Published in J Biol Chem on July 05, 1996
A functional genomic screen identifies cellular cofactors of hepatitis C virus replication. Cell Host Microbe (2009) 4.24
BDNF-induced TrkB activation down-regulates the K+-Cl- cotransporter KCC2 and impairs neuronal Cl- extrusion. J Cell Biol (2002) 2.40
Two developmental switches in GABAergic signalling: the K+-Cl- cotransporter KCC2 and carbonic anhydrase CAVII. J Physiol (2004) 2.11
KCC2 expression promotes the termination of cortical interneuron migration in a voltage-sensitive calcium-dependent manner. Neuron (2009) 2.08
Disrupted dentate granule cell chloride regulation enhances synaptic excitability during development of temporal lobe epilepsy. J Neurosci (2007) 2.00
Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family. Pflugers Arch (2003) 1.69
NMDA receptor activity downregulates KCC2 resulting in depolarizing GABAA receptor-mediated currents. Nat Neurosci (2011) 1.65
Expression of GABA signaling molecules KCC2, NKCC1, and GAD1 in cortical development and schizophrenia. J Neurosci (2011) 1.61
The thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKs. Am J Physiol Renal Physiol (2009) 1.58
Altered chloride homeostasis removes synaptic inhibitory constraint of the stress axis. Nat Neurosci (2009) 1.58
Regulation of K-Cl cotransport: from function to genes. J Membr Biol (2004) 1.52
Cation-chloride cotransporters in neuronal development, plasticity and disease. Nat Rev Neurosci (2014) 1.50
Metabolic and hemodynamic events after changes in neuronal activity: current hypotheses, theoretical predictions and in vivo NMR experimental findings. J Cereb Blood Flow Metab (2008) 1.47
Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2. Proc Natl Acad Sci U S A (2009) 1.45
The Na-K-Cl cotransporters. J Bioenerg Biomembr (1998) 1.45
Loss of K-Cl co-transporter KCC3 causes deafness, neurodegeneration and reduced seizure threshold. EMBO J (2003) 1.42
GABAA receptors at hippocampal mossy fibers. Neuron (2003) 1.41
The K+-Cl cotransporter KCC2 promotes GABAergic excitation in the mature rat hippocampus. J Physiol (2010) 1.36
Shift from depolarizing to hyperpolarizing glycine action in rat auditory neurones is due to age-dependent Cl- regulation. J Physiol (1999) 1.33
NKCC1 cotransporter inactivation underlies embryonic development of chloride-mediated inhibition in mouse spinal motoneuron. J Physiol (2007) 1.26
KCC2 expression in immature rat cortical neurons is sufficient to switch the polarity of GABA responses. Eur J Neurosci (2005) 1.25
An efficient DNA sequencing strategy based on the bacteriophage mu in vitro DNA transposition reaction. Genome Res (1999) 1.23
Phosphoregulation of the Na-K-2Cl and K-Cl cotransporters by the WNK kinases. Biochim Biophys Acta (2010) 1.22
Modulation of neuronal activity by phosphorylation of the K-Cl cotransporter KCC2. Trends Neurosci (2013) 1.20
Molecular physiology of SPAK and OSR1: two Ste20-related protein kinases regulating ion transport. Physiol Rev (2012) 1.18
Role of the neuronal K-Cl co-transporter KCC2 in inhibitory and excitatory neurotransmission. Front Cell Neurosci (2012) 1.15
Activation of 5-HT2A receptors upregulates the function of the neuronal K-Cl cotransporter KCC2. Proc Natl Acad Sci U S A (2012) 1.12
Altered expression of regulators of the cortical chloride transporters NKCC1 and KCC2 in schizophrenia. Arch Gen Psychiatry (2010) 1.11
Sexually dimorphic expression of KCC2 and GABA function. Epilepsy Res (2008) 1.10
Microglia control neuronal network excitability via BDNF signalling. Neural Plast (2013) 1.08
