Published in Gastroenterology on March 01, 1996
Microsatellite instability in colorectal cancer. Gastroenterology (2010) 7.39
Genetic susceptibility to non-polyposis colorectal cancer. J Med Genet (1999) 4.16
Health benefits and cost-effectiveness of primary genetic screening for Lynch syndrome in the general population. Cancer Prev Res (Phila) (2010) 2.86
High prevalence of activated intraepithelial cytotoxic T lymphocytes and increased neoplastic cell apoptosis in colorectal carcinomas with microsatellite instability. Am J Pathol (1999) 2.80
Choice of management strategy for colorectal cancer based on a diagnostic immunohistochemical test for defective mismatch repair. Gut (1999) 2.68
The frequency of hereditary defective mismatch repair in a prospective series of unselected colorectal carcinomas. Am J Hum Genet (2001) 2.68
Microsatellite instability and the clinicopathological features of sporadic colorectal cancer. Gut (2001) 2.08
Mismatch repair status in the prediction of benefit from adjuvant fluorouracil chemotherapy in colorectal cancer. Gut (2005) 1.87
Deficient mismatch repair system in patients with sporadic advanced colorectal cancer. Br J Cancer (2009) 1.75
Accumulated clonal genetic alterations in familial and sporadic colorectal carcinomas with widespread instability in microsatellite sequences. Am J Pathol (1998) 1.55
Decision analysis in the surgical treatment of colorectal cancer due to a mismatch repair gene defect. Gut (2003) 1.55
Survival of MUTYH-associated polyposis patients with colorectal cancer and matched control colorectal cancer patients. J Natl Cancer Inst (2010) 1.48
Use of microsatellite instability and immunohistochemistry testing for the identification of individuals at risk for Lynch syndrome. Fam Cancer (2005) 1.47
Microsatellite instability in sporadic colorectal cancer is not an independent prognostic factor. Br J Cancer (1999) 1.36
Detection of microsatellite instability by fluorescence multiplex polymerase chain reaction. J Mol Diagn (2000) 1.33
Comparison of the microsatellite instability analysis system and the Bethesda panel for the determination of microsatellite instability in colorectal cancers. J Mol Diagn (2006) 1.30
Clinical description of the Lynch syndrome [hereditary nonpolyposis colorectal cancer (HNPCC)]. Fam Cancer (2005) 1.15
Current hypotheses on how microsatellite instability leads to enhanced survival of Lynch Syndrome patients. Clin Dev Immunol (2010) 1.12
Frequent mutations in the RPL22 gene and its clinical and functional implications. Gynecol Oncol (2012) 1.03
Low level microsatellite instability may be associated with reduced cancer specific survival in sporadic stage C colorectal carcinoma. Gut (2005) 1.02
The role of microsatellite instability in gastric carcinoma. Gut (1998) 0.99
Lymphocyte recruitment into the tumor site is altered in patients with MSI-H colon cancer. Fam Cancer (2009) 0.98
Survival of hereditary non-polyposis colorectal cancer patients compared with sporadic colorectal cancer patients. J Exp Clin Cancer Res (2008) 0.98
Survival of patients with ovarian cancer due to a mismatch repair defect. Fam Cancer (2005) 0.98
Prognostic significance of microsatellite instability in sporadic colorectal cancer. Int J Colorectal Dis (2004) 0.96
Prognosis in DNA mismatch repair deficient colorectal cancer: are all MSI tumours equivalent? Fam Cancer (2004) 0.96
Colorectal carcinomas in MUTYH-associated polyposis display histopathological similarities to microsatellite unstable carcinomas. BMC Cancer (2009) 0.94
Tracing cell fates in human colorectal tumors from somatic microsatellite mutations: evidence of adenomas with stem cell architecture. Am J Pathol (1998) 0.91
The impact of family history on the outcome of patients with colorectal cancer in a veterans' hospital. Int J Colorectal Dis (2009) 0.89
What we could do now: molecular pathology of colorectal cancer. Mol Pathol (2001) 0.88
