in patients with rheumatoid arthritis. J Rheumatol (1995) 0.89
Prevention of pulmonary emboli in a respiratory intensive care unit: efficacy of low-dose heparin. Chest (1981) 0.89
Helium-oxygen mixtures during bronchoscopy. Crit Care Med (1980) 0.88
Immunoglobulin G-induced single ionic channels in human alveolar macrophage membranes. J Clin Invest (1985) 0.88
Monoclonal antibodies to endotoxin. New allies against sepsis? JAMA (1991) 0.88
Prostaglandins, cyclo-oxygenase inhibitors, and thromboxane synthetase inhibitors in the pathogenesis of multiple systems organ failure. Crit Care Clin (1989) 0.88
The ARDS lung. New insights from computed tomography. JAMA (1993) 0.87
Nitric oxide in the pathogenesis of sepsis. Infect Dis Clin North Am (1999) 0.87
Noninvasive respiratory care unit. A cost effective solution for the future. Chest (1988) 0.87
Mechanical ventilation in respiratory failure. Med Clin North Am (1983) 0.87
To SIRS with love. Crit Care Med (1998) 0.86
Pulmonary extraction and pharmacokinetics of prostaglandin E1 during continuous intravenous infusion in patients with adult respiratory distress syndrome. Am Rev Respir Dis (1988) 0.85
Thrombotic thrombocytopenic purpura in carbon monoxide poisoning. Report of a case. Arch Intern Med (1980) 0.85
Determination of cardiac output in critically ill patients by dual beam Doppler echocardiography. J Am Coll Cardiol (1989) 0.85
Economics of mechanical ventilation. Clin Chest Med (1988) 0.84
Element content of intracochlear fluids, outer hair cells, and stria vascularis as determined by energy-dispersive roentgen ray analysis. Otolaryngol Head Neck Surg (1979) (1980) 0.84
Important new findings in sepsis. JAMA (1997) 0.84
Laryngopyocele. Laryngoscope (1973) 0.84
Detrimental effects of high-dose methylprednisolone sodium succinate on serum concentrations of hepatic and renal function indicators in severe sepsis and septic shock. The Methylprednisolone Severe Sepsis Study Group. Crit Care Med (1993) 0.84
Effect of cigarette smoke on human serum trypsin inhibitory capacity and antitrypsin concentration. Am Rev Respir Dis (1982) 0.84
Physiologic effects of oral bronchodilators during rest and exercise in chronic obstructive pulmonary disease. Chest (1983) 0.84
Treatment of adult respiratory distress syndrome with diuretics, dialysis, and positive end-expiratory pressure. Crit Care Med (1978) 0.84
Extraglandular Warthin's tumors. Laryngoscope (1985) 0.84
Contamination of a fiberoptic bronchoscope with Proteus species. Am Rev Respir Dis (1977) 0.83
Treatment of acute exacerbations in chronic obstructive pulmonary disease. Med Clin North Am (1990) 0.83
Low dose ibuprofen reverses the hemodynamic alterations of canine endotoxin shock. Crit Care Med (1988) 0.83
New creations? Hastings Cent Rep (1991) 0.83
Lymphocyte subpopulations of blood and alveolar lavage in blastomycosis. Chest (1985) 0.82
Non-simultaneous Interaction of exposure to noise and kanamycin intoxication in the chinchilla. Am J Otolaryngol (1983) 0.82
Flexible fiberoptic laryngobronchoscopy. Laryngoscope (1974) 0.82
Effects of ibuprofen on neutrophil function and acute lung injury in canine endotoxin shock. Crit Care Med (1988) 0.81
Ultrastructural correlates of selective outer hair cell destruction following kanamycin intoxication in the chinchilla. Hear Res (1980) 0.81
Potentiation of kanamycin ototoxicity by a history of noise exposure. Otolaryngology (1979) 0.81
Differential effects of tumor necrosis factor-alpha on the expression of fibronectin and collagen genes in cultured bovine endothelial cells. Cell Mol Biol Res (1995) 0.81
Hepatic dysfunction in the adult respiratory distress syndrome. Chest (1989) 0.81
Reduced alveolar macrophage production of tumor necrosis factor during sepsis in mice and men. Crit Care Med (1991) 0.81