Published in N Engl J Med on April 11, 1996
Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom Prospective Diabetes Study (UKPDS: 23) BMJ (1998) 7.48
Insulin resistance and hypersecretion in obesity. European Group for the Study of Insulin Resistance (EGIR). J Clin Invest (1997) 3.66
Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. J Clin Invest (1999) 3.18
Association between high-normal levels of alanine aminotransferase and risk factors for atherogenesis. Gastroenterology (2013) 2.82
Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. Diabetes Care (2011) 2.75
Cardiovascular mortality after androgen deprivation therapy for locally advanced prostate cancer: RTOG 85-31. J Clin Oncol (2008) 2.20
Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice. Cell Metab (2010) 2.09
Androgen-deprivation therapy in prostate cancer and cardiovascular risk: a science advisory from the American Heart Association, American Cancer Society, and American Urological Association: endorsed by the American Society for Radiation Oncology. CA Cancer J Clin (2010) 2.05
Insulin resistance syndrome, body mass index and the risk of ischemic heart disease. CMAJ (2005) 1.86
Metabolic complications of androgen deprivation therapy for prostate cancer. J Urol (2009) 1.86
Mechanisms of human insulin resistance and thiazolidinedione-mediated insulin sensitization. Proc Natl Acad Sci U S A (2009) 1.75
Central obesity, insulin resistance, syndrome X, lipoprotein(a), and cardiovascular risk in Indians, Malays, and Chinese in Singapore. J Epidemiol Community Health (1997) 1.73
Insulin resistance and the relationship of a dyslipidemia to coronary heart disease: the Framingham Heart Study. Arterioscler Thromb Vasc Biol (2011) 1.66
Thiazolidinediones and the promise of insulin sensitization in type 2 diabetes. Cell Metab (2014) 1.53
Usefulness of the triglyceride-high-density lipoprotein versus the cholesterol-high-density lipoprotein ratio for predicting insulin resistance and cardiometabolic risk (from the Framingham Offspring Cohort). Am J Cardiol (2008) 1.49
Intrauterine exposure to diabetes is a determinant of hemoglobin A(1)c and systolic blood pressure in pima Indian children. J Clin Endocrinol Metab (2005) 1.43
Genetic and environmental architecture of the features of the insulin-resistance syndrome. Am J Hum Genet (1997) 1.42
Cutoff values of surrogate measures of insulin resistance for metabolic syndrome in Korean non-diabetic adults. J Korean Med Sci (2006) 1.38
Childhood obesity and cardiovascular disease: links and prevention strategies. Nat Rev Cardiol (2011) 1.38
Screening, prevention, counseling, and treatment for the complications of type II diabetes mellitus. Putting evidence into practice. J Gen Intern Med (1997) 1.36
Cardiovascular disease, diabetes and established risk factors among populations of sub-Saharan African descent in Europe: a literature review. Global Health (2009) 1.34
Endothelial activation markers are linked to HIV status and are independent of antiretroviral therapy and lipoatrophy. J Acquir Immune Defic Syndr (2008) 1.25
Metabolic syndrome and cancer. Metab Syndr Relat Disord (2009) 1.24
Diabetic cardiomyopathy: from the pathophysiology of the cardiac myocytes to current diagnosis and management strategies. Vasc Health Risk Manag (2010) 1.24
Fasting insulin reflects heterogeneous physiological processes: role of insulin clearance. Am J Physiol Endocrinol Metab (2011) 1.23
Assessing the prevalence of the Metabolic Syndrome according to NCEP ATP III in Germany: feasibility and quality aspects of a two step approach in 1550 randomly selected primary health care practices. Ger Med Sci (2006) 1.20
Heritabilities of the metabolic syndrome and its components in the Northern Manhattan Family Study. Diabetologia (2005) 1.20
Portal venous and enteric exocrine drainage versus systemic venous and bladder exocrine drainage of pancreas grafts: clinical outcome of 40 consecutive transplant recipients. Ann Surg (2000) 1.14
Metabolic syndrome as a predictor of type 2 diabetes, and its clinical interpretations and usefulness. J Diabetes Investig (2013) 1.13
Salt, aldosterone, and insulin resistance: impact on the cardiovascular system. Nat Rev Cardiol (2010) 1.13
