Published in Nature on June 27, 1996
A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing. Genome Res (2011) 4.15
Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney. EMBO J (2006) 3.26
Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase. Genes Dev (1998) 2.51
Hirschsprung disease, associated syndromes, and genetics: a review. J Med Genet (2001) 2.32
SIX2 and BMP4 mutations associate with anomalous kidney development. J Am Soc Nephrol (2008) 2.30
Novel targets in non-small cell lung cancer: ROS1 and RET fusions. Oncologist (2013) 2.04
Cessation of renal morphogenesis in mice. Dev Biol (2007) 1.94
Molecular identification of rapidly adapting mechanoreceptors and their developmental dependence on ret signaling. Neuron (2009) 1.88
c-Jun in Schwann cells promotes axonal regeneration and motoneuron survival via paracrine signaling. J Cell Biol (2012) 1.38
Pax3 is required for enteric ganglia formation and functions with Sox10 to modulate expression of c-ret. J Clin Invest (2000) 1.37
Paracrine regulation of pancreatic cancer cell invasion by peripheral nerves. J Natl Cancer Inst (2010) 1.36
Cell and molecular biology of kidney development. Semin Nephrol (2009) 1.32
Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins. Proc Natl Acad Sci U S A (1997) 1.28
Branching morphogenesis independent of mesenchymal-epithelial contact in the developing kidney. Proc Natl Acad Sci U S A (1999) 1.27
beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity. Development (2009) 1.27
Signaling pathways mediating alcohol effects. Curr Top Behav Neurosci (2013) 1.20
Neurturin shares receptors and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic neurons. Proc Natl Acad Sci U S A (1997) 1.17
Molecular pathology and genetics of congenital hepatorenal fibrocystic syndromes. J Med Genet (2003) 1.17
Eya 1 acts as a critical regulator for specifying the metanephric mesenchyme. Dev Biol (2005) 1.17
The Caenorhabditis elegans odr-2 gene encodes a novel Ly-6-related protein required for olfaction. Genetics (2001) 1.10
Various mechanisms cause RET-mediated signaling defects in Hirschsprung's disease. J Clin Invest (1998) 1.10
Notch in the kidney: development and disease. J Pathol (2011) 1.08
GDNF--a potential target to treat addiction. Pharmacol Ther (2008) 1.07
A Drosophila model of multiple endocrine neoplasia type 2. Genetics (2005) 1.03
The number of fetal nephron progenitor cells limits ureteric branching and adult nephron endowment. Cell Rep (2014) 1.03
Molecular determinants of the face map development in the trigeminal brainstem. Anat Rec A Discov Mol Cell Evol Biol (2006) 1.02
Development of medullary thyroid carcinoma in transgenic mice expressing the RET protooncogene altered by a multiple endocrine neoplasia type 2A mutation. Proc Natl Acad Sci U S A (1997) 1.00
Analysis of the RET, GDNF, EDN3, and EDNRB genes in patients with intestinal neuronal dysplasia and Hirschsprung disease. Gut (2001) 0.99
RET is a potential tumor suppressor gene in colorectal cancer. Oncogene (2012) 0.98
Shc and Enigma are both required for mitogenic signaling by Ret/ptc2. Mol Cell Biol (1998) 0.96
TGFbeta induces GDNF responsiveness in neurons by recruitment of GFRalpha1 to the plasma membrane. J Cell Biol (2002) 0.95
Expression and regulation of GFRalpha3, a glial cell line-derived neurotrophic factor family receptor. Proc Natl Acad Sci U S A (1998) 0.94
The differential axonal degradation of Ret accounts for cell-type-specific function of glial cell line-derived neurotrophic factor as a retrograde survival factor. J Neurosci (2010) 0.93
Mutations in the extracellular domain cause RET loss of function by a dominant negative mechanism. Mol Cell Biol (1998) 0.92
Structure and physiology of the RET receptor tyrosine kinase. Cold Spring Harb Perspect Biol (2013) 0.90
Localization of a gene for nonsyndromic renal hypodysplasia to chromosome 1p32-33. Am J Hum Genet (2007) 0.90
Expression pattern of Drosophila ret suggests a common ancestral origin between the metamorphosis precursors in insect endoderm and the vertebrate enteric neurons. Proc Natl Acad Sci U S A (2001) 0.89
