Published in Genomics on September 20, 1995
Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. Am J Hum Genet (2003) 21.52
Linkage disequilibrium in humans: models and data. Am J Hum Genet (2001) 14.97
Genetic signatures of strong recent positive selection at the lactase gene. Am J Hum Genet (2004) 11.90
A fine-scale linkage-disequilibrium measure based on length of haplotype sharing. Am J Hum Genet (2006) 6.02
GERBIL: Genotype resolution and block identification using likelihood. Proc Natl Acad Sci U S A (2004) 4.36
Mapping trait loci by use of inferred ancestral recombination graphs. Am J Hum Genet (2006) 4.01
Novel multilocus measure of linkage disequilibrium to estimate past effective population size. Genome Res (2003) 3.83
Extent and distribution of linkage disequilibrium in three genomic regions. Am J Hum Genet (2000) 3.68
Leveraging the HapMap correlation structure in association studies. Am J Hum Genet (2007) 3.57
A highly significant association between a COMT haplotype and schizophrenia. Am J Hum Genet (2002) 3.52
Population substructure and control selection in genome-wide association studies. PLoS One (2008) 3.44
Linkage-disequilibrium mapping of disease genes by reconstruction of ancestral haplotypes in founder populations. Am J Hum Genet (1999) 3.16
A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities. Nat Genet (2005) 3.15
Homozygosity and linkage disequilibrium. Genetics (2002) 3.04
Genome screens using linkage disequilibrium tests: optimal marker characteristics and feasibility. Am J Hum Genet (1998) 2.86
Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing. J Clin Invest (1997) 2.85
A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. Nat Genet (2010) 2.81
Genetic epidemiology of single-nucleotide polymorphisms. Proc Natl Acad Sci U S A (1999) 2.81
Evidence of a large-scale functional organization of mammalian chromosomes. PLoS Genet (2005) 2.73
Complete sequencing shows a role for MSX1 in non-syndromic cleft lip and palate. J Med Genet (2003) 2.72
Screen and clean: a tool for identifying interactions in genome-wide association studies. Genet Epidemiol (2010) 2.70
Common genetic variants, acting additively, are a major source of risk for autism. Mol Autism (2012) 2.67
Chapter 11: Genome-wide association studies. PLoS Comput Biol (2012) 2.46
The genetic architecture of response to long-term artificial selection for oil concentration in the maize kernel. Genetics (2004) 2.45
The optimal measure of allelic association. Proc Natl Acad Sci U S A (2001) 2.41
Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus. Nat Genet (2007) 2.38
Rapid and accurate multiple testing correction and power estimation for millions of correlated markers. PLoS Genet (2009) 2.30
The effect that genotyping errors have on the robustness of common linkage-disequilibrium measures. Am J Hum Genet (2001) 2.29
Biases and reconciliation in estimates of linkage disequilibrium in the human genome. Am J Hum Genet (2006) 2.26
Linkage disequilibrium and allele-frequency distributions for 114 single-nucleotide polymorphisms in five populations. Am J Hum Genet (2000) 2.25
VALID: visualization of association study results and linkage disequilibrium. Genet Epidemiol (2009) 2.18
Extent of genome-wide linkage disequilibrium in Australian Holstein-Friesian cattle based on a high-density SNP panel. BMC Genomics (2008) 2.16
Localization of a small genomic region associated with elevated ACE. Am J Hum Genet (2000) 2.13
Characterizing linkage disequilibrium in pig populations. Int J Biol Sci (2007) 2.10
Hierarchical modeling of linkage disequilibrium: genetic structure and spatial relations. Am J Hum Genet (2003) 2.05
The extent of linkage disequilibrium in four populations with distinct demographic histories. Am J Hum Genet (2000) 2.03
Variation in the interleukin 4-receptor alpha gene confers susceptibility to asthma and atopy in ethnically diverse populations. Am J Hum Genet (2000) 1.94
Sequence variation and linkage disequilibrium in the human T-cell receptor beta (TCRB) locus. Am J Hum Genet (2001) 1.91
