Immunosuppressant FK506 induces interleukin-6 production through the activation of transcription factor nuclear factor (NF)-kappa(B). Implications for FK506 nephropathy.

PubWeight™: 0.83‹?›

🔗 View Article (PMC 507328)

Published in J Clin Invest on June 01, 1996

Authors

K Muraoka1, K Fujimoto, X Sun, K Yoshioka, K Shimizu, M Yagi, H Bose, I Miyazaki, K Yamamoto

Author Affiliations

1: Department of Molecular Pathology, Cancer Research Institute, School of Medicine, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920, Japan.

Articles cited by this

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res (1983) 124.30

Function and activation of NF-kappa B in the immune system. Annu Rev Immunol (1994) 17.04

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell (1991) 15.76

A method for isolation of intact, translationally active ribonucleic acid. DNA (1983) 13.67

pEF-BOS, a powerful mammalian expression vector. Nucleic Acids Res (1990) 12.75

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. EMBO J (1991) 11.86

Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. Science (1995) 11.16

The mitogen-activated protein kinase signal transduction pathway. J Biol Chem (1993) 8.77

A highly sensitive method to assay FK-506 levels in plasma. Transplant Proc (1987) 8.45

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature (1992) 8.15

The mechanism of action of cyclosporin A and FK506. Immunol Today (1992) 7.57

Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses. Cell (1995) 7.55

The biology of interleukin-6. Blood (1989) 6.65

FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin. Nature (1992) 5.75

The I kappa B proteins: multifunctional regulators of Rel/NF-kappa B transcription factors. Genes Dev (1993) 4.93

Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids. Science (1995) 4.85

Molecular structure of the human cytoplasmic beta-actin gene: interspecies homology of sequences in the introns. Proc Natl Acad Sci U S A (1985) 4.80

Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein. Cell (1994) 4.26

IgG1 plasmacytosis in interleukin 6 transgenic mice. Proc Natl Acad Sci U S A (1989) 4.03

Rel-associated pp40: an inhibitor of the rel family of transcription factors. Science (1991) 3.76

Kidney transplantation under FK 506 immunosuppression. Transplant Proc (1991) 3.31

The actions of cyclosporin A and FK506 suggest a novel step in the activation of T lymphocytes. EMBO J (1990) 2.74

Incidence and treatment of rejection episodes in primary orthotopic liver transplantation under FK 506. Transplant Proc (1991) 2.59

Pharmacokinetics of FK 506: preclinical and clinical studies. Transplant Proc (1990) 2.48

Dysregulated interleukin 6 expression produces a syndrome resembling Castleman's disease in mice. J Clin Invest (1990) 2.37

Involvement of a NF-kappa B-like transcription factor in the activation of the interleukin-6 gene by inflammatory lymphokines. Mol Cell Biol (1990) 2.34

Calcineurin acts in synergy with PMA to inactivate I kappa B/MAD3, an inhibitor of NF-kappa B. EMBO J (1994) 2.03

Involvement of IL-6 in mesangial proliferative glomerulonephritis. J Immunol (1989) 1.89

Kappa B site-dependent induction of gene expression by diverse inducers of nuclear factor kappa B requires Raf-1. J Biol Chem (1993) 1.74

Development of progressive kidney damage and myeloma kidney in interleukin-6 transgenic mice. Blood (1994) 1.45

Immunophilins and the nervous system. Nat Med (1995) 1.34

A lymphoid cell-specific nuclear factor containing c-Rel-like proteins preferentially interacts with interleukin-6 kappa B-related motifs whose activities are repressed in lymphoid cells. Mol Cell Biol (1992) 1.20

Histopathology of human renal allograft rejection under FK 506: a comparison with cyclosporine. Transplant Proc (1991) 1.02

Japanese study of FK 506 on kidney transplantation: results of an early phase II study. Japanese FK 506 Study Group. Transplant Proc (1991) 0.94

The native v-Raf.hsp90.p50 heterocomplex contains a novel immunophilin of the FK506 binding class. J Biol Chem (1994) 0.92