Cancer prone persons. A randomized screening trial based on colonoscopy: background, design and recruitment. Fam Cancer (2001) 0.87
Pathological examination of 12 regional lymph nodes and long-term survival in stages I-III colon cancer patients: an analysis of 2,056 consecutive patients in two branches of same institution. Int J Colorectal Dis (2010) 0.87
Opportunities for immunotherapy in microsatellite instable colorectal cancer. Cancer Immunol Immunother (2016) 0.86
Survival from colorectal carcinoma in HNPCC families as compared to the general population in Lithuania--initial results. Fam Cancer (2006) 0.84
Clinicopathologic Significance of Mismatch Repair Defects in Endometrial Cancer: An NRG Oncology/Gynecologic Oncology Group Study. J Clin Oncol (2016) 0.82
Immunology and the Lynch syndrome. Gastroenterology (2008) 0.82
Is reduced expression of mismatch repair genes MLH1 and MSH2 in patients with sporadic colorectal cancer related to their prognosis? Clin Exp Metastasis (2002) 0.82
Clinicopathological and molecular genetic analysis of HNPCC in China. World J Gastroenterol (2005) 0.81
Hereditary ovarian cancer: not only BRCA 1 and 2 genes. Biomed Res Int (2015) 0.81
Genetic prognostic markers in colorectal cancer. Mol Pathol (1997) 0.79
Inherited colorectal cancer syndromes. Clin Colon Rectal Surg (2009) 0.79
First case report of Muir-Torre syndrome associated with non-small cell lung cancer. Fam Cancer (2009) 0.79
Clinicopathological features and management of cancers in lynch syndrome. Patholog Res Int (2012) 0.78
Lynch syndrome: clinical, pathological, and genetic insights. Langenbecks Arch Surg (2012) 0.78
Clinical significance of mismatch repair gene expression in sporadic colorectal cancer. Exp Ther Med (2014) 0.78
The revised Bethesda guidelines: extent of utilization in a university hospital medical center with a cancer genetics program. Hered Cancer Clin Pract (2010) 0.78
Prevalence and Penetrance of Major Genes and Polygenes for Colorectal Cancer. Cancer Epidemiol Biomarkers Prev (2016) 0.78
Analysis of microsatellite instability in colorectal carcinoma by microfluidic-based chip electrophoresis. J Clin Pathol (2008) 0.77
Prognostic impact of mismatch repair genes germline defects in colorectal cancer patients: are all mutations equal? Oncotarget (2015) 0.76
Colorectal cancer, survival advantage, and hereditary nonpolyposis colorectal carcinoma. Gastroenterology (1996) 0.75
Human mutL homolog 1 expression characteristic and prognostic effect on patients with sporadic colorectal cancer. Int J Clin Exp Med (2015) 0.75
Host susceptibility to cancer progression. Am J Hum Genet (1998) 0.75
An alternative to prophylactic colectomy for colon cancer prevention in HNPCC syndrome. Gut (2005) 0.75
Sidedness is prognostic in locoregional colon cancer: an analysis of 9509 Australian patients. BMC Cancer (2017) 0.75
Approach to Lynch Syndrome for the Gastroenterologist. Dig Dis Sci (2016) 0.75
[Clinical, pathological and molecular prognostic factors in colorectal carcinomas]. Pathologe (2003) 0.75
No major difference in K-ras and p53 abnormalities in sporadic and hereditary nonpolyposis colorectal adenomas. Dig Dis Sci (2000) 0.75
Prognostic value of BRCA1 mutations in familial breast cancer patients affected by a second primary cancer. Fam Cancer (2007) 0.75
Clues to the pathogenesis of familial colorectal cancer. Science (1993) 14.52
New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC. Gastroenterology (1999) 11.94
A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature (1998) 10.35
Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell (1993) 9.93
The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC). Dis Colon Rectum (1991) 9.82
Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease. N Engl J Med (1998) 8.47
Controlled 15-year trial on screening for colorectal cancer in families with hereditary nonpolyposis colorectal cancer. Gastroenterology (2000) 8.41
