Published in Proc Natl Acad Sci U S A on February 15, 1993
DNA fingerprinting of medically important microorganisms by use of PCR. Clin Microbiol Rev (1994) 4.86
Molecular markers reveal cryptic sex in the human pathogen Coccidioides immitis. Proc Natl Acad Sci U S A (1996) 3.95
Molecular genetic basis of allelic polymorphism in malate dehydrogenase (mdh) in natural populations of Escherichia coli and Salmonella enterica. Proc Natl Acad Sci U S A (1994) 3.90
RAPD (arbitrary primer) PCR is more sensitive than multilocus enzyme electrophoresis for distinguishing related bacterial strains. Nucleic Acids Res (1993) 3.10
The ins and outs of DNA fingerprinting the infectious fungi. Clin Microbiol Rev (2000) 2.95
Malaria's Eve: evidence of a recent population bottleneck throughout the world populations of Plasmodium falciparum. Proc Natl Acad Sci U S A (1998) 2.76
Parity among the randomly amplified polymorphic DNA method, multilocus enzyme electrophoresis, and Southern blot hybridization with the moderately repetitive DNA probe Ca3 for fingerprinting Candida albicans. J Clin Microbiol (1997) 2.35
Nucleotide sequences provide evidence of genetic exchange among distantly related lineages of Trypanosoma cruzi. Proc Natl Acad Sci U S A (2001) 2.29
Three distinct genotypes within Candida parapsilosis from clinical sources. J Clin Microbiol (1995) 2.13
Comparison of multilocus enzyme electrophoresis and random amplified polymorphic DNA analysis for molecular subtyping of Cryptococcus neoformans. The Cryplococcal Disease Active Surveillance Group. J Clin Microbiol (1995) 1.80
Probing the genetic population structure of Trypanosoma cruzi with polymorphic microsatellites. Proc Natl Acad Sci U S A (1998) 1.56
Development and characterization of complex DNA fingerprinting probes for the infectious yeast Candida dubliniensis. J Clin Microbiol (1999) 1.56
Genetic diversity of Toxoplasma gondii in animals and humans. Philos Trans R Soc Lond B Biol Sci (2009) 1.54
Clonal diversity of the taxon Porphyromonas gingivalis assessed by random amplified polymorphic DNA fingerprinting. Infect Immun (1995) 1.48
Prevalence of virulence genes and clonality in Escherichia coli strains that cause bacteremia in cancer patients. Infect Immun (2000) 1.47
Elucidating the origins of nosocomial infections with Candida albicans by DNA fingerprinting with the complex probe Ca3. J Clin Microbiol (1999) 1.44
Reproductive clonality of pathogens: a perspective on pathogenic viruses, bacteria, fungi, and parasitic protozoa. Proc Natl Acad Sci U S A (2012) 1.26
Characterization of Streptococcus agalactiae strains by randomly amplified polymorphic DNA analysis. J Clin Microbiol (1997) 1.21
Recent, independent and anthropogenic origins of Trypanosoma cruzi hybrids. PLoS Negl Trop Dis (2011) 1.17
Chemotherapy with benznidazole and itraconazole for mice infected with different Trypanosoma cruzi clonal genotypes. Antimicrob Agents Chemother (2003) 1.17
Evidence for clonal propagation in natural isolates of Plasmodium falciparum from Venezuela. Proc Natl Acad Sci U S A (2001) 1.14
Flow cytometric analysis and microsatellite genotyping reveal extensive DNA content variation in Trypanosoma cruzi populations and expose contrasts between natural and experimental hybrids. Int J Parasitol (2009) 1.12
Genetic diversity of Pseudomonas aeruginosa strains isolated from ventilated patients with nosocomial pneumonia, cancer patients with bacteremia, and environmental water. Infect Immun (2001) 1.11
Development of two species-specific fingerprinting probes for broad computer-assisted epidemiological studies of Candida tropicalis. J Clin Microbiol (1996) 1.08
Is sex better? Parasites say "no". Proc Natl Acad Sci U S A (1998) 1.08
Combined ribotyping and random multiprimer DNA analysis to probe the population structure of Listeria monocytogenes. Appl Environ Microbiol (2002) 1.07
Concordance between genetic relatedness and phenotypic similarities of Trichomonas vaginalis strains. BMC Evol Biol (2001) 1.04
Analyses of 32 loci clarify phylogenetic relationships among Trypanosoma cruzi lineages and support a single hybridization prior to human contact. PLoS Negl Trop Dis (2011) 1.02