Clinicopathological evaluation of kidney transplants in patients given a fixed dose of FK 506. Japanese FK 506 Study Group. Transplant Proc (1991) 0.83

Chronic cyclosporine-induced nephropathy in the rat. A medullary ray and inner stripe injury. Transplantation (1990) 0.80

Toxicity of FK 506 in the cynomolgus monkey: noncorrelation with FK 506 serum levels. Transplant Proc (1991) 0.78

FK506-induced kidney tubular cell injury. Transplantation (1992) 0.77

Articles by these authors

International uniform response criteria for multiple myeloma. Leukemia (2006) 17.78

Toward a protein-protein interaction map of the budding yeast: A comprehensive system to examine two-hybrid interactions in all possible combinations between the yeast proteins. Proc Natl Acad Sci U S A (2000) 10.98

Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J Cell Biol (1998) 7.78

Hd1, a major photoperiod sensitivity quantitative trait locus in rice, is closely related to the Arabidopsis flowering time gene CONSTANS. Plant Cell (2000) 6.93

A high-density rice genetic linkage map with 2275 markers using a single F2 population. Genetics (1998) 6.82

Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change. Nature (1982) 6.78

Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. Proc Natl Acad Sci U S A (1999) 5.54

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature (1996) 5.45

Structure and activation of the human N-ras gene. Cell (1983) 5.25

Full-length sequence of a hepatitis C virus genome having poor homology to reported isolates: comparative study of four distinct genotypes. Virology (1992) 5.16

A 300 kilobase interval genetic map of rice including 883 expressed sequences. Nat Genet (1994) 5.08

t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1. Proc Natl Acad Sci U S A (1991) 4.96

A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts. J Cell Biol (1998) 4.64

Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1. Nature (1983) 4.44

Culture conditions for stimulating cholera toxin production by Vibrio cholerae O1 El Tor. Microbiol Immunol (1986) 4.38

Identification of the coding sequence for a reverse transcriptase-like enzyme in a transposable genetic element in Drosophila melanogaster. Nature (1985) 4.31

Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells. Nature (1982) 4.30

Human-tumor-derived cell lines contain common and different transforming genes. Cell (1981) 4.29

Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1. Mol Cell Biol (2001) 4.09

Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha. J Clin Invest (1999) 4.00

Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed. Development (1999) 3.84

An essential part for Rho-associated kinase in the transcellular invasion of tumor cells. Nat Med (1999) 3.76

Expression of the J chain gene during B cell differentiation is inversely correlated with DNA methylation. Proc Natl Acad Sci U S A (1981) 3.68

Experimental transmission of Bartonella henselae by the cat flea. J Clin Microbiol (1996) 3.67

Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2. Proc Natl Acad Sci U S A (1997) 3.66

Occludin-deficient embryonic stem cells can differentiate into polarized epithelial cells bearing tight junctions. J Cell Biol (1998) 3.62

Rapid exchange of histone H1.1 on chromatin in living human cells. Nature (2000) 3.59

p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage. Nature (1999) 3.55

Genetic relationships of Asians and Northern Europeans, revealed by Y-chromosomal DNA analysis. Am J Hum Genet (1997) 3.54

Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line. Proc Natl Acad Sci U S A (1983) 3.52

Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2). Proc Natl Acad Sci U S A (1985) 3.46

A human RNA polymerase II complex containing factors that modify chromatin structure. Mol Cell Biol (1998) 3.45

International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders. Leukemia (2008) 3.41

Signaling by the cytokine receptor superfamily: JAKs and STATs. Trends Biochem Sci (1994) 3.36

Production of cholera-like enterotoxin by a Vibrio cholerae non-O1 strain isolated from the environment. Infect Immun (1981) 3.21

Intron function in the nonsense-mediated decay of beta-globin mRNA: indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm. RNA (1998) 3.18

Three human transforming genes are related to the viral ras oncogenes. Proc Natl Acad Sci U S A (1983) 3.06