Lower-than-expected linkage disequilibrium between tightly linked markers in humans suggests a role for gene conversion. Am J Hum Genet (2001) 1.80
Comprehensive analysis of APOE and selected proximate markers for late-onset Alzheimer's disease: patterns of linkage disequilibrium and disease/marker association. Genomics (2007) 1.78
Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. Am J Obstet Gynecol (2010) 1.75
Prospects for association mapping in classical inbred mouse strains. Genetics (2007) 1.71
Linkage disequilibrium decay and haplotype block structure in the pig. Genetics (2008) 1.71
Efficient selection of tagging single-nucleotide polymorphisms in multiple populations. Hum Genet (2006) 1.66
Genetics of the Framingham Heart Study population. Adv Genet (2008) 1.62
Genetic variation in the 22q11 locus and susceptibility to schizophrenia. Proc Natl Acad Sci U S A (2002) 1.60
Haplotype fine mapping by evolutionary trees. Am J Hum Genet (2000) 1.57
SNP-SNP interactions in breast cancer susceptibility. BMC Cancer (2006) 1.56
Successful design and conduct of genome-wide association studies. Hum Mol Genet (2007) 1.55
Comparison of linkage disequilibrium and haplotype diversity on macro- and microchromosomes in chicken. BMC Genet (2009) 1.52
Mathematical properties of the r2 measure of linkage disequilibrium. Theor Popul Biol (2008) 1.51
Association of IRF5 in UK SLE families identifies a variant involved in polyadenylation. Hum Mol Genet (2006) 1.51
JLIN: a java based linkage disequilibrium plotter. BMC Bioinformatics (2006) 1.51
Analysis of European mtDNAs for recombination. Am J Hum Genet (2000) 1.51
Whole genome scan detects an allelic variant of fad2 associated with increased oleic acid levels in maize. Mol Genet Genomics (2007) 1.50
Estimation of linkage disequilibrium in four US pig breeds. BMC Genomics (2012) 1.50
Developmentally restricted genetic determinants of human arsenic metabolism: association between urinary methylated arsenic and CYT19 polymorphisms in children. Environ Health Perspect (2005) 1.49
Association of the gene encoding wingless-type mammary tumor virus integration-site family member 5B (WNT5B) with type 2 diabetes. Am J Hum Genet (2004) 1.49
Association of IL10 and other immune response- and obesity-related genes with prostate cancer in CLUE II. Prostate (2009) 1.45
Beta 2-adrenergic receptor polymorphisms: pharmacogenetic response to bronchodilator among African American asthmatics. Hum Genet (2006) 1.43
A high-density SNP genomewide linkage scan for chronic lymphocytic leukemia-susceptibility loci. Am J Hum Genet (2005) 1.43
Nucleotide diversity and haplotype structure of the human angiotensinogen gene in two populations. Am J Hum Genet (2001) 1.43
Genetic variation in the one-carbon transfer pathway and ovarian cancer risk. Cancer Res (2008) 1.42
SNPs for a universal individual identification panel. Hum Genet (2010) 1.42
Genome-wide haplotype changes produced by artificial selection during modern rice breeding in Japan. PLoS One (2012) 1.42
beta(2)-adrenergic receptor promoter haplotype influences spirometric response during an acute asthma exacerbation. Clin Transl Sci (2008) 1.41
Application of association mapping to understanding the genetic diversity of plant germplasm resources. Int J Plant Genomics (2008) 1.40
Candidate SNPs for a universal individual identification panel. Hum Genet (2007) 1.39
Polymorphisms in the VKORC1 gene are strongly associated with warfarin dosage requirements in patients receiving anticoagulation. J Med Genet (2006) 1.38
A single nucleotide polymorphism within the acetyl-coenzyme A carboxylase beta gene is associated with proteinuria in patients with type 2 diabetes. PLoS Genet (2010) 1.38
Increasing power in association studies by using linkage disequilibrium structure and molecular function as prior information. Genome Res (2008) 1.37
Oestrogen receptor alpha gene haplotype and postmenopausal breast cancer risk: a case control study. Breast Cancer Res (2004) 1.36
Fine mapping of complex trait genes combining pedigree and linkage disequilibrium information: a Bayesian unified framework. Genetics (2003) 1.34