Cardiac and skeletal muscle insulin resistance in patients with coronary heart disease. A study with positron emission tomography. J Clin Invest (1996) 1.10
Utility of the modified ATP III defined metabolic syndrome and severe obesity as predictors of insulin resistance in overweight children and adolescents: a cross-sectional study. Cardiovasc Diabetol (2007) 1.10
Metabolic sequelae associated with androgen deprivation therapy for prostate cancer. Curr Opin Endocrinol Diabetes Obes (2010) 1.09
Androgen deprivation therapy for the treatment of prostate cancer: consider both benefits and risks. Eur Urol (2008) 1.08
Effects of nasal CPAP treatment on insulin resistance, lipid profile, and plasma leptin in sleep apnea. Lung (2009) 1.07
The efficacy and safety of insulin-sensitizing drugs in HIV-associated lipodystrophy syndrome: a meta-analysis of randomized trials. BMC Infect Dis (2010) 1.07
Type 2 Diabetes Mellitus and Insulin Resistance: Stroke Prevention and Management. Curr Treat Options Neurol (2004) 1.06
Sleep Apnea and Metabolic Dysfunction: Cause or Co-Relation? Sleep Med Clin (2007) 1.04
Prostate cancer survivorship: prevention and treatment of the adverse effects of androgen deprivation therapy. J Gen Intern Med (2009) 1.03
Is metabolic syndrome a discrete entity in the general population? Evidence from the Caerphilly and Speedwell population studies. Heart (1998) 1.03
Insulin resistance. BMJ (1996) 1.00
Phenotypic, genetic, and genome-wide structure in the metabolic syndrome. BMC Genet (2003) 1.00
Vitamin D replacement in Asians with diabetes may increase insulin resistance. Postgrad Med J (1998) 0.99
Insulin resistance and hyperinsulinemia: you can't have one without the other. Diabetes Care (2008) 0.99
Effect of adjunct metformin treatment in patients with type-1 diabetes and persistent inadequate glycaemic control. A randomized study. PLoS One (2008) 0.98
Insulin resistance predicts progression of de novo atherosclerotic plaques in patients with coronary heart disease: a one-year follow-up study. Cardiovasc Diabetol (2012) 0.98
Concentration-dependent dual effects of hydrogen peroxide on insulin signal transduction in H4IIEC hepatocytes. PLoS One (2011) 0.97
Adolescents with metabolic syndrome have a history of low aerobic fitness and physical activity levels. Dyn Med (2008) 0.97
The interplay of autoimmunity and insulin resistance in type 1 diabetes. Discov Med (2012) 0.96
Protopanaxatriol, a novel PPARγ antagonist from Panax ginseng, alleviates steatosis in mice. Sci Rep (2014) 0.96
Adipokines, inflammation, insulin resistance, and carotid atherosclerosis in patients with rheumatoid arthritis. Arthritis Res Ther (2013) 0.95
Sympathetic overactivity precedes metabolic dysfunction in a fructose model of glucose intolerance in mice. Am J Physiol Regul Integr Comp Physiol (2012) 0.95
Androgen deprivation therapy and risk for diabetes and cardiovascular disease in prostate cancer survivors. Curr Urol Rep (2008) 0.94
Metabolic phenotype in the brothers of women with polycystic ovary syndrome. Diabetes Care (2008) 0.93
Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells. Mol Cell Biol (2013) 0.92
Entero-insular axis and postprandial insulin differences in African American and European American children. Am J Clin Nutr (2008) 0.91
Insulin resistance functionally limits endothelium-dependent coronary vasodilation in nondiabetic patients. Heart Vessels (2008) 0.91
Adverse effects of androgen deprivation therapy: defining the problem and promoting health among men with prostate cancer. J Natl Compr Canc Netw (2010) 0.90
Increased atherosclerosis and endothelial dysfunction in mice bearing constitutively deacetylated alleles of Foxo1 gene. J Biol Chem (2012) 0.90
Increased insulin sensitivity and reduced micro and macro vascular disease induced by 2-deoxy-D-glucose during metabolic syndrome in obese JCR: LA-cp rats. Br J Pharmacol (2007) 0.88
Insulin resistance as a predictor of cardiovascular disease in patients on peritoneal dialysis. Perit Dial Int (2013) 0.88
Salt restriction among hypertensive patients: modest blood pressure effect and no adverse effects. Scand J Prim Health Care (2009) 0.88