The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript. EMBO J (1993) 3.00

Prognostic factors of hepatocellular carcinoma in patients undergoing hepatic resection. Gastroenterology (1994) 2.99

Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B. Blood (1996) 2.98

Occludin as a possible determinant of tight junction permeability in endothelial cells. J Cell Sci (1997) 2.97

Mutations in the cytoplasmic domain of the 275 kd mannose 6-phosphate receptor differentially alter lysosomal enzyme sorting and endocytosis. Cell (1989) 2.97

A pre-mRNA-binding protein accompanies the RNA from the gene through the nuclear pores and into polysomes. Cell (1996) 2.94

Dedifferentiation of epidermal cells to stem cells in vivo. Lancet (2001) 2.90

Multiple functional domains of human transcription factor IIB: distinct interactions with two general transcription factors and RNA polymerase II. Genes Dev (1993) 2.87

Diagnosis of nasopharyngeal carcinoma by DNA amplification of tissue obtained by fine-needle aspiration. N Engl J Med (1992) 2.85

Alterations in the DNA topoisomerase IV grlA gene responsible for quinolone resistance in Staphylococcus aureus. Antimicrob Agents Chemother (1996) 2.84

At least one intron is required for the nonsense-mediated decay of triosephosphate isomerase mRNA: a possible link between nuclear splicing and cytoplasmic translation. Mol Cell Biol (1998) 2.79

Prevention of thalidomide- and lenalidomide-associated thrombosis in myeloma. Leukemia (2007) 2.76

Similarity among the Drosophila (6-4)photolyase, a human photolyase homolog, and the DNA photolyase-blue-light photoreceptor family. Science (1996) 2.74

alpha-Catenin-vinculin interaction functions to organize the apical junctional complex in epithelial cells. J Cell Biol (1998) 2.74

Non-O1 Vibrio cholerae hemolysin: purification, partial characterization, and immunological relatedness to El Tor hemolysin. Infect Immun (1984) 2.72

The NPH4 locus encodes the auxin response factor ARF7, a conditional regulator of differential growth in aerial Arabidopsis tissue. Plant Cell (2000) 2.68

Mechanism of action of globomycin. J Antibiot (Tokyo) (1978) 2.66

Comparison of aminoglycoside resistance patterns in Japan, Formosa, and Korea, Chile, and the United States. Antimicrob Agents Chemother (1985) 2.66

Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients. J Clin Invest (1993) 2.64

Purification and some properties of a non-o1 Vibrio cholerae enterotoxin that is identical to cholera enterotoxin. Infect Immun (1983) 2.62

Risk factors for hepatocellular carcinoma and its incidence after interferon treatment in patients with chronic hepatitis C. Osaka Liver Disease Study Group. Hepatology (1998) 2.62

Signaling through the hematopoietic cytokine receptors. Annu Rev Immunol (1995) 2.61

Neurotransmitter functions of mammalian tachykinins. Physiol Rev (1993) 2.59

The early prediction of mortality in acute pancreatitis: a large population-based study. Gut (2008) 2.59

Outbreak of Burkitt's-like lymphoma in homosexual men. Lancet (1982) 2.58

Purification and partial characterization of heat-stable enterotoxin of enterotoxigenic Escherichia coli. Infect Immun (1979) 2.55

Better pulmonary function and prognosis with video-assisted thoracic surgery than with thoracotomy. Ann Thorac Surg (2000) 2.49

Borrelia burgdorferi strain 25015: characterization of outer surface protein A and vaccination against infection. J Immunol (1992) 2.49

Silicatein filaments and subunits from a marine sponge direct the polymerization of silica and silicones in vitro. Proc Natl Acad Sci U S A (1999) 2.47

Enterotoxicity of El Tor-like hemolysin of non-O1 Vibrio cholerae. Infect Immun (1987) 2.46

Association of amino acid substitutions in penicillin-binding protein 3 with beta-lactam resistance in beta-lactamase-negative ampicillin-resistant Haemophilus influenzae. Antimicrob Agents Chemother (2001) 2.46