Between a bug and a hard place: Trypanosoma cruzi genetic diversity and the clinical outcomes of Chagas disease. Expert Rev Anti Infect Ther (2015) 1.02
A simple strain typing assay for Trypanosoma cruzi: discrimination of major evolutionary lineages from a single amplification product. PLoS Negl Trop Dis (2012) 0.94
Detection of Trypanosoma cruzi and Trypanosoma rangeli infection by duplex PCR assay based on telomeric sequences. Clin Diagn Lab Immunol (2003) 0.92
Genetic diversity of Leishmania amazonensis strains isolated in northeastern Brazil as revealed by DNA sequencing, PCR-based analyses and molecular karyotyping. Kinetoplastid Biol Dis (2007) 0.90
Phylogenetic character mapping of proteomic diversity shows high correlation with subspecific phylogenetic diversity in Trypanosoma cruzi. Proc Natl Acad Sci U S A (2010) 0.89
Commonly conserved genetic fragments revealed by genome profiling can serve as tracers of evolution. Nucleic Acids Res (2002) 0.87
Molecular characterization of Tb, a new approach for an ancient Brucellaphage. Int J Mol Sci (2009) 0.84
Geographical clustering of Trypanosoma cruzi I groups from Colombia revealed by low-stringency single specific primer-PCR of the intergenic regions of spliced-leader genes. Parasitol Res (2008) 0.83
Identification and detection of Trypanosoma cruzi by using a DNA amplification fingerprint obtained from the ribosomal intergenic spacer. J Clin Microbiol (1994) 0.82
A survey of the inter- and intraspecific RAPD markers of Eimeria spp. of the domestic fowl and the development of reliable diagnostic tools. Parasitol Res (2002) 0.82
Genetic variation in the free-living amoeba Naegleria fowleri. Appl Environ Microbiol (1998) 0.80
Impact of dual infections on chemotherapeutic efficacy in BALB/c mice infected with major genotypes of Trypanosoma cruzi. Antimicrob Agents Chemother (2007) 0.80
Random amplified polymorphic DNA profiles of Trypanosoma cruzi isolates from chagasic patients with different clinical forms. Parasitol Res (2006) 0.79
Homogeneity of Trypanosoma cruzi I, II, and III populations and the overlap of wild and domestic transmission cycles by Triatoma brasiliensis in northeastern Brazil. Parasitol Res (2013) 0.79
Characterization of the recent clinical isolates of Indian Kala-azar patients by RAPD-PCR method. J Parasit Dis (2011) 0.78
Genetic characterization of populations of a de novo arisen sugar beet pest, Aubeonymus mariaefranciscae (Coleoptera, Curculionidae), by RAPD analysis. J Mol Evol (1997) 0.77
Genetic diversity analysis reveals that geographical environment plays a more important role than rice cultivar in Villosiclava virens population selection. Appl Environ Microbiol (2014) 0.77
LSSP-PCR of Trypanosoma cruzi: how the single primer sequence affects the kDNA signature. BMC Res Notes (2013) 0.75
Relevant units of analysis for applied and basic research dealing with neglected transmissible diseases: The predominant clonal evolution model of pathogenic microorganisms. PLoS Negl Trop Dis (2017) 0.75
Molecular identification of an old clinical isolate of Indian Kala-azar. J Parasit Dis (2016) 0.75
DNA polymorphisms amplified by arbitrary primers are useful as genetic markers. Nucleic Acids Res (1990) 47.84
Fingerprinting genomes using PCR with arbitrary primers. Nucleic Acids Res (1990) 23.96
The stability of linked systems of loci with a small population size. Genetics (1968) 10.19
Genomic fingerprints produced by PCR with consensus tRNA gene primers. Nucleic Acids Res (1991) 5.70
Are eukaryotic microorganisms clonal or sexual? A population genetics vantage. Proc Natl Acad Sci U S A (1991) 4.30
A clonal theory of parasitic protozoa: the population structures of Entamoeba, Giardia, Leishmania, Naegleria, Plasmodium, Trichomonas, and Trypanosoma and their medical and taxonomical consequences. Proc Natl Acad Sci U S A (1990) 4.07
Polymorphisms generated by arbitrarily primed PCR in the mouse: application to strain identification and genetic mapping. Nucleic Acids Res (1991) 3.45
Excess of non-parental bands in offspring from known primate pedigrees assayed using RAPD PCR. Nucleic Acids Res (1992) 3.10