Insulin resistance, cystatin C, and mortality among older adults. Diabetes Care (2012) 0.88
The effects of high dose pravastatin and low dose pravastatin and ezetimibe combination therapy on lipid, glucose metabolism and inflammation. Inflammation (2007) 0.88
Strategies for optimizing glycemic control and cardiovascular prognosis in patients with type 2 diabetes mellitus. Mayo Clin Proc (2011) 0.87
Insulin-like growth factor-1 receptor expression masks the antiinflammatory and glucose uptake capacity of insulin in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol (2009) 0.87
Comparison between serum insulin levels and its resistance with biochemical, clinical and anthropometric parameters in South Indian children and adolescents. Indian J Clin Biochem (2010) 0.86
Gonadotrophin-releasing hormone agonists, diabetes and cardiovascular disease in men with prostate cancer: which metabolic syndrome? BJU Int (2008) 0.86
Hyperinsulinemia does not change atherosclerosis development in apolipoprotein E null mice. Arterioscler Thromb Vasc Biol (2012) 0.86
Hypogonadism and metabolic syndrome in nigerian male patients with both type 2 diabetes and hypertension. Int J Endocrinol Metab (2014) 0.85
Miglitol improves postprandial endothelial dysfunction in patients with acute coronary syndrome and new-onset postprandial hyperglycemia. Cardiovasc Diabetol (2013) 0.83
Improved sleep quality in older adults with insomnia reduces biomarkers of disease risk: pilot results from a randomized controlled comparative efficacy trial. Psychoneuroendocrinology (2015) 0.83
Selective Insulin Resistance and the Development of Cardiovascular Diseases in Diabetes: The 2015 Edwin Bierman Award Lecture. Diabetes (2016) 0.83
Advantages of the single delay model for the assessment of insulin sensitivity from the intravenous glucose tolerance test. Theor Biol Med Model (2010) 0.83
Insulin resistance: an additional risk factor in the pathogenesis of cardiovascular disease in type 2 diabetes. Heart Fail Rev (2016) 0.82
Differential associations of angiographic extent and severity of coronary artery disease with asymmetric dimethylarginine but not insulin resistance in non-diabetic men with stable angina: a cross-sectional study. Cardiovasc Diabetol (2013) 0.82
Should all women with PCOS be treated for insulin resistance? Fertil Steril (2012) 0.82
Cardiovascular risk factors in overweight and obese Chinese children: a comparison of weight-for-height index and BMI as the screening criterion. Eur J Nutr (2008) 0.82
Relationships of obesity and fat distribution with atherothrombotic risk factors: baseline results from the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial. Obesity (Silver Spring) (2009) 0.82
Insulin resistance may contribute to vascular dysfunction in patients with chronic obstructive pulmonary disease. Wien Klin Wochenschr (2013) 0.81
Prevalence of insulin resistance and its relationship with cardiovascular disease risk factors among Thai adults over 35 years old. Diabetes Res Clin Pract (2010) 0.81
Acute effects of hyperinsulinemia and hyperglycemia on vascular inflammatory biomarkers and endothelial function in overweight and obese humans. Am J Physiol Endocrinol Metab (2015) 0.81
Adiposity is associated with endothelial activation in healthy 2-3 year-old children. J Pediatr Endocrinol Metab (2009) 0.81
Irbesartan-mediated reduction of renal and cardiac damage in insulin resistant JCR : LA-cp rats. Br J Pharmacol (2009) 0.81
Differential vascular dysfunction in response to diets of differing macronutrient composition: a phenomenonological study. Nutr Metab (Lond) (2007) 0.81
Insulin decreases atherosclerosis by inducing endothelin receptor B expression. JCI Insight (2016) 0.80
Recent pharmacological developments on rhodanines and 2,4-thiazolidinediones. Int J Med Chem (2013) 0.80
Myocardial glucose utilisation in type II diabetes mellitus patients treated with sulphonylurea drugs. Eur J Nucl Med Mol Imaging (2006) 0.80
Association of insulin resistance indexes to carotid intima-media thickness. PLoS One (2013) 0.80
Transdermal delivery of insulin by amidated pectin hydrogel matrix patch in streptozotocin-induced diabetic rats: effects on some selected metabolic parameters. PLoS One (2014) 0.80