Mammalian occludin in epithelial cells: its expression and subcellular distribution. Eur J Cell Biol (1997) 2.46

Fgf8 signalling from the AER is essential for normal limb development. Nat Genet (2000) 2.44

Complete nucleotide sequences of 93-kb and 3.3-kb plasmids of an enterohemorrhagic Escherichia coli O157:H7 derived from Sakai outbreak. DNA Res (1998) 2.43

New medium for the production of cholera toxin by Vibrio cholerae O1 biotype El Tor. J Clin Microbiol (1985) 2.43

Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction. J Biol Chem (1999) 2.43

Evidence for a 'paravascular' fluid circulation in the mammalian central nervous system, provided by the rapid distribution of tracer protein throughout the brain from the subarachnoid space. Brain Res (1985) 2.43

Estrogen activates telomerase. Cancer Res (1999) 2.41

G to A substitution in the distal CCAAT box of the A gamma-globin gene in Greek hereditary persistence of fetal haemoglobin. Nature (1985) 2.41

Significant association between leukoaraiosis and metabolic syndrome in healthy subjects. Neurology (2007) 2.41

Claudin-11/OSP-based tight junctions of myelin sheaths in brain and Sertoli cells in testis. J Cell Biol (1999) 2.40

A new murine model of accelerated senescence. Mech Ageing Dev (1981) 2.40

Genetic analyses of proteolysis, hemoglobin binding, and hemagglutination of Porphyromonas gingivalis. Construction of mutants with a combination of rgpA, rgpB, kgp, and hagA. J Biol Chem (1999) 2.39

Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. Diabetologia (2011) 2.37

Pravastatin attenuates allergic airway inflammation by suppressing antigen sensitisation, interleukin 17 production and antigen presentation in the lung. Thorax (2008) 2.37

Regulation of pigment synthesis in mammalian cells, as studied by somatic hybridization. Proc Natl Acad Sci U S A (1966) 2.36

The apoptotic v-cyclin-CDK6 complex phosphorylates and inactivates Bcl-2. Nat Cell Biol (2000) 2.36

Involvement of a NF-kappa B-like transcription factor in the activation of the interleukin-6 gene by inflammatory lymphokines. Mol Cell Biol (1990) 2.34

Synthesis and antitumor activity of benzimidazolyl-1,3,5-triazine and benzimidazolylpyrimidine derivatives. Chem Pharm Bull (Tokyo) (2000) 2.30

Production and properties of immune interferon from spleen cell cultures of Toxoplasma-infected mice. Microbiol Immunol (1980) 2.28

Serum insulin-like growth factor-1 in centenarians: implications of IGF-1 as a rapid turnover protein. J Gerontol A Biol Sci Med Sci (2001) 2.27

Effects of propofol on hemodynamic and inflammatory responses to endotoxemia in rats. Crit Care Med (2000) 2.25

Collective review of small carcinomas of the pancreas. Ann Surg (1986) 2.24

Hepatitis C virus antibody and hepatitis C virus replication in chronic hepatitis B patients. J Hepatol (1994) 2.23

Effects of moderate-intensity endurance and high-intensity intermittent training on anaerobic capacity and VO2max. Med Sci Sports Exerc (1996) 2.23

Construction and characterization of arginine-specific cysteine proteinase (Arg-gingipain)-deficient mutants of Porphyromonas gingivalis. Evidence for significant contribution of Arg-gingipain to virulence. J Biol Chem (1995) 2.23

The tumor promoter arsenite stimulates AP-1 activity by inhibiting a JNK phosphatase. EMBO J (1996) 2.22

Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons. J Neurosci (2000) 2.21

Overexpression of occludin, a tight junction-associated integral membrane protein, induces the formation of intracellular multilamellar bodies bearing tight junction-like structures. J Cell Sci (1996) 2.20

Induction of inflammatory arthropathy resembling rheumatoid arthritis in mice transgenic for HTLV-I. Science (1991) 2.18

The controlling role of ATM in homologous recombinational repair of DNA damage. EMBO J (2000) 2.17