Recombination in human mitochondrial DNA? Genetics (2001) 1.32
Genetic variation in APOL1 and MYH9 genes is associated with chronic kidney disease among Nigerians. Int Urol Nephrol (2012) 1.32
Haplotype analysis of hemochromatosis: evaluation of different linkage-disequilibrium approaches and evolution of disease chromosomes. Am J Hum Genet (1997) 1.31
Haplotype diversity in four genes (CLCNKA, CLCNKB, BSND, NEDD4L) involved in renal salt reabsorption. Hum Hered (2007) 1.30
Integration of association statistics over genomic regions using Bayesian adaptive regression splines. Hum Genomics (2003) 1.28
Significant association of a M129V independent polymorphism in the 5' UTR of the PRNP gene with sporadic Creutzfeldt-Jakob disease in a large German case-control study. J Med Genet (2006) 1.28
Estimating heritability of complex traits from genome-wide association studies using IBS-based Haseman-Elston regression. Front Genet (2014) 1.28
Polymorphisms in the 3' UTR in the neurocalcin delta gene affect mRNA stability, and confer susceptibility to diabetic nephropathy. Hum Genet (2007) 1.25
Genetic ancestry modifies pharmacogenetic gene-gene interaction for asthma. Pharmacogenet Genomics (2009) 1.24
An isochore transition in the NF1 gene region coincides with a switch in the extent of linkage disequilibrium. Am J Hum Genet (2000) 1.23
SNPAnalyzer: a web-based integrated workbench for single-nucleotide polymorphism analysis. Nucleic Acids Res (2005) 1.23
Ancestral origin of the ATTCT repeat expansion in spinocerebellar ataxia type 10 (SCA10). PLoS One (2009) 1.23
Genetic background of patients from a university medical center in Manhattan: implications for personalized medicine. PLoS One (2011) 1.21
Measuring gametic disequilibrium from multilocus data. Genetics (2001) 1.21
Genetic polymorphisms in arginase I and II and childhood asthma and atopy. J Allergy Clin Immunol (2005) 1.19
IL-6 gene variation is associated with IL-6 and C-reactive protein levels but not cardiovascular outcomes in the Cardiovascular Health Study. Hum Genet (2007) 1.18
Common variants in interleukin-1-Beta gene are associated with intracranial hemorrhage and susceptibility to brain arteriovenous malformation. Cerebrovasc Dis (2008) 1.17
Genetic variation in the rhythmonome: ethnic variation and haplotype structure in candidate genes for arrhythmias. Pharmacogenomics (2009) 1.16
Genetic anthropology of the colorectal cancer-susceptibility allele APC I1307K: evidence of genetic drift within the Ashkenazim. Am J Hum Genet (2003) 1.16
Polymorphisms and haplotypes of the estrogen receptor-beta gene (ESR2) and cardiovascular disease in men and women. Clin Chem (2007) 1.14
Genes at human chromosome 5q31.1 regulate delayed-type hypersensitivity responses associated with Leishmania chagasi infection. Genes Immun (2007) 1.14
Examining the effect of linkage disequilibrium on multipoint linkage analysis. BMC Genet (2005) 1.14
Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants. PLoS One (2008) 1.14
Properties of linkage disequilibrium (LD) maps. Proc Natl Acad Sci U S A (2002) 1.14
Haplotype block structure is conserved across mammals. PLoS Genet (2006) 1.13
Genetic analysis of breast cancer in the cancer and steroid hormone study. Am J Hum Genet (1991) 7.87
Genetic susceptibility to death from coronary heart disease in a study of twins. N Engl J Med (1994) 7.47
A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2. Nat Genet (1996) 6.58
Statistical analysis of multilocus recombination. Biometrics (1983) 6.49
An alternative model of recombination and interference. Ann Hum Genet (1979) 6.26
Assessing the role of HLA-linked and unlinked determinants of disease. Am J Hum Genet (1987) 5.47
Statistical evaluation of DNA fingerprinting: a critique of the NRC's report. Science (1993) 4.79
Autosomal dominant inheritance of early-onset breast cancer. Implications for risk prediction. Cancer (1994) 4.37
High-throughput genotyping with single nucleotide polymorphisms. Genome Res (2001) 3.55
Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups. Am J Hum Genet (2001) 3.51
Bayesian analysis of haplotypes for linkage disequilibrium mapping. Genome Res (2001) 3.49
No excess of homozygosity at loci used for DNA fingerprinting. Science (1990) 3.46
Diminished support for linkage between manic depressive illness and X-chromosome markers in three Israeli pedigrees. Nat Genet (1993) 3.40
A full genome search in multiple sclerosis. Nat Genet (1996) 2.96
Disequilibrium mapping: composite likelihood for pairwise disequilibrium. Genomics (1996) 2.90
Estimating morbidity risks in relatives: the effect of reduced fertility. Behav Genet (1983) 2.90
Segregation analysis incorporating linkage markers. I. Single-locus models with an application to type I diabetes. Am J Hum Genet (1984) 2.74
Localization of a gene for partial epilepsy to chromosome 10q. Nat Genet (1995) 2.72
An association between the risk of cancer and mutations in the HRAS1 minisatellite locus. N Engl J Med (1993) 2.62
Genetic linkage between X-chromosome markers and bipolar affective illness. Nature (1987) 2.44
Spontaneous mutation and parental age in humans. Am J Hum Genet (1987) 2.37
Evaluating genetic association among ovarian, breast, and endometrial cancer: evidence for a breast/ovarian cancer relationship. Am J Hum Genet (1989) 2.37
Screening a large reference sample to identify very low frequency sequence variants: comparisons between two genes. Nat Genet (2001) 2.07
Affected-sib-pair interval mapping and exclusion for complex genetic traits: sampling considerations. Genet Epidemiol (1996) 2.06
The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases. II. Individual genotyping. Genome Res (1999) 2.04
Application of a recombination model in calculating the variance of sib pair genetic identity. Ann Hum Genet (1979) 2.01
Idiopathic dystonia among Ashkenazi Jews: evidence for autosomal dominant inheritance. Ann Neurol (1989) 2.00
Evaluation of a susceptibility gene for schizophrenia on chromosome 6p by multipoint affected sib-pair linkage analysis. Nat Genet (1995) 1.90
Dystonia gene in Ashkenazi Jewish population is located on chromosome 9q32-34. Ann Neurol (1990) 1.89
A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus. Nat Genet (1998) 1.87
The A1 allele at the D2 dopamine receptor gene and alcoholism. A reappraisal. JAMA (1993) 1.83
Male homosexuality: absence of linkage to microsatellite markers at Xq28. Science (1999) 1.78
A manic depressive history. Nat Genet (1996) 1.74
X-linkage and genetic heterogeneity in bipolar-related major affective illness: reanalysis of linkage data. Ann Hum Genet (1982) 1.71
Mode of inheritance of nonsyndromic cleft lip with or without cleft palate: a reanalysis. Am J Hum Genet (1992) 1.66
Association between migraine and stroke in a large-scale epidemiological study of the United States. Arch Neurol (1997) 1.58
No association between an allele at the D2 dopamine receptor gene (DRD2) and alcoholism. JAMA (1991) 1.56
Estimation of morbid risk and age at onset with missing information. Am J Hum Genet (1991) 1.56
Diminished recall and the cohort effect of major depression: a simulation study. Psychol Med (1994) 1.53
Co-morbidity and familial aggregation of alcoholism and anxiety disorders. Psychol Med (1998) 1.52
Human gene for torsion dystonia located on chromosome 9q32-q34. Neuron (1989) 1.51
Lack of evidence for an association between alpha-adducin and blood pressure regulation in Asian populations. Am J Hypertens (2000) 1.51
The calculation of breast cancer risk for women with a first degree family history of ovarian cancer. Breast Cancer Res Treat (1993) 1.50
Relations of genetic and environmental factors in the etiology of epilepsy. Ann Neurol (1996) 1.47
Strong allelic association between the torsion dystonia gene (DYT1) andloci on chromosome 9q34 in Ashkenazi Jews. Am J Hum Genet (1992) 1.46
Risk factors predicting the incidence of second primary breast cancer among women diagnosed with a first primary breast cancer. Am J Epidemiol (1992) 1.42