Retinol binding protein 4 promotes hyperinsulinism‑induced proliferation of rat aortic smooth muscle cells. Mol Med Rep (2014) 0.80
Targeting hepatic glucose metabolism in the treatment of type 2 diabetes. Nat Rev Drug Discov (2016) 0.80
The fractionalization of physical activity throughout the week is associated with the cardiometabolic health of children and youth. BMC Public Health (2013) 0.79
Effects of diet-induced obesity on protein expression in insulin signaling pathways of skeletal muscle in male Wistar rats. Int J Gen Med (2012) 0.79
A double-blind randomized study comparing the effects of continuing or not continuing rosiglitazone + metformin therapy when starting insulin therapy in people with Type 2 diabetes. Diabet Med (2007) 0.79
Insulin resistance is associated with new-onset cardiovascular events in nondiabetic patients undergoing peritoneal dialysis. Kidney Res Clin Pract (2014) 0.79
Short-Term Estrogen Withdrawal Increases Adiposity in Healthy Men. J Clin Endocrinol Metab (2016) 0.78
Effect of St. John's Wort (Hypericum perforatum) on obesity, lipid metabolism and uterine epithelial proliferation in ovariectomized rats. Nutr Res Pract (2014) 0.78
Waist circumference and abdominal sagittal diameter: best simple anthropometric indexes of abdominal visceral adipose tissue accumulation and related cardiovascular risk in men and women. Am J Cardiol (1994) 7.21
The response to long-term overfeeding in identical twins. N Engl J Med (1990) 6.10
Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis. JAMA (2005) 5.60
Small, dense low-density lipoprotein particles as a predictor of the risk of ischemic heart disease in men. Prospective results from the Québec Cardiovascular Study. Circulation (1997) 4.81
The relationship between dysglycaemia and cardiovascular and renal risk in diabetic and non-diabetic participants in the HOPE study: a prospective epidemiological analysis. Diabetologia (2005) 4.45
Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolaemia. Nat Genet (1994) 4.33
Regional distribution of body fat, plasma lipoproteins, and cardiovascular disease. Arteriosclerosis (1990) 4.01
The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases. Eur J Epidemiol (2007) 3.81
Hypertriglyceridemic waist: A marker of the atherogenic metabolic triad (hyperinsulinemia; hyperapolipoprotein B; small, dense LDL) in men? Circulation (2000) 3.78
A comparison of management patterns after acute myocardial infarction in Canada and the United States. The SAVE investigators. N Engl J Med (1993) 3.75
Quantitative two-dimensional echocardiographic measurements are major predictors of adverse cardiovascular events after acute myocardial infarction. The protective effects of captopril. Circulation (1994) 2.74
A pilot study of ex vivo gene therapy for homozygous familial hypercholesterolaemia. Nat Med (1995) 2.65
Visceral obesity in men. Associations with glucose tolerance, plasma insulin, and lipoprotein levels. Diabetes (1992) 2.36
Fasting insulin and apolipoprotein B levels and low-density lipoprotein particle size as risk factors for ischemic heart disease. JAMA (1998) 2.28
Total cholesterol/HDL cholesterol ratio vs LDL cholesterol/HDL cholesterol ratio as indices of ischemic heart disease risk in men: the Quebec Cardiovascular Study. Arch Intern Med (2001) 2.22
Role of deep abdominal fat in the association between regional adipose tissue distribution and glucose tolerance in obese women. Diabetes (1989) 1.96
Is lipoprotein(a) an independent risk factor for ischemic heart disease in men? The Quebec Cardiovascular Study. J Am Coll Cardiol (1998) 1.88
The response to exercise with constant energy intake in identical twins. Obes Res (1994) 1.77
HDL-cholesterol as a marker of coronary heart disease risk: the Québec cardiovascular study. Atherosclerosis (2000) 1.68
Everolimus versus mycophenolate mofetil in heart transplantation: a randomized, multicenter trial. Am J Transplant (2013) 1.65
Genetic and nongenetic determinants of regional fat distribution. Endocr Rev (1993) 1.63
Prevalence of dyslipidemic phenotypes in ischemic heart disease (prospective results from the Québec Cardiovascular Study) Am J Cardiol (1995) 1.59
