The crystal structure of GMP synthetase reveals a novel catalytic triad and is a structural paradigm for two enzyme families.

PubWeight™: 2.11‹?› | Rank: Top 2%

🔗 View Article (PMID 8548458)

Published in Nat Struct Biol on January 01, 1996


J J Tesmer1, T J Klem, M L Deras, V J Davisson, J L Smith

Author Affiliations

1: Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA.

Articles citing this

KH domain: one motif, two folds. Nucleic Acids Res (2001) 2.21

The nitrilase superfamily: classification, structure and function. Genome Biol (2001) 2.19

Asparagine synthetase chemotherapy. Annu Rev Biochem (2006) 1.82

The 1.6-A crystal structure of the class of chaperones represented by Escherichia coli Hsp31 reveals a putative catalytic triad. Proc Natl Acad Sci U S A (2003) 1.72

Crystal structure of an intracellular protease from Pyrococcus horikoshii at 2-A resolution. Proc Natl Acad Sci U S A (2000) 1.65

Crystal structure of the quorum-sensing protein LuxS reveals a catalytic metal site. Proc Natl Acad Sci U S A (2001) 1.62

The 1.8-A resolution crystal structure of YDR533Cp from Saccharomyces cerevisiae: a member of the DJ-1/ThiJ/PfpI superfamily. Proc Natl Acad Sci U S A (2004) 1.52

Substrate recognition, protein dynamics, and iron-sulfur cluster in Pseudomonas aeruginosa adenosine 5'-phosphosulfate reductase. J Mol Biol (2006) 1.42

From fold predictions to function predictions: automation of functional site conservation analysis for functional genome predictions. Protein Sci (1999) 1.33

The structures of anthranilate synthase of Serratia marcescens crystallized in the presence of (i) its substrates, chorismate and glutamine, and a product, glutamate, and (ii) its end-product inhibitor, L-tryptophan. Proc Natl Acad Sci U S A (2001) 1.30

The crystal structure of anthranilate synthase from Sulfolobus solfataricus: functional implications. Proc Natl Acad Sci U S A (1999) 1.26

Allosteric pathways in imidazole glycerol phosphate synthase. Proc Natl Acad Sci U S A (2012) 1.24

EBNA1-mediated recruitment of a histone H2B deubiquitylating complex to the Epstein-Barr virus latent origin of DNA replication. PLoS Pathog (2009) 1.16

Crystal structure of NH3-dependent NAD+ synthetase from Bacillus subtilis. EMBO J (1996) 1.16

Regulation of the nitrogen transfer pathway in the arbuscular mycorrhizal symbiosis: gene characterization and the coordination of expression with nitrogen flux. Plant Physiol (2010) 1.12

Crystal structure of Escherichia coli cytidine triphosphate synthetase, a nucleotide-regulated glutamine amidotransferase/ATP-dependent amidoligase fusion protein and homologue of anticancer and antiparasitic drug targets. Biochemistry (2004) 1.11

Using genomic information to investigate the function of ThiI, an enzyme shared between thiamin and 4-thiouridine biosynthesis. Protein Sci (1999) 1.08

Molecular dynamics analysis of structural factors influencing back door pi release in myosin. Biophys J (2004) 1.07

Identification and in vitro analysis of the GatD/MurT enzyme-complex catalyzing lipid II amidation in Staphylococcus aureus. PLoS Pathog (2012) 1.06

The RNA acetyltransferase driven by ATP hydrolysis synthesizes N4-acetylcytidine of tRNA anticodon. EMBO J (2008) 1.06

Structural basis for lysidine formation by ATP pyrophosphatase accompanied by a lysine-specific loop and a tRNA-recognition domain. Proc Natl Acad Sci U S A (2005) 1.04

The MTCY428.08 gene of Mycobacterium tuberculosis codes for NAD+ synthetase. J Bacteriol (1998) 1.01

Adenylating enzymes in Mycobacterium tuberculosis as drug targets. Curr Top Med Chem (2012) 1.00

An embarrassment of riches: the enzymology of RNA modification. Curr Opin Chem Biol (2008) 1.00