The potassium chloride cotransporter KCC-2 coordinates development of inhibitory neurotransmission and synapse structure in Caenorhabditis elegans. J Neurosci (2009) 1.03
Physiology of SLC12 transporters: lessons from inherited human genetic mutations and genetically engineered mouse knockouts. Am J Physiol Cell Physiol (2013) 1.01
Novel repression of Kcc2 transcription by REST-RE-1 controls developmental switch in neuronal chloride. J Neurosci (2009) 1.01
Coexpression and heteromerization of two neuronal K-Cl cotransporter isoforms in neonatal brain. J Biol Chem (2009) 1.00
Molecular and functional expression of cation-chloride cotransporters in dorsal root ganglion neurons during postnatal maturation. J Neurophysiol (2012) 0.98
Altered inhibition in tuberous sclerosis and type IIb cortical dysplasia. Ann Neurol (2012) 0.98
NKCC1 upregulation disrupts chloride homeostasis in the hypothalamus and increases neuronal activity-sympathetic drive in hypertension. J Neurosci (2012) 0.97
GABA is excitatory in adult vasopressinergic neuroendocrine cells. J Neurosci (2012) 0.96
Developmental hearing loss disrupts synaptic inhibition: implications for auditory processing. Future Neurol (2009) 0.96
Hyperpolarizing inhibition develops without trophic support by GABA in cultured rat midbrain neurons. J Physiol (2003) 0.95
Wrong-way chloride transport: is it a treatable cause of some intractable seizures? Epilepsy Curr (2007) 0.95
Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: development of a highly selective and more potent in vitro probe. Bioorg Med Chem Lett (2012) 0.95
Mutagenic mapping of the Na-K-Cl cotransporter for domains involved in ion transport and bumetanide binding. J Gen Physiol (1998) 0.95
Factors defining a pacemaker region for synchrony in the hippocampus. J Physiol (2007) 0.94
Novel determinants of the neuronal Cl(-) concentration. J Physiol (2014) 0.94
Role of an apical K,Cl cotransporter in urine formation by renal tubules of the yellow fever mosquito (Aedes aegypti). Am J Physiol Regul Integr Comp Physiol (2011) 0.92
The potassium-chloride cotransporter 2 promotes cervical cancer cell migration and invasion by an ion transport-independent mechanism. J Physiol (2011) 0.92
Development of epileptiform excitability in the deep entorhinal cortex after status epilepticus. Eur J Neurosci (2009) 0.90
GABA(A) receptors in normal development and seizures: friends or foes? Curr Neuropharmacol (2008) 0.90
Postnatal development of Na(+)-K(+)-2Cl(-) co-transporter 1 and K(+)-Cl(-) co-transporter 2 immunoreactivity in multiple brain stem respiratory nuclei of the rat. Neuroscience (2012) 0.89
Taurine inhibits K+-Cl- cotransporter KCC2 to regulate embryonic Cl- homeostasis via with-no-lysine (WNK) protein kinase signaling pathway. J Biol Chem (2012) 0.89
Chronic stress shifts the GABA reversal potential in the hippocampus and increases seizure susceptibility. Epilepsy Res (2014) 0.89
Components of neuronal chloride transport in rat and human neocortex. J Physiol (2011) 0.88
The role of transmembrane domain 2 in cation transport by the Na-K-Cl cotransporter. Proc Natl Acad Sci U S A (1998) 0.87
Differences in the large extracellular loop between the K(+)-Cl(-) cotransporters KCC2 and KCC4. J Biol Chem (2010) 0.87
Enhanced Synaptic Activity and Epileptiform Events in the Embryonic KCC2 Deficient Hippocampus. Front Cell Neurosci (2011) 0.86
Characteristics of the cation cotransporter NKCC1 in human brain: alternate transcripts, expression in development, and potential relationships to brain function and schizophrenia. J Neurosci (2014) 0.86
GABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor-associated epilepsy. Glia (2014) 0.85
Differential distribution of the KCl cotransporter KCC2 in thalamic relay and reticular nuclei. Eur J Neurosci (2004) 0.85
Hyperpolarizing GABAergic transmission requires the KCC2 C-terminal ISO domain. J Neurosci (2012) 0.85
Heterogeneous chloride homeostasis and GABA responses in the median preoptic nucleus of the rat. J Physiol (2005) 0.84
The role of ovarian hormone-derived neurosteroids on the regulation of GABAA receptors in affective disorders. Psychopharmacology (Berl) (2014) 0.84
Theta-bursts induce a shift in reversal potentials for GABA-A receptor-mediated postsynaptic currents in rat hippocampal CA1 neurons. Exp Neurol (2007) 0.84
The emerging role of KCl cotransport in tumor biology. Am J Transl Res (2010) 0.83
Regional differences in the expression of K(+)-Cl(-) 2 cotransporter in the developing rat cortex. Brain Struct Funct (2013) 0.82
Etomidate elevates intracellular calcium levels and promotes catecholamine secretion in bovine chromaffin cells. J Physiol (2004) 0.81
Maturation of the GABAergic transmission in normal and pathologic motoneurons. Neural Plast (2011) 0.81
K-Cl cotransporters, cell volume homeostasis, and neurological disease. Trends Mol Med (2015) 0.81
K-Cl cotransporter KCC2--a moonlighting protein in excitatory and inhibitory synapse development and function. Pflugers Arch (2014) 0.81
Phospholipase C-related but catalytically inactive protein modulates pain behavior in a neuropathic pain model in mice. Mol Pain (2013) 0.80
The K-Cl cotransporter KCC3 as an independent prognostic factor in human esophageal squamous cell carcinoma. Biomed Res Int (2014) 0.80
Functional and molecular characterization of multiple K-Cl cotransporter isoforms in corneal epithelial cells. Exp Eye Res (2007) 0.80
Retracted A plant cation-chloride co-transporter promoting auxin-independent tobacco protoplast division. EMBO J (1997) 0.80
Hyperpolarizing GABAergic transmission depends on KCC2 function and membrane potential. Channels (Austin) (2011) 0.79
Molecular and evolutionary insights into the structural organization of cation chloride cotransporters. Front Cell Neurosci (2015) 0.79
Chloride Homeostasis Critically Regulates Synaptic NMDA Receptor Activity in Neuropathic Pain. Cell Rep (2016) 0.79
Effect of the calcineurin inhibitor FK506 on K+-Cl- cotransporter 2 expression in the mouse hippocampus after kainic acid-induced status epilepticus. J Neural Transm (Vienna) (2011) 0.79
Computational modeling reveals dendritic origins of GABA(A)-mediated excitation in CA1 pyramidal neurons. PLoS One (2012) 0.78
A novel regulatory locus of phosphorylation in the C terminus of the potassium chloride cotransporter KCC2 that interferes with N-ethylmaleimide or staurosporine-mediated activation. J Biol Chem (2014) 0.78
Kinase-KCC2 coupling: Cl- rheostasis, disease susceptibility, therapeutic target. J Neurophysiol (2015) 0.78
Chloride Cotransporters as a Molecular Mechanism underlying Spreading Depolarization-Induced Dendritic Beading. J Neurosci (2015) 0.78
K+-Cl- cotransporter-2 KCC2 in chicken cardiomyocytes. Am J Physiol Cell Physiol (2012) 0.78
Decreased chloride channel expression in the dorsolateral prefrontal cortex in schizophrenia. PLoS One (2015) 0.77
Impaired neuronal KCC2 function by biallelic SLC12A5 mutations in migrating focal seizures and severe developmental delay. Sci Rep (2016) 0.76
Ovariectomy modulation of morphine analgesia of neuropathic pain is associated with the change of K(+)-Cl(-) cotransporter 2 protein level in spinal dorsal horn. Int J Clin Exp Med (2014) 0.76