Apolipoprotein A-I and B levels and the risk of ischemic heart disease during a five-year follow-up of men in the Québec cardiovascular study. Circulation (1996) 1.54
Selection bias in the use of thrombolytic therapy in acute myocardial infarction. The SAVE Investigators. JAMA (1991) 1.50
Psychosocial factors at work, smoking, sedentary behavior, and body mass index: a prevalence study among 6995 white collar workers. J Occup Environ Med (2000) 1.50
The insulin resistance-dyslipidemic syndrome: contribution of visceral obesity and therapeutic implications. Int J Obes Relat Metab Disord (1995) 1.49
Body weight loss increases plasma and adipose tissue concentrations of potentially toxic pollutants in obese individuals. Int J Obes Relat Metab Disord (2000) 1.47
Psychological stress and incidence of ischaemic heart disease. Int J Epidemiol (1999) 1.46
Assessment of adipose tissue distribution by computed axial tomography in obese women: association with body density and anthropometric measurements. Br J Nutr (1989) 1.46
Are gender differences in cardiovascular disease risk factors explained by the level of visceral adipose tissue? Diabetologia (1994) 1.46
Effect of sitagliptin therapy on postprandial lipoprotein levels in patients with type 2 diabetes. Diabetes Obes Metab (2011) 1.45
Plasma leptin concentrations: gender differences and associations with metabolic risk factors for cardiovascular disease. Diabetologia (1997) 1.45
The dense LDL phenotype. Association with plasma lipoprotein levels, visceral obesity, and hyperinsulinemia in men. Diabetes Care (1996) 1.43
Alcohol consumption and plasma lipoproteins. CMAJ (1990) 1.42
Heterozygous familial hypercholesterolemia. Relationship between plasma lipids, lipoproteins, clinical manifestations and ischaemic heart disease in men and women. Atherosclerosis (1979) 1.40
Free fatty acid oxidation by forearm muscle at rest, and evidence for an intramuscular lipid pool in the human forearm. J Clin Invest (1976) 1.40
Lipoprotein(a) distribution in a French Canadian population and its relation to intermittent claudication (the Québec Cardiovascular Study) Am J Cardiol (1995) 1.36
Gender difference in postprandial lipemia : importance of visceral adipose tissue accumulation. Arterioscler Thromb Vasc Biol (1999) 1.35
Reduction of LDL cholesterol by 25% to 60% in patients with primary hypercholesterolemia by atorvastatin, a new HMG-CoA reductase inhibitor. Arterioscler Thromb Vasc Biol (1995) 1.31
Effects of endurance exercise training on plasma HDL cholesterol levels depend on levels of triglycerides: evidence from men of the Health, Risk Factors, Exercise Training and Genetics (HERITAGE) Family Study. Arterioscler Thromb Vasc Biol (2001) 1.31
Acute enhancement of insulin secretion by FFA in humans is lost with prolonged FFA elevation. Am J Physiol (1999) 1.30
Associations of HDL2 and HDL3 subfractions with ischemic heart disease in men. Prospective results from the Québec Cardiovascular Study. Arterioscler Thromb Vasc Biol (1997) 1.30
Systematically missing confounders in individual participant data meta-analysis of observational cohort studies. Stat Med (2009) 1.27
A hepatic lipase gene mutation associated with heritable lipolytic deficiency. J Clin Endocrinol Metab (1991) 1.21
Age and duration of follow-up as modulators of the risk for ischemic heart disease associated with high plasma C-reactive protein levels in men. Arch Intern Med (2001) 1.20
Hyperleptinemia is more closely associated with adipose cell hypertrophy than with adipose tissue hyperplasia. Int J Obes Relat Metab Disord (2000) 1.19
Reduced HDL particle size as an additional feature of the atherogenic dyslipidemia of abdominal obesity. J Lipid Res (2001) 1.18
Loss of abdominal fat and metabolic response to exercise training in obese women. Am J Physiol (1991) 1.16
Survival of patients with a strongly positive exercise electrocardiogram. Circulation (1982) 1.16
Appetite after weight loss by energy restriction and a low-fat diet-exercise follow-up. Int J Obes Relat Metab Disord (2000) 1.15
Serum potassium, cardiovascular risk, and effects of an ACE inhibitor: results of the HOPE study. Clin Nephrol (2005) 1.15