Autism and the X chromosome. Multipoint sib-pair analysis. Arch Gen Psychiatry (1996) 1.42
The relationship between maternal age and chromosome size in autosomal trisomy. Am J Hum Genet (1986) 1.40
Multilocus linkage of familial hyperkalaemia and hypertension, pseudohypoaldosteronism type II, to chromosomes 1q31-42 and 17p11-q21. Nat Genet (1997) 1.39
Estimation of allele frequencies for VNTR loci. Am J Hum Genet (1991) 1.38
Relationship between breast histopathology and family history of breast cancer. Cancer (1993) 1.38
The genetics of infantile hypertrophic pyloric stenosis. A reanalysis. Am J Dis Child (1993) 1.25
Genetic analysis of vitamin D related genes in Canadian multiple sclerosis patients. Canadian Collaborative Study Group. Neurology (2000) 1.23
Ethnic differentiation at VNTR loci, with special reference to forensic applications. Am J Hum Genet (1992) 1.23
Clinical indicators of genetic susceptibility to epilepsy. Epilepsia (1996) 1.23
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Gaucher disease: the origins of the Ashkenazi Jewish N370S and 84GG acid beta-glucosidase mutations. Am J Hum Genet (2000) 1.09
Tay-Sachs screening in the Jewish Ashkenazi population: DNA testing is the preferred procedure. Am J Med Genet (2001) 1.07
Birth cohort and familial risk of epilepsy: the effect of diminished recall in studies of lifetime prevalence. Am J Epidemiol (1995) 1.07
Absence of linkage and linkage disequilibrium to chromosome 15q11-q13 markers in 139 multiplex families with autism. Am J Med Genet (1999) 1.06
Minimum incidence of primary cervical dystonia in a multiethnic health care population. Neurology (2007) 1.05
Mapping quantitative-trait loci in humans by use of extreme concordant sib pairs: selected sampling by parental phenotypes. Am J Hum Genet (1996) 1.03
Physical properties of VNTR data, and their impact on a test of allelic independence. Am J Hum Genet (1993) 1.03
A note on Hardy-Weinberg equilibrium of VNTR data by using the Federal Bureau of Investigation's fixed-bin method. Am J Hum Genet (1992) 1.02
The effects of reduced fertility, method of ascertainment, and a second unlinked locus on affected sib-pair marker allele sharing. Am J Med Genet (1983) 1.02
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Genetic variation in aldosterone synthase predicts plasma glucose levels. Proc Natl Acad Sci U S A (2001) 0.95
Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response. Clin Pharmacol Ther (2015) 0.93
The glycine allele of a glycine/arginine polymorphism in the beta2-adrenergic receptor gene is associated with essential hypertension in a population of Chinese origin. Am J Hypertens (2001) 0.92
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Inheritance of idiopathic torsion dystonia among Ashkenazi Jews. Adv Neurol (1988) 0.91
Lack of association of the angiotensinogen-6 polymorphism with blood pressure levels in the comprehensive NHLBI Family Blood Pressure Program. National Heart, Lung and Blood Institute. J Hypertens (2000) 0.91
Influence of dietary fat, apolipoprotein E phenotype, and sex on plasma lipoprotein levels. Circulation (1992) 0.89
A multigenerational family with multiple sclerosis. Brain (2002) 0.89
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Fine localization of the torsion dystonia gene (DYT1) on human chromosome 9q34: YAC map and linkage disequilibrium. Genome Res (1997) 0.87
Genetic variation in the human urea transporter-2 is associated with variation in blood pressure. Hum Mol Genet (2001) 0.87
Segregation analysis of cryptogenic epilepsy and an empirical test of the validity of the results. Am J Hum Genet (1997) 0.86
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Bacteriochlorophyll cs, a new bacteriochlorophyll from Chloroflexus aurantiacus. Arch Microbiol (1978) 0.85
Haemochromatosis, HFE and genetic complexity. Nat Genet (1997) 0.85
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Age at onset in bipolar-related major affective illness: clinical and genetic implications. J Psychiatr Res (1983) 0.84
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