Natural populations of Trypanosoma cruzi, the agent of Chagas disease, have a complex multiclonal structure. Proc Natl Acad Sci U S A (1986) 2.48
Isozymic heterogeneity of Trypanosoma cruzi in the first autochthonous patients with Chagas' disease in Amazonian Brazil. Nature (1978) 2.09
Towards a population genetics of microorganisms: The clonal theory of parasitic protozoa. Parasitol Today (1991) 1.34
[High correlation between isoenzyme classification and kinetoplast DNA variability in Trypanosoma cruzi]. C R Acad Sci III (1987) 1.17
Enzyme variability in the Drosophila willistoni group. IV. Genic variation in natural populations of Drosophila willistoni. Genetics (1972) 9.38
Polymorphisms in continental and island populations of Drosophila willistoni. Proc Natl Acad Sci U S A (1971) 6.28
Evidence for positive selection in the superoxide dismutase (Sod) region of Drosophila melanogaster. Genetics (1994) 5.05
Phylogeny of the malarial genus Plasmodium, derived from rRNA gene sequences. Proc Natl Acad Sci U S A (1994) 4.50
Are eukaryotic microorganisms clonal or sexual? A population genetics vantage. Proc Natl Acad Sci U S A (1991) 4.30
A clonal theory of parasitic protozoa: the population structures of Entamoeba, Giardia, Leishmania, Naegleria, Plasmodium, Trichomonas, and Trypanosoma and their medical and taxonomical consequences. Proc Natl Acad Sci U S A (1990) 4.07
Genetic variation in natural populations of five Drosophila species and the hypothesis of the selective neutrality of protein polymorphisms. Genetics (1974) 3.97
A highly polymorphic locus very tightly linked to the Huntington's disease gene. Nature (1988) 3.90
Evolutionary origin of Plasmodium and other Apicomplexa based on rRNA genes. Proc Natl Acad Sci U S A (1995) 3.73
Enzyme variability in the Drosophila willistoni group. I. Genetic differentiation among sibling species. Proc Natl Acad Sci U S A (1970) 3.59
Genetic load in natural populations: is it compatible with the hypothesis that many polymorphisms are maintained by natural selection? Genetics (1974) 3.45
Genetic and biochemical basis of enzyme activity variation in natural populations. I. Alcohol dehydrogenase in Drosophila melanogaster. Genetics (1978) 3.05
Mutation and selection in bacterial populations: alternatives to the hypothesis of directed mutation. Proc Natl Acad Sci U S A (1989) 2.95
The yeast Candida albicans has a clonal mode of reproduction in a population of infected human immunodeficiency virus-positive patients. Proc Natl Acad Sci U S A (1993) 2.94
Evolutionary origin of human and primate malarias: evidence from the circumsporozoite protein gene. Mol Biol Evol (1995) 2.93
Malaria's Eve: evidence of a recent population bottleneck throughout the world populations of Plasmodium falciparum. Proc Natl Acad Sci U S A (1998) 2.76
Origin of the metazoan phyla: molecular clocks confirm paleontological estimates. Proc Natl Acad Sci U S A (1998) 2.72
Natural populations of Trypanosoma cruzi, the agent of Chagas disease, have a complex multiclonal structure. Proc Natl Acad Sci U S A (1986) 2.48
Genetic polymorphism and natural selection in the malaria parasite Plasmodium falciparum. Genetics (1998) 2.36
Rat liver myofibroblasts and hepatic stellate cells: different cell populations of the fibroblast lineage with fibrogenic potential. Gastroenterology (1999) 2.30
Nucleotide sequences provide evidence of genetic exchange among distantly related lineages of Trypanosoma cruzi. Proc Natl Acad Sci U S A (2001) 2.29
Competition between species: theoretical models and experimental tests. Theor Popul Biol (1973) 2.24
A population cage test for heterosis in Drosophila pseudoobscura. Genetics (1970) 2.23
Isolation of DNA markers in the direction of the Huntington disease gene from the G8 locus. Am J Hum Genet (1988) 2.11
Experimental invalidation of the principle of competitive exclusion. Nature (1969) 2.06
Genetic differentiation within and between species of the Drosophila willistoni group. Proc Natl Acad Sci U S A (1974) 2.04
Identification of six Trypanosoma cruzi phylogenetic lineages by random amplified polymorphic DNA and multilocus enzyme electrophoresis. Int J Parasitol (2000) 2.03