Mutations in the SMAD4/DPC4 gene in juvenile polyposis. Science (1998) 7.08
Cancer risk in mutation carriers of DNA-mismatch-repair genes. Int J Cancer (1999) 6.73
Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history. Cancer Res (1993) 4.93
Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis. Nat Genet (1997) 4.27
Genetic mapping of a locus predisposing to human colorectal cancer. Science (1993) 4.12
Population-based molecular detection of hereditary nonpolyposis colorectal cancer. J Clin Oncol (2000) 3.98
Screening reduces colorectal cancer rate in families with hereditary nonpolyposis colorectal cancer. Gastroenterology (1995) 3.45
Inherited susceptibility to uterine leiomyomas and renal cell cancer. Proc Natl Acad Sci U S A (2001) 3.31
Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients. Cancer Res (1994) 3.25
Microsatellite instability is a favorable prognostic indicator in patients with colorectal cancer receiving chemotherapy. Gastroenterology (2000) 3.01
Life-time risk of different cancers in hereditary non-polyposis colorectal cancer (HNPCC) syndrome. Int J Cancer (1995) 2.85
BRAF screening as a low-cost effective strategy for simplifying HNPCC genetic testing. J Med Genet (2004) 2.75
Loss-of-function mutations in PPAR gamma associated with human colon cancer. Mol Cell (1999) 2.71
Female fecundity before and after operation for familial adenomatous polyposis. Br J Surg (2003) 2.54
DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis. Hum Mol Genet (2001) 2.50
Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome. Cancer Res (1993) 2.48
Founding mutations and Alu-mediated recombination in hereditary colon cancer. Nat Med (1995) 2.40
Early cholecystectomy for acute cholecystitis: a prospective randomized study. Ann Surg (1980) 2.32
Differential gene expression in colon cancer of the caecum versus the sigmoid and rectosigmoid. Gut (2005) 2.13
Microsatellite marker analysis in screening for hereditary nonpolyposis colorectal cancer (HNPCC). Cancer Res (2001) 2.12
The prevalence of MADH4 and BMPR1A mutations in juvenile polyposis and absence of BMPR2, BMPR1B, and ACVR1 mutations. J Med Genet (2004) 2.10
Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer. Nat Genet (1994) 2.08
Age-related hypermethylation of the 5' region of MLH1 in normal colonic mucosa is associated with microsatellite-unstable colorectal cancer development. Cancer Res (2001) 1.93
The clinical features of ovarian cancer in hereditary nonpolyposis colorectal cancer. Gynecol Oncol (2001) 1.84
MSH2 and MLH1 mutations in sporadic replication error-positive colorectal carcinoma as assessed by two-dimensional DNA electrophoresis. Genes Chromosomes Cancer (1997) 1.83
Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome. Oncogene (2000) 1.83
Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes. Am J Hum Genet (2001) 1.81
Clinical features of colorectal carcinoma in cancer family syndrome. Dis Colon Rectum (1986) 1.79
Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer. Hum Mol Genet (1999) 1.79
LKB1 somatic mutations in sporadic tumors. Am J Pathol (1999) 1.79
Semiautomated assessment of loss of heterozygosity and replication error in tumors. Cancer Res (1996) 1.77
Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors. Cancer Res (1998) 1.75
p53, CHK2, and CHK1 genes in Finnish families with Li-Fraumeni syndrome: further evidence of CHK2 in inherited cancer predisposition. Cancer Res (2001) 1.74
Diagnostic cancer genome sequencing and the contribution of germline variants. Science (2013) 1.65
DNA mismatch repair gene mutations in 55 kindreds with verified or putative hereditary non-polyposis colorectal cancer. Hum Mol Genet (1996) 1.64
Genetic reconstruction of individual colorectal tumor histories. Proc Natl Acad Sci U S A (2000) 1.63
COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer. Br J Cancer (2009) 1.62
Increased risk of cancer in patients with fumarate hydratase germline mutation. J Med Genet (2005) 1.61
