Extensive polymorphisms observed in HIV-1 clade B protease gene using high-density oligonucleotide arrays.

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Published in Nat Med on July 01, 1996

Authors

M J Kozal1, N Shah, N Shen, R Yang, R Fucini, T C Merigan, D D Richman, D Morris, E Hubbell, M Chee, T R Gingeras

Author Affiliations

1: Department of Molecular Biology, Affymetrix, Santa Clara, California 95051, USA.

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On-line computer quality control of antibiotic-sensitivity testing. N Engl J Med (1970) 2.88

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Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1. J Clin Invest (1991) 2.82

Effect of human leukocyte interferon on hepatitis B virus infection in patients with chronic active hepatitis. N Engl J Med (1976) 2.80

Inhibition of TRIC agents by virus-induced interferon. Proc Soc Exp Biol Med (1966) 2.78

Transplantation of umbilical cord blood after myeloablative therapy: analysis of engraftment. Blood (1992) 2.77

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Discrepant legacies: premature mortality in two industrial towns. Soc Sci Med (1991) 2.62

Physical properties of human interferon prepared in vitro and in vivo. Virology (1966) 2.62