CD2AP and Cbl-3/Cbl-c constitute a critical checkpoint in the regulation of ret signal transduction. J Neurosci (2008) 0.88
New roles for glial cell line-derived neurotrophic factor and neurturin: involvement in hair cycle control. Am J Pathol (2000) 0.87
COUP-TFII is essential for metanephric mesenchyme formation and kidney precursor cell survival. Development (2012) 0.87
Vagal Afferent Innervation of the Airways in Health and Disease. Physiol Rev (2016) 0.86
Neurotrophic factors. Crossing receptor boundaries. Nature (1996) 0.86
Emerging roles of gut microbiota and the immune system in the development of the enteric nervous system. J Clin Invest (2015) 0.86
Decreased expression of glial cell line-derived neurotrophic factor signaling in rat models of neuropathic pain. Br J Pharmacol (2003) 0.85
Sominone enhances neurite outgrowth and spatial memory mediated by the neurotrophic factor receptor, RET. Br J Pharmacol (2009) 0.85
Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract. Hum Genet (2015) 0.84
Use of genetically modified mesenchymal stem cells to treat neurodegenerative diseases. Int J Mol Sci (2014) 0.84
Oncological implications of RET gene mutations in Hirschsprung's disease. Gut (1998) 0.83
Intracellular signal transduction and modification of the tumor microenvironment induced by RET/PTCs in papillary thyroid carcinoma. Front Endocrinol (Lausanne) (2012) 0.83
GDNF stimulates the proliferation of cultured mouse immature Sertoli cells via its receptor subunit NCAM and ERK1/2 signaling pathway. BMC Cell Biol (2010) 0.82
Enhancement of spontaneous transmitter release at neonatal mouse neuromuscular junctions by the glial cell line-derived neurotrophic factor (GDNF). J Physiol (1998) 0.82
Changes in Glial cell line-derived neurotrophic factor expression in the rostral and caudal stumps of the transected adult rat spinal cord. Neurochem Res (2007) 0.80
The insulin resistance Grb14 adaptor protein promotes thyroid cancer ret signaling and progression. Oncogene (2011) 0.80
Enteric nervous system and developmental abnormalities in childhood. Pediatr Surg Int (2006) 0.79
Xenopus: leaping forward in kidney organogenesis. Pediatr Nephrol (2016) 0.78
Glial cell line-derived neurotrophic factor promotes the development of adrenergic neurons in mouse neural crest cultures. Proc Natl Acad Sci U S A (1996) 0.77
Multiple Endocrine Neoplasia: Genetics and Clinical Management. Surg Oncol Clin N Am (2015) 0.77
Gene-environment interactions and the enteric nervous system: Neural plasticity and Hirschsprung disease prevention. Dev Biol (2016) 0.77
Internalization of glial cell-derived neurotrophic factor receptor GFR alpha 1 in the absence of the ret tyrosine kinase coreceptor. Cell Mol Neurobiol (2003) 0.77
Gene therapy for the treatment of Parkinson's disease: the nature of the biologics expands the future indications. Pharmaceuticals (Basel) (2012) 0.77
Mouse models of Hirschsprung disease and other developmental disorders of the enteric nervous system: Old and new players. Dev Biol (2016) 0.77
Developmental regulation of trigeminal TRPA1 by the cornea. Invest Ophthalmol Vis Sci (2014) 0.76
Mechanisms of Perineural Invasion. J Neurol Surg B Skull Base (2016) 0.76
Molecular fingerprinting delineates progenitor populations in the developing zebrafish enteric nervous system. Dev Dyn (2016) 0.75
The RET proto-oncogene: a challenge to our understanding of disease pathogenesis. Pediatr Surg Int (1997) 0.75
A newly identified RET proto-oncogene polymorphism is found in a high number of endocrine tumor patients. Hum Genet (2005) 0.75
A PCR-mutagenesis strategy for rapid detection of mutations in codon 634 of the ret proto-oncogene related to MEN 2A. BMC Med Genet (2002) 0.75
A Brief Review on The Molecular Basis of Medullary Tyroid Carcinoma. Cell J (2016) 0.75
Osr1 Interacts Synergistically with Wt1 to Regulate Kidney Organogenesis. PLoS One (2016) 0.75
Genetics of Congenital Anomalies of the Kidney and Urinary Tract: The Current State of Play. Int J Mol Sci (2017) 0.75
Knockout mouse models of Hirschsprung's disease. Pediatr Surg Int (2015) 0.75