Characterization of LtsA from Rhodococcus erythropolis, an enzyme with glutamine amidotransferase activity. J Bacteriol (2005) 0.99

Structural elements in IGP synthase exclude water to optimize ammonia transfer. Biophys J (2005) 0.98

Regulation of active site coupling in glutamine-dependent NAD(+) synthetase. Nat Struct Mol Biol (2009) 0.97

Developing an energy landscape for the novel function of a (beta/alpha)8 barrel: ammonia conduction through HisF. Proc Natl Acad Sci U S A (2003) 0.95

Intraflagellar transport proteins 172, 80, 57, 54, 38, and 20 form a stable tubulin-binding IFT-B2 complex. EMBO J (2016) 0.94

Subunit interactions and glutamine utilization by Escherichia coli imidazole glycerol phosphate synthase. J Bacteriol (2001) 0.93

Inhibition of Escherichia coli CTP synthase by glutamate gamma-semialdehyde and the role of the allosteric effector GTP in glutamine hydrolysis. Biochem J (2001) 0.93

RASPBERRY3 gene encodes a novel protein important for embryo development. Plant Physiol (2002) 0.91

Glutamine versus ammonia utilization in the NAD synthetase family. PLoS One (2012) 0.88

A highly conserved family of domains related to the DNA-glycosylase fold helps predict multiple novel pathways for RNA modifications. RNA Biol (2014) 0.87

Aspartate-107 and leucine-109 facilitate efficient coupling of glutamine hydrolysis to CTP synthesis by Escherichia coli CTP synthase. Biochem J (2003) 0.84

Crystal structure of glutamine amidotransferase from Thermotoga maritima. Proteins (2002) 0.83

Transition-state inhibitors of purine salvage and other prospective enzyme targets in malaria. Future Med Chem (2013) 0.83

Molecular dynamics simulations of a helicase. Proteins (2003) 0.81

NMR structure of the conserved hypothetical protein TM0487 from Thermotoga maritima: implications for 216 homologous DUF59 proteins. Protein Sci (2005) 0.81

Iron-sulfur cluster engineering provides insight into the evolution of substrate specificity among sulfonucleotide reductases. ACS Chem Biol (2011) 0.80

Convergent evolution of AUA decoding in bacteria and archaea. RNA Biol (2014) 0.79

TtcA a new tRNA-thioltransferase with an Fe-S cluster. Nucleic Acids Res (2014) 0.79

Mutation analysis of carbamoyl phosphate synthetase: does the structurally conserved glutamine amidotransferase triad act as a functional dyad? Protein Sci (2008) 0.78

Molecular characterization of argininosuccinate synthase and argininosuccinate lyase from the liver of the African lungfish Protopterus annectens, and their mRNA expression levels in the liver, kidney, brain and skeletal muscle during aestivation. J Comp Physiol B (2014) 0.78

Substrate activation and conformational dynamics of guanosine 5'-monophosphate synthetase. Biochemistry (2013) 0.78

Conformational changes involving ammonia tunnel formation and allosteric control in GMP synthetase. Arch Biochem Biophys (2014) 0.78

Importance of hydrophobic cavities in allosteric regulation of formylglycinamide synthetase: insight from xenon trapping and statistical coupling analysis. PLoS One (2013) 0.77

Temperature-dependent function of the glutamine phosphoribosylpyrophosphate amidotransferase ammonia channel and coupling with glycinamide ribonucleotide synthetase in a hyperthermophile. J Bacteriol (2000) 0.77

Active site coupling in Plasmodium falciparum GMP synthetase is triggered by domain rotation. Nat Commun (2015) 0.76

Partial randomization of the four sequential amidation reactions catalyzed by cobyric acid synthetase with a single point mutation. Biochemistry (2007) 0.75

GMP Synthase is Required for Virulence Factor Production and Infection by Cryptococcus neoformans. J Biol Chem (2017) 0.75

Inhibition of guanosine monophosphate synthetase by the substrate enantiomer L-XMP. Chembiochem (2012) 0.75