K-Cl cotransporter gene expression during human and murine erythroid differentiation. J Biol Chem (2011) 0.76
Neuronal chloride regulation via KCC2 is modulated through a GABAB receptor protein complex. J Neurosci (2017) 0.75
Long-range and short-range tumor-stroma networks synergistically contribute to tumor-associated epilepsy. Oncotarget (2016) 0.75
K+-Cl- cotransport: 'to be or not to be' oxygen sensitive. J Physiol (1998) 0.75
Regulation of Neuronal Activity in Hypothalamic Vasopressin Neurons. Interdiscip Inf Sci (2015) 0.75
A noninvasive optical approach for assessing chloride extrusion activity of the K-Cl cotransporter KCC2 in neuronal cells. BMC Neurosci (2017) 0.75
Solute carrier family 12 member 5 promotes tumor invasion/metastasis of bladder urothelial carcinoma by enhancing NF-κB/MMP-7 signaling pathway. Cell Death Dis (2017) 0.75
Effects of essential amino acid deficiency: down-regulation of KCC2 and the GABAA receptor; disinhibition in the anterior piriform cortex. J Neurochem (2013) 0.75
Compromising KCC2 transporter activity enhances the development of continuous seizure activity. Neuropharmacology (2016) 0.75
Non-linear leak currents affect mammalian neuron physiology. Front Cell Neurosci (2015) 0.75
A kainate receptor subunit promotes the recycling of the neuron-specific K(+)-Cl(-) co-transporter KCC2 in hippocampal neurons. J Biol Chem (2017) 0.75
Preferential activation of HIF-2α adaptive signalling in neuronal-like cells in response to acute hypoxia. PLoS One (2017) 0.75
Molecular cloning and biochemical characterization of two cation chloride cotransporter subfamily members of Hydra vulgaris. PLoS One (2017) 0.75
Sometimes you see them, sometimes you don't: IPSCs in the rat superficial superior colliculus. Exp Brain Res (2003) 0.75
Postural responses to unilateral arm perturbation in young, elderly, and hemiplegic subjects. Arch Phys Med Rehabil (1997) 1.13
Cyclooxygenase-1 is a marker for a subpopulation of putative nociceptive neurons in rat dorsal root ganglia. Eur J Neurosci (2000) 1.07
Glucocorticoid receptor and NGFI-A gene expression are induced in the hippocampus after environmental enrichment in adult rats. Brain Res Mol Brain Res (1994) 0.92
Unilateral arthritis: contralateral effects. Trends Neurosci (1999) 0.88
Spontaneous firing in C-fibers and increased mechanical sensitivity in A-fibers of knee joint-associated mechanoreceptive primary afferent neurones during MIA-induced osteoarthritis in the rat. Osteoarthritis Cartilage (2012) 0.88
Transcription factor AP-2 gene expression in adult rat hippocampal regions: effects of environmental manipulations. Neurosci Lett (1995) 0.87
Ovarian VEGF(165)b expression regulates follicular development, corpus luteum function and fertility. Reproduction (2012) 0.83
Specific testicular cellular localization and hormonal regulation of the PKIalpha and PKIbeta isoforms of the inhibitor protein of the cAMP-dependent protein kinase. J Biol Chem (1997) 0.83
Transient receptor potential channel A1 and noxious cold responses in rat cutaneous nociceptors. Neuroscience (2009) 0.82
Identification of a prostaglandin E2 receptor splice variant and its expression in rat tissues. Prostaglandins Other Lipid Mediat (2001) 0.80
Effects of acute abstinence and nicotine administration on taste perception in cigarette smokers. J Psychopharmacol (2009) 0.78
The changing face of public health. Br J Hosp Med (1990) 0.75
The dust distribution within the inner coma of comet P/Halley 1982i: encounter by Giotto's impact detectors. Astron Astrophys (1987) 0.75