Simultaneous Detection of Both GDNF and GFRα1 Expression Patterns in the Mouse Central Nervous System. Front Neuroanat (2016) 0.75
Mutation and deletion analysis of GFR alpha-1, encoding the co-receptor for the GDNF/RET complex, in human brain tumours. Br J Cancer (1999) 0.75
Experimental neurotrophic factor therapy leads to cortical synaptic remodeling and compensates for behavioral deficits. J Psychiatry Neurosci (1997) 0.75
Defining the transcriptomic landscape of the developing enteric nervous system and its cellular environment. BMC Genomics (2017) 0.75
Ret is critical for podocyte survival following glomerular injury in vivo. Am J Physiol Renal Physiol (2015) 0.75
Ape1/Ref-1 Stimulates GDNF/GFRalpha1-mediated Downstream Signaling and Neuroblastoma Proliferation. Korean J Physiol Pharmacol (2009) 0.75
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev Biol (2001) 31.56
Guidelines for reporting experiments involving animals: the ARRIVE guidelines. Br J Pharmacol (2010) 13.76
Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature (1991) 10.30
The Complex Carbohydrate Structure Database. Trends Biochem Sci (1989) 9.00
A novel phenotypic drug susceptibility assay for human immunodeficiency virus type 1. Antimicrob Agents Chemother (2000) 8.54
Oral lesions in sheep and cattle in Dumfries and Galloway. Vet Rec (2001) 7.78
The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation. Nature (1999) 7.66
The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation. Cell (1997) 6.10
Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature (2000) 5.86
Altered fidelity of mitotic chromosome transmission in cell cycle mutants of S. cerevisiae. Genetics (1985) 5.75
Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret. Nature (1994) 5.61
Regulation of cell fate decision of undifferentiated spermatogonia by GDNF. Science (2000) 5.44
Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization. Nucleic Acids Res (1985) 5.22
The extent of Down's syndrome screening in Britain in 1991. Lancet (1992) 5.20
Maternal serum screening for Down's syndrome: the effect of routine ultrasound scan determination of gestational age and adjustment for maternal weight. Br J Obstet Gynaecol (1992) 5.11
Control of acid resistance in Escherichia coli. J Bacteriol (1999) 4.93
Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus. Nature (1986) 4.70
Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice. Nature (1990) 4.53
A good practice guide to the administration of substances and removal of blood, including routes and volumes. J Appl Toxicol (2001) 4.39
Single-molecule studies of DNA mechanics. Curr Opin Struct Biol (2000) 4.39
Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats. J Clin Invest (1987) 4.26
Analysis of yeast protein kinases using protein chips. Nat Genet (2000) 3.94
Transcriptional activation functions in BRCA2. Nature (1997) 3.86
Defects in enteric innervation and kidney development in mice lacking GDNF. Nature (1996) 3.82
Classification, nomenclature, and database development for hepatitis C virus (HCV) and related viruses: proposals for standardization. International Committee on Virus Taxonomy. Arch Virol (1998) 3.77
Transgenic mice expressing a human poliovirus receptor: a new model for poliomyelitis. Cell (1990) 3.70
Developmental regulation of a cloned adult beta-globin gene in transgenic mice. Nature (1985) 3.63
Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion. EMBO J (1994) 3.60
Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation. Cell (1999) 3.58
Bone lead as a biological marker in epidemiologic studies of chronic toxicity: conceptual paradigms. Environ Health Perspect (1998) 3.51
Multiple promoters direct tissue-specific expression of the rat BDNF gene. Neuron (1993) 3.44
Assessment of commercial laboratories performing hair mineral analysis. JAMA (2001) 3.42
Introduction of a mu immunoglobulin gene into the mouse germ line: specific expression in lymphoid cells and synthesis of functional antibody. Cell (1984) 3.24