A Cascade of Thermophilic Enzymes As an Approach to the Synthesis of Modified Nucleotides. Acta Naturae (2017) 0.75

Comparative genomic analysis of novel Acinetobacter symbionts: A combined systems biology and genomics approach. Sci Rep (2016) 0.75

A conserved glutamate controls the commitment to acyl-adenylate formation in asparagine synthetase. Biochemistry (2010) 0.75

Singular points of protein beta-sheets. Protein Sci (1998) 0.75

Articles by these authors

(truncated to the top 100)

Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia (2003) 13.41

The mass and oxygen capacity of the blood in man. J Physiol (1900) 10.55

Distinct dendritic cell subsets differentially regulate the class of immune response in vivo. Proc Natl Acad Sci U S A (1999) 5.66

Crystal structure of core streptavidin determined from multiwavelength anomalous diffraction of synchrotron radiation. Proc Natl Acad Sci U S A (1989) 5.57

The Absorption of Oxygen by the Lungs. J Physiol (1897) 4.50

A prospective study of advance directives for life-sustaining care. N Engl J Med (1991) 3.72

Phenotypic and functional characterization of mice that lack the type I receptor for IL-1. J Immunol (1997) 3.56

The Oxygen Tension of Arterial Blood. J Physiol (1896) 3.40

oskar mRNA is localized to the posterior pole of the Drosophila oocyte. Cell (1991) 3.39

The course of patients after variceal hemorrhage. Gastroenterology (1981) 3.33

A protein catalytic framework with an N-terminal nucleophile is capable of self-activation. Nature (1995) 3.30

The pathological effects due to increase of oxygen tension in the air breathed. J Physiol (1899) 3.28

Stages in the nuclear association of the herpes simplex virus transcriptional activator protein ICP4. J Virol (1987) 3.24

Hepatitis B infection in physicians. Results of a nationwide seroepidemiologic survey. JAMA (1978) 3.24

Structure of myohemerythrin in the azidomet state at 1.7/1.3 A resolution. J Mol Biol (1987) 2.79

Variceal hemorrhage: a critical evaluation of survival analysis. Gastroenterology (1982) 2.60

Immunologic tolerance to renal allografts after bone marrow transplants from the same donors. Ann Intern Med (1991) 2.46

Generation of murine dendritic cells from flt3-ligand-supplemented bone marrow cultures. Blood (2000) 2.45

Paracentric inversions in humans: a review of 446 paracentric inversions with presentation of 120 new cases. Am J Med Genet (1995) 2.39

Spirochetes in the aqueous humor in seronegative ocular syphilis. Persistence after penicillin therapy. Arch Ophthalmol (1967) 2.30

Synthesis of allylic and homoallylic isoprenoid pyrophosphates. Methods Enzymol (1985) 2.18

Motility in Pseudomonas fluorescens with special reference to survival advantage and negative chemotaxis. Life Sci (1968) 2.17


Spontaneous regression of primary malignant melanomas with regional metastases. Cancer (1965) 2.15

Structure of a dehydratase-isomerase from the bacterial pathway for biosynthesis of unsaturated fatty acids: two catalytic activities in one active site. Structure (1996) 2.14

Alteplase versus heparin in acute pulmonary embolism: randomised trial assessing right-ventricular function and pulmonary perfusion. Lancet (1993) 2.12

A new modification of the Krajian silver stain for Treponema pallidum. Br J Vener Dis (1969) 2.09

Using the Internet for psychological research: personality testing on the World Wide Web. Br J Psychol (1999) 2.06

Gastroduodenal mucosa and dyspeptic symptoms in arthritic patients during chronic nonsteroidal anti-inflammatory drug use. Am J Gastroenterol (1987) 2.05

Direct phase determination based on anomalous scattering. Methods Enzymol (1985) 2.02

Hereditary aspects of malignant melanoma. JAMA (1967) 1.98

Iatrogenic Campylobacter pylori infection is a cause of epidemic achlorhydria. Am J Gastroenterol (1988) 1.97