Risk of cancer and secondary proctectomy after colectomy and ileorectal anastomosis in familial adenomatous polyposis. Int J Colorectal Dis (2013) 1.59
Impact of clinical symptoms and referral volume on endoscopy for detecting peptic ulcer and gastric neoplasms. Scand J Gastroenterol (2003) 1.57
LKB1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndrome. J Med Genet (2006) 1.56
The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability. Nat Genet (1999) 1.56
Comparison of CA 19-9 and carcinoembryonic antigen (CEA) levels in the serum of patients with colorectal diseases. Br J Cancer (1984) 1.56
Colorectal adenoma and cancer divergence. Evidence of multilineage progression. Am J Pathol (1999) 1.50
Survival of patients with pseudomyxoma peritonei treated by serial debulking. Colorectal Dis (2009) 1.49
A randomised study of colostomies in low colorectal anastomoses. Eur J Surg (1997) 1.49
Predictive genetic testing for hereditary non-polyposis colorectal cancer: uptake and long-term satisfaction. Int J Cancer (2000) 1.49
Characteristics of small bowel carcinoma in hereditary nonpolyposis colorectal carcinoma. International Collaborative Group on HNPCC. Cancer (1998) 1.48
Tumor spectrum in cancer family syndrome (hereditary nonpolyposis colorectal cancer). Cancer (1991) 1.48
Exclusion of PTEN and 10q22-24 as the susceptibility locus for juvenile polyposis syndrome. Cancer Res (1997) 1.47
Familial cutaneous leiomyomatosis is a two-hit condition associated with renal cell cancer of characteristic histopathology. Am J Pathol (2001) 1.46
The I1307K polymorphism of the APC gene in colorectal cancer. Gastroenterology (1999) 1.43
Serrated carcinomas form a subclass of colorectal cancer with distinct molecular basis. Oncogene (2006) 1.43
Gene expression signatures for colorectal cancer microsatellite status and HNPCC. Br J Cancer (2005) 1.40
Dysregulation of the transcription factors SOX4, CBFB and SMARCC1 correlates with outcome of colorectal cancer. Br J Cancer (2009) 1.40
Microsatellite instability in adenomas as a marker for hereditary nonpolyposis colorectal cancer. Am J Pathol (1999) 1.38
A novel approach to estimate the proportion of hereditary nonpolyposis colorectal cancer of total colorectal cancer burden. Cancer Detect Prev (1994) 1.36
The MDM2 promoter polymorphism SNP309T-->G and the risk of uterine leiomyosarcoma, colorectal cancer, and squamous cell carcinoma of the head and neck. J Med Genet (2005) 1.34
Follow-up of patients operated on for colorectal carcinoma. Am J Surg (1990) 1.33
Somatic microsatellite mutations as molecular tumor clocks. Nat Med (1996) 1.31
Screening for microsatellite instability target genes in colorectal cancers. J Med Genet (2002) 1.29
Epigenetic phenotypes distinguish microsatellite-stable and -unstable colorectal cancers. Proc Natl Acad Sci U S A (1999) 1.28
Gastroesophageal reflux disease: prevalence, clinical, endoscopic and histopathological findings in 1,128 consecutive patients referred for endoscopy due to dyspeptic and reflux symptoms. Digestion (2000) 1.27
Anastomotic leakage after anterior resection of the rectum. Eur J Surg (1994) 1.26
Occurrence of desmoid tumours in familial adenomatous polyposis and results of treatment. Int J Colorectal Dis (1996) 1.24
Expression of cyclooxygenase-2 in dysplasia of the stomach and in intestinal-type gastric adenocarcinoma. Clin Cancer Res (2001) 1.24
Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer. Br J Cancer (2012) 1.24
Psychological consequences of predictive genetic testing for hereditary non-polyposis colorectal cancer (HNPCC): a prospective follow-up study. Int J Cancer (2001) 1.23
Extensive somatic microsatellite mutations in normal human tissue. Cancer Res (2001) 1.22
Female fertility and childbirth after ileal pouch-anal anastomosis for ulcerative colitis. Br J Surg (2007) 1.19
Frequent loss of SMAD4/DPC4 protein in colorectal cancers. Gut (2002) 1.18