Temperate Bacteriophage Which Causes the Production of a New Major Outer Membrane Protein by Escherichia coli. J Virol (1975) 3.11
An embryonic pattern of expression of a human fetal globin gene in transgenic mice. Nature (1986) 3.07
The medial ganglionic eminence gives rise to a population of early neurons in the developing cerebral cortex. J Neurosci (1999) 3.03
Haplotype and phenotype analysis of six recurrent BRCA1 mutations in 61 families: results of an international study. Am J Hum Genet (1996) 2.97
In vivo formation of 8-iso-prostaglandin f2alpha and platelet activation in diabetes mellitus: effects of improved metabolic control and vitamin E supplementation. Circulation (1999) 2.90
Distinct mechanism for antidepressant activity by blockade of central substance P receptors. Science (1998) 2.83
Introduction of a rabbit beta-globin gene into the mouse germ line. Nature (1981) 2.82
Specific expression of a foreign beta-globin gene in erythroid cells of transgenic mice. Nature (1985) 2.79
Development of hematopoietic cells lacking transcription factor GATA-1. Development (1995) 2.78
The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins. Mol Biol Cell (1999) 2.75
Retrohoming of a bacterial group II intron: mobility via complete reverse splicing, independent of homologous DNA recombination. Cell (1998) 2.74
Expression of the c-ret proto-oncogene during mouse embryogenesis. Development (1993) 2.74
AIDS and self-organization among intravenous drug users. Int J Addict (1987) 2.73
Rescue of erythroid development in gene targeted GATA-1- mouse embryonic stem cells. Nat Genet (1992) 2.66
The National Health Service needs a voice of its own. J R Soc Med (2000) 2.65
Accreditation in transoesophageal echocardiography: statement from the Association of Cardiothoracic Anaesthetists and the British Society of Echocardiography Joint TOE Accreditation Committee. Br J Anaesth (2003) 2.64
A functional mitotic spindle prepared from mammalian cells in culture. Proc Natl Acad Sci U S A (1974) 2.64
Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate. EMBO J (1990) 2.52
Retrotransposition of a bacterial group II intron. Nature (2000) 2.51
Psychological interventions to improve adherence to oral hygiene instructions in adults with periodontal diseases. Cochrane Database Syst Rev (2007) 2.47
Cancer. Gene losses in human tumours. Nature (1988) 2.41
Additional educational needs in children born to mothers with epilepsy. J Neurol Neurosurg Psychiatry (2001) 2.40
Serum screening for Down's syndrome between 8 and 14 weeks of pregnancy. International Prenatal Screening Research Group. Br J Obstet Gynaecol (1996) 2.40
Treatment of advanced breast cancer with sterically stabilized liposomal doxorubicin: results of a multicenter phase II trial. J Clin Oncol (1997) 2.39
Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain. J Biol Chem (1999) 2.38
Prognostic indicators for AIDS and infectious disease death in HIV-infected injection drug users: plasma viral load and CD4+ cell count. JAMA (1998) 2.37
Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization. J Cell Biol (1999) 2.36
A nested-PCR-based schizodeme method for identifying Leishmania kinetoplast minicircle classes directly from clinical samples and its application to the study of the epidemiology of Leishmania tropica in Pakistan. J Clin Microbiol (1998) 2.35
Amino acid sequence of the alpha subunit of transducin deduced from the cDNA sequence. Proc Natl Acad Sci U S A (1985) 2.34
Expression of green fluorescent protein in the ureteric bud of transgenic mice: a new tool for the analysis of ureteric bud morphogenesis. Dev Genet (1999) 2.34
Patterns of differentiation and hybridization in North American wolflike canids, revealed by analysis of microsatellite loci. Mol Biol Evol (1994) 2.28
Hormone receptors: studies on the interaction of estrogen with the uterus. Recent Prog Horm Res (1968) 2.28
Identification of Harper-Cawston factor as thymidine phosphorylase and removal from media of substances interfering with susceptibility testing to sulfonamides and diaminopyrimidines. Antimicrob Agents Chemother (1975) 2.22