Genetic response to environmental heterogeneity. Nature (1974) 1.95
Enzyme variability in the Drosophila Willistoni group. V. Genic variation in natural populations of Drosophila equinoxialis. Genet Res (1972) 1.92
Global models of growth and competition. Proc Natl Acad Sci U S A (1973) 1.85
Simplified technique with short and long-term followup of conversion of an ileal conduit to an Indiana pouch. J Urol (2000) 1.84
Climate change and the integrity of science. Science (2010) 1.80
Adaptive response due to changes in gene regulation: a study with Drosophila. Proc Natl Acad Sci U S A (1977) 1.78
Allozymes as diagnostic characters of sibling species of Drosophila. Proc Natl Acad Sci U S A (1972) 1.75
Genetic variability in a temperate intertidal phoronid, Phoronopsis viridis. Biochem Genet (1974) 1.72
Biological evolution: natural selection or random walk? Am Sci (1975) 1.66
Temporal frequency changes of enzyme and chromosomal polymorphisms in natural populations of Drosophila. Proc Natl Acad Sci U S A (1973) 1.64
Gene frequency comparisons between taxa: support for the natural selection of protein polymorphisms. Proc Natl Acad Sci U S A (1974) 1.60
Deletion mapping of human chromosome 5 using chromosome-specific DNA probes. Am J Hum Genet (1985) 1.60
Evidence of natural selection in molecular evolution. Nat New Biol (1973) 1.60
Trade-off between r-selection and K-selection in Drosophila populations. Proc Natl Acad Sci U S A (1981) 1.58
Population structure and recent evolution of Plasmodium falciparum. Proc Natl Acad Sci U S A (2000) 1.56
DNA variation at the Sod locus of Drosophila melanogaster: an unfolding story of natural selection. Proc Natl Acad Sci U S A (1997) 1.56
Proposed changes for NIH's Center for Scientific Review. Panel on Scientific Boundaries for Review. Center for Scientific Review Advisory Committee, National Institutes of Health. Science (1999) 1.52
Evolution of fitness in experimental populations of Drosophila serrata. Science (1965) 1.52
Structural analysis of the ADHS electromorph of Drosophila melanogaster. Proc Natl Acad Sci U S A (1978) 1.52
Estimation and interpretation of genetic distance in empirical studies. Genet Res (1982) 1.51
Darwinian fitness and adaptedness in experimental populations of Drosophilia willistoni. Genetica (1972) 1.49
Linkage disequilibrium in natural populations of Trypanosoma cruzi (flagellate), the agent of Chagas' disease. J Protozool (1988) 1.48
Prevalence of virulence genes and clonality in Escherichia coli strains that cause bacteremia in cancer patients. Infect Immun (2000) 1.47
Plasmodium falciparum antigenic diversity: evidence of clonal population structure. Proc Natl Acad Sci U S A (1997) 1.47
Localization of liver myofibroblasts and hepatic stellate cells in normal and diseased rat livers: distinct roles of (myo-)fibroblast subpopulations in hepatic tissue repair. Histochem Cell Biol (1999) 1.43
Exon/intron structure of aldehyde dehydrogenase genes supports the "introns-late" theory. Proc Natl Acad Sci U S A (1997) 1.42
Branched-chain amino acid supplementation during trekking at high altitude. The effects on loss of body mass, body composition, and muscle power. Eur J Appl Physiol Occup Physiol (1992) 1.41
"Clonal" population structure of the malaria agent Plasmodium falciparum in high-infection regions. Proc Natl Acad Sci U S A (2005) 1.41
The origin of antigenic diversity in Plasmodium falciparum. Parasitol Today (2000) 1.39
Complete amino acid sequence of copper-zinc superoxide dismutase from Drosophila melanogaster. Arch Biochem Biophys (1985) 1.38
Use of polymerase chain reaction to amplify segments outside boundaries of known sequences. Methods Enzymol (1993) 1.36
Chromosome interactions in Drosophila melanogaster. I. Viability studies. Genetics (1982) 1.36
Phylogeny of Drosophila and related genera inferred from the nucleotide sequence of the Cu,Zn Sod gene. J Mol Evol (1994) 1.35
Evolution of mitochondrial DNA in Drosophila subobscura. Proc Natl Acad Sci U S A (1986) 1.35
Towards a population genetics of microorganisms: The clonal theory of parasitic protozoa. Parasitol Today (1991) 1.34
Enzyme variability in the Drosophila willistoni group. VI. Levels of polymorphism and the physiological function of enzymes. Biochem Genet (1972) 1.34