Gastric adaptation. Studies in humans during continuous aspirin administration. Gastroenterology (1988) 1.97

Incidence of reactive VDRL tests in the normal rabbit. Br J Vener Dis (1967) 1.94

T and B lymphocytes and Reed-Sternberg cells in Hodgkin's disease lymph nodes and spleens. Clin Exp Immunol (1976) 1.91


B- and T-lymphocyte markers on transformed lymphocytes from mitogen-stimulated cultures of normal and CLL lymphocytes and on tonsil blasts. Clin Exp Immunol (1974) 1.86

Multiple RNA regulatory elements mediate distinct steps in localization of oskar mRNA. Development (1993) 1.86

Optic nerve sheath decompression for relief of chronic monocular choked disc. Am J Ophthalmol (1969) 1.84

Microbiology of the frankfurter process: salmonella and natural aerobic flora. Appl Microbiol (1974) 1.83

Muscle fibre type populations of human leg muscles. Histochem J (1975) 1.83

Characterisation of malignant mediastinal lymphoid neoplasm (Sternberg sarcoma) as thymic in origin. Lancet (1973) 1.78

Aspirin and the stomach. Ann Intern Med (1986) 1.77

RNA regulatory element BLE1 directs the early steps of bicoid mRNA localization. Development (1993) 1.76

Whence pseudotumor cerebri? J Clin Neuroophthalmol (1985) 1.76

Recovery of Treponema pallidum from aqueous humor removed at cataract surgery in man by passive transfer to rabbit testis. Am J Ophthalmol (1968) 1.76

A mutant herpesvirus protein leads to a block in nuclear localization of other viral proteins. Mol Cell Biol (1986) 1.75

Immunological reason for chronic ill health after infectious mononucleosis. Br Med J (Clin Res Ed) (1983) 1.74

Locally critical quantum phase transitions in strongly correlated metals. Nature (2001) 1.74

Studies on negative chemotaxis and the survival value of motility in Pseudomonas fluorescens. J Gen Microbiol (1969) 1.71

Non-tumor causes of the Foster Kennedy syndrome. J Neurosurg (1967) 1.71

Coupled formation of an amidotransferase interdomain ammonia channel and a phosphoribosyltransferase active site. Biochemistry (1997) 1.70

The current status of treponema cuniculi. Review of the literature. Br J Vener Dis (1967) 1.69

Painful ophthalmoplegia. The Tolosa-Hunt syndrome. Am J Ophthalmol (1966) 1.68

Enzymes utilizing glutamine as an amide donor. Adv Enzymol Relat Areas Mol Biol (1998) 1.67

Cloning, expression, and characterization of (+)-delta-cadinene synthase: a catalyst for cotton phytoalexin biosynthesis. Arch Biochem Biophys (1995) 1.64

Crystallographic structure analysis of lamprey hemoglobin from anomalous dispersion of synchrotron radiation. Proteins (1988) 1.64

Mechanisms of neurulation: traditional viewpoint and recent advances. Development (1990) 1.64

Effect of incorporation of cidofovir into DNA by human cytomegalovirus DNA polymerase on DNA elongation. Antimicrob Agents Chemother (1997) 1.60

The fluorescent antibody tissue stain for Treponema pallidum in the eye. Am J Ophthalmol (1967) 1.59

Experimental seronegative syphilis. Am J Ophthalmol (1965) 1.56

Multiple folding pathways for the P4-P6 RNA domain. Biochemistry (2000) 1.51

Skin involvement in Hodgkin's disease. Cancer (1980) 1.51

Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: parallels with Alzheimer's disease and correction by insulin. J Neurosci Res (2008) 1.50

Ischemic optic neuropathy. Am J Ophthalmol (1966) 1.49

Leber's idiopathic stellate neuroretinitis. Arch Ophthalmol (1984) 1.49

Visual morbidity in giant cell arteritis. Clinical characteristics and prognosis for vision. Ophthalmology (1994) 1.49

Fast folding of a ribozyme by stabilizing core interactions: evidence for multiple folding pathways in RNA. J Mol Biol (2000) 1.48