Severe adverse life events and depressive symptoms among women with, or at risk for, HIV infection in four cities in the United States of America. AIDS (1999) 2.20
The natural history of treated and untreated primary hyperparathyroidism: the parathyroid epidemiology and audit research study. QJM (2011) 2.20
Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis. Genes Dev (1996) 2.18
Randomized phase II study of two gemcitabine schedules for patients with impaired performance status (Karnofsky performance status </= 70) and advanced non-small-cell lung cancer. J Clin Oncol (2005) 2.17
Familial cancer syndromes. Lancet (1994) 2.16
An association between type 1 diabetes and idiopathic generalized epilepsy. Ann Neurol (2006) 2.15
Measurement and characterization of postischemic free radical generation in the isolated perfused heart. J Biol Chem (1989) 2.14
Observations in the Haight-Ashbury Medical Clinic of San Francisco. Health problems in a "hippie" subculture. Clin Pediatr (Phila) (1968) 2.12
Functional receptor for GDNF encoded by the c-ret proto-oncogene. Nature (1996) 2.09
Ribonuclease P: function and variation. J Biol Chem (1990) 2.07
National Confidential Enquiry into counselling for genetic disorders by non-geneticists: general recommendations and specific standards for improving care. Br J Obstet Gynaecol (1999) 2.06
Glial-cell-line-derived neurotrophic factor is required for bud initiation from ureteric epithelium. Development (1997) 2.05
Biological properties of a CD4 immunoadhesin. Nature (1990) 2.05
Differential distribution of 5HT1D- and 5HT1B-immunoreactivity within the human trigemino-cerebrovascular system: implications for the discovery of new antimigraine drugs. Cephalalgia (1997) 1.99
Insulin resistance in uremia. J Clin Invest (1981) 1.98
Renal agenesis and hypodysplasia in ret-k- mutant mice result from defects in ureteric bud development. Development (1996) 1.96
A transgenic immunoglobulin mu gene prevents rearrangement of endogenous genes. Cell (1985) 1.96
An outcome analysis of 100 women after explantation of silicone gel breast implants. Ann Plast Surg (1997) 1.93
A 3' enhancer contributes to the stage-specific expression of the human beta-globin gene. Genes Dev (1987) 1.91
Effect of treatment with cyclosporine versus azathioprine on incidence and severity of cytomegalovirus infection posttransplantation. Transplantation (1985) 1.90
Classifying general medicine readmissions. Are they preventable? Veterans Affairs Cooperative Studies in Health Services Group on Primary Care and Hospital Readmissions. J Gen Intern Med (1996) 1.89
A prospective study of neurofibromatosis type 1 cancer incidence in the UK. Br J Cancer (2006) 1.86
Upstream G gamma-globin and downstream beta-globin sequences required for stage-specific expression in transgenic mice. Mol Cell Biol (1987) 1.86
Control of oxidative metabolism and oxygen delivery in human skeletal muscle: a steady-state analysis of the work/energy cost transfer function. Proc Natl Acad Sci U S A (1985) 1.86
Circadian regulation of cAMP response element-mediated gene expression in the suprachiasmatic nuclei. J Biol Chem (1999) 1.85
Detection of breast cancer micrometastases in axillary lymph nodes by using polymerase chain reaction. Cancer Res (1994) 1.84
Coronary angioplasty versus medical therapy for angina. Health service costs based on the second Randomized Intervention Treatment of Angina (RITA-2) trial. Eur Heart J (2002) 1.83
Comparison of the effectiveness of inhaler devices in asthma and chronic obstructive airways disease: a systematic review of the literature. Health Technol Assess (2001) 1.82
Identifying and separating the effects of practice and of cognitive ageing during a large longitudinal study of elderly community residents. Neuropsychologia (2001) 1.81
Relationship of clinical diabetes and asymptomatic hyperglycemia to risk of coronary heart disease mortality in men and women. Am J Epidemiol (1986) 1.80
A novel addition to the T cell repertory. Cell surface expression of tumor necrosis factor/cachectin by activated normal human T cells. J Exp Med (1990) 1.80