Tempo and mode in evolution. Proc Natl Acad Sci U S A (1994) 1.33
Drosophila melanogaster Cu, Zn superoxide dismutase gene sequence. Nucleic Acids Res (1989) 1.33
Genetic variation in natural populations: problem of electrophoretically cryptic alleles. Proc Natl Acad Sci U S A (1982) 1.33
Gene regulation in adaptive evolution. Can J Genet Cytol (1978) 1.31
On the virtues and pitfalls of the molecular evolutionary clock. J Hered (1986) 1.28
Isozyme evidence of lack of speciation between wild and domestic Triatoma infestans (Heteroptera: Reduviidae) in Bolivia. J Med Entomol (1987) 1.27
Structure and sequence of the Cu,Zn Sod gene in the Mediterranean fruit fly, Ceratitis capitata: intron insertion/deletion and evolution of the gene. Mol Phylogenet Evol (1992) 1.26
Genetic variation for superoxide dismutase level in Drosophila melanogaster. Biochem Genet (1986) 1.26
Superoxide dismutase in Drosophila melanogaster: biochemical and structural characterization of allozyme variants. Proc Natl Acad Sci U S A (1981) 1.23
Density-dependent natural selection and trade-offs in life history traits. Science (1991) 1.23
Genetic heterozygosity in pneumococcal transformation. Proc Natl Acad Sci U S A (1968) 1.23
MHC polymorphism and human origins. Sci Am (1993) 1.22
Meager genetic variability of the human malaria agent Plasmodium vivax. Proc Natl Acad Sci U S A (2004) 1.20
Correlations between development rates, enzyme activities, ribosomal DNA spacer-length phenotypes, and adaptation in Drosophila melanogaster. Proc Natl Acad Sci U S A (1987) 1.20
Competition between Species: Frequency Dependence. Science (1971) 1.20
Trypanosoma cruzi: impact of clonal evolution of the parasite on its biological and medical properties. Exp Parasitol (1998) 1.20
Natural selection vs. random drift: evidence from temporal variation in allele frequencies in nature. Genetics (1985) 1.19
Expression and regulation of cell adhesion molecules by hepatic stellate cells (HSC) of rat liver: involvement of HSC in recruitment of inflammatory cells during hepatic tissue repair. Am J Pathol (1999) 1.18
Chromosome interactions in Drosophila melanogaster. II. Total fitness. Genetics (1982) 1.17
[High correlation between isoenzyme classification and kinetoplast DNA variability in Trypanosoma cruzi]. C R Acad Sci III (1987) 1.17
Chromosomal and allozymic diagnosis of three species of Drosophila. Drosophila pseudoobscura, D. persimilis, and D. miranda. J Hered (1977) 1.16
Trypanosomatidae from wild mammals in the neotropical rainforest of French Guiana. Ann Trop Med Parasitol (2001) 1.15
The superoxide dismutase molecular clock revisited. Proc Natl Acad Sci U S A (1994) 1.14
Erratic overdispersion of three molecular clocks: GPDH, SOD, and XDH. Proc Natl Acad Sci U S A (2001) 1.14
New Drosophila introns originate by duplication. Proc Natl Acad Sci U S A (1998) 1.14
Evidence for clonal propagation in natural isolates of Plasmodium falciparum from Venezuela. Proc Natl Acad Sci U S A (2001) 1.14
Evidence for hybridization by multilocus enzyme electrophoresis and random amplified polymorphic DNA between Leishmania braziliensis and Leishmania panamensis/guyanensis in Ecuador. J Eukaryot Microbiol (1997) 1.12
Restricted genetic and antigenic diversity of Plasmodium falciparum under mesoendemic transmission in the Venezuelan Amazon. Parasitology (2002) 1.11
Founder-effect speciation theory: failure of experimental corroboration. Proc Natl Acad Sci U S A (1995) 1.11
Another alternative to directed mutation. Nature (1989) 1.10
The bcl, NFkappaB and p53/p21WAF1 systems are involved in spontaneous apoptosis and in the anti-apoptotic effect of TGF-beta or TNF-alpha on activated hepatic stellate cells. Eur J Cell Biol (2001) 1.09
On the asymmetry of lambda integration sites. J Mol Biol (1969) 1.09
Fitness of allozyme variants in Drosophila pseudoobscura. I. Selection at the PGM-1 and Me-2 loci. Genetics (1975) 1.09
Cell-type-specific expression of neural cell adhesion molecule (N-CAM) in Ito cells of rat liver. Up-regulation during in vitro activation and in hepatic tissue repair. Am J Pathol (1996) 1.08