Published in Mol Cell Biol on March 01, 1996
Loss of Raf kinase inhibitor protein promotes cell proliferation and migration of human hepatoma cells. Gastroenterology (2006) 1.49
Expression and function of the insulin receptor substrate proteins in cancer. Cell Commun Signal (2009) 1.35
A carboxy-terminal truncated insulin receptor substrate-1 dominant negative protein reverses the human hepatocellular carcinoma malignant phenotype. J Clin Invest (1996) 1.18
Insulin receptor substrates (IRSs) and breast tumorigenesis. J Mammary Gland Biol Neoplasia (2008) 1.07
Differential growth factor regulation of aspartyl-(asparaginyl)-beta-hydroxylase family genes in SH-Sy5y human neuroblastoma cells. BMC Cell Biol (2006) 1.04
Antineoplastic effect of rapamycin is potentiated by inhibition of IRS-1 signaling in prostate cancer cells xenografts. J Cancer Res Clin Oncol (2008) 1.03
Overexpression of insulin receptor substrate-1 and hepatitis Bx genes causes premalignant alterations in the liver. Hepatology (2009) 1.01
Heparanase enhances the insulin receptor signaling pathway to activate extracellular signal-regulated kinase in multiple myeloma. J Biol Chem (2012) 0.94
Targeting the insulin-like growth factor receptor: developing biomarkers from gene expression profiling. Crit Rev Oncog (2012) 0.92
Alcohol, insulin resistance and the liver-brain axis. J Gastroenterol Hepatol (2012) 0.83
Role of Raf Kinase Inhibitor Protein in Hepatocellular Carcinoma. For Immunopathol Dis Therap (2011) 0.80
Transgenic overexpression of insulin receptor substrate 1 in hepatocytes enhances hepatocellular proliferation in young mice only. Hepatol Res (2008) 0.77
The Ras/Raf/MEK/ERK signaling pathway and its role in the occurrence and development of HCC. Oncol Lett (2016) 0.77
Preclinical Effectiveness of Selective Inhibitor of IRS-1/2 NT157 in Osteosarcoma Cell Lines. Front Endocrinol (Lausanne) (2015) 0.77
Activation of signal transduction pathways during hepatic oncogenesis. Cancer Lett (2015) 0.77
Oncogenes and signal transduction. Cell (1991) 14.84
Proteins regulating Ras and its relatives. Nature (1993) 9.87
Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell (1994) 9.73
The mitogen-activated protein kinase signal transduction pathway. J Biol Chem (1993) 8.77
Transformation of mammalian cells by constitutively active MAP kinase kinase. Science (1994) 8.69
Raf-1 activates MAP kinase-kinase. Nature (1992) 7.05
Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation. EMBO J (1992) 5.84
The insulin signaling system. J Biol Chem (1994) 5.25
Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1. Nature (1993) 4.88
The MAP kinase cascade is essential for diverse signal transduction pathways. Trends Biochem Sci (1993) 4.62
Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate. Nature (1994) 4.49
Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein. EMBO J (1992) 4.00
The origin, hormonal nature, and action of hepatotrophic substances in portal venous blood. Surg Gynecol Obstet (1973) 3.84
In vitro effects on microtubule dynamics of purified Xenopus M phase-activated MAP kinase. Nature (1991) 3.59
The function of GRB2 in linking the insulin receptor to Ras signaling pathways. Science (1993) 3.12
Binding of G protein beta gamma-subunits to pleckstrin homology domains. J Biol Chem (1994) 2.91
Raf meets Ras: completing the framework of a signal transduction pathway. Trends Biochem Sci (1994) 2.75
IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85. Proc Natl Acad Sci U S A (1992) 2.75
A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase. Mol Cell Biol (1994) 2.66
Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation. Science (1994) 2.44
Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1. Mol Cell Biol (1993) 2.44
Extracellular signals and reversible protein phosphorylation: what to Mek of it all. Cell (1993) 2.31
Activation of Raf-1 by 14-3-3 proteins. Nature (1994) 2.22
Stimulatory effects of yeast and mammalian 14-3-3 proteins on the Raf protein kinase. Science (1994) 2.21
Binding of the Ras activator son of sevenless to insulin receptor substrate-1 signaling complexes. Science (1993) 2.14
The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp. J Biol Chem (1993) 2.13
Expression and function of IRS-1 in insulin signal transmission. J Biol Chem (1992) 1.98
Regulation of hepatic regeneration in rats by synergistic action of insulin and glucagon. Proc Natl Acad Sci U S A (1975) 1.84