Crystal structure of chloroplast cytochrome f reveals a novel cytochrome fold and unexpected heme ligation. Structure (1994) 1.47

Clinical relevance of intraoperative embolization detected by transcranial Doppler ultrasonography during carotid endarterectomy: a prospective study of 100 patients. Br J Surg (1994) 1.46

Simultaneous, multiple cranial neuropathies in diabetes mellitus. J Neuroophthalmol (1995) 1.45

Assessment of intracranial primary collaterals using transcranial color-coded real-time sonography. J Neuroimaging (1995) 1.45

Imidazole glycerol phosphate synthase: the glutamine amidotransferase in histidine biosynthesis. Biochemistry (1993) 1.45

Ocular Lyme borreliosis. Am J Ophthalmol (1989) 1.45

N5-carboxyaminoimidazole ribonucleotide: evidence for a new intermediate and two new enzymatic activities in the de novo purine biosynthetic pathway of Escherichia coli. Biochemistry (1994) 1.43

Response of lymphocytes in chronic lymphocytic leukaemia to plant mitogens. Lancet (1972) 1.42

Foveal cone dysfunction syndrome. J Neuroophthalmol (1998) 1.42

Acquired intermittent Brown's syndrome. Neurology (1974) 1.41

Postoperative complications after splenectomy for hematologic malignancies. Ann Surg (1996) 1.40

Neuro-ophthalmological study of late yaws and pinta. II. The Caracas project. Br J Vener Dis (1971) 1.39

Significant activity of paclitaxel in advanced transitional-cell carcinoma of the urothelium: a phase II trial of the Eastern Cooperative Oncology Group. J Clin Oncol (1994) 1.39

Localization of a parathyroid adenoma by thermography. West J Med (1974) 1.39

Pinning frequencies of the collective modes in alpha-uranium. Phys Rev Lett (2006) 1.39

Pulmonary microvascular fat: the significance? Crit Care Med (1993) 1.39

Toxicity of vidarabine. JAMA (1979) 1.39

Free light chain synthesis by neoplastic cells in chronic lymphocytic leukaemia and non-Hodgkin's lymphoma. Immunology (1978) 1.39

Crystal structure of Bacillus subtilis YabJ, a purine regulatory protein and member of the highly conserved YjgF family. Proc Natl Acad Sci U S A (1999) 1.39

Pathogenesis and management of abdominal wall hematomas. Arch Surg (1966) 1.38

On-table diagnosis of incipient carotid artery thrombosis during carotid endarterectomy by transcranial Doppler scanning. J Vasc Surg (1994) 1.38

Crystal structure of glutamine phosphoribosylpyrophosphate amidotransferase from Escherichia coli. Protein Sci (1998) 1.37

Further observations in progressive supranuclear palsy. Neurology (1968) 1.37

Antiviral treatment of chronic hepatitis B virus infection. I. Changes in viral markers with interferon combined with adenine arabinoside. J Infect Dis (1981) 1.36

Sphingofungins E and F: novel serinepalmitoyl transferase inhibitors from Paecilomyces variotii. J Antibiot (Tokyo) (1992) 1.36

Immunoglobulin synthesis by neoplastic B lymphocytes: free light chain synthesis as a marker of B cell differentiation. J Immunol (1980) 1.35

Effect of meal volume and energy density on the gastric emptying of carbohydrates. Gastroenterology (1985) 1.35

Diverse styles of submarine venting on the ultraslow spreading Mid-Cayman Rise. Proc Natl Acad Sci U S A (2010) 1.34

Effect of vidarabine on chronic hepatitis B virus infection. JAMA (1978) 1.34

Sequence analysis of the Candida albicans ADE2 gene and physical separation of the two functionally distinct domains of the phosphoribosylaminoimidazole carboxylase. Yeast (1997) 1.33

Molecular characterization of calmodulin trapping by calcium/calmodulin-dependent protein kinase II. J Biol Chem (2001) 1.33

Intra-abdominal lymphangiomata. Arch Surg (1966) 1.33