PubRank

M B Kastan

Author PubWeight™ 150.16‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 1998 11.90
2 Cell cycle control and cancer. Science 1994 10.90
3 Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc Natl Acad Sci U S A 1992 8.87
4 The complexity of p53 modulation: emerging patterns from divergent signals. Genes Dev 1998 7.46
5 Substrate specificities and identification of putative substrates of ATM kinase family members. J Biol Chem 1999 6.14
6 Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. Science 1994 6.11
7 DNA damage induces phosphorylation of the amino terminus of p53. Genes Dev 1997 5.76
8 ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway. Nature 2000 5.55
9 Conversion of Bcl-2 to a Bax-like death effector by caspases. Science 1997 4.55
10 Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation. Mol Cell Biol 2001 4.35
11 DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways. Mol Cell Biol 1994 4.14
12 ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. Genes Dev 2001 4.06
13 Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage. Proc Natl Acad Sci U S A 1993 3.32
14 Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation. Nature 1997 2.98
15 p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein. Proc Natl Acad Sci U S A 1994 2.63
16 Modulation of cell death by Bcl-XL through caspase interaction. Proc Natl Acad Sci U S A 1998 2.42
17 The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia. Cancer Res 1994 2.41
18 Growth factor modulation of p53-mediated growth arrest versus apoptosis. Genes Dev 1995 2.17
19 Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1. Nat Cell Biol 2000 2.17
20 Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c. J Biol Chem 1999 2.12
21 ATM: genome stability, neuronal development, and cancer cross paths. Adv Cancer Res 2001 2.05
22 Fragments of ATM which have dominant-negative or complementing activity. Mol Cell Biol 1997 1.99
23 Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage. Cancer Res 1993 1.92
24 The ATM-dependent DNA damage signaling pathway. Cold Spring Harb Symp Quant Biol 2005 1.83
25 p53 and ATM: cell cycle, cell death, and cancer. Adv Cancer Res 1997 1.77
26 Tumor-suppressor p53: implications for tumor development and prognosis. J Clin Oncol 1998 1.63
27 ATM binds to beta-adaptin in cytoplasmic vesicles. Proc Natl Acad Sci U S A 1998 1.63
28 Ionizing radiation activates the ATM kinase throughout the cell cycle. Oncogene 2000 1.60
29 Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway. Proc Natl Acad Sci U S A 1994 1.53
30 Frequent detection of tumor cells in hematopoietic grafts in neuroblastoma and Ewing's sarcoma. Bone Marrow Transplant 1998 1.51
31 Signal transduction. Three paths to stress relief. Nature 1996 1.35
32 Methylation of deoxycytidine incorporated by excision-repair synthesis of DNA. Cell 1982 1.30
33 Influence of ATM function on telomere metabolism. Oncogene 1997 1.29
34 The p53-dependent gamma-ray response of GADD45. Cancer Res 1994 1.25
35 Reversal of apoptosis by the leukaemia-associated E2A-HLF chimaeric transcription factor. Nature 1996 1.24
36 Altered cytoplasmic/nuclear distribution of the c-myc protein in differentiating ML-1 human myeloid leukemia cells. Cell Growth Differ 1993 1.21
37 Loss of atm radiosensitizes multiple p53 null tissues. Cancer Res 1998 1.20
38 The p53 signal transduction pathway is intact in human neuroblastoma despite cytoplasmic localization. Am J Pathol 1996 1.15
39 Phenylbutyrate-induced G1 arrest and apoptosis in myeloid leukemia cells: structure-function analysis. Leukemia 1999 1.05
40 Chromosome end-to-end associations and telomerase activity during cancer progression in human cells after treatment with alpha-particles simulating radon progeny. Oncogene 1996 1.04
41 DNA damage responses: p53 induction, cell cycle perturbations, and apoptosis. Cold Spring Harb Symp Quant Biol 1994 1.02
42 Distribution of repair-incorporated nucleotides and nucleosome rearrangement in the chromatin of normal and xeroderma pigmentosum human fibroblasts. Biochemistry 1979 1.01
43 Dissociation of radiation-induced phosphorylation of replication protein A from the S-phase checkpoint. Cancer Res 1997 1.01
44 Human smooth muscle alpha-actin gene is a transcriptional target of the p53 tumor suppressor protein. Oncogene 1998 1.00
45 Topoisomerase II levels during granulocytic maturation in vitro and in vivo. Cancer Res 1991 0.97
46 Cell cycle. Checking two steps. Nature 2001 0.96
47 Induction of apoptosis by tumor suppressor genes and oncogenes. Semin Cancer Biol 1995 0.95
48 Role of p53 in apoptosis. Adv Pharmacol 1997 0.90
49 Acute neurotoxicity after intrathecal cytosine arabinoside in two adolescents with acute lymphoblastic leukemia of B-cell type. Cancer 1993 0.90
50 p53 does not repress hypoxia-induced transcription of the vascular endothelial growth factor gene. Cancer Res 1997 0.89
51 Small contribution of G1 checkpoint control manipulation to modulation of p53-mediated apoptosis. Oncogene 1998 0.87
52 Separate pathways for p53 induction by ionizing radiation and N-(phosphonoacetyl)-L-aspartate. Cancer Res 1996 0.87
53 Expression and assay of recombinant ATM. Methods Mol Biol 2000 0.87
54 The role of p53 in cell-cycle control and apoptosis: implications for cancer. Important Adv Oncol 1995 0.85
55 Rapamycin and p53 act on different pathways to induce G1 arrest in mammalian cells. Oncogene 1997 0.85
56 Distribution of 5-methyldeoxycytidine in products of staphylococcal nuclease digestion of nuclei and purified DNA. Biochemistry 1985 0.84
57 Pilot study of modified LMB-based therapy for children with ataxia-telangiectasia and advanced stage high grade mature B-cell malignancies. Pediatr Blood Cancer 2013 0.84
58 Normal human bone marrow precursors that express terminal deoxynucleotidyl transferase include T-cell precursors and possible lymphoid stem cells. Blood 1991 0.83
59 Cancer. A radical approach to treatment. Nature 2000 0.82
60 Defective potassium currents in ataxia telangiectasia fibroblasts. Genes Dev 1998 0.81
61 Cytoprotective effects of hematopoietic growth factors on primary human acute myeloid leukemias are not mediated through changes in BCL-2, bax, or p21WAF1/CIP1. In Vivo 1999 0.78
62 Experimental models of human carcinogenesis. Nat Genet 1993 0.78
63 The production and characterization of murine monoclonal antibodies to human Gadd45 raised against a recombinant protein. Hybridoma 1995 0.77
64 HSV-1 amplicon vector-mediated expression of ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype. Gene Ther 2003 0.77
65 To oxidize or not to oxidize? Nat Med 1997 0.75
66 Apoptosis in haematological malignancies. J Clin Pathol 1997 0.75
67 Cellular survival pathways and resistance to cancer therapy. Drug Resist Updat 1998 0.75
68 Resolution of nephrocalcinosis associated with tumor lysis syndrome. Pediatr Hematol Oncol 1994 0.75
69 Detection of minimal residual T cell acute lymphoblastic leukemia by flow cytometry. J Immunol Methods 1990 0.75