Mitogen-activated protein kinase/extracellular signal-regulated protein kinase activation by oncogenes, serum, and 12-O-tetradecanoylphorbol-13-acetate requires Raf and is necessary for transformation. J Biol Chem (1994) 1.74
The IRS-1 signaling system. Trends Biochem Sci (1994) 1.53
Signal transduction pathways from insulin receptors to Ras. Analysis by mutant insulin receptors. J Biol Chem (1994) 1.33
Insulin receptor substrate 1 is required for insulin-mediated mitogenic signal transduction. Proc Natl Acad Sci U S A (1994) 1.33
Binding of NCK to SOS and activation of ras-dependent gene expression. Mol Cell Biol (1995) 1.30
Functional expression of insulin receptor substrate-1 is required for insulin-stimulated mitogenic signaling. J Biol Chem (1993) 1.20
Ethanol impairs insulin receptor substrate-1 mediated signal transduction during rat liver regeneration. Biochem Biophys Res Commun (1994) 1.10
Cloning and increased expression of an insulin receptor substrate-1-like gene in human hepatocellular carcinoma. Biochem Biophys Res Commun (1992) 1.09
Association of insulin receptor substrate 1 with simian virus 40 large T antigen. Mol Cell Biol (1995) 1.07
Cloning and characterization of a thermolabile v-src gene for use in reversible transformation of mammalian cells. Oncogene (1992) 1.07
Expression and phosphorylation of insulin receptor substrate 1 during rat liver regeneration. J Biol Chem (1993) 0.93
Hormonal factors concerned with liver regeneration. Ciba Found Symp (1977) 0.91
Insulin and insulin-like growth factor-I signal transduction requires p21ras. J Biol Chem (1994) 0.85
Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry (1984) 10.83
AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nat Genet (2000) 5.26
Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity. Immunity (2001) 5.14
Distinct roles of ROCK (Rho-kinase) and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibers and focal adhesions in 3T3 fibroblasts. J Cell Biol (2000) 4.34
Human cerebellar activity reflecting an acquired internal model of a new tool. Nature (2000) 4.29
Perceptual learning without perception. Nature (2001) 3.48
N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation. Proc Natl Acad Sci U S A (1981) 3.04
A hepatitis B virus mutant associated with an epidemic of fulminant hepatitis. N Engl J Med (1991) 2.68
Abnormal structure and expression of p53 gene in human hepatocellular carcinoma. Proc Natl Acad Sci U S A (1990) 2.59
Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors. J Neurosci (2001) 2.54
Characteristics of macrolide-resistant Mycoplasma pneumoniae strains isolated from patients and induced with erythromycin in vitro. Microbiol Immunol (2001) 2.52
Impaired allostimulatory capacity of peripheral blood dendritic cells recovered from hepatitis C virus-infected individuals. J Immunol (1999) 2.44
Hepatitis C virus: epidemiology and transmission. Hepatology (1997) 2.43
Activation of the beta-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3. Cancer Res (1998) 2.42
Increased expression of sialyl Lewisx antigen correlates with poor survival in patients with colorectal carcinoma: clinicopathological and immunohistochemical study. Cancer Res (1993) 2.39
Circulating immune complexes and complement activation in primary biliary cirrhosis. N Engl J Med (1978) 2.30
Characterization of cell lines allowing tightly regulated expression of hepatitis C virus core protein. Virology (1996) 2.18
The pathogenesis of arthritis associated with acute hepatitis-B surface antigen-positive hepatitis. Complement activation and characterization of circulating immune complexes. J Clin Invest (1975) 2.13
Reduced myocardial flow reserve in non-insulin-dependent diabetes mellitus. J Am Coll Cardiol (1997) 2.11
Identification of a new variable sequence in the P1 cytadhesin gene of Mycoplasma pneumoniae: evidence for the generation of antigenic variation by DNA recombination between repetitive sequences. Infect Immun (1999) 2.11
Fukuyama-type congenital muscular dystrophy and the Walker-Warburg syndrome. Brain Dev (1993) 2.08
Serial studies of hepatitis-associated antigen and antibody in patients receiving antitumor chemotherapy for myeloproliferative and lymphoproliferative disorders. Gastroenterology (1975) 2.08
Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth. J Biol Chem (1997) 2.03
Epidemiological study of Mycoplasma pneumoniae infections in japan based on PCR-restriction fragment length polymorphism of the P1 cytadhesin gene. J Clin Microbiol (1996) 2.02
Hepatitis B virus mutants associated with 3TC and famciclovir administration are replication defective. Hepatology (1998) 2.01
Activation of mitogen-activated protein kinases/extracellular signal-regulated kinases in human hepatocellular carcinoma. Hepatology (1998) 1.97
Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse. Nat Neurosci (2001) 1.96
Posttranscriptional regulation of hepatitis B virus replication by the precore protein. J Virol (1997) 1.96
Cloning and characterization of a novel hepatitis B virus x binding protein that inhibits viral replication. J Virol (1998) 1.96
The increasing incidence of hepatocellular carcinoma. N Engl J Med (1999) 1.92
Hepatitis B virus X protein is not central to the viral life cycle in vitro. J Virol (1992) 1.92
The native form and maturation process of hepatitis C virus core protein. J Virol (1998) 1.91
Primary hepatocellular carcinoma. N Engl J Med (1991) 1.91
Endoscopic neck surgery by the axillary approach. J Am Coll Surg (2000) 1.90
Phytochrome-mediated regulation of two mRNAs, encoded by nuclei and chloroplasts of ribulose-1,5-bisphosphate carboxylase/oxygenase. Eur J Biochem (1983) 1.88
Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells. J Antibiot (Tokyo) (1991) 1.86
Transition of brain activation from frontal to parietal areas in visuomotor sequence learning. J Neurosci (1998) 1.85
Changes in distribution of hepatic blood flow induced by intra-arterial infusion of angiotensin II in human hepatic cancer. Cancer (1985) 1.84
Acetyl-CoA carboxylase in higher plants: most plants other than gramineae have both the prokaryotic and the eukaryotic forms of this enzyme. Plant Cell Physiol (1996) 1.83
Enhanced myosin light chain phosphorylations as a central mechanism for coronary artery spasm in a swine model with interleukin-1beta. Circulation (1997) 1.83
Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer. Oncogene (2007) 1.81
Effect of captopril on heavy proteinuria in azotemic diabetics. N Engl J Med (1985) 1.81
Compartmentalization of two forms of acetyl-CoA carboxylase in plants and the origin of their tolerance toward herbicides. Proc Natl Acad Sci U S A (1994) 1.80
Decreased suppressor cell activity in inflammatory bowel disease. Clin Exp Immunol (1978) 1.75
Practical usefulness of lymphatic and connective tissue clearance for the carcinoma of the pancreas head. Ann Surg (1988) 1.74
Involvement of Iba1 in membrane ruffling and phagocytosis of macrophages/microglia. J Cell Sci (2000) 1.74
Expression of vascular permeability factor/vascular endothelial growth factor in human hepatocellular carcinoma. Cancer Res (1996) 1.74
Solid and papillary neoplasm arising from an ectopic pancreas in the mesocolon. Am J Gastroenterol (1990) 1.74
Normal serum ferritin concentrations in precirrhotic hemochromatosis. N Engl J Med (1976) 1.68
A monoclonal antibody against Igh6-4 determinant. Immunogenetics (1986) 1.68
Cell-mediated immunity in acute and chronic hepatitis. J Clin Invest (1975) 1.63
Naturally occurring missense mutation in the polymerase gene terminating hepatitis B virus replication. J Virol (1991) 1.61
Task-dependent influences of attention on the activation of human primary visual cortex. Proc Natl Acad Sci U S A (1998) 1.60
Common dysregulation of Wnt/Frizzled receptor elements in human hepatocellular carcinoma. Br J Cancer (2008) 1.59
Cellular and humoral immune response to hepatitis B virus structural proteins in mice after DNA-based immunization. Gastroenterology (1997) 1.58
Alteration in suppressor cell activity in chronic active hepatitis. Proc Natl Acad Sci U S A (1978) 1.57
Hepatitis B transmission by dentists. JAMA (1974) 1.57
High affinity monoclonal antibodies to hepatitis B surface antigen (HBsAg) produced by somatic cell hybrids. Gastroenterology (1981) 1.55
A phase II study of eribulin in Japanese patients with heavily pretreated metastatic breast cancer. Ann Oncol (2011) 1.54
Neointimal formation at the sites of anastomosis of the internal thoracic artery grafts after coronary artery bypass grafting in human subjects: an immunohistochemical analysis. J Thorac Cardiovasc Surg (2000) 1.54
Light-induced increase of mRNA activity coding for the small subunit of ribulose-1,5-bisphosphate carboxylase. J Biol Chem (1981) 1.53
Cystic lesions of the maxillomandibular region: MR imaging distinction of odontogenic keratocysts and ameloblastomas from other cysts. AJR Am J Roentgenol (1996) 1.52
Biologic properties of hepatitis B viral genomes with mutations in the precore promoter and precore open reading frame. Virology (1997) 1.52
Clinical experience with 118 hepatic resections for hepatocellular carcinoma. Surgery (1986) 1.50
Quantitative in vivo measurement of thyroidal iodine content by static x-ray fluorescent technique: some preliminary clinical observations. Invest Radiol (1979) 1.49
Comparative study of thyroidectomies. Endoscopic surgery versus conventional open surgery. Surg Endosc (2002) 1.49
Silver staining of nucleolar organizer regions in prostatic lesions. Histopathology (1991) 1.49
Virulence of Rhodococcus equi isolates from patients with and without AIDS. J Clin Microbiol (1994) 1.49
Immunodiagnosis of hepatitis B with high-affinity IgM monoclonal antibodies. Proc Natl Acad Sci U S A (1981) 1.48
Interaction between duck hepatitis B virus and a 170-kilodalton cellular protein is mediated through a neutralizing epitope of the pre-S region and occurs during viral infection. J Virol (1995) 1.48
Cyclooxygenase inhibitors suppress angiogenesis and reduce tumor growth in vivo. Lab Invest (1999) 1.45
Quantitative analysis of peripheral blood Th0, Th1, Th2 and the Th1:Th2 cell ratio during normal human pregnancy and preeclampsia. Clin Exp Immunol (1999) 1.44
Rho kinase inhibitor HA-1077 prevents Rho-mediated myosin phosphatase inhibition in smooth muscle cells. Am J Physiol Cell Physiol (2000) 1.44
Studies of the circulation with radioactive microspheres. Invest Radiol (1970) 1.43
Establishment and characterization of a new human hepatocellular carcinoma cell line. In Vitro (1984) 1.43
Overexpression of human aspartyl(asparaginyl)beta-hydroxylase in hepatocellular carcinoma and cholangiocarcinoma. J Clin Invest (1996) 1.43
Tight clustering of human hepatitis B virus integration sites in hepatomas near a triple-stranded region. J Virol (1987) 1.42
Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma. J Clin Invest (1999) 1.42
Plasma IL-6 levels during arm exercise in persons with spinal cord injury. Spinal Cord (2011) 1.42
A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. Proc Natl Acad Sci U S A (1998) 1.42
Second hepatic resection for recurrent hepatocellular carcinoma. Br J Surg (1986) 1.41
Usefulness of PET with 11C-methionine for the detection of hilar and mediastinal lymph node metastasis in lung cancer. J Nucl Med (2000) 1.40
A new approach to chemoembolization therapy for hepatoma using ethiodized oil, cisplatin, and gelatin sponge. Cancer (1987) 1.40
Adrenal-sparing adrenalectomy in hereditary bilateral phaeochromocytoma. ANZ J Surg (2001) 1.40
Fulminant hepatitis complicated by pancreatitis. Johns Hopkins Med J (1973) 1.40
Detection of bacterial deconjugation of bile salts by a convenient breath-analysis technic. N Engl J Med (1971) 1.40
Arthritis associated with intestinal-bypass procedure for morbid obesity. Complement activation and characterization of circulating cryoproteins. N Engl J Med (1976) 1.39
Application of sentinel node biopsy to gastric cancer surgery. Surgery (2001) 1.39
Gonadal mixed germ cell tumor combined with a large hemangiomatous lesion in a patient with Turner's syndrome and 45,X/46,X, +mar karyotype. Arch Pathol Lab Med (1994) 1.39
Relationship of uptake of technetium-99m(Sn)-N-pyridoxyl-5-methyltryptophan by hepatocellular carcinoma to prognosis. J Nucl Med (1991) 1.39
Significance of serum soluble Fas antigen level in chronic hepatitis C patients treated with interferon: relationship to the therapeutic response. J Gastroenterol Hepatol (2001) 1.39
Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT. J Exp Med (1999) 1.39
Turner syndrome and ganglioneuroma. J Pediatr Hematol Oncol (2000) 1.38
Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA. Mol Cell Biol (2000) 1.37
Rapid identification of low level hepatitis B-related viral genome in serum. J Clin Invest (1989) 1.37
Coordinate light-induction of two mRNAs, encoded in nuclei and chloroplasts, of ribulose 1,5-bisphosphate carboxylase/oxygenase. FEBS Lett (1982) 1.37
Thymidylate synthase predictive power is overcome by irinotecan combination therapy with S-1 for gastric cancer. Br J Cancer (2004) 1.37
Ground-water radon anomaly before the kobe earthquake in Japan. Science (1995) 1.36
Dynamics of myosin light chain phosphorylation at Ser19 and Thr18/Ser19 in smooth muscle cells in culture. Am J Physiol